KEGG   PATHWAY: omy05168
Entry
omy05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Oncorhynchus mykiss (rainbow trout)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
omy05168  Herpes simplex virus 1 infection
omy05168

Disease
H00365  Herpes simplex virus infection
Organism
Oncorhynchus mykiss (rainbow trout) [GN:omy]
Gene
100135858  tap2t; transporter associated with antigen processing, subunit type t, teleost specific [KO:K05654] [EC:7.4.2.14]
100135918  [KO:K03990]
100135953  [KO:K03237]
100135962  c5; complement C5 [KO:K03994]
100136024  [KO:K04519]
100136034  tnf-alpha; putative tumour necrosis factor alpha [KO:K03156]
100136054  [KO:K12881]
100136058  [KO:K04734]
100136064  tnf; tumor necrosis factor [KO:K03156]
100136086  si:dkey-88e18.2; interleukin-12 beta chain precursor [KO:K05425]
100136087  traf2; tumor necrosis factor receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
100136117  ifngr1l; interferon gamma receptor 1 precursor [KO:K05132]
100136123  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100136140  [KO:K05414]
100136156  [KO:K06505]
100136157  [KO:K06505]
100136202  crt; calreticulin [KO:K08057]
100136273  ifn1; interferon a3 precursor [KO:K05414]
100136299  tapbp.1; TAP binding protein (tapasin), tandem duplicate 1 precursor [KO:K08058]
100136300  tapbpl; TAP binding protein like precursor [KO:K28445]
100136319  light; TNF superfamily member 14 [KO:K05477]
100136325  [KO:K08058]
100136342  tlr3; toll-like receptor 3 precursor [KO:K05401]
100136643  ifng; interferon, gamma precursor [KO:K04687]
100136651  [KO:K15412]
100136668  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100136676  [KO:K04399] [EC:3.4.22.62]
100136689  il6; interleukin-6 precursor [KO:K05405]
100136723  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100136737  tp53; cellular tumor antigen p53 [KO:K04451]
100136755  stat1-1; signal transducer/activator of transcription [KO:K11220]
100136952  c3-3; complement C3-like [KO:K03990]
100137016  stat1-2; signal transducer/activator of transcription [KO:K11220]
100271898  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100272212  socs3; suppressor of cytokine signaling 3 [KO:K04696]
100286821  ifn5; type I interferon 5 precursor [KO:K05414]
100301673  ifn3; type I interferon 3 precursor [KO:K05414]
100301675  ifngamma2; interferon gamma 2 [KO:K04687]
100301676  ifn2; type I interferon 2 precursor [KO:K05414]
100305173  ei2ba; Translation initiation factor eIF-2B subunit alpha [KO:K03239]
100305244  4ebp2; Eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
100305279  tnr5; tumor necrosis factor receptor superfamily member 5 [KO:K05152]
100305297  sfrs3; Splicing factor, arginine/serine-rich 3 [KO:K12892]
100499612  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100499614  mavs; mitochondrial antiviral signaling [KO:K12648]
100500795  oncmyk-dbb; MHC class II beta chain precursor [KO:K06752]
100653429  pfc; properdin P factor complement 2 precursor [KO:K15412]
100653443  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
100653451  [KO:K06081]
100750228  [KO:K09447]
100750229  irf3; interferon regulatory factor 3 [KO:K05411]
100750259  tlr2; toll-like receptor 2 [KO:K10159]
101268911  casp8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
101268961  [KO:K08056] [EC:5.3.4.1]
110485144  [KO:K05414]
110485148  [KO:K05414]
110485516  [KO:K06752]
110485597  [KO:K04403]
110485821  si:ch73-22o12.1; poliovirus receptor isoform X1 [KO:K06531]
110485858  [KO:K05132]
110485929  [KO:K12881]
110486000  [KO:K04456] [EC:2.7.11.1]
110486074  [KO:K09849]
110486080  [KO:K12896]
110486231  [KO:K06493]
110486294  [KO:K02159]
110486365  [KO:K11219] [EC:2.7.10.2]
110486583  [KO:K12891]
110486660  [KO:K06269] [EC:3.1.3.16]
110486729  [KO:K05477]
110487251  tlr18; toll-like receptor 18 [KO:K10159]
110487764  [KO:K12654]
110487866  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
110487867  tnfa; tumor necrosis factor [KO:K03156]
110487881  [KO:K12893]
110488283  [KO:K08056] [EC:5.3.4.1]
110488326  [KO:K06751]
110488340  [KO:K06751]
