KEGG   PATHWAY: snh04010
Entry
snh04010                    Pathway                                
Name
MAPK signaling pathway - Salvelinus namaycush (lake trout)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
snh04010  MAPK signaling pathway
snh04010

Other DBs
GO: 0000165
Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120023380  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
120023395  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
120034271  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
120021376  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
120025510  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
120063571  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
120032122  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
120063162  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
120065363  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
120059461  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
120061615  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
120020661  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
120052069  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
120054257  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
120055320  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
120061553  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
120029650  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
120041637  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
120044082  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
120037668  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
120021753  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
120064811  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
120060984  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
120031842  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
120050077  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
120053242  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
120065854  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
120020369  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
120021849  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
120021859  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
120065592  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
120021818  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
120064821  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
120061676  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
120051824  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
120066590  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
120044523  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
120034351  voltage-dependent L-type calcium channel subunit beta-1-like [KO:K04862]
120027642  voltage-dependent L-type calcium channel subunit beta-2-like [KO:K04863]
120051157  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
120058983  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
120060958  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
120050549  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
120050568  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
120063766  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
120057914  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
120022592  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
120032395  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
120044133  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
120044647  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
120034605  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
120042474  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
120042772  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
120032361  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
120044717  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
120027277  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
120040628  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120032372  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
120027286  voltage-dependent calcium channel gamma-5 subunit-like isoform X1 [KO:K04870]
120034035  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120022347  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
120026782  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
120022725  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
120026907  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
120047773  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
120022068  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
120026823  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
120047712  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
120047774  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
120019042  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
120020291  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
120039714  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120033914  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120055956  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
120054595  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
120032664  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
120065642  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120042471  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
120036642  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
120035391  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
120020511  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
120041236  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
120042049  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
120051882  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
120054543  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120055493  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
120021106  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120030311  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120040599  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
120025674  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
120044980  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
120047390  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120062153  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120049598  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120063358  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
120057586  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120030074  calcineurin subunit B type 1-like [KO:K06268]
