KEGG   PATHWAY: ncar05022
Entry
ncar05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Sciurus carolinensis (gray squirrel)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ncar05022  Pathways of neurodegeneration - multiple diseases
ncar05022

Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124993088  amyloid-beta precursor protein isoform X1 [KO:K04520]
124980973  microtubule-associated protein tau isoform X1 [KO:K04380]
124994728  alpha-synuclein [KO:K04528]
124991957  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
124970068  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
124992482  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
124990900  LOW QUALITY PROTEIN: ataxin-2-like [KO:K23625]
124970572  ataxin-2-like protein isoform X1 [KO:K23625]
124994030  huntingtin isoform X1 [KO:K04533]
124988312  ataxin-1 [KO:K23616]
124966591  ataxin-1-like isoform X1 [KO:K23616]
124977157  ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
124977490  major prion protein [KO:K05634]
124958827  muscarinic acetylcholine receptor M1 [KO:K04129]
124962023  muscarinic acetylcholine receptor M3 [KO:K04131]
124970388  muscarinic acetylcholine receptor M5 [KO:K04133]
124958385  spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
124989681  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
124958602  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
124964255  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124987958  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
124976705  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124959812  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977474  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124972679  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
124977089  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
124979014  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124970211  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124967611  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124994631  short transient receptor potential channel 3 isoform X1 [KO:K04966]
124965028  sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
124970932  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124983533  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124988553  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
124966810  ryanodine receptor 1 isoform X1 [KO:K04961]
124961919  ryanodine receptor 2 isoform X1 [KO:K04962]
124976404  ryanodine receptor 3 [KO:K04963]
124971818  proenkephalin-B-like [KO:K15840]
124981029  disks large homolog 4 isoform X1 [KO:K11828]
124964369  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
124970656  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A-like [KO:K05209]
124983215  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
124979849  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
124966828  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
124986940  glutamate receptor 1 isoform X1 [KO:K05197]
124994514  glutamate receptor 2 isoform X1 [KO:K05198]
124971795  glutamate receptor 3 isoform X1 [KO:K05199]
124958112  glutamate receptor 4 isoform X1 [KO:K05200]
124964767  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
124982084  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124968359  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
124971751  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
124961645  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
124970311  syntaxin-1A isoform X1 [KO:K04560]
124976997  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
124990126  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
124969905  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
124980515  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
124976090  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
124962040  presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
124995293  derlin-1 [KO:K11519]
124964729  transitional endoplasmic reticulum ATPase [KO:K13525]
124988961  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
124968426  ubiquitin-60S ribosomal protein L40 [KO:K02927]
124968641  ubiquitin-like [KO:K02927]
124980787  ubiquitin-like [KO:K02927]
124963395  ubiquitin-40S ribosomal protein S27a [KO:K02977]
124980729  polyubiquitin-B [KO:K04551]
124974413  polyubiquitin-B-like [KO:K04551]
124974416  polyubiquitin-like [KO:K04551]
124975875  polyubiquitin-like [KO:K04551]
124991900  polyubiquitin-C [KO:K08770]
124971341  proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
124991689  proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
124978206  proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
124988985  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124965646  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
124976222  proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
124964531  proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
124960605  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
124986978  LOW QUALITY PROTEIN: proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
124977179  proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
124980525  proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
124964184  proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
124981343  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
124991378  LOW QUALITY PROTEIN: proteasome subunit beta type-2-like [KO:K02734] [EC:3.4.25.1]
124962291  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
124978282  proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
124989624  proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
124959256  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
124991795  26S proteasome regulatory subunit 7 [KO:K03061]
124975937  26S proteasome regulatory subunit 7-like [KO:K03061]
124977836  26S proteasome regulatory subunit 4 [KO:K03062]
124966865  26S proteasome regulatory subunit 6B [KO:K03063]
124977927  26S proteasome regulatory subunit 10B [KO:K03064]
124994866  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A-like [KO:K03065]
124995331  26S proteasome regulatory subunit 6A [KO:K03065]
124979791  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
124992732  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
124979673  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
124980991  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
