KEGG   PATHWAY: hsa05208
Entry
hsa05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05208

Network
  Element
N01389  Lead to SOD/Cat-mediated ROS neutralization
N01390  p,p'-DDT to SOD/Cat-mediated ROS neutralization
N01391  Lead to SOD/Cat-mediated ROS neutralization
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01394  Arsenic to electron transfer in complex IV
N01395  Cadmium to electron transfer in complex III
N01396  4-Aminobiphenyl to CYP-mediated metabolism
N01397  4-Aminobiphenyl to CYP-mediated metabolism
N01398  Pentachlorophenol to CYP-mediated metabolism
N01399  Benzene to CYP-mediated metabolism
N01400  Benzene to CYP-mediated metabolism
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01404  17beta-estradiol to CYP-mediated metabolism
N01405  17beta-estradiol to CYP-mediated metabolism
N01406  Ethanol to CYP-mediated metabolism
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
N01409  Metals to PI3K signaling pathway
N01410  Metals to NFKB signaling pathway
N01411  Metals to NFKB signaling pathway
N01412  Metals to HTF-1 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Organism
Homo sapiens (human) [GN:hsa]
Gene
57412  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
221357  GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
2939  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
2941  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
119391  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
2948  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
2952  GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
2947  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
4257  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4259  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
2944  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
2949  GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
4258  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
2938  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
2946  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
2940  GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
9446  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
653689  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
25774  GSTT4; glutathione S-transferase theta 4 [KO:K00799] [EC:2.5.1.18]
4535  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4536  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4537  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4538  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4539  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4540  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4541  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
4723  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
4729  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
4731  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
4694  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
4695  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
4696  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
4697  NDUFA4; NDUFA4 mitochondrial complex associated [KO:K03948]
56901  NDUFA4L2; NDUFA4 mitochondrial complex associated like 2 [KO:K03948]
107984365  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
4698  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
4700  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
4701  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
4702  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
4704  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
4705  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
4706  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
126328  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
55967  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
51079  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
4707  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
4708  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
4709  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
4710  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
4711  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
4712  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
4713  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
4714  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
4715  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
4716  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
54539  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
4719  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
4720  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
4722  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
4724  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
4725  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
4726  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
374291  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
4728  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
4717  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
4718  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
100532726  NDUFC2-KCTD14; NDUFC2-KCTD14 readthrough [KO:K03968]
6389  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
6390  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
6391  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
6392  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
7386  UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
4519  CYTB; cytochrome b [KO:K00412]
1537  CYC1; cytochrome c1 [KO:K00413]
7384  UQCRC1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
7385  UQCRC2; ubiquinol-cytochrome c reductase core protein 2 [KO:K00415]
7388  UQCRH; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
440567  UQCRHL; ubiquinol-cytochrome c reductase hinge protein like [KO:K00416]
7381  UQCRB; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
27089  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII [KO:K00418]
29796  UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
10975  UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
4514  COX3; cytochrome c oxidase subunit III [KO:K02262]
4512  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4513  COX2; cytochrome c oxidase subunit II [KO:K02261]