120032996  calcineurin subunit B type 1 [KO:K06268]
120046079  calcineurin subunit B type 1-like [KO:K06268]
120065389  calcineurin subunit B type 1 [KO:K06268]
120053231  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
120065846  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
120044158  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
120026513  ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326]
120044975  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
120023444  RAS guanyl-releasing protein 1-like [KO:K04350]
120060220  RAS guanyl-releasing protein 1-like [KO:K04350]
120021813  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
120030628  RAS guanyl-releasing protein 2-like [KO:K12361]
120049216  RAS guanyl-releasing protein 2-like [KO:K12361]
120017621  ras guanyl-releasing protein 3-like [KO:K12362]
120045625  ras guanyl-releasing protein 3-like [KO:K12362]
120048027  rap guanine nucleotide exchange factor 2-like [KO:K08018]
120062243  rap guanine nucleotide exchange factor 2-like [KO:K08018]
120018118  neurofibromin-like [KO:K08052]
120057192  neurofibromin [KO:K08052]
120047874  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
120063054  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
120018294  ras GTPase-activating protein 2-like [KO:K08053]
120028709  ras GTPase-activating protein 2-like [KO:K08053]
120058606  ras-related protein Rap-1A-like [KO:K04353]
120065036  ras-related protein Rap-1A-like [KO:K04353]
120059240  ras-related protein Rap-1A-like [KO:K04353]
120061134  ras-related protein O-Krev isoform X1 [KO:K04353]
120050139  ras-related protein Rap-1b [KO:K07836]
120061877  pro-epidermal growth factor-like [KO:K04357]
120021555  protransforming growth factor alpha-like [KO:K08774]
120064795  tgfa; protransforming growth factor alpha [KO:K08774]
120053525  LOW QUALITY PROTEIN: proepiregulin-like [KO:K09784]
120047375  putative fibroblast growth factor 1 [KO:K18496]
120056452  putative fibroblast growth factor 1 [KO:K18496]
120048001  fibroblast growth factor 2-like [KO:K18497]
120062265  fibroblast growth factor 2-like [KO:K18497]
120023180  fibroblast growth factor 8b-like [KO:K04358]
120017410  fgf8a; fibroblast growth factor 8 [KO:K04358]
120049095  fibroblast growth factor 4B-like [KO:K04358]
120024689  fibroblast growth factor 4B-like [KO:K04358]
120024785  fgf7; fibroblast growth factor 7 [KO:K04358]
120041990  fibroblast growth factor 6-like [KO:K04358]
120042218  fibroblast growth factor 7-like [KO:K04358]
120025076  fibroblast growth factor 3-like [KO:K04358]
120032082  fibroblast growth factor 4B-like [KO:K04358]
120032924  fibroblast growth factor 8b-like [KO:K04358]
120044229  fibroblast growth factor 10-like [KO:K04358]
120026499  fibroblast growth factor 10-like [KO:K04358]
120034647  fgf20a; fibroblast growth factor 20a [KO:K04358]
120045864  fibroblast growth factor 8-like [KO:K04358]
120045983  fibroblast growth factor 4B-like [KO:K04358]
120036189  fibroblast growth factor 20-like [KO:K04358]
120038216  fibroblast growth factor 16 [KO:K04358]
120047427  fibroblast growth factor 18-like [KO:K04358]
120047485  fgf18a; fibroblast growth factor 18a [KO:K04358]
120062060  fgf20b; fibroblast growth factor 20b [KO:K04358]
120062704  fibroblast growth factor 17-like [KO:K04358]
120062925  fibroblast growth factor 10-like [KO:K04358]
120062947  fibroblast growth factor 5-like [KO:K04358]
120057528  fibroblast growth factor 18-like [KO:K04358]
120051777  fibroblast growth factor 10-like [KO:K04358]
120052032  fibroblast growth factor 10-like [KO:K04358]
120052179  fibroblast growth factor 3-like [KO:K04358]
120065783  fibroblast growth factor 4B-like [KO:K04358]
120065788  fibroblast growth factor 3-like [KO:K04358]
120053534  fibroblast growth factor 3-like [KO:K04358]
120053536  fibroblast growth factor 4B-like [KO:K04358]
120053848  fibroblast growth factor 17 [KO:K04358]
120054107  fibroblast growth factor 6-like [KO:K04358]
120055189  fibroblast growth factor 10-like [KO:K04358]
120061885  fibroblast growth factor 18-like [KO:K04358]
120061898  fibroblast growth factor 18-like [KO:K04358]
120045973  fibroblast growth factor 19-like [KO:K22603]
120045769  fgf21; fibroblast growth factor 21 [KO:K22429]
120049094  fibroblast growth factor 23-like [KO:K22428]
120049360  fibroblast growth factor 23-like [KO:K22428]
120042004  fibroblast growth factor 23-like [KO:K22428]
120031911  fibroblast growth factor 23-like [KO:K22428]
120031922  fibroblast growth factor 23-like [KO:K22428]
120054106  fibroblast growth factor 23-like isoform X1 [KO:K22428]
120039573  nerve growth factor-like [KO:K02582]
120024336  nerve growth factor-like [KO:K02582]
120064924  nerve growth factor-like [KO:K02582]
120061462  nerve growth factor-like [KO:K02582]
120025232  brain-derived neurotrophic factor [KO:K04355]
120036154  brain-derived neurotrophic factor-like [KO:K04355]
120036478  ntf3; neurotrophin-3 [KO:K04356]
120044421  insulin [KO:K04526]
120046921  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
120062047  insulin-like [KO:K04526]
120056420  insulin-like [KO:K04526]
120031740  insulin-like growth factor I isoform X1 [KO:K05459]
120049944  insulin-like growth factor I isoform X1 [KO:K05459]
120066020  igf2b; insulin-like growth factor 2b [KO:K13769]
120042520  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
120032526  platelet-derived growth factor subunit A-like [KO:K04359]
120032527  platelet-derived growth factor subunit A-like [KO:K04359]
120036319  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
120032626  transcription activator MSS11-like [KO:K17386]
120047418  pdgfc; platelet-derived growth factor C [KO:K05450]
120061873  LOW QUALITY PROTEIN: platelet-derived growth factor C-like [KO:K05450]
120026095  uncharacterized protein LOC120026095 [KO:K05453]
120054158  kitlga; kit ligand a [KO:K05461]
120019024  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
120030848  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
120048255  vascular endothelial growth factor A-A [KO:K05448]
120024517  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
120046927  vegfba; snake venom vascular endothelial growth factor toxin HF [KO:K05448]
120062443  vascular endothelial growth factor A-like [KO:K05448]
120023725  pgfb; placenta growth factor [KO:K16859]
120023936  vascular endothelial growth factor A-like [KO:K16859]
120059887  placenta growth factor-like [KO:K16859]
120039972  vegfd; vascular endothelial growth factor D [KO:K05449]
120035094  vascular endothelial growth factor C-like [KO:K05449]
120057607  vascular endothelial growth factor C-like [KO:K05449]
120051992  vascular endothelial growth factor C-like [KO:K05449]
