KEGG   PATHWAY: sbq05200
Entry
sbq05200                    Pathway                                
Name
Pathways in cancer - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Class
Human Diseases; Cancer: overview
Pathway map
sbq05200  Pathways in cancer
sbq05200

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101030507  DCC; netrin receptor DCC [KO:K06765]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101051525  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101034147  APPL1; DCC-interacting protein 13-alpha [KO:K08733]
101049706  CDH1; cadherin-1 [KO:K05689]
101043327  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101037437  CTNNA2; catenin alpha-2 isoform X4 [KO:K05691]
101030426  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
101038365  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
101035780  AXIN1; axin-1 isoform X2 [KO:K02157]
101036328  AXIN2; axin-2 isoform X1 [KO:K04385]
101034942  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101049516  adenomatous polyposis coli protein isoform X1 [KO:K02085]
101051107  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101029076  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101033762  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101037011  TCF7L2; transcription factor 7-like 2 [KO:K04491]
101047688  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101046847  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101044133  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101037307  WNT2; protein Wnt-2 [KO:K00182]
101051098  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
101035500  WNT3A; protein Wnt-3a [KO:K00312]
101048838  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
101050255  WNT4; protein Wnt-4 [KO:K00408]
101038250  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
101040063  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
101028364  WNT6; protein Wnt-6 [KO:K00445]
101027644  WNT7A; protein Wnt-7a [KO:K00572]
101041057  WNT8B; protein Wnt-8b [KO:K00714]
101037830  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
104650180  WNT9B; protein Wnt-9b [KO:K01064]
101029432  WNT10A; protein Wnt-10a [KO:K01357]
101043819  WNT10B; protein Wnt-10b [KO:K01357]
101050295  WNT11; protein Wnt-11 [KO:K01384]
101032778  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
101030044  FZD1; frizzled-1 [KO:K02432]
101049451  FZD7; frizzled-7 [KO:K02432]
101046720  FZD2; frizzled-2 [KO:K02235]
101037304  FZD3; frizzled-3 [KO:K02329]
101054300  FZD4; frizzled-4 [KO:K02354]
101036058  FZD5; frizzled-5 [KO:K02375]
101047742  FZD6; frizzled-6 [KO:K02376]
101030134  FZD9; frizzled-9 [KO:K02842]
101032028  FZD10; frizzled-10 [KO:K02842]
101045022  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101054518  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
101035529  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101028835  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
101044711  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101053270  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101049318  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101040311  AGT; angiotensinogen [KO:K09821]
101048036  F2R; proteinase-activated receptor 1 [KO:K03914]
101029013  F2RL3; proteinase-activated receptor 4 [KO:K04236]
101035023  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101048307  LPAR2; lysophosphatidic acid receptor 2 isoform X2 [KO:K04291]
101044775  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101044548  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101037682  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101038623  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101037991  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101042405  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101034540  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101040423  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101038799  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X8 [KO:K12331]
101043419  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101030480  PLEKHG5; pleckstrin homology domain-containing family G member 5 [KO:K19464]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101051787  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101028677  LOW QUALITY PROTEIN: rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
101039371  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101050663  CXCL12; stromal cell-derived factor 1 isoform X3 [KO:K10031]
101042221  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101042629  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101041681  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101032105  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101043873  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
104649855  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101032719  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101043452  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104652116  neuroendocrine secretory protein 55 [KO:K04632]
101027981  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101043334  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101040601  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101044688  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101049747  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101037803  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101032672  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101034552  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
101052034  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101041488  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101050677  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101030203  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101030409  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
101038619  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101041345  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101030348  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101037908  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101030524  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101044875  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101051683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101046368  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101044114  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101035708  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
101051846  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101038957  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101034927  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101035241  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101044518  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101032961  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101041079  LAMA1; laminin subunit alpha-1 [KO:K05637]
101042136  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
104650868  laminin subunit alpha-3-like [KO:K06240]
101046958  LAMA5; laminin subunit alpha-5 [KO:K06240]
101054093  LAMA4; laminin subunit alpha-4 [KO:K06241]
101045731  LAMB1; laminin subunit beta-1 [KO:K05636]
101027384  LAMB2; laminin subunit beta-2 [KO:K06243]
101041547  LAMB3; laminin subunit beta-3 [KO:K06244]
101050272  LAMB4; laminin subunit beta-4 [KO:K06245]
101037029  LAMC1; laminin subunit gamma-1 [KO:K05635]
101035864  LAMC2; laminin subunit gamma-2 [KO:K06246]
101054103  LAMC3; laminin subunit gamma-3 [KO:K06247]
101045340  FN1; fibronectin isoform X10 [KO:K05717]
101041311  ITGA2; integrin alpha-2 [KO:K06481]
101031876  ITGA2B; integrin alpha-IIb [KO:K06476]
