Entry Name Chemokine signaling pathway - Oryctolagus cuniculus (rabbit)
Description Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Other DBs Organism Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene 100008941 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
108176185 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Wong MM, Fish EN
Title Chemokines: attractive mediators of the immune response.
Journal Reference Authors Curnock AP, Logan MK, Ward SG
Title Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
Journal Reference Authors Olson TS, Ley K
Title Chemokines and chemokine receptors in leukocyte trafficking.
Journal Reference Authors Busillo JM, Benovic JL
Title Regulation of CXCR4 signaling.
Journal Reference Authors Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
Title Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
Journal Reference Authors Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
Title Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
Journal Reference Authors Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
Title p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
Journal Reference Authors Sai J, Raman D, Liu Y, Wikswo J, Richmond A
Title Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
Journal Reference Authors Hauck CR, Klingbeil CK, Schlaepfer DD
Title Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
Journal Reference Authors Chandrasekar B, Bysani S, Mummidi S
Title CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
Journal Reference Authors Smith L, Webb A, Ward SG
Title T-lymphocyte navigation and migration: beyond the PI3K paradigm.
Journal Reference Authors Huttenrauch F, Pollok-Kopp B, Oppermann M
Title G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
Journal Reference Authors Thelen M, Stein JV
Title How chemokines invite leukocytes to dance.
Journal Reference Authors Ward SG, Marelli-Berg FM
Title Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
Journal Reference Authors Schwartzberg PL, Finkelstein LD, Readinger JA
Title TEC-family kinases: regulators of T-helper-cell differentiation.
Journal Reference Authors Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
Title Tec family kinases in T lymphocyte development and function.
Journal Reference Authors Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
Title Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
Journal Reference Authors Korchak HM, Rossi MW, Kilpatrick LE
Title Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
Journal Reference Authors Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
Title Chemokine inhibition--why, when, where, which and how?
Journal Reference Authors Zhelev DV, Alteraifi A
Title Signaling in the motility responses of the human neutrophil.
Journal Reference Authors Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
Title Phospholipase cbeta is critical for T cell chemotaxis.
Journal Reference Authors Hornstein I, Alcover A, Katzav S
Title Vav proteins, masters of the world of cytoskeleton organization.
Journal Related ocu04060 Cytokine-cytokine receptor interaction
ocu04670 Leukocyte transendothelial migration
ocu04810 Regulation of actin cytoskeleton
KO pathway