120031931  hepatocyte growth factor-like [KO:K05460]
120050076  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
120053977  hepatocyte growth factor-like isoform X1 [KO:K05460]
120066298  hepatocyte growth factor-like [KO:K05460]
120022754  angiopoietin-1-like isoform X1 [KO:K05465]
120026976  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
120047339  angiopoietin-1-like [KO:K05465]
120021988  angiopoietin-2-like [KO:K05466]
120046651  angpt2a; angiopoietin-2a [KO:K05466]
120029386  angiopoietin-2-like [KO:K05466]
120022616  ephrin-A1-like [KO:K05462]
120022415  ephrin-A3-like [KO:K05462]
120021911  ephrin-A5-like [KO:K05462]
120039355  ephrin-A3-like [KO:K05462]
120043065  ephrin-A1-like [KO:K05462]
120025528  ephrin-A5-like [KO:K05462]
120043285  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
120033253  ephrin-A2-like [KO:K05462]
120026750  ephrin-A3-like [KO:K05462]
120027291  ephrin-A1-like [KO:K05462]
120047781  ephrin-A1-like [KO:K05462]
120062749  ephrin-A5-like [KO:K05462]
120050809  ephrin-A2-like [KO:K05462]
120053918  ephrin-A2-like [KO:K05462]
120055120  ephrin-A5b-like [KO:K05462]
120055156  ephrin-A2-like [KO:K05462]
120044236  glial cell line-derived neurotrophic factor-like [KO:K05452]
120026435  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
120053636  glial cell line-derived neurotrophic factor [KO:K05452]
120053173  neurturin-like [KO:K25414]
120055179  nrtn; neurturin [KO:K25414]
120019894  artemin-like [KO:K25415]
120054342  neurturin [KO:K25415]
120055498  artemin [KO:K25415]
120032467  persephin-like [KO:K25416]
120032468  persephin-like [KO:K25416]
120020248  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
120028154  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
120055996  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120051015  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
120046383  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120059115  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
120065194  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
120061027  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
120061323  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
120050848  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
120063924  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
120057804  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
120021867  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
120025797  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
120063215  fgfr1a; fibroblast growth factor receptor 1-A [KO:K04362] [EC:2.7.10.1]
120066669  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
120017472  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
120046432  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
120030600  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
120057032  fibroblast growth factor receptor 4-like isoform X1 [KO:K05095] [EC:2.7.10.1]
120031322  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120042766  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
120034288  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
120048389  high affinity nerve growth factor receptor-like isoform X1 [KO:K03176] [EC:2.7.10.1]
120031620  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
120025623  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
120044794  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
120050479  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
120063544  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
120020095  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120056144  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
120052701  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
120055081  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
120065838  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
120053452  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120052582  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120054283  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
120048189  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
120062390  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
120057342  LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
120021110  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
120047076  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
120062391  macrophage colony-stimulating factor 1 receptor 1-like isoform X1 [KO:K05090] [EC:2.7.10.1]
120056654  macrophage colony-stimulating factor 1 receptor 1-like [KO:K05090] [EC:2.7.10.1]
120036035  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
120052583  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
120054924  LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
120028108  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120050607  receptor-type tyrosine-protein kinase FLT3-like [KO:K05092] [EC:2.7.10.1]
120046992  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
120062328  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
120050608  vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
120052584  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
120041135  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
120054155  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
120026142  tyrosine-protein kinase receptor Tie-2-like [KO:K05121] [EC:2.7.10.1]
120036876  tek; tyrosine-protein kinase receptor Tie-2 isoform X1 [KO:K05121] [EC:2.7.10.1]
120065048  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
120058928  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
120059286  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
120061592  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
120017384  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120045844  proto-oncogene tyrosine-protein kinase receptor Ret-like [KO:K05126] [EC:2.7.10.1]
120032581  growth factor receptor-bound protein 2-like [KO:K04364]
120033929  growth factor receptor-bound protein 2 [KO:K04364]
120039012  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
120066644  growth factor receptor-bound protein 2-like [KO:K04364]
120032369  son of sevenless homolog 1-like isoform X1 [KO:K03099]
120065085  son of sevenless homolog 1-like [KO:K03099]
120060118  sos2; son of sevenless homolog 2 [KO:K03099]
120054020  GTPase HRas-like [KO:K02833]
120066370  GTPase HRas [KO:K02833]
120043786  zgc:55558 [KO:K07827]
120054052  GTPase KRas isoform X1 [KO:K07827]
120066403  kras; GTPase KRas isoform X1 [KO:K07827]
120049278  ras-related protein R-Ras2 [KO:K07830]
120024722  ras-related protein R-Ras2 [KO:K07830]