101050876  ITGA3; integrin alpha-3 [KO:K06482]
101045102  ITGA6; integrin alpha-6 isoform X2 [KO:K06485]
101032614  ITGAV; integrin alpha-V [KO:K06487]
101040620  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101052217  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101039215  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101050593  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101044006  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101052971  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101043425  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101048714  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101027608  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101035406  RELA; transcription factor p65 [KO:K04735]
101027603  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101041016  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101051366  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101043827  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101027816  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
101031174  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101028078  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
101039294  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101041198  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
101035434  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101043245  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
101050448  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
101031994  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101033308  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101033758  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101038541  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101049631  BAD; bcl2-associated agonist of cell death [KO:K02158]
101053657  FOXO1; forkhead box protein O1 [KO:K07201]
101036938  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101043647  TP53; cellular tumor antigen p53 [KO:K04451]
101030975  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101032575  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
101046557  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101051048  CRKL; crk-like protein [KO:K04438]
101029260  CRK; adapter molecule crk [KO:K04438]
101053489  CBL; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101049987  signal transducer and activator of transcription 5A [KO:K11223]
101043203  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101047113  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
101029517  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
101030410  KNG1; kininogen-1 isoform X1 [KO:K03898]
101052988  EDN1; endothelin-1 isoform X2 [KO:K16366]
101044388  BDKRB1; B1 bradykinin receptor [KO:K03915]
101043867  BDKRB2; B2 bradykinin receptor [KO:K03916]
101032195  EDNRA; endothelin-1 receptor [KO:K04197]
101052365  EDNRB; endothelin B receptor [KO:K04198]
101051855  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101032578  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101046851  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101047168  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101052271  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101029401  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101046010  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101039384  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101032613  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101028427  IL2; interleukin-2 [KO:K05429]
101043897  IL3; interleukin-3 [KO:K04736]
101038267  IL4; interleukin-4 isoform X1 [KO:K05430]
101039737  IL5; interleukin-5 [KO:K05428]
101034757  IL6; interleukin-6 [KO:K05405]
101048813  IL7; interleukin-7 [KO:K05431]
101044358  IL12A; interleukin-12 subunit alpha [KO:K05406]
101049311  IL12B; interleukin-12 subunit beta [KO:K05425]
101038789  IL13; interleukin-13 [KO:K05435]
101043435  IL15; interleukin-15 [KO:K05433]
101034582  IL23A; interleukin-23 subunit alpha [KO:K05426]
101049694  EPO; erythropoietin isoform X1 [KO:K05437]
101032308  interferon alpha-8-like [KO:K05414]
101032622  interferon alpha-2-like [KO:K05414]
101032943  IFNA13; interferon alpha-1/13 [KO:K05414]
104649849  interferon alpha-5-like [KO:K05414]
101034105  interferon alpha-8-like [KO:K05414]
101034416  interferon alpha-5-like [KO:K05414]
101034728  IFNA21; interferon alpha-21 [KO:K05414]
101033464  IFNG; interferon gamma [KO:K04687]
101036589  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
101030332  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101047979  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101039092  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
101044733  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101033804  CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738]
101032072  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
101037958  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101029979  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101044161  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101032718  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
101048468  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
101045372  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101036913  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101049947  IL23R; interleukin-23 receptor [KO:K05065]
101035236  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
101035044  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101054160  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
101050965  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101039462  EML4; echinoderm microtubule-associated protein-like 4 isoform X2 [KO:K15420]
101044905  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
101030982  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101053574  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101043633  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101048039  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101031615  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101034707  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101030811  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101029836  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101030273  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
101029869  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101032691  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
101028762  VEGFB; vascular endothelial growth factor B [KO:K16858]
101042551  PGF; placenta growth factor isoform X1 [KO:K16859]
101044650  FIGF; vascular endothelial growth factor D isoform X1 [KO:K05449]
101048128  VEGFC; vascular endothelial growth factor C [KO:K05449]
101045311  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101052478  EGF; pro-epidermal growth factor [KO:K04357]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101043415  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101034511  PDGFA; platelet-derived growth factor subunit A isoform X6 [KO:K04359]
101043776  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101040158  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101036963  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101036519  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
101039763  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101047247  KITLG; kit ligand isoform X1 [KO:K05461]
101037282  KIT; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
101030168  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101027591  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101045517  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101038696  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
