KEGG   PATHWAY: rno05022
Entry
rno05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Rattus norvegicus (rat)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
rno05022  Pathways of neurodegeneration - multiple diseases
rno05022

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
54226  App; amyloid-beta precursor protein precursor [KO:K04520]
29477  Mapt; microtubule-associated protein tau [KO:K04380]
29219  Snca; alpha-synuclein [KO:K04528]
298648  Tardbp; TAR DNA-binding protein 43 isoform 2 [KO:K23600]
317385  Fus; RNA-binding protein FUS [KO:K13098]
501526  Fusl1; RNA-binding protein FUS-like [KO:K13098]
24786  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
288663  Atxn2; ataxin-2 [KO:K23625]
361649  Atxn2l; ataxin-2-like protein isoform 1 [KO:K23625]
29424  Htt; huntingtin [KO:K04533]
103694328  Atxn1l; ataxin-1-like [KO:K23616]
25049  Atxn1; ataxin-1 [KO:K23616]
60331  Atxn3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
24686  Prnp; major prion protein precursor [KO:K05634]
25229  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
24260  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
53949  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
29211  Sptbn2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
24414  Grm1; metabotropic glutamate receptor 1 isoform alpha precursor [KO:K04603]
24418  Grm5; metabotropic glutamate receptor 5 precursor [KO:K04604]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
56816  Prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
60395  Trpc3; short transient receptor potential channel 3 [KO:K04966]
29336  Sigmar1; sigma non-opioid intracellular receptor 1 [KO:K20719]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114207  Ryr1; ryanodine receptor 1 [KO:K04961]
689560  Ryr2; ryanodine receptor 2 isoform 1 [KO:K04962]
170546  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
29190  Pdyn; proenkephalin-B preproprotein [KO:K15840]
29495  Dlg4; disks large homolog 4 [KO:K11828]
24408  Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208]
24409  Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
24410  Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
24411  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
24412  Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212]
50592  Gria1; glutamate receptor 1 precursor [KO:K05197]
29627  Gria2; glutamate receptor 2 isoform 2 precursor [KO:K05198]
29628  Gria3; glutamate receptor 3 isoform 2 precursor [KO:K05199]
29629  Gria4; glutamate receptor 4 isoform 2 precursor [KO:K05200]
257648  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [KO:K04849]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
114493  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
682930  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116470  Stx1a; syntaxin-1A [KO:K04560]
25302  Chrna7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
116601  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
25391  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
29693  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [KO:K05853] [EC:7.2.2.10]
29192  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
81751  Psen2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
362912  Derl1; derlin-1 [KO:K11519]
120094610  derlin-1-like [KO:K11519]
116643  Vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
64156  Uba52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
364068  Uba52-ps19; ubiquitin-ribosomal protein eL40 fusion protein-like [KO:K02927]
100912032  Rps27a; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
192255  Ubb; polyubiquitin-B precursor [KO:K04551]
50522  Ubc; polyubiquitin-C isoform 3 precursor [KO:K08770]
29673  Psma6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
29669  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
29671  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
29674  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
364814  Psma8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
29672  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
29668  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
29670  Psma3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
29666  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100360846  Psmb6l1; proteasome 20S subunit beta 6 like 1 [KO:K02738] [EC:3.4.25.1]
85492  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
29676  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
296169  Psmb3l2; proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
29675  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
29425  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
94198  Psmb1; proteasome subunit beta type-1 precursor [KO:K02732] [EC:3.4.25.1]
58854  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
25581  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
117263  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
117262  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
289990  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
29677  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
81827  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
287984  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
83806  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
287670  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
161475  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
287772  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
303353  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
289924  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
307821  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
