Entry
Name
Spliceosome - Raphanus sativus (radish)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Raphanus sativus (radish) [GN:
rsz ]
Gene
108862430 probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820 ] [EC:5.6.2.6 ]
108847518 probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH3 isoform X1 [KO:K12820 ] [EC:5.6.2.6 ]
130510198 probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH3 isoform X1 [KO:K12820 ] [EC:5.6.2.6 ]
108811619 LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093 ]
130494460 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
130507913 U2 small nuclear ribonucleoprotein B''-like isoform X1 [KO:K11094 ]
108813428 LOW QUALITY PROTEIN: splicing factor U2af large subunit B [KO:K12837 ]
130494382 DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840 ]
108836638 U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662 ]
108849140 U4/U6 small nuclear ribonucleoprotein PRP4-like protein isoform X1 [KO:K12662 ]
108850826 U4/U6 small nuclear ribonucleoprotein Prp31 homolog isoform X1 [KO:K12844 ]
108817792 LOW QUALITY PROTEIN: uncharacterized protein LOC108817792 [KO:K12846 ]
108820587 110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852 ]
108861027 110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852 ]
130496996 110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852 ]
108806902 LOW QUALITY PROTEIN: cell division cycle 5-like protein [KO:K12860 ]
108831768 LOW QUALITY PROTEIN: zinc finger CCCH domain-containing protein 25-like [KO:K12872 ]
108863353 glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741 ]
108861621 glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741 ]
130501417 glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741 ]
108806208 serine/arginine-rich splicing factor SR34A isoform X1 [KO:K12890 ]
108813187 serine/arginine-rich splicing factor RS31A isoform X1 [KO:K12893 ]
108859667 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor RS31 [KO:K12893 ]
108863324 serine/arginine-rich splicing factor RS2Z32 isoform X1 [KO:K12896 ]
108818072 serine/arginine-rich splicing factor RS2Z32 isoform X2 [KO:K12896 ]
108843904 serine/arginine-rich splicing factor RS2Z33 isoform X1 [KO:K12896 ]
108853868 serine/arginine-rich splicing factor RSZ22 isoform X1 [KO:K12896 ]
108810847 serine/arginine-rich splicing factor RSZ21 isoform X1 [KO:K12896 ]
108836064 serine/arginine-rich splicing factor RS2Z33 isoform X1 [KO:K12896 ]
108859230 serine/arginine-rich splicing factor RS2Z33 isoform X1 [KO:K12896 ]
108842431 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor SR45a [KO:K12897 ]
108857126 serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900 ]
108806084 serine/arginine-rich SC35-like splicing factor SCL30A isoform X1 [KO:K12900 ]
108808641 serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900 ]
130494347 serine/arginine-rich SC35-like splicing factor SCL30A isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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