101040924  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101030554  FGF2; fibroblast growth factor 2 [KO:K18497]
101048161  FGF8; fibroblast growth factor 8 [KO:K04358]
101040388  FGF20; fibroblast growth factor 20 [KO:K04358]
101040926  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101047221  FGF4; fibroblast growth factor 4 [KO:K04358]
101046667  FGF18; fibroblast growth factor 18 [KO:K04358]
101046606  FGF10; fibroblast growth factor 10 [KO:K04358]
101042449  FGF3; fibroblast growth factor 3 [KO:K04358]
101048187  FGF6; fibroblast growth factor 6 [KO:K04358]
101052821  FGF9; fibroblast growth factor 9 [KO:K04358]
101031255  FGF7; fibroblast growth factor 7 [KO:K04358]
101050264  FGF16; fibroblast growth factor 16 [KO:K04358]
101031426  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101047544  FGF19; fibroblast growth factor 19 [KO:K22603]
101048392  FGF21; fibroblast growth factor 21 [KO:K22429]
101048503  FGF23; fibroblast growth factor 23 [KO:K22428]
101033213  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101033845  FGFR2; fibroblast growth factor receptor 2 isoform X11 [KO:K05093] [EC:2.7.10.1]
101051421  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101027585  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101047035  KRAS; GTPase KRas isoform X1 [KO:K07827]
101036877  NRAS; GTPase NRas [KO:K07828]
101043605  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101052142  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101040361  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101036151  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101043809  JUN; transcription factor AP-1 [KO:K04448]
101046701  FOS; proto-oncogene c-Fos [KO:K04379]
101036161  ETS1; protein C-ets-1 [KO:K02678]
101051246  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101042210  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101036569  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101049298  CXCL8; interleukin-8 [KO:K10030]
101040767  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101047847  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101053966  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101037811  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
101046425  NCOA4; LOW QUALITY PROTEIN: nuclear receptor coactivator 4 [KO:K09289]
101035626  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101052619  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101038731  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
101052248  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101040194  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101053929  TPR; nucleoprotein TPR [KO:K09291]
101027540  TFG; protein TFG isoform X1 [KO:K09292]
101037299  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
101054503  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
101046861  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101036686  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
101029536  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
101043395  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
101046976  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101030999  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101045005  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101036413  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101031785  calmodulin-alpha-like [KO:K02183]
101041174  CALML6; calmodulin-like protein 6 isoform X2 [KO:K02183]
101029957  CALM3; calmodulin [KO:K02183]
101047982  CALM2; calmodulin [KO:K02183]
101039332  CALML3; calmodulin-like protein 3 [KO:K02183]
101039863  CALML5; calmodulin-like protein 5 [KO:K02183]
101049022  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
101031635  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101041452  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101052251  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101041781  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II delta chain-like [KO:K04515] [EC:2.7.11.17]
101038342  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10 [KO:K04515] [EC:2.7.11.17]
101029174  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
101045370  RALA; ras-related protein Ral-A [KO:K07834]
101052488  RALB; ras-related protein Ral-B [KO:K07835]
101047017  RALBP1; ralA-binding protein 1 [KO:K08773]
101050895  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101029481  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101046124  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101035480  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101028583  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101036832  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
101028278  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
101044148  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101040304  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101040247  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101053144  RARB; retinoic acid receptor beta isoform X2 [KO:K08528]
101034130  estrogen receptor [KO:K08550]
101046392  ESR2; estrogen receptor beta [KO:K08551]
101039086  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
101032962  NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48]
101048381  SP1; transcription factor Sp1 [KO:K04684]
101031846  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
101049756  JUP; junction plakoglobin [KO:K10056]
101046694  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
101036514  RARA; retinoic acid receptor alpha isoform X2 [KO:K08527]
104652690  CCNA2; cyclin-A2 [KO:K06627]
101040909  CCNA1; cyclin-A1 [KO:K06627]
101042469  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101047789  RUNX1; runt-related transcription factor 1 [KO:K08367]
101046150  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
101028746  SPI1; transcription factor PU.1 isoform X2 [KO:K09438]
104651063  CEBPA; LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein alpha [KO:K09055]
101038788  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
101042318  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101043573  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101038444  cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [KO:K06621]
101029045  E2F1; transcription factor E2F1 [KO:K17454]
101042612  E2F2; transcription factor E2F2 [KO:K09389]
101034207  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
101027820  MAX; protein max isoform X2 [KO:K04453]
101048455  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X4 [KO:K10500]
101030939  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101040507  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101049141  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101047749  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101033528  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
101030146  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101051291  CUL1; cullin-1 [KO:K03347]
101031903  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101041621  S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
101053477  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101036684  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101052282  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101038309  RB1; retinoblastoma-associated protein [KO:K06618]
101030208  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101039106  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101047513  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101050177  BAX; apoptosis regulator BAX [KO:K02159]