120033390  rras; ras-related protein R-Ras [KO:K07830]
120052736  ras-related protein R-Ras-like [KO:K07830]
120033394  ras-related protein M-Ras isoform X1 [KO:K07831]
120051267  ras-related protein M-Ras isoform X1 [KO:K07831]
120064247  ras-related protein M-Ras-like [KO:K07831]
120058309  ras-related protein M-Ras-like [KO:K07831]
120041600  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120063367  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
120050158  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
120059498  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
120061320  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
120042460  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
120020580  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
120056021  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
120052438  dual specificity mitogen-activated protein kinase kinase 2-like isoform X1 [KO:K04369] [EC:2.7.12.2]
120054777  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120023714  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
120042809  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120033084  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120037194  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120052722  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120056207  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
120052488  MAP kinase-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K04372] [EC:2.7.11.1]
120053659  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
120054826  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
120021459  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
120023564  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120045664  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
120027827  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
120029857  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120050951  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
120057286  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
120060162  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
120032473  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
120034366  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
120034522  atf4b; activating transcription factor 4b isoform X1 [KO:K04374]
120061411  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
120025122  ETS domain-containing protein Elk-4-like [KO:K04376]
120065157  ETS domain-containing protein Elk-4-like isoform X1 [KO:K04376]
120028045  transcriptional regulator Myc-like [KO:K04377]
120055724  mycb; transcriptional regulator Myc-B [KO:K04377]
120050402  transcriptional regulator Myc [KO:K04377]
120026673  mych; myelocytomatosis oncogene homolog [KO:K04377]
120064987  transcriptional regulator Myc-2-like [KO:K04377]
120017476  serum response factor-like isoform X1 [KO:K04378]
120032800  serum response factor-like isoform X1 [KO:K04378]
120046439  LOW QUALITY PROTEIN: serum response factor-like [KO:K04378]
120065022  serum response factor-like isoform X1 [KO:K04378]
120019205  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
120019412  proto-oncogene c-Fos-like [KO:K04379]
120023674  proto-oncogene c-Fos-like [KO:K04379]
120024158  proto-oncogene c-Fos-like [KO:K04379]
120024271  proto-oncogene c-Fos-like [KO:K04379]
120060304  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
120033944  microtubule-associated protein tau-like [KO:K04380]
120034665  microtubule-associated protein tau-like [KO:K04380]
120045543  mapta; microtubule-associated protein tau [KO:K04380]
120022212  stathmin-like [KO:K04381]
120031416  stmn1b; stathmin 1b [KO:K04381]
120026939  stathmin-like [KO:K04381]
120047523  stathmin-like [KO:K04381]
120063397  stathmin-like [KO:K04381]
120020039  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
120017415  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
120030466  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120051922  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
120055022  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
120022601  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120027290  tumor necrosis factor-like [KO:K03156]
120031280  tumor necrosis factor-like [KO:K03156]
120021395  interleukin-1 beta-like [KO:K04519]
120026221  il1b; LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
120062835  interleukin-1 beta-like [KO:K04519]
120055353  interleukin-1 beta [KO:K04519]
120021386  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
120028313  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
120056617  transforming growth factor beta-1 proprotein-like isoform X1 [KO:K13375]
120031484  transforming growth factor beta-2 proprotein-like [KO:K13376]
120047387  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
120047527  transforming growth factor beta-2 proprotein-like [KO:K13376]
120062054  transforming growth factor beta-2 proprotein-like [KO:K13376]
120023224  transforming growth factor beta-3 proprotein-like isoform X1 [KO:K13377]
120019489  transforming growth factor beta-3 proprotein-like [KO:K13377]
120040181  transforming growth factor beta-3 proprotein-like [KO:K13377]
120060301  transforming growth factor beta-3 proprotein-like [KO:K13377]
120048603  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120048707  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120057936  interleukin-1 receptor type 1-like [KO:K04386]
120028321  interleukin-1 receptor accessory protein [KO:K04723]
120020326  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120028096  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120051069  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
120055556  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
120022652  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120027347  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
120063757  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120057931  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120046999  CD40 ligand-like [KO:K04389]
120062108  CD40 ligand-like [KO:K04389]
120051847  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120054895  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
120017657  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
120045631  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
120030096  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120040646  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
120040650  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