124991897  26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
124960430  26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
124980492  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
124981390  26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
124968854  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
124967565  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
124958474  26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
124982161  26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
124973164  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124975004  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4-like [KO:K03029]
124980521  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
124966972  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
124964751  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8-like [KO:K03031]
124976847  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
124973604  LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1-like [KO:K06691]
124983588  26S proteasome complex subunit SEM1 [KO:K10881]
124994651  ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
124972450  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
124973030  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
124992897  ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
124991040  ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
124969269  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
124963283  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
124965632  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
124958349  ubiquitin/ISG15-conjugating enzyme E2 L6-like isoform X1 [KO:K04553] [EC:2.3.2.23]
124958898  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
124989000  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
124986490  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
124992606  uncharacterized protein LOC124992606 isoform X1 [KO:K04555] [EC:2.3.2.23]
124980010  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
124991922  prosaposin receptor GPR37 [KO:K04243]
124990882  septin-5 isoform X1 [KO:K04557]
124987238  synphilin-1 isoform X1 [KO:K04558]
124964798  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
124976087  vesicle-associated membrane protein-associated protein B/C [KO:K10707]
124986518  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
124983170  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
124991760  LOW QUALITY PROTEIN: uncharacterized protein LOC124991760 [KO:K09027]
124979930  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
124964641  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
124988565  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
124968601  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124986765  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124994121  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124984745  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124967089  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
124975124  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
124976810  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
124984025  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124987217  sodium-dependent dopamine transporter [KO:K05036]
124983421  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
124960411  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
124965286  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
124993284  suppressor protein SRP40-like isoform X1 [KO:K03944]
124962734  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124980697  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
124971899  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
124986769  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
124967150  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
124958341  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124989721  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124991046  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
124966837  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124972400  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
124983813  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
124993505  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
124991763  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
124982312  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
124968718  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
124985829  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
124964968  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
124983572  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
124979118  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
124986398  LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial-like [KO:K03955]
124970777  acyl carrier protein, mitochondrial-like [KO:K03955]
124972499  acyl carrier protein, mitochondrial-like [KO:K03955]
124968683  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
124983083  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
124967816  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
124977589  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
124990972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
124980197  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
124992578  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
124992876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
124987541  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124982958  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124983344  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
124964468  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
124968580  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
124984628  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
124962972  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
124970425  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
124971919  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
124979719  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
124994753  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
124958469  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
124987567  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
124992960  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
