Entry
Name
Epstein-Barr virus infection - Felis catus (domestic cat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Disease
H00367 Infectious mononucleosis
Organism
Felis catus (domestic cat) [GN:
fca ]
Gene
100142683 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100271864 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
101080604 CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453 ]
101080675 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
101082082 PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032 ]
101082744 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X3 [KO:K16195 ] [EC:2.7.11.1 ]
101083107 CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450 ]
101083606 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
101084561 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
101085106 PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037 ]
101085141 CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492 ]
101085363 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
101085709 MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648 ]
101086509 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
101087092 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
101087971 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
101088572 SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202 ]
101088656 RBPJL; recombining binding protein suppressor of hairless-like protein isoform X2 [KO:K06053 ]
101088996 DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752 ]
101091665 PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036 ]
101091892 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101093586 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101094274 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101094305 PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X3 [KO:K03033 ]
101095118 PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030 ]
101095190 PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028 ]
101095457 PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
101095479 FLAI-K; saoe class I histocompatibility antigen, A alpha chain-like precursor [KO:K06751 ]
101095698 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
101096291 FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X3 [KO:K06468 ]
101097360 PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066 ]
101097413 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101097773 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171 ]
101098564 PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029 ]
101098635 SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644 ]
101098714 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
101098797 PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064 ]
101098912 PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
101099224 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
101099259 NFKBIB; LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta [KO:K02581 ]
101100207 RBPJ; recombining binding protein suppressor of hairless isoform X7 [KO:K06053 ]
101100851 PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
101101277 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392 ]
101101591 PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039 ]
493881 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
493936 CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451 ]
493943 CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
493958 CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
768257 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Young LS, Rickinson AB.
Title
Epstein-Barr virus: 40 years on.
Journal
Reference
Authors
Saha A, Robertson ES
Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal
Reference
Authors
Ning S
Title
Innate immune modulation in EBV infection.
Journal
Reference
Authors
Stanfield BA, Luftig MA
Title
Recent advances in understanding Epstein-Barr virus.
Journal
Reference
Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal
Reference
Authors
Rajsbaum R, Garcia-Sastre A
Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal
Reference
Authors
Hoffmann HH, Schneider WM, Rice CM
Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal
Reference
Authors
Spender LC, Inman GJ
Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal
Reference
Authors
Fu Q, He C, Mao ZR
Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal
Reference
Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal
Reference
Authors
Melchjorsen J
Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal
Reference
Authors
Hansen TH, Bouvier M
Title
MHC class I antigen presentation: learning from viral evasion strategies.
Journal
Reference
Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Ghosh Roy S, Robertson ES, Saha A
Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal
Reference
Authors
Dawson CW, Port RJ, Young LS
Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal
Reference
Authors
Cai Q, Chen K, Young KH
Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal
Reference
Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
Authors
Ersing I, Bernhardt K, Gewurz BE
Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal
Reference
Authors
Wang LW, Jiang S, Gewurz BE
Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal
Reference
Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal
Reference
Authors
Edwards RH, Marquitz AR, Raab-Traub N
Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal
Reference
Authors
Thorley-Lawson DA
Title
Epstein-Barr virus: exploiting the immune system.
Journal
Reference
Authors
Eliopoulos AG, Young LS
Title
LMP1 structure and signal transduction.
Journal
Reference
Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal
Reference
Authors
Kang H, Kiess A, Chung CH
Title
Emerging biomarkers in head and neck cancer in the era of genomics.
Journal
Reference
Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal
Reference
Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal
Reference
Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal
Reference
Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal
Reference
Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal
Reference
Authors
Longnecker R
Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal
Reference
Authors
El-Sharkawy A, Al Zaidan L, Malki A
Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal
Reference
Authors
Dolcetti R, Masucci MG
Title
Epstein-Barr virus: induction and control of cell transformation.
Journal
Reference
Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal
Related pathway
fca04612 Antigen processing and presentation
fca04620 Toll-like receptor signaling pathway
fca04622 RIG-I-like receptor signaling pathway
fca04662 B cell receptor signaling pathway
KO pathway