120046821  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120032580  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
120044645  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
120034160  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
120030095  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
120042789  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
120044712  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
120045718  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
120022191  cell division control protein 42 homolog [KO:K04393]
120048613  cell division control protein 42 homolog [KO:K04393]
120048723  cell division control protein 42 homolog [KO:K04393]
120027141  cell division control protein 42 homolog [KO:K04393]
120065151  cell division control protein 42 homolog [KO:K04393]
120059210  cell division control protein 42 homolog [KO:K04393]
120060785  cell division control protein 42 homolog [KO:K04393]
120061169  cell division control protein 42 homolog isoform X1 [KO:K04393]
120025171  tumor necrosis factor receptor type 1-associated DEATH domain protein-like isoform X1 [KO:K03171]
120047474  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120040359  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120035095  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120062476  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
120052764  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
120021709  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
120021774  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120025680  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120025896  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120055078  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120022705  death domain-associated protein 6-like [KO:K02308]
120027430  death domain-associated protein 6-like [KO:K02308]
120050282  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120061459  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120066164  interleukin-1 receptor-associated kinase 4-like isoform X1 [KO:K04733] [EC:2.7.11.1]
120020508  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
120021704  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120021736  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120042825  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120025527  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120026357  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120062802  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120051883  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
120053376  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
120054420  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
120054544  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
120055494  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
120032447  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
120019676  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
120024108  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
120030554  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405]
120017719  mitogen-activated protein kinase kinase kinase kinase 3-like [KO:K04406] [EC:2.7.11.1]
120046614  mitogen-activated protein kinase kinase kinase kinase 3-like isoform X1 [KO:K04406] [EC:2.7.11.1]
120065093  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
120048234  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
120062551  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
120051330  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
120064272  traf2 and NCK-interacting protein kinase-like isoform X1 [KO:K04407] [EC:2.7.11.1]
120058370  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
120018241  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
120028675  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
120035285  serine/threonine-protein kinase PAK 2-like isoform X1 [KO:K04410] [EC:2.7.11.1]
120052497  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120054838  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
120064966  serine/threonine-protein kinase 4-like [KO:K04411]
120026944  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
120021585  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
120030616  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
120049588  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
120057341  mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
120027948  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
120050434  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
120020909  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
120026372  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
120030570  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
120049599  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
120033319  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
120051283  mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
120044068  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
120034406  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
120059721  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
120018414  mitogen-activated protein kinase kinase kinase 10-like isoform X1 [KO:K04418] [EC:2.7.11.25]
120029063  mitogen-activated protein kinase kinase kinase 10-like [KO:K04418] [EC:2.7.11.25]
120046847  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K17534] [EC:2.7.11.25]
120029729  map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
120020134  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
120058738  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
120065563  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
120061623  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
120036444  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
120020183  mitogen-activated protein kinase kinase kinase 21-like isoform X1 [KO:K04424] [EC:2.7.11.25]
120058253  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
120064386  mitogen-activated protein kinase kinase kinase 20-like isoform X1 [KO:K04424] [EC:2.7.11.25]
120019685  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
120024017  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
120048328  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
120031096  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
120019658  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
120023627  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
120024287  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
120059771  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