124987606  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
124968482  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
124958631  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
124994343  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
124981096  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
124960623  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
124986669  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
124994572  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
124961406  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
124958779  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
124967159  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
124976441  cytochrome c1, heme protein, mitochondrial [KO:K00413]
124993792  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
124985946  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
124969833  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
124976494  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
124960250  cytochrome b-c1 complex subunit 7 [KO:K00417]
124963228  cytochrome b-c1 complex subunit 7-like [KO:K00417]
124986976  cytochrome b-c1 complex subunit 8 [KO:K00418]
124991001  cytochrome b-c1 complex subunit 9 [KO:K00419]
124969484  cytochrome b-c1 complex subunit 10 [KO:K00420]
124977244  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
124967440  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
124977063  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
124959708  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
124963339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
124991034  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
124970560  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
124966941  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
124979836  cytochrome c oxidase subunit 6B1-like [KO:K02267]
124966431  cytochrome c oxidase subunit 6B1 [KO:K02267]
124984069  cytochrome c oxidase subunit 6C [KO:K02268]
124979038  cytochrome c oxidase subunit 6C-like [KO:K02268]
124961590  cytochrome c oxidase subunit 6C-like [KO:K02268]
124988296  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
124963329  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
124966433  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
124994104  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
124978951  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
124972073  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
124986386  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124986478  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124987029  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
124980275  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124980291  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
124959872  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
124988623  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124965845  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
124983743  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
124961688  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
124968690  ATP synthase subunit delta, mitochondrial [KO:K02134]
124978256  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
124984257  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
124994886  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124961875  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
124979929  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
124980241  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
124983026  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
124958764  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
124980569  ATP synthase subunit d, mitochondrial [KO:K02138]
124993299  ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
124992905  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
124965545  apoptosis regulator Bcl-2 [KO:K02161]
124986880  voltage-dependent anion-selective channel protein 1 [KO:K05862]
124967586  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
124985084  mitochondrial import receptor subunit TOM40B [KO:K11518]
124980274  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
124985196  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
124976834  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
124967357  calmodulin-1 [KO:K02183]
124967948  calmodulin-like protein 6 [KO:K02183]
124962006  calmodulin-like [KO:K02183]
124962112  calmodulin-A-like [KO:K02183]
124962222  calmodulin-like protein 3 [KO:K02183]
124963056  calmodulin-1 [KO:K02183]
124976085  calmodulin-1 [KO:K02183]
124994051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124984768  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124982403  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124963548  calcineurin subunit B type 1 [KO:K06268]
124963939  calcineurin subunit B type 2 [KO:K06268]
124958534  bcl2-associated agonist of cell death-like [KO:K02158]
124962014  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
124984583  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
124960510  FAS-associated death domain protein-like [KO:K02373]
124980441  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
124982226  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
124966672  apoptosis regulator BAX isoform X1 [KO:K02159]
124988289  bcl-2 homologous antagonist/killer-like [KO:K14021]
124988679  bcl-2 homologous antagonist/killer [KO:K14021]
124974602  bcl-2 homologous antagonist/killer-like [KO:K14021]
124982607  LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2-like [KO:K08844] [EC:2.7.11.1]
124970288  heat shock protein 75 kDa, mitochondrial [KO:K09488]
124984706  voltage-dependent anion-selective channel protein 2 [KO:K15040]
124983451  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
124994584  ADP/ATP translocase 4 isoform X1 [KO:K05863]
124972172  ADP/ATP translocase 3 [KO:K05863]
124972520  ADP/ATP translocase 2 [KO:K05863]
124983822  ADP/ATP translocase 1 [KO:K05863]
124984875  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
124994683  cytochrome c, somatic-like [KO:K08738]
124991556  cytochrome c, somatic [KO:K08738]
124991711  cytochrome c, somatic-like [KO:K08738]
124979232  cytochrome c, somatic-like [KO:K08738]
124961943  cytochrome c, somatic-like [KO:K08738]
124962143  cytochrome c-like [KO:K08738]