365388  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
83499  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
311078  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
292766  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
65138  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
680532  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
29545  Uchl1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
314432  Uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
103694557  Ube1y1; ubiquitin-like modifier-activating enzyme 1 Y [KO:K03178] [EC:6.2.1.45]
25225  Uba1y; ubiquitin-activating enzyme, Chr Y [KO:K03178] [EC:6.2.1.45]
134484397  ubiquitin-like modifier-activating enzyme 1 Y [KO:K03178] [EC:6.2.1.45]
363836  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
295704  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
298689  Ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
294331  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
64631  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
117549  Gpr37; prosaposin receptor GPR37 precursor [KO:K04243]
116728  Septin5; septin-5 [KO:K04557]
307309  Sncaip; synphilin-1 [KO:K04558]
25617  Hspa5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
60431  Vapb; vesicle-associated membrane protein-associated protein B [KO:K10707]
304962  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
29467  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
289754  Xbp1; X-box-binding protein 1 isoform XBP1(U) [KO:K09027]
498013  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
365057  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
363855  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431] [EC:2.7.12.2]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
156117  Casp12; caspase-12 [KO:K04741] [EC:3.4.22.-]
308463  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
29702  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860] [EC:2.7.11.1]
54318  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
24898  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
26193  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26194  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26199  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26201  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26200  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26202  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26203  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
293655  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
81728  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor [KO:K03943] [EC:7.1.1.2]
64539  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2 [KO:K03944]
363441  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
291660  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
120099907  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
691001  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
681024  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100362331  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
25488  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
315167  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
299643  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
120101567  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
296658  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
362440  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
316632  Ndufa10l1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [KO:K03954]
678759  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor [KO:K03954]
293453  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
301123  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
299739  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100911483  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
362344  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
301427  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103690609  Ndufb3l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103694107  Ndufb3l3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
103691697  Ndufb3l2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
120098318  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
288088  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
499131  Ndufb4l3; similar to NADH:ubiquinone oxidoreductase B15 subunit [KO:K03960]
100361934  Ndufb4l4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
103691107  Ndufb4l5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
120094308  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
501886  Ndufb4l1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
294964  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
297990  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
361385  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
293991  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
299954  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
681418  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
299310  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
301458  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
289218  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [KO:K03935] [EC:7.1.1.2]
295923  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
499529  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
362588  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
679739  Ndufs6; NADH:ubiquinone oxidoreductase subunit S6-like 1 [KO:K03939]
362837  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
293652  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
