KEGG   PATHWAY: osa03040
Entry
osa03040                    Pathway                                
Name
Spliceosome - Oryza sativa japonica (Japanese rice)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
osa03040  Spliceosome
osa03040

Other DBs
GO: 0005681
Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
107275655  [KO:K06063]
107275752  [KO:K12900]
107275844  [KO:K03283]
107275966  [KO:K12662]
107277261  [KO:K12831]
107277487  [KO:K12834]
107279546  [KO:K03283]
107281411  [KO:K12850]
112936013  [KO:K12625]
136351103  [KO:K12818] [EC:5.6.2.6]
4323935  [KO:K12840]
4324080  [KO:K12896]
4324332  [KO:K12865]
4324336  [KO:K12879]
4324412  [KO:K13098]
4324760  [KO:K12873]
4325074  [KO:K12622]
4325413  [KO:K12837]
4326190  OsJ_02174; dEAD-box ATP-dependent RNA helicase 40 [KO:K12823] [EC:5.6.2.7]
4326192  AIP1; dEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
4326193  AIP2; dEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
4326212  OsJ_01215; rNA-binding protein P [KO:K12741]
4326227  OsJ_01157; probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
4326580  EIF4A3A; eukaryotic initiation factor 4A-III homolog A [KO:K13025] [EC:5.6.2.7]
4326641  [KO:K12741]
4327388  [KO:K03283]
4327645  [KO:K12823] [EC:5.6.2.7]
4327802  [KO:K12821]
4327991  [KO:K11088]
4328024  [KO:K12854] [EC:5.6.2.6]
4328133  [KO:K12893]
4328158  [KO:K11097]
4328237  [KO:K12830]
4328284  [KO:K12828]
4328484  [KO:K11098]
4328504  [KO:K12842]
4328758  [KO:K12741]
4328823  [KO:K11092]
4328860  [KO:K12825]
4328900  [KO:K12900]
4328958  [KO:K11095]
4329095  [KO:K12818] [EC:5.6.2.6]
4329300  [KO:K12846]
4329449  [KO:K12625]
4329455  [KO:K11984]
4329810  [KO:K11087]
4329902  [KO:K12870]
4329903  [KO:K12741]
4329951  Os-RSZ23; serine/arginine-rich splicing factor RSZ23 isoform 1 [KO:K12896]
4329963  CBP20; nuclear cap-binding protein subunit 2 [KO:K12883]
4330613  [KO:K12844]
4330796  [KO:K06063]
4330968  Os-RSZ21; serine/arginine-rich splicing factor RSZ21 [KO:K12896]
4331222  [KO:K12829]
4331250  [KO:K12864]
4331353  [KO:K12878]
4331556  [KO:K12837]
4332206  [KO:K11088]
4332209  [KO:K12845]
4332334  [KO:K12826]
4332413  [KO:K03283]
4332416  [KO:K03283]
4332420  [KO:K03283]
4332426  [KO:K12881]
4332476  [KO:K12896]
4332557  OsJ_10509; U2 small nuclear ribonucleoprotein B'' isoform 1 [KO:K11094]
4332617  [KO:K12835] [EC:5.6.2.7]
4332645  [KO:K12820] [EC:5.6.2.6]
4332781  [KO:K12862]
4332806  [KO:K12890]
4332822  ABH1; nuclear cap-binding protein subunit 1 [KO:K12882]
4332861  [KO:K12662]
4332903  [KO:K12900]
4332988  [KO:K12875]
4332999  [KO:K12874]
4333005  [KO:K12891]
4333045  [KO:K12816]
4333092  [KO:K11099]
4333273  eIF4A-III; eukaryotic initiation factor 4A-III homolog B [KO:K13025] [EC:5.6.2.7]
4333826  [KO:K12817]
4333866  OsJ_12293; dEAD-box ATP-dependent RNA helicase 21 isoform X1 [KO:K12858] [EC:5.6.2.7]
4333915  [KO:K12827]
4334528  OsY14b; rNA-binding protein Y14B [KO:K12876]
4334542  [KO:K09567] [EC:5.2.1.8]
4334543  [KO:K12833]
4334598  [KO:K03283]
4334674  [KO:K12848]
4334964  [KO:K12893]
4335542  [KO:K12860]
4336118  [KO:K11087]
4336619  [KO:K12844]
4337147  [KO:K12741]