124962144  cytochrome c-like [KO:K08738]
124962145  cytochrome c-like [KO:K08738]
124962146  cytochrome c-like [KO:K08738]
124970186  cytochrome c, somatic-like [KO:K08738]
124980035  cytochrome c, testis-specific [KO:K08738]
124965714  cytochrome c, somatic-like [KO:K08738]
124982341  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
124966493  caspase-9-like [KO:K04399] [EC:3.4.22.62]
124972492  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
124983898  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
124970175  huntingtin-interacting protein 1 isoform X1 [KO:K04559]
124993076  intraflagellar transport protein 57 homolog [KO:K04638]
124972561  3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
124994383  peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
124983002  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
124976128  bcl-2-like protein 1 isoform X1 [KO:K04570]
124993046  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
124978147  mitofusin-2 [KO:K06030] [EC:3.6.5.-]
124962278  optineurin isoform X1 [KO:K19946]
124986635  sequestosome-1 [KO:K14381]
124960323  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
124977765  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
124962379  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
124966331  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
124983333  LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
124979950  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
124987577  WD repeat-containing protein 41 isoform X1 [KO:K23610]
124980778  guanine nucleotide exchange protein SMCR8 isoform X1 [KO:K23611]
124964945  guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
124985792  LOW QUALITY PROTEIN: ras-related protein Rab-8A-like [KO:K07901]
124969448  ras-related protein Rab-8A [KO:K07901]
124972087  ras-related protein Rab-39B [KO:K07925]
124963464  ras-related protein Rab-1A [KO:K07874]
124979992  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
124990355  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
124985429  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
124979750  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
124982613  autophagy-related protein 101 [KO:K19730]
124959733  autophagy-related protein 13 isoform X1 [KO:K08331]
124992972  RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
124958674  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
124961355  beclin-2-like [KO:K08334]
124979174  beclin-1 isoform X1 [KO:K08334]
124992962  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
124977862  beclin 1-associated autophagy-related key regulator [KO:K17889]
124984919  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
124965428  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
124960149  autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
124972994  autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
124970455  WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
124980634  WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
124977776  zinc finger FYVE domain-containing protein 1 [KO:K17603]
124979695  alsin isoform X1 [KO:K04575]
124968730  ras-related protein Rab-5A [KO:K07887]
124970797  ras-related protein Rab-5A-like [KO:K07887]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124992306  charged multivesicular body protein 2b [KO:K12192]
124989551  polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
124977421  spatacsin-like isoform X1 [KO:K19026]
124988890  tumor necrosis factor [KO:K03156]
124984003  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
124983857  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
124988670  death domain-associated protein 6 [KO:K02308]
124980599  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
124981341  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
124988515  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
124989076  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124978202  mitogen-activated protein kinase 14-like isoform X1 [KO:K04441] [EC:2.7.11.24]
124982485  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
124982486  LOW QUALITY PROTEIN: mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
124991150  nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
124960609  copper chaperone for superoxide dismutase [KO:K04569]
124986561  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
124958491  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
124992895  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
124987590  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
124988541  epididymal secretory glutathione peroxidase-like isoform X1 [KO:K00432] [EC:1.11.1.9]
124988542  glutathione peroxidase 6-like isoform X1 [KO:K00432] [EC:1.11.1.9]
124976946  glutathione peroxidase 2-like [KO:K00432] [EC:1.11.1.9]
124959884  catalase [KO:K03781] [EC:1.11.1.6]
124981894  neurofilament light polypeptide [KO:K04572]
124983779  neurofilament medium polypeptide-like [KO:K04573]
124990122  neurofilament heavy polypeptide isoform X1 [KO:K04574]
124961723  kinesin-1 heavy chain [KO:K10396]
124979764  kinesin heavy chain [KO:K10396]
124982292  LOW QUALITY PROTEIN: kinesin heavy chain-like [KO:K10396]
124958444  kinesin light chain 2 isoform X1 [KO:K10407]
124988614  kinesin light chain 4 [KO:K10407]
124976841  kinesin light chain 1 isoform X1 [KO:K10407]
124966675  kinesin light chain 3 [KO:K10407]
124990413  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
124990575  tubulin alpha-3 chain [KO:K07374]
124990878  tubulin alpha-3 chain [KO:K07374]
124992512  tubulin alpha-1A chain-like [KO:K07374]
124978858  tubulin alpha-1D chain [KO:K07374]
124978859  tubulin alpha-4A chain [KO:K07374]
124961678  tubulin alpha-8 chain isoform X1 [KO:K07374]
124961964  tubulin alpha chain-like 3 [KO:K07374]
124982222  tubulin alpha-1B chain isoform X1 [KO:K07374]
124982223  tubulin alpha-1A chain [KO:K07374]
124982391  tubulin alpha-8 chain [KO:K07374]
124986665  tubulin beta chain-like [KO:K07375]
124988071  tubulin beta chain [KO:K07375]
124988155  tubulin beta-2A chain [KO:K07375]
124989446  tubulin beta-2A chain-like [KO:K07375]
124989671  tubulin beta-2B chain [KO:K07375]
124990586  tubulin beta chain-like [KO:K07375]
124968782  tubulin beta-4A chain [KO:K07375]
124978255  tubulin beta-1 chain [KO:K07375]
124964452  tubulin beta-4B chain [KO:K07375]
124965280  tubulin beta-5 chain [KO:K07375]