120041312  mitogen-activated protein kinase kinase kinase 4-like isoform X1 [KO:K04428] [EC:2.7.11.25]
120029587  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
120018182  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
120021131  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
120032847  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
120043854  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
120026117  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
120045028  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
120028232  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
120046417  taok2b; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
120062946  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
120063407  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
120052704  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
120039974  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
120034212  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
120046086  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
120029571  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
120039715  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
120066408  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
120043801  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
120045697  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
120029867  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
120052013  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
120053312  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
120065885  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
120020879  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
120053241  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
120044435  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
120052154  C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
120037700  flna; filamin-A isoform X1 [KO:K04437]
120018356  adapter molecule crk-like [KO:K04438]
120021245  crk-like protein [KO:K04438]
120025840  crk-like protein isoform X1 [KO:K04438]
120044371  adapter molecule crk-like [KO:K04438]
120028347  adapter molecule crk-like [KO:K04438]
120056896  adapter molecule crk-like [KO:K04438]
120030609  arrestin red cell-like [KO:K04439]
120045158  arrestin red cell isoform X1 [KO:K04439]
120037048  arrb1; beta-arrestin-1 [KO:K04439]
120049801  arrb2b; arrestin, beta 2b [KO:K04439]
120057103  arrestin red cell [KO:K04439]
120017495  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
120017496  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
120021529  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
120030103  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
120048203  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
120025947  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120044174  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120046176  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120046442  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
120031745  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120031746  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
120049930  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
120049931  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
120057678  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120058796  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
120065006  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120059107  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120059400  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120054081  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120066420  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
120060612  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
120060986  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
120046043  MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
120063026  MAP kinase-activated protein kinase 5-like isoform X1 [KO:K04442] [EC:2.7.11.1]
120059520  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
120061372  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
120065083  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
120065209  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
120060471  MAP kinase-activated protein kinase 3-like [KO:K04444] [EC:2.7.11.1]
120061422  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
120023023  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
120060063  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
120021364  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
120057254  ribosomal protein S6 kinase alpha-4-like isoform X1 [KO:K16510] [EC:2.7.11.1]
120023512  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
120038953  M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
120022776  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
120031237  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
120026743  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
120047116  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
120048266  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
120025379  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
120054141  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
120066325  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
120020236  transcription factor AP-1-like [KO:K04448]
120056039  transcription factor AP-1-like [KO:K04448]
120052552  transcription factor AP-1-like isoform X1 [KO:K04448]
120054896  transcription factor AP-1-like [KO:K04448]
120026472  transcription factor AP-1-like [KO:K04448]
120036885  transcription factor AP-1-like [KO:K04448]
120019989  transcription factor jun-D-like [KO:K04449]
120055803  transcription factor jun-D-like [KO:K04449]
120053368  transcription factor jun-D-like [KO:K04449]
120054423  transcription factor jun-D-like isoform X1 [KO:K04449]
120058257  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120030359  cellular tumor antigen p53-like [KO:K04451]
120049611  cellular tumor antigen p53-like isoform X1 [KO:K04451]
120057360  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120058213  uncharacterized protein LOC120058213 [KO:K04452]
120064996  DNA damage-inducible transcript 3 protein-like [KO:K04452]
120023545  protein max-like isoform X1 [KO:K04453]
120024281  protein max-like isoform X1 [KO:K04453]
120060156  protein max isoform X1 [KO:K04453]
120060226  protein max-like isoform X1 [KO:K04453]
120021331  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
120048122  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
