KEGG   PATHWAY: fca05169
Entry
fca05169                    Pathway                                
Name
Epstein-Barr virus infection - Felis catus (domestic cat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
fca05169  Epstein-Barr virus infection
fca05169

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101094393  CR2; complement receptor type 2 isoform X1 [KO:K04012]
100125860  CD19; B-lymphocyte antigen CD19 isoform X3 [KO:K06465]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
493797  TLR2; toll-like receptor 2 [KO:K10159]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101083606  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
101098714  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101090622  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101096604  RELA; transcription factor p65 [KO:K04735]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493687  IL6; interleukin-6 precursor [KO:K05405]
101095926  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:3.6.4.13]
101085709  MAVS; mitochondrial antiviral-signaling protein isoform X2 [KO:K12648]
101096739  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101086282  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101084060  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101095934  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
101088440  interferon alpha-2-like [KO:K05414]
101081371  interferon alpha-like [KO:K05414]
493840  IFNA5; LOW QUALITY PROTEIN: interferon alpha-5 [KO:K05414]
111557596  interferon alpha-like [KO:K05414]
493849  IFNB1; interferon beta precursor [KO:K05415]
101092535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101090285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101084377  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101090171  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101084561  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101099224  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101100970  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101082744  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101087875  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
102902426  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101088116  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101100131  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100174787  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
100142684  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100502578  BID; BH3-interacting domain death agonist [KO:K04726]
101084615  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493837  BAX; apoptosis regulator BAX [KO:K02159]
101093435  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101098213  cytochrome c [KO:K08738]
101094614  cytochrome c, testis-specific-like [KO:K08738]
101088122  cytochrome c-like [KO:K08738]
101100947  cytochrome c [KO:K08738]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
111559549  uncharacterized protein LOC111559549 [KO:K10785]
493936  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
101089292  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101083107  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
101080604  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
101086215  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101094025  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101082405  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
101090224  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
101098797  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
101095435  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101097360  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
101095190  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101082082  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101094305  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X2 [KO:K03033]
101100851  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101091665  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101085106  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101098912  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101101591  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101098564  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101095118  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101095457  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101097227  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101086493  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
101094744  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
101083591  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
111560442  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
101089770  LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
111556311  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
101091023  tapasin isoform X2 [KO:K08058]
111560449  TAPBP; tapasin isoform X1 [KO:K08058]
101097245  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101087384  CALR; calreticulin [KO:K08057]
101095479  FLAI-K; saoe class I histocompatibility antigen, A alpha chain-like precursor [KO:K06751]
105260551  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
101081297  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
101080790  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111556177  HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X1 [KO:K06751]
101099296  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
101094232  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101080285  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
494145  B2M; beta-2-microglobulin precursor [KO:K08055]
101081813  SNW1; SNW domain-containing protein 1 [KO:K06063]
101098635  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
101088165  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
101099228  HDAC1; histone deacetylase 1 isoform X3 [KO:K06067] [EC:3.5.1.98]
101083973  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
101096700  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
101088572  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
101095430  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
101100207  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
101088656  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
101091223  HES1; transcription factor HES-1 [KO:K06054]
101096291  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X3 [KO:K06468]
101080466  RUNX3; runt-related transcription factor 3 [KO:K09279]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
101088134  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
493939  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
493943  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101087971  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101086509  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101092211  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101099613  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
101086032  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101094274  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101083468  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101085762  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
101080578  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
101097773  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101099259  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
101096065  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
101086432  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101087663  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101085582  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
101096356  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
101098083  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101098744  CD44; CD44 antigen isoform X9 [KO:K06256]
101085940  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101085141  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
101089421  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
101091951  VIM; vimentin [KO:K07606]
101083682  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
101092339  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101096633  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101087013  SYK; tyrosine-protein kinase SYK isoform X3 [KO:K05855] [EC:2.7.10.2]
101085214  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X2 [KO:K10591] [EC:2.3.2.26]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101088062  BTK; LOW QUALITY PROTEIN: tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
111559190  LOW QUALITY PROTEIN: tyrosine-protein kinase BTK-like [KO:K07370] [EC:2.7.10.2]
101086423  BLNK; B-cell linker protein isoform X1 [KO:K07371]
101080675  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101099275  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
493958  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101090950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101101311  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101097903  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100037415  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101088573  CCNA2; cyclin-A2 [KO:K06627]
101085426  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
101086192  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101085347  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
101093368  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101101356  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
101098454  E2F1; transcription factor E2F1 [KO:K17454]
101098067  E2F2; transcription factor E2F2 [KO:K09389]
101089768  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Epstein-Barr virus: 40 years on.
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Nat Rev Cancer 4:757-68 (2004)
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Reference
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Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
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Reference
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Reference
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Recent advances in understanding Epstein-Barr virus.
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Reference
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Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
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PLoS Pathog 10:e1003960 (2014)
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Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
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Trends Microbiol 21:421-9 (2013)
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Reference
PMID:25704559
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Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
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Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
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Adv Hematol 2011:829525 (2011)
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Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
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J Zhejiang Univ Sci B 14:8-24 (2013)
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Reference
PMID:29116588
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Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
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The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
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Reference
PMID:23435233
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Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
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Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
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Nat Rev Immunol 9:503-13 (2009)
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Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
fca03050  Proteasome
fca04010  MAPK signaling pathway
fca04020  Calcium signaling pathway
fca04064  NF-kappa B signaling pathway
fca04110  Cell cycle
fca04115  p53 signaling pathway
fca04210  Apoptosis
fca04612  Antigen processing and presentation
fca04620  Toll-like receptor signaling pathway
fca04622  RIG-I-like receptor signaling pathway
fca04630  JAK-STAT signaling pathway
fca04662  B cell receptor signaling pathway
KO pathway
ko05169   
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