110488345  [KO:K05654] [EC:7.4.2.14]
110488352  [KO:K06751]
110488353  [KO:K06751]
110488354  [KO:K06751]
110488355  [KO:K02308]
110488365  [KO:K06531]
110488367  [KO:K09364]
110488722  [KO:K02580]
110489008  [KO:K03990]
110489018  [KO:K03990]
110489027  [KO:K03990]
110489078  zgc:153681; nuclear RNA export factor 1 isoform X1 [KO:K14284]
110489275  [KO:K17834] [EC:2.7.7.86]
110489482  [KO:K05425]
110489699  [KO:K04693]
110489720  bcl2a; apoptosis regulator Bcl-2 [KO:K02161]
110489739  [KO:K07208]
110490337  [KO:K27390]
110490504  [KO:K06752]
110490516  [KO:K06752]
110490568  [KO:K02084]
110491527  [KO:K04467] [EC:2.7.11.10]
110491676  [KO:K06493]
110491770  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
110491813  [KO:K04467] [EC:2.7.11.10]
110491865  [KO:K07293] [EC:3.1.3.48]
110491889  [KO:K08055]
110491891  [KO:K08055]
110491892  [KO:K08055]
110491893  [KO:K08055]
110491894  [KO:K08055]
110492035  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
110492053  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110492096  itga5; integrin alpha-5 [KO:K06484]
110492341  [KO:K12893]
110492635  [KO:K04570]
110492651  [KO:K15409] [EC:2.7.11.1]
110492703  [KO:K14966]
110492704  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110492712  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110493262  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
110493506  [KO:K02649]
110493590  ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
110493646  [KO:K04733] [EC:2.7.11.1]
110493654  [KO:K12881]
110493716  [KO:K04456] [EC:2.7.11.1]
110493771  [KO:K09849]
110493794  [KO:K12896]
110493886  [KO:K05704] [EC:2.7.10.2]
110493946  [KO:K06484]
110494100  [KO:K12892]
110494318  [KO:K07208]
110494323  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110494353  srsf3b; serine/arginine-rich splicing factor 3 [KO:K12892]
110494409  [KO:K06752]
110494565  [KO:K04570]
110494567  [KO:K14966]
110494755  [KO:K15409] [EC:2.7.11.1]
110494935  [KO:K04403]
110495049  tsc2; tuberin isoform X1 [KO:K07207]
110495512  [KO:K09364]
110496144  [KO:K17834] [EC:2.7.7.86]
110496210  [KO:K09364]
110496212  pvrl2l; poliovirus receptor isoform X1 [KO:K06531]
110496222  [KO:K02308]
110496224  [KO:K06751]
110496230  [KO:K05654] [EC:7.4.2.14]
110496241  [KO:K06751]
110496294  [KO:K08056] [EC:5.3.4.1]
110496560  [KO:K08738]
110496708  [KO:K12893]
110496727  [KO:K03156]
110496949  [KO:K05405]
110497044  [KO:K09447]
110497496  [KO:K02187] [EC:3.4.22.56]
110497638  [KO:K03237]
110497707  [KO:K03174]
110497729  [KO:K04734]
110497958  [KO:K16196] [EC:2.7.11.1]
110497971  [KO:K04456] [EC:2.7.11.1]
110498078  [KO:K04427] [EC:2.7.11.25]
110498185  bida; BH3 interacting domain death agonist [KO:K04726]
110499151  [KO:K04467] [EC:2.7.11.10]
110499283  [KO:K05132]
110499295  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110499415  [KO:K04696]
110499427  [KO:K12891]
110499902  [KO:K02084]
110500149  [KO:K27390]
110500680  [KO:K04451]
110500690  [KO:K06269] [EC:3.1.3.16]
110500691  [KO:K04735]
110501335  [KO:K09364]
110501419  ifngr2b; uncharacterized protein ifngr2b [KO:K05133]
110501424  [KO:K05131]
110501544  stat1b; signal transducer and activator of transcription 1b isoform X1 [KO:K11220]
110501897  [KO:K06751]
110501918  [KO:K08738]
110502170  [KO:K04398] [EC:3.4.22.61]
110502447  [KO:K17834] [EC:2.7.7.86]
110502471  [KO:K04390]
110502743  [KO:K04696]
110502751  srsf2a; serine and arginine rich splicing factor 2a [KO:K12891]
110502921  [KO:K16194] [EC:2.7.11.1]
110503149  [KO:K00922] [EC:2.7.1.153]
110503157  [KO:K06751]
110503159  [KO:K04456] [EC:2.7.11.1]
110503453  [KO:K05406]
110503706  [KO:K12896]
110503923  [KO:K12890]
110504199  [KO:K16196] [EC:2.7.11.1]
110504273  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
110504616  [KO:K05425]
110504688  [KO:K12654]
110504918  [KO:K02580]
110505368  [KO:K04427] [EC:2.7.11.25]
110505486  [KO:K04456] [EC:2.7.11.1]
110505735  nfkbiab; NF-kappa-B inhibitor alpha [KO:K04734]
110505762  [KO:K03174]
110505817  eif2s1a; eukaryotic translation initiation factor 2 subunit 1a [KO:K03237]