120025500  myocyte-specific enhancer factor 2C-like [KO:K04454]
120063057  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
120018547  heat shock protein beta-1-like [KO:K04455]
120032670  heat shock protein beta-1-like [KO:K04455]
120026118  heat shock protein beta-1-like [KO:K04455]
120045029  heat shock protein beta-1-like [KO:K04455]
120056804  LOW QUALITY PROTEIN: heat shock protein beta-1-like [KO:K04455]
120023179  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120018091  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120019020  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
120021584  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120023915  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120033010  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120028361  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120029418  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120057353  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
120065545  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120060247  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120023085  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
120018880  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
120024494  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
120044283  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
120029078  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
120056556  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
120060341  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
120051694  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
120066574  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
120058922  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
120060797  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
120047837  dual specificity protein phosphatase 1-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120062585  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120040140  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120031889  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120025863  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120032901  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120044985  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120062754  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120058246  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120052369  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120052735  si:ch211-195b15.8; tyrosine-protein phosphatase vhp-1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120059494  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120066125  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120061316  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120043585  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120054157  dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120019554  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120024503  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120045526  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120029695  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120052159  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120018901  serine/threonine-protein phosphatase 5-like [KO:K04460] [EC:3.1.3.16]
120028818  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
120030106  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
120046121  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
120046809  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
120030013  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
120018166  heat shock cognate 70 kDa protein-like [KO:K03283]
120031350  heat shock cognate 70 kDa protein-like [KO:K03283]
120033976  heat shock 70 kDa protein [KO:K03283]
120033986  heat shock 70 kDa protein [KO:K03283]
120033995  heat shock 70 kDa protein-like [KO:K03283]
120034006  heat shock 70 kDa protein [KO:K03283]
120034017  heat shock 70 kDa protein [KO:K03283]
120034028  heat shock 70 kDa protein [KO:K03283]
120034038  heat shock 70 kDa protein [KO:K03283]
120034045  heat shock 70 kDa protein-like [KO:K03283]
120034050  heat shock 70 kDa protein-like [KO:K03283]
120034057  heat shock 70 kDa protein-like [KO:K03283]
120035777  heat shock 70 kDa protein-like [KO:K03283]
120028757  heat shock cognate 70 kDa protein-like [KO:K03283]
120056977  heat shock cognate 70 kDa protein [KO:K03283]
120061456  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
120018783  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
120028738  MDS1 and EVI1 complex locus protein EVI1-A-like [KO:K04462] [EC:2.1.1.367]
120024738  dual specificity mitogen-activated protein kinase kinase 5-like [KO:K04463] [EC:2.7.12.2]
120024759  dual specificity mitogen-activated protein kinase kinase 5-like [KO:K04463] [EC:2.7.12.2]
120058506  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
120062345  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
120065235  probable nuclear hormone receptor HR38 [KO:K04465]
120061245  probable nuclear hormone receptor HR38 [KO:K04465]
120034417  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
120036304  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
120046219  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
120046430  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
120029505  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
120039020  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120039965  NF-kappa-B essential modulator-like [KO:K07210]
120061717  ikbkg; NF-kappa-B essential modulator [KO:K07210]
120018106  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
120033006  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
120028227  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
120052706  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
120048158  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
120062367  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
120017404  uncharacterized protein LOC120017404 [KO:K04469]
120046525  nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469]
120030357  putative transcription factor p65 homolog [KO:K04735]
120049602  transcription factor p65-like isoform X1 [KO:K04735]
120018409  transcription factor RelB-like [KO:K09253]
120028279  transcription factor RelB-like isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
snh04070  Phosphatidylinositol signaling system
snh04110  Cell cycle
snh04115  p53 signaling pathway
snh04210  Apoptosis
snh04310  Wnt signaling pathway
KO pathway
ko04010   
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