689938  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
293130  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
157074  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
298596  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
289217  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
363061  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
291103  Uqcrfs1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
26192  CYTB; cytochrome b [KO:K00412]
300047  Cyc1; cytochrome c-1 [KO:K00413]
301011  Uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial precursor [KO:K00414]
293448  Uqcrc2; cytochrome b-c1 complex subunit 2, mitochondrial precursor [KO:K00415]
366448  Uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
362897  Uqcrb; cytochrome b-c1 complex subunit 7 [KO:K00417]
103693740  Uqcrbl2; cytochrome b-c1 complex subunit 7-like [KO:K00417]
685596  Uqcrbl1; cytochrome b-c1 complex subunit 7-like [KO:K00417]
497902  Uqcrq; cytochrome b-c1 complex subunit 8 [KO:K00418]
685322  Uqcr10; ubiquinol-cytochrome c reductase complex 7.2kDa protein [KO:K00419]
690848  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
120097699  cytochrome b-c1 complex subunit 10-like [KO:K00420]
100362798  Uqcr11l1; cytochrome b-c1 complex subunit 10-like [KO:K00420]
26204  COX3; cytochrome c oxidase subunit III [KO:K02262]
26195  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26198  COX2; cytochrome c oxidase subunit II [KO:K02261]
84683  Cox4i2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor [KO:K02263]
29445  Cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
252934  Cox5a; cytochrome c oxidase subunit 5A, mitochondrial precursor [KO:K02264]
100361008  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
94194  Cox5b; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
25278  Cox6a2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
25282  Cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
688869  Cox6b1; cytochrome c oxidase subunit 6B1 [KO:K02267]
654441  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
120103152  cytochrome c oxidase subunit 6B1-like [KO:K02267]
54322  Cox6c; cytochrome c oxidase subunit 6C-2 [KO:K02268]
120098258  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
29507  Cox7a2; cytochrome c oxidase subunit 7A2, mitochondrial precursor [KO:K02270]
298762  Cox7a2l; cytochrome c oxidase subunit 7A2 like isoform 1 [KO:K02270]
688386  Cox7a2l2; cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
687508  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
303393  Cox7b; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100361960  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
100188937  Cox7c; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100360357  Cox7cl1; cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
120095266  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
25250  Cox8b; cytochrome c oxidase subunit 8B, mitochondrial precursor [KO:K02273]
360229  Cox8c; cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
171335  Cox8a; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
65262  Atp5f1a; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
171374  Atp5f1b; ATP synthase subunit beta, mitochondrial precursor [KO:K02133] [EC:7.1.2.2]
116550  Atp5f1c; ATP synthase subunit gamma, mitochondrial [KO:K02136]
245965  Atp5f1d; ATP synthase subunit delta, mitochondrial precursor [KO:K02134]
245958  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100361879  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
26197  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
171375  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
171082  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
114630  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
29754  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial precursor [KO:K02128]
100361833  Atp5mc2l1; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
499512  Atp5mc2l2; ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
689961  Atp5mc1l1; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
366614  Atp5mc1l2; ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
120098314  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
641434  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
688022  Atp5pdl1; ATP synthase subunit d, mitochondrial-like [KO:K02138]
192241  Atp5po; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
94271  Atp5pf; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
26196  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
308416  Tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
304971  Tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518]
294560  Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
50663  Calm2; calmodulin-2 [KO:K02183]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
24887  Bax; apoptosis regulator BAX [KO:K02159]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
681314  apoptosis regulator BAX-like [KO:K02159]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
300160  Lrrk2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
297376  Htra2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
287069  Trap1; heat shock protein 75 kDa, mitochondrial precursor [KO:K09488]
83531  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
25176  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
85333  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
689108  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
498885  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
500871  Slc25a5l1; ADP/ATP translocase 2-like [KO:K05863]