110505971  [KO:K12893]
110505977  srsf5a; serine/arginine-rich splicing factor 5 [KO:K12893]
110506216  [KO:K03175] [EC:2.3.2.27]
110506335  [KO:K02373]
110506337  [KO:K02159]
110506559  [KO:K03171]
110506983  [KO:K03175] [EC:2.3.2.27]
110507192  [KO:K00922] [EC:2.7.1.153]
110507254  [KO:K06081]
110507263  [KO:K05406]
110507583  [KO:K12896]
110507763  [KO:K12890]
110507997  [KO:K04456] [EC:2.7.11.1]
110508222  [KO:K00922] [EC:2.7.1.153]
110508466  [KO:K04398] [EC:3.4.22.61]
110508523  [KO:K02649]
110508652  [KO:K02161]
110508735  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
110508839  [KO:K08057]
110508876  [KO:K05406]
110508877  [KO:K06751]
110508907  [KO:K02649]
110509035  [KO:K11217] [EC:2.7.10.2]
110509528  [KO:K03158]
110509537  [KO:K03158]
110509557  [KO:K04519]
110509592  [KO:K28445]
110509690  [KO:K03173] [EC:2.3.2.27]
110509692  [KO:K02649]
110509856  [KO:K07206]
110509964  [KO:K02158]
110509974  [KO:K14284]
110510210  [KO:K04456] [EC:2.7.11.1]
110510303  [KO:K12890]
110510382  [KO:K07207]
110510821  [KO:K05414]
110511235  [KO:K05414]
110512608  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110512638  [KO:K06531]
110513534  pdia7; protein disulfide isomerase family A, member 7 [KO:K08056] [EC:5.3.4.1]
110513828  [KO:K09364]
110514337  ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
110514649  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
110514733  [KO:K10159]
110514932  [KO:K06081]
110515374  [KO:K06752]
110516895  [KO:K06752]
110517168  [KO:K05414]
110517235  [KO:K07208]
110517348  [KO:K03990]
110517705  [KO:K05414]
110517824  [KO:K05414]
110520020  [KO:K11220]
110520139  [KO:K08738]
110520142  [KO:K04398] [EC:3.4.22.61]
110520558  [KO:K09364]
110520638  [KO:K05131]
110521348  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
110521567  calr; calreticulin [KO:K08057]
110521615  [KO:K04389]
110521800  [KO:K11217] [EC:2.7.10.2]
110521824  pik3r3b; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110521871  [KO:K02159]
110522049  [KO:K04734]
110522122  [KO:K04427] [EC:2.7.11.25]
110522153  [KO:K04404]
110522300  [KO:K04456] [EC:2.7.11.1]
110522515  [KO:K06269] [EC:3.1.3.16]
110522591  [KO:K12893]
110522643  [KO:K03754]
110522648  eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
110522811  il1b; interleukin-1 beta [KO:K04519]
110522917  tsc1b; TSC complex subunit 1b [KO:K07206]
110523154  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
110523473  [KO:K03173] [EC:2.3.2.27]
110523476  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110523569  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
110523758  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
110523836  [KO:K07293] [EC:3.1.3.48]
110523953  [KO:K04447] [EC:2.7.10.2]
110524144  [KO:K02649]
110524201  [KO:K08057]
110524465  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110524498  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110524729  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110524761  [KO:K02649]
110525015  [KO:K04389]
110525340  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
110525449  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110525529  [KO:K06269] [EC:3.1.3.16]
110525744  [KO:K21123]
110525880  [KO:K02187] [EC:3.4.22.56]
110525908  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110526086  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
110526129  [KO:K02649]
110526221  fadd; protein FADD [KO:K02373]
110526223  [KO:K02159]
110527112  [KO:K05410] [EC:2.7.11.10]
110527523  [KO:K11220]
110527592  [KO:K05130]
110527716  [KO:K15409] [EC:2.7.11.1]
110527899  [KO:K14966]
110527901  [KO:K04570]
110528119  [KO:K07208]
110528326  [KO:K12892]
110528502  [KO:K06484]
110528533  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
110528955  [KO:K12893]
110529004  [KO:K04390]
110529042  [KO:K05704] [EC:2.7.10.2]
110529266  [KO:K03680]
110529271  [KO:K03754]
110529302  [KO:K12893]
110529509  [KO:K04427] [EC:2.7.11.25]
110529530  [KO:K04404]
110529687  [KO:K04456] [EC:2.7.11.1]
110529802  [KO:K06269] [EC:3.1.3.16]
110530021  [KO:K11217] [EC:2.7.10.2]