84701  COX4I2; cytochrome c oxidase subunit 4I2 [KO:K02263]
1327  COX4I1; cytochrome c oxidase subunit 4I1 [KO:K02263]
9377  COX5A; cytochrome c oxidase subunit 5A [KO:K02264]
1329  COX5B; cytochrome c oxidase subunit 5B [KO:K02265]
1337  COX6A1; cytochrome c oxidase subunit 6A1 [KO:K02266]
1339  COX6A2; cytochrome c oxidase subunit 6A2 [KO:K02266]
1340  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
125965  COX6B2; cytochrome c oxidase subunit 6B2 [KO:K02267]
1345  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
1346  COX7A1; cytochrome c oxidase subunit 7A1 [KO:K02270]
1347  COX7A2; cytochrome c oxidase subunit 7A2 [KO:K02270]
9167  COX7A2L; cytochrome c oxidase subunit 7A2 like [KO:K02270]
1349  COX7B; cytochrome c oxidase subunit 7B [KO:K02271]
170712  COX7B2; cytochrome c oxidase subunit 7B2 [KO:K02271]
1350  COX7C; cytochrome c oxidase subunit 7C [KO:K02272]
341947  COX8C; cytochrome c oxidase subunit 8C [KO:K02273]
1351  COX8A; cytochrome c oxidase subunit 8A [KO:K02273]
498  ATP5F1A; ATP synthase F1 subunit alpha [KO:K02132]
506  ATP5F1B; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
509  ATP5F1C; ATP synthase F1 subunit gamma [KO:K02136]
513  ATP5F1D; ATP synthase F1 subunit delta [KO:K02134]
514  ATP5F1E; ATP synthase F1 subunit epsilon [KO:K02135]
4508  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
515  ATP5PB; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
516  ATP5MC1; ATP synthase membrane subunit c locus 1 [KO:K02128]
517  ATP5MC2; ATP synthase membrane subunit c locus 2 [KO:K02128]
518  ATP5MC3; ATP synthase membrane subunit c locus 3 [KO:K02128]
10476  ATP5PD; ATP synthase peripheral stalk subunit d [KO:K02138]
539  ATP5PO; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
522  ATP5PF; ATP synthase peripheral stalk subunit F6 [KO:K02131]
4509  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
6648  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
7416  VDAC1; voltage dependent anion channel 1 [KO:K05862]
7417  VDAC2; voltage dependent anion channel 2 [KO:K15040]
7419  VDAC3; voltage dependent anion channel 3 [KO:K15041]
291  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
292  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
293  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
83447  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
10105  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
6647  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
847  CAT; catalase [KO:K03781] [EC:1.11.1.6]
10861  SLC26A1; solute carrier family 26 member 1 [KO:K14700]
1836  SLC26A2; solute carrier family 26 member 2 [KO:K14701]
65010  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
115019  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
1572  CYP2F1; cytochrome P450 family 2 subfamily F member 1 [KO:K07416] [EC:1.14.14.1]
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
2052  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
2053  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
79852  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
253152  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
10327  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
1645  AKR1C1; aldo-keto reductase family 1 member C1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
1646  AKR1C2; aldo-keto reductase family 1 member C2 [KO:K00089] [EC:1.1.1.213 1.1.1.357]
8644  AKR1C3; aldo-keto reductase family 1 member C3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
1109  AKR1C4; aldo-keto reductase family 1 member C4 [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
1728  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
873  CBR1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
196  AHR; aryl hydrocarbon receptor [KO:K09093]
4025  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
50507  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
1535  CYBA; cytochrome b-245 alpha chain [KO:K08009]
27035  NOX1; NADPH oxidase 1 [KO:K08008]
653361  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
4688  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
1950  EGF; epidermal growth factor [KO:K04357]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
3082  HGF; hepatocyte growth factor [KO:K05460]
4233  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
2885  GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
6416  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
5609  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
110117499  P3R3URF-PIK3R3; P3R3URF-PIK3R3 readthrough [KO:K02649]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
5170  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2309  FOXO3; forkhead box O3 [KO:K09408]
572  BAD; BCL2 associated agonist of cell death [KO:K02158]
5770  PTPN1; protein tyrosine phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
5728  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467] [EC:2.7.11.10]
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5580  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
5795  PTPRJ; protein tyrosine phosphatase receptor type J [KO:K05698] [EC:3.1.3.48]
52  ACP1; acid phosphatase 1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
27  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
5587  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
23683  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
25865  PRKD2; protein kinase D2 [KO:K06070] [EC:2.7.11.13]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
9020  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
3091  HIF1A; hypoxia inducible factor 1 subunit alpha [KO:K08268]
405  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
7422  VEGFA; vascular endothelial growth factor A [KO:K05448]
9817  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
4780  NFE2L2; NFE2 like bZIP transcription factor 2 [KO:K05638]
3162  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
hsa00190  Oxidative phosphorylation
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05207  Chemical carcinogenesis - receptor activation
hsa05211  Renal cell carcinoma
hsa05215  Prostate cancer
hsa05219  Bladder cancer
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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