282819  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
120099910  cytochrome c, somatic-like [KO:K08738]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
78963  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
192154  Hip1; huntingtin-interacting protein 1 isoform 2 [KO:K04559]
303968  Ift57; intraflagellar transport protein 57 homolog [KO:K04638]
63864  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
361967  Ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
501204  Ppidl1; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
117287  Park7; Parkinson disease protein 7 homolog isoform 2 [KO:K05687] [EC:3.5.1.124]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
192647  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
64476  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
246294  Optn; optineurin [KO:K19946]
113894  Sqstm1; sequestosome-1 isoform 1 [KO:K14381]
362245  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
64862  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
252961  Tank; TRAF family member-associated NF-kappa-B activator isoform 2 [KO:K12650]
497918  Smcr8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
313155  RGD1359108; guanine nucleotide exchange factor C9orf72 homolog [KO:K23609]
117103  Rab8a; ras-related protein Rab-8A [KO:K07901]
81754  Rab1a; ras-related protein Rab-1A [KO:K07874]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
360827  Ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
303206  Ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
300240  Atg101; autophagy-related protein 101 isoform 2 [KO:K19730]
362164  Atg13; autophagy-related protein 13 [KO:K08331]
312927  Rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
59319  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
114558  Becn1; beclin-1 [KO:K08334]
363131  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
305831  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
58839  Nrbf2; nuclear receptor-binding factor 2 [KO:K21246]
100363472  nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
499670  RGD1560263; nuclear receptor-binding factor 2-like isoform X1 [KO:K21246]
65052  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
689688  Atg2a; autophagy-related protein 2 homolog A [KO:K17906]
288498  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
303630  Wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
299188  Zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
363235  Als2; alsin [KO:K04575]
64633  Rab5a; ras-related protein Rab-5A [KO:K07887]
100361891  Rab5al1; ras-related protein Rab-5A [KO:K07887]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
363720  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
309855  Fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
311372  Spg11; spatacsin [KO:K19026]
24835  Tnf; tumor necrosis factor [KO:K03156]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
156767  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141]
140926  Daxx; death domain-associated protein 6 [KO:K02308]
303200  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
114495  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
24598  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
84485  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
24404  Gpx1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
64317  Gpx3; glutathione peroxidase 3 precursor [KO:K00432] [EC:1.11.1.9]
259233  Gpx6; glutathione peroxidase 6 precursor [KO:K00432] [EC:1.11.1.9]
29326  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
113919  Gpx5; epididymal secretory glutathione peroxidase precursor [KO:K00432] [EC:1.11.1.9]
298376  Gpx7; glutathione peroxidase 7 precursor [KO:K00432] [EC:1.11.1.9]
294744  Gpx8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
24248  Cat; catalase [KO:K03781] [EC:1.11.1.6]
24688  Prph; peripherin [KO:K07607]
83613  Nefl; neurofilament light polypeptide [KO:K04572]
24588  Nefm; neurofilament medium polypeptide [KO:K04573]
24587  Nefh; neurofilament heavy polypeptide [KO:K04574]
117550  Kif5b; kinesin-1 heavy chain [KO:K10396]
311024  Kif5c; kinesin heavy chain isoform 5C [KO:K10396]
314906  Kif5a; kinesin heavy chain isoform 5A [KO:K10396]
171041  Klc1; kinesin light chain 1 isoform C [KO:K10407]
171549  Klc3; kinesin light chain 3 [KO:K10407]
316226  Klc4; kinesin light chain 4 [KO:K10407]
309159  Klc2; kinesin light chain 2 [KO:K10407]
64158  Tuba1a; tubulin alpha-1A chain [KO:K07374]
291287  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
300218  Tuba1c; tubulin alpha-1C chain [KO:K07374]
316531  Tuba4a; tubulin alpha-4A chain [KO:K07374]
500319  Tuba3a; tubulin alpha-3 chain [KO:K07374]
500363  Tuba3b; tubulin alpha-3 chain [KO:K07374]
500377  Tuba8; tubulin alpha-8 chain [KO:K07374]
500929  Tuba1b; tubulin alpha-1B chain [KO:K07374]
29214  Tubb5; tubulin beta-5 chain [KO:K07375]
246118  Tubb3; tubulin beta-3 chain [KO:K07375]
291081  Tubb2b; tubulin beta-2B chain [KO:K07375]
29213  Tubb4a; tubulin beta-4A chain [KO:K07375]
307351  Tubb6; tubulin beta-6 chain [KO:K07375]
498736  Tubb2a; tubulin beta-2A chain [KO:K07375]
679312  Tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
296554  Tubb4b; tubulin beta-4B chain [KO:K07375]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
116549  Csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
307641  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
81650  Csnk2b; casein kinase II subunit beta [KO:K03115]
24225  Bdnf; brain-derived neurotrophic factor isoform 3 preproprotein [KO:K04355]
29167  Dctn1; dynactin subunit 1 [KO:K04648]
299850  Dctn2; dynactin subunit 2 [KO:K10424]
362504  Dctn3; dynactin subunit 3 [KO:K10425]