124966012  tubulin beta-3 chain [KO:K07375]
124992642  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124966476  LOW QUALITY PROTEIN: casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
124976114  LOW QUALITY PROTEIN: casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
124989016  casein kinase II subunit beta [KO:K03115]
124963060  dynactin subunit 1 isoform X1 [KO:K04648]
124982924  LOW QUALITY PROTEIN: dynactin subunit 2-like [KO:K10424]
124964864  dynactin subunit 3 isoform X1 [KO:K10425]
124987220  dynactin subunit 4 [KO:K10426]
124970248  dynactin subunit 5 [KO:K10427]
124983775  dynactin subunit 6 isoform X1 [KO:K10428]
124985187  alpha-centractin [KO:K16575]
124963652  beta-centractin isoform X1 [KO:K16575]
124977628  actin-related protein 10 [KO:K16576]
124980080  huntingtin-associated protein 1-like isoform X1 [KO:K04647]
124987094  LOW QUALITY PROTEIN: dynein axonemal heavy chain 5-like [KO:K10408]
124988587  LOW QUALITY PROTEIN: dynein axonemal heavy chain 8-like [KO:K10408]
124991529  LOW QUALITY PROTEIN: dynein axonemal heavy chain 10-like [KO:K10408]
124991625  LOW QUALITY PROTEIN: dynein axonemal heavy chain 11-like [KO:K10408]
124968533  LOW QUALITY PROTEIN: dynein axonemal heavy chain 1-like [KO:K10408]
124978883  dynein axonemal heavy chain 17 [KO:K10408]
124969088  dynein axonemal heavy chain 12 [KO:K10408]
124962941  LOW QUALITY PROTEIN: dynein axonemal heavy chain 6-like [KO:K10408]
124970714  dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
124980287  dynein axonemal heavy chain 9 isoform X1 [KO:K10408]
124980995  LOW QUALITY PROTEIN: dynein axonemal heavy chain 7-like [KO:K10408]
124981143  dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
124958810  axonemal dynein light intermediate polypeptide 1 [KO:K10410]
124964088  LOW QUALITY PROTEIN: dynein axonemal intermediate chain 1-like [KO:K10409]
124981414  dynein axonemal intermediate chain 2 isoform X1 [KO:K11143]
124977604  dynein axonemal light chain 1 [KO:K10411]
124983212  dynein axonemal light chain 4 [KO:K10412]
124985817  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124986742  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124994412  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124990768  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124958508  LOW QUALITY PROTEIN: calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
124961543  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
124978832  cyclin-dependent kinase 5 activator 1 [KO:K11716]
124990793  cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
124985521  caspase-7 [KO:K04397] [EC:3.4.22.60]
124985471  dickkopf-related protein 1 [KO:K02165]
124994556  dickkopf-related protein 2 [KO:K02165]
124981939  dickkopf-related protein 4 [KO:K02165]
124981913  proto-oncogene Wnt-1 [KO:K03209]
124987877  protein Wnt-2b [KO:K00182]
124990144  protein Wnt-2 [KO:K00182]
124978881  proto-oncogene Wnt-3 [KO:K00312]
124975085  LOW QUALITY PROTEIN: protein Wnt-3a-like [KO:K00312]
124994115  protein Wnt-4 isoform X1 [KO:K00408]
124969304  protein Wnt-5a isoform X1 [KO:K00444]
124983449  protein Wnt-5b isoform X1 [KO:K00444]
124981136  protein Wnt-6 [KO:K00445]
124971065  protein Wnt-7a [KO:K00572]
124983640  protein Wnt-7b isoform X1 [KO:K00572]
124985494  protein Wnt-8b [KO:K00714]
124987547  protein Wnt-8a [KO:K00714]
124979888  protein Wnt-9b [KO:K01064]
124975097  protein Wnt-9a isoform X1 [KO:K01064]
124981135  protein Wnt-10a [KO:K01357]
124983510  protein Wnt-10b [KO:K01357]
124960559  protein Wnt-11 isoform X1 [KO:K01384]
124990121  protein Wnt-16 [KO:K01558]
124991618  frizzled-1 [KO:K02432]
124980367  frizzled-7 [KO:K02432]
124980045  frizzled-2 [KO:K02235]
124983712  frizzled-3 isoform X1 [KO:K02329]
124959741  frizzled-4 [KO:K02354]
124979128  frizzled-5 [KO:K02375]
124962109  frizzled-8 [KO:K02375]
124962453  LOW QUALITY PROTEIN: frizzled-6-like [KO:K02376]
124990891  frizzled-10 [KO:K02842]
124970452  frizzled-9 [KO:K02842]
124958409  low-density lipoprotein receptor-related protein 5 [KO:K03068]
124982584  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6-like [KO:K03068]
124982481  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
124993254  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
124961693  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
124981030  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
124984918  proto-oncogene FRAT1-like [KO:K03069]
124984951  GSK-3-binding protein FRAT2-like [KO:K03096]
124970513  axin-1 isoform X1 [KO:K02157]
124980732  axin-2 isoform X1 [KO:K04385]
124986583  adenomatous polyposis coli protein isoform X1 [KO:K02085]
124967865  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
124969493  catenin beta-1 [KO:K02105]
124986275  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
124961975  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
124982688  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
124988641  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124971762  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
124990234  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124977990  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124969568  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124972125  NADPH oxidase 1 isoform X1 [KO:K08008]
124972580  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
124958702  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
124960546  transcription factor p65 [KO:K04735]
124994613  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
124979775  nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
124962420  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
124990183  interleukin-6-like [KO:K05405]
124963656  interleukin-1 alpha-like [KO:K04383]
124969224  macrophage colony-stimulating factor 1-like isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
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Related
pathway
ncar00190  Oxidative phosphorylation
ncar03050  Proteasome
ncar04020  Calcium signaling pathway
ncar04120  Ubiquitin mediated proteolysis
ncar04137  Mitophagy - animal
ncar04140  Autophagy - animal
ncar04141  Protein processing in endoplasmic reticulum
ncar04142  Lysosome
ncar04210  Apoptosis
ncar04310  Wnt signaling pathway
ncar04724  Glutamatergic synapse
ncar04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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