101041291  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101027903  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
101034259  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
101033079  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101044788  MITF; microphthalmia-associated transcription factor isoform X2 [KO:K09455]
101047980  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
101044624  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101048819  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
101030583  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101034142  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101040653  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101039593  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101032066  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101051357  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X6 [KO:K04462] [EC:2.1.1.367]
101048278  CTBP2; C-terminal-binding protein 2 isoform X2 [KO:K04496] [EC:1.1.1.428]
101045392  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
101041477  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101039964  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101028074  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
101044013  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
101044317  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
101039649  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
101048321  breast cancer type 2 susceptibility protein-like [KO:K08775]
101033301  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
101035660  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101035635  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101046905  FADD; FAS-associated death domain protein [KO:K02373]
101053601  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101040331  BID; BH3-interacting domain death agonist [KO:K04726]
101044364  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
104653273  bcl-2-binding component 3-like [KO:K10132]
101034279  bcl-2-binding component 3 [KO:K10132]
101043528  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101033270  cytochrome c [KO:K08738]
101034412  cytochrome c-like [KO:K08738]
101048222  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101036039  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101029728  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101029719  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101039608  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
101038404  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
101041476  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
101040943  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
104651131  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101048510  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101048833  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101049145  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
101046934  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101042271  MGST3; microsomal glutathione S-transferase 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
101039426  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101047714  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101030375  LOW QUALITY PROTEIN: glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
101034128  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
101034438  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101033808  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101039061  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
101038805  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
101029537  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101040789  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
101049993  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
101035031  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
104651216  VHL; LOW QUALITY PROTEIN: von Hippel-Lindau disease tumor suppressor [KO:K03871]
101050065  TCEB1; transcription elongation factor B polypeptide 1 isoform X1 [KO:K03872]
101037906  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
101031320  transcription elongation factor B polypeptide 2 [KO:K03873]
101050933  uncharacterized protein LOC101050933 [KO:K03873]
101051445  CUL2; cullin-2 [KO:K03870]
101051675  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
101029000  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
101045149  EGLN2; egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
101048662  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
101044689  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
101052563  EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095]
101038733  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101033734  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X2 [KO:K15589]
101033803  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101050224  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101049410  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101043243  JAG1; protein jagged-1 isoform X1 [KO:K06052]
101029483  JAG2; protein jagged-2 isoform X1 [KO:K21635]
101044427  DLL4; delta-like protein 4 [KO:K06051]
101041321  DLL1; delta-like protein 1 [KO:K06051]
101036391  DLL3; delta-like protein 3 [KO:K06051]
101030819  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
101041963  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
101043110  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
101035143  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
101047984  HES1; transcription factor HES-1 [KO:K06054]
101041773  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
101047640  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
101050354  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
101033672  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101034605  SHH; sonic hedgehog protein [KO:K11988]
101048276  PTCH1; protein patched homolog 1 [KO:K06225]
101028873  SMO; smoothened homolog [KO:K06226]
101052615  KIF7; kinesin-like protein KIF7 [KO:K18806]
101051448  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
101033043  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101053117  GLI2; zinc finger protein GLI2 isoform X1 [KO:K16798]
101048440  GLI3; transcriptional activator GLI3 [KO:K06230]
101050026  BMP2; bone morphogenetic protein 2 [KO:K21283]
101038031  BMP4; bone morphogenetic protein 4 [KO:K04662]
101039152  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
101032669  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
101033641  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101035124  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101039180  heat shock protein HSP 90-beta [KO:K04079]
101051018  heat shock protein 90 homolog [KO:K04079]
101028609  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101038228  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
sbq03320  PPAR signaling pathway
sbq04010  MAPK signaling pathway
sbq04020  Calcium signaling pathway
sbq04024  cAMP signaling pathway
sbq04060  Cytokine-cytokine receptor interaction
sbq04066  HIF-1 signaling pathway
sbq04110  Cell cycle
sbq04115  p53 signaling pathway
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
sbq04310  Wnt signaling pathway
sbq04330  Notch signaling pathway
sbq04340  Hedgehog signaling pathway
sbq04350  TGF-beta signaling pathway
sbq04370  VEGF signaling pathway
sbq04510  Focal adhesion
sbq04512  ECM-receptor interaction
sbq04520  Adherens junction
sbq04630  JAK-STAT signaling pathway
sbq04915  Estrogen signaling pathway
KO pathway
ko05200   
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