4337198  [KO:K12873]
4337303  [KO:K12834]
4337644  [KO:K12896]
4337757  OsY14a; rNA-binding protein Y14A [KO:K12876]
4337846  OsJ_17170; U1 small nuclear ribonucleoprotein A [KO:K11091]
4337897  [KO:K12896]
4337900  [KO:K12856]
4337972  [KO:K12850]
4338298  [KO:K12869]
4338354  [KO:K03283]
4338385  [KO:K11096]
4338552  [KO:K12890]
4338563  [KO:K12834]
4338670  [KO:K12624]
4338675  [KO:K12813] [EC:5.6.2.6]
4338860  [KO:K12831]
4338942  OsJ_18724; protein BUD31 homolog 2 [KO:K12873]
4339012  [KO:K03283]
4339621  OsC3H38; splicing factor U2af small subunit B [KO:K12836]
4339810  [KO:K12627]
4339866  [KO:K12863]
4340248  [KO:K12856]
4340263  OsC3H40; zinc finger CCCH domain-containing protein 40 [KO:K12872]
4340353  Os-RSZ21a; serine/arginine-rich splicing factor RSZ21A [KO:K12896]
4340375  [KO:K12818] [EC:5.6.2.6]
4340675  [KO:K12881]
4341330  [KO:K12741]
4341492  [KO:K12852]
4341706  [KO:K12857]
4342038  [KO:K12868]
4342102  [KO:K12897]
4342149  [KO:K12871]
4342372  [KO:K12844]
4342674  [KO:K12830]
4342793  [KO:K12881]
4342926  OsC3H49; zinc finger CCCH domain-containing protein 49 [KO:K12872]
4343339  [KO:K12815] [EC:5.6.2.6]
4343671  [KO:K12817]
4343831  [KO:K12741]
4343870  [KO:K11099]
4343939  [KO:K12818] [EC:5.6.2.6]
4343955  [KO:K12891]
4343967  [KO:K12875]
4344009  [KO:K12900]
4344088  [KO:K12867]
4344256  [KO:K12890]
4344462  MAGO1; protein mago nashi homolog 1 isoform 1 [KO:K12877]
4344474  [KO:K12839]
4344572  OsJ_25904; pre-mRNA-splicing factor SLU7 [KO:K12819]
4344666  [KO:K11097]
4344682  [KO:K12811] [EC:5.6.2.7]
4344686  [KO:K12621]
4344716  OsJ_26125; DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
4344803  [KO:K12626]
4345254  [KO:K12741]
4345304  [KO:K12813] [EC:5.6.2.6]
4345455  [KO:K12897]
4345578  [KO:K12822]
4345621  [KO:K12881]
4345702  [KO:K12832]
4345884  [KO:K12891]
4345910  [KO:K12741]
4346316  OsCyp3; peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
4346374  [KO:K12849]
4346506  [KO:K12843]
4346657  [KO:K12880]
4347019  [KO:K12847]
4347985  [KO:K11093]
4348007  [KO:K12845]
4348309  [KO:K12741]
4348330  [KO:K12869]
4348798  [KO:K12831]
4348844  OsJ_31829; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
4348939  [KO:K12824]
4348949  [KO:K12859]
4349020  [KO:K12855]
4349526  [KO:K12881]
4349971  [KO:K03283]
4349972  [KO:K03283]
4350353  [KO:K12818] [EC:5.6.2.6]
4350981  OsJ_34542; splicing factor U2af large subunit A [KO:K12837]
4351052  [KO:K11098]
4351124  U2AF65B; splicing factor U2af large subunit B isoform 1 [KO:K12837]
4351155  [KO:K12823] [EC:5.6.2.7]
4351208  [KO:K03283]
4351215  [KO:K12900]
4351236  [KO:K12881]
4351510  [KO:K12873]
4351875  [KO:K03283]
4351998  MAGO2; protein mago nashi homolog 2 [KO:K12877]
4352279  [KO:K12741]
9268085  [KO:K12900]
9268087  P0431A02.2; thioredoxin-like protein YLS8 [KO:K12859]
9268567  OsC3H60; splicing factor U2af small subunit A [KO:K12836]
9268869  [KO:K12823] [EC:5.6.2.7]
9270807  [KO:K11086]
9271426  [KO:K03283]
9271802  [KO:K12823] [EC:5.6.2.7]
9272163  [KO:K12861]
9272211  [KO:K12832]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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