110530052  [KO:K00922] [EC:2.7.1.153]
110530129  [KO:K02649]
110530192  [KO:K08057]
110530404  [KO:K02161]
110530540  [KO:K02649]
110530587  [KO:K03990]
110530629  [KO:K04398] [EC:3.4.22.61]
110530795  calr3b; calreticulin 3b [KO:K08057]
110530828  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
110531824  [KO:K04451]
110531833  [KO:K06269] [EC:3.1.3.16]
110531834  [KO:K04735]
110532062  [KO:K12893]
110532179  [KO:K07293] [EC:3.1.3.48]
110532256  [KO:K04570]
110532334  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110532566  [KO:K06484]
110532620  [KO:K05704] [EC:2.7.10.2]
110532760  [KO:K05152]
110532762  [KO:K05152]
110532763  [KO:K05152]
110532768  [KO:K05152]
110532769  [KO:K05152]
110532774  [KO:K05152]
110532780  [KO:K15409] [EC:2.7.11.1]
110532840  hcfc1b; host cell factor 1b isoform X1 [KO:K14966]
110532862  [KO:K07210]
110532989  badb; BCL2 associated agonist of cell death b [KO:K02158]
110533029  [KO:K04399] [EC:3.4.22.62]
110533227  [KO:K12890]
110533228  [KO:K16060]
110533322  [KO:K05425]
110533452  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
110533497  [KO:K12896]
110533975  [KO:K02158]
110533985  [KO:K14284]
110534202  [KO:K04456] [EC:2.7.11.1]
110534285  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
110534406  pou2f2a; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
110535269  [KO:K07208]
110535287  [KO:K02161]
110535315  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110535585  [KO:K06752]
110535743  [KO:K12794]
110535906  [KO:K06269] [EC:3.1.3.16]
110536086  [KO:K07205]
110536185  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110536401  [KO:K04519]
110536802  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
110536972  [KO:K04447] [EC:2.7.10.2]
110537088  [KO:K03239]
110537166  [KO:K21123]
110537505  [KO:K09364]
110537650  [KO:K12896]
110537685  [KO:K06752]
110537686  [KO:K06752]
110537693  [KO:K09364]
110537792  il12bb; interleukin-12 subunit beta [KO:K05425]
110537938  [KO:K02159]
110538043  [KO:K05414]
110538045  [KO:K05414]
110538046  [KO:K05414]
110538047  [KO:K05414]
110538048  [KO:K05414]
110538049  [KO:K05414]
110538051  ifnphi1; interferon a3 [KO:K05414]
110538053  [KO:K05414]
110538058  [KO:K05414]
110538059  [KO:K05414]
110538161  [KO:K06493]
110538228  [KO:K02159]
110538425  [KO:K11219] [EC:2.7.10.2]
110538528  [KO:K12881]
110538542  [KO:K12891]
110538620  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
110538937  [KO:K05414]
110538938  [KO:K05414]
110538940  [KO:K05414]
110538941  [KO:K05414]
110538942  [KO:K05414]
110539157  [KO:K05414]
110539158  [KO:K05414]
110539160  [KO:K05414]
110539161  [KO:K05414]
118936262  [KO:K05414]
118936349  [KO:K05410] [EC:2.7.11.10]
118936363  [KO:K05414]
118936387  [KO:K16194] [EC:2.7.11.1]
118936417  [KO:K05414]
118936465  [KO:K06081]
118936567  [KO:K06751]
118937708  [KO:K05414]
118937709  [KO:K05414]
118937711  [KO:K05414]
118937713  [KO:K05414]
118937780  [KO:K04696]
118937891  [KO:K05414]
118937892  [KO:K05414]
118937893  [KO:K05414]
118938066  [KO:K05414]
118938067  [KO:K05414]
118938165  [KO:K05477]
118938265  [KO:K05414]
118938266  [KO:K05414]
118938267  [KO:K05414]
118938268  [KO:K05414]
118938269  [KO:K05414]
118938270  [KO:K05414]
118938271  [KO:K05414]
118938272  [KO:K05414]
118938273  [KO:K05414]
118938274  [KO:K05414]
118938933  [KO:K04687]
118939581  [KO:K03990]
118940033  [KO:K06752]
118940077  [KO:K05477]
118942837  [KO:K08055]
118942980  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118943990  [KO:K06081]
118944713  [KO:K06081]
118944870  [KO:K07208]
118946544  [KO:K06751]
118951907  [KO:K05414]
118951912  [KO:K05414]
118951913  [KO:K05414]
118951914  [KO:K05414]
118951915  [KO:K05414]
118951916  [KO:K05414]
118951917  [KO:K05414]
118951919  [KO:K07207]
118959021  [KO:K07207]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
omy03040  Spliceosome
omy03050  Proteasome
omy04115  p53 signaling pathway
omy04210  Apoptosis
omy04620  Toll-like receptor signaling pathway
omy04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

DBGET integrated database retrieval system