498977  Dctn3l1; dynactin 3-like 1 [KO:K10425]
84428  Dctn4; dynactin subunit 4 [KO:K10426]
308961  Dctn5; dynactin subunit 5 [KO:K10427]
290798  Dctn6; dynactin subunit 6 [KO:K10428]
294010  Actr1a; alpha-centractin [KO:K16575]
316333  Actr1b; beta-centractin [KO:K16575]
299121  Actr10; actin-related protein 10 [KO:K16576]
29430  Hap1; huntingtin-associated protein 1 isoform B [KO:K04647]
171339  Dnah1; dynein axonemal heavy chain 1 [KO:K10408]
303242  Dnah2; dynein axonemal heavy chain 2 [KO:K10408]
117249  Dnah3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
252893  Dnah7; dynein axonemal heavy chain 7 [KO:K10408]
294854  Dnah5; dynein axonemal heavy chain 5 [KO:K10408]
117250  Dnah6; dynein axonemal heavy chain 6 [KO:K10408]
117251  Dnah9; dynein, axonemal, heavy chain 9 [KO:K10408]
117253  Dnah11; dynein axonemal heavy chain 11 isoform X2 [KO:K10408]
252959  Dnah12; dynein axonemal heavy chain 12 [KO:K10408]
207117  Dnah8; dynein heavy chain 8, axonemal [KO:K10408]
117252  Dnah10; dynein axonemal heavy chain 10 isoform X1 [KO:K10408]
287845  Dnah17; dynein axonemal heavy chain 17 [KO:K10408]
690288  Dnah14; dynein axonemal heavy chain 14 isoform X1 [KO:K10408]
298524  Dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
500442  Dnai1; dynein axonemal intermediate chain 1 [KO:K10409]
360654  Dnai2; dynein axonemal intermediate chain 2 [KO:K11143]
685664  Dnal1; dynein axonemal light chain 1 [KO:K10411]
300078  Dnal4; dynein axonemal light chain 4 [KO:K10412]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
29153  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
29154  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116671  Cdk5r1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
140908  Cdk5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
64026  Casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
293897  Dkk1; dickkopf-related protein 1 precursor [KO:K02165]
295445  Dkk2; dickkopf-related protein 2 precursor [KO:K02165]
502097  Dkk4; dickkopf-related protein 4 precursor [KO:K02165]
24881  Wnt1; proto-oncogene Wnt-1 precursor [KO:K03209]
116466  Wnt2b; protein Wnt-2b [KO:K00182]
114487  Wnt2; protein Wnt-2 precursor [KO:K00182]
24882  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
303181  Wnt3a; protein Wnt-3a precursor [KO:K00312]
84426  Wnt4; protein Wnt-4 precursor [KO:K00408]
64566  Wnt5a; protein Wnt-5a precursor [KO:K00444]
282582  Wnt5b; protein Wnt-5b precursor [KO:K00444]
316526  Wnt6; protein Wnt-6 precursor [KO:K00445]
114850  Wnt7a; protein Wnt-7a precursor [KO:K00572]
315196  Wnt7b; protein Wnt-7b isoform 1 [KO:K00572]
291678  Wnt8a; protein Wnt-8a precursor [KO:K00714]
293990  Wnt8b; protein Wnt-8b precursor [KO:K00714]
287357  Wnt9a; protein Wnt-9a precursor [KO:K01064]
303586  Wnt9b; protein Wnt-9b precursor [KO:K01064]
315294  Wnt10b; protein Wnt-10b precursor [KO:K01357]
316527  Wnt10a; protein Wnt-10a precursor [KO:K01357]
140584  Wnt11; protein Wnt-11 [KO:K01384]
500047  Wnt16; protein Wnt-16 precursor [KO:K01558]
58868  Fzd1; frizzled-1 precursor [KO:K02432]
100360552  Fzd7; frizzled-7 precursor [KO:K02432]
64512  Fzd2; frizzled-2 precursor [KO:K02235]
266715  Fzd3; frizzled-3 precursor [KO:K02329]
64558  Fzd4; frizzled-4 precursor [KO:K02354]
317674  Fzd5; frizzled-5 precursor [KO:K02375]
364754  Fzd8; frizzled-8 precursor [KO:K02375]
282581  Fzd6; frizzled-6 precursor [KO:K02376]
266608  Fzd9; frizzled-9 precursor [KO:K02842]
363913  Fzd10; frizzled-10 precursor [KO:K02842]
293649  Lrp5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068]
312781  Lrp6; low-density lipoprotein receptor-related protein 6 isoform 2 precursor [KO:K03068]
58822  Csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
83721  Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
303811  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
303251  Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
308692  Peg12; paternally expressed 12 [KO:K03069]
103691373  Frat1; proto-oncogene FRAT1 [KO:K03069]
679110  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
79257  Axin1; axin-1 [KO:K02157]
29134  Axin2; axin-2 [KO:K04385]
24205  Apc; adenomatous polyposis coli protein [KO:K02085]
299611  Apc2; adenomatous polyposis coli protein 2 [KO:K02085]
84353  Ctnnb1; catenin beta-1 [KO:K02105]
113927  Csnk1a1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
81722  Ager; advanced glycosylation end product-specific receptor precursor [KO:K19722]
293621  Hras; GTPase HRas [KO:K02833]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114243  Nox1; NADPH oxidase 1 [KO:K08008]
66021  Cybb; cytochrome b-245 beta chain [KO:K21421] [EC:1.-.-.-]
85431  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
309165  Rela; transcription factor p65 [KO:K04735]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
24599  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
29527  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
24498  Il6; interleukin-6 precursor [KO:K05405]
24493  Il1a; interleukin-1 alpha [KO:K04383]
24494  Il1b; interleukin-1 beta [KO:K04519]
78965  Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
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Related
pathway
rno00190  Oxidative phosphorylation
rno03050  Proteasome
rno04020  Calcium signaling pathway
rno04120  Ubiquitin mediated proteolysis
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04141  Protein processing in endoplasmic reticulum
rno04142  Lysosome
rno04210  Apoptosis
rno04310  Wnt signaling pathway
rno04724  Glutamatergic synapse
rno04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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