KEGG   ORTHOLOGY: K04368
Entry
K04368                      KO                                     
Symbol
MAP2K1, MEK1
Name
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04140  Autophagy - animal
map04148  Efferocytosis
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04320  Dorso-ventral axis formation
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04380  Osteoclast differentiation
map04510  Focal adhesion
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04626  Plant-pathogen interaction
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04668  TNF signaling pathway
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01745  Cardiofaciocutaneous syndrome
H02425  Erdheim-Chester disease
H02631  Melorheostosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04013 MAPK signaling pathway - fly
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04012 ErbB signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04014 Ras signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04015 Rap1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04370 VEGF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04371 Apelin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04668 TNF signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04066 HIF-1 signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04068 FoxO signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04072 Phospholipase D signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04071 Sphingolipid signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04024 cAMP signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04022 cGMP-PKG signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04151 PI3K-Akt signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04150 mTOR signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04148 Efferocytosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04210 Apoptosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04218 Cellular senescence
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04540 Gap junction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04620 Toll-like receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04650 Natural killer cell mediated cytotoxicity
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04660 T cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04662 B cell receptor signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04664 Fc epsilon RI signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04666 Fc gamma R-mediated phagocytosis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04062 Chemokine signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04929 GnRH secretion
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04912 GnRH signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04915 Estrogen signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04914 Progesterone-mediated oocyte maturation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04917 Prolactin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04921 Oxytocin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04926 Relaxin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04935 Growth hormone synthesis, secretion and action
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04919 Thyroid hormone signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04916 Melanogenesis
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09156 Nervous system
   04725 Cholinergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04726 Serotonergic synapse
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04720 Long-term potentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04730 Long-term depression
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04722 Neurotrophin signaling pathway
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   04380 Osteoclast differentiation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09159 Environmental adaptation
   04626 Plant-pathogen interaction
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05206 MicroRNAs in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05205 Proteoglycans in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05207 Chemical carcinogenesis - receptor activation
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05230 Central carbon metabolism in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05231 Choline metabolism in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05212 Pancreatic cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05225 Hepatocellular carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05226 Gastric cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05214 Glioma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05216 Thyroid cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05221 Acute myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05220 Chronic myeloid leukemia
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05218 Melanoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05211 Renal cell carcinoma
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05219 Bladder cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05215 Prostate cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05213 Endometrial cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05224 Breast cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05223 Non-small cell lung cancer
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05170 Human immunodeficiency virus 1 infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05161 Hepatitis B
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05160 Hepatitis C
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05164 Influenza A
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05163 Human cytomegalovirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05165 Human papillomavirus infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05135 Yersinia infection
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   05022 Pathways of neurodegeneration - multiple diseases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09165 Substance dependence
   05034 Alcoholism
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
   01522 Endocrine resistance
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1
Other DBs
GO: 0004708
Genes
HSA: 5604(MAP2K1)
PTR: 450188(MAP2K1)
PPS: 100988422(MAP2K1)
GGO: 101132391(MAP2K1)
PON: 100446021(MAP2K1)
PPYG: 129014430(MAP2K1)
NLE: 100579506(MAP2K1)
HMH: 116482295(MAP2K1)
SSYN: 129482364(MAP2K1)
MCC: 710415(MAP2K1)
MCF: 102141214(MAP2K1)
MTHB: 126957976
MNI: 105488275(MAP2K1)
CSAB: 103245451(MAP2K1)
CATY: 105601165(MAP2K1)
PANU: 101008394(MAP2K1)
TGE: 112627624(MAP2K1)
MLEU: 105530797(MAP2K1)
RRO: 104662575(MAP2K1)
RBB: 108514672(MAP2K1)
TFN: 117070473(MAP2K1)
PTEH: 111548354(MAP2K1)
CANG: 105510526(MAP2K1)
CJC: 100387394(MAP2K1)
SBQ: 101040361(MAP2K1)
CIMI: 108282680
ANAN: 105718717(MAP2K1)
CSYR: 103277453(MAP2K1)
MMUR: 105868083(MAP2K1)
LCAT: 123631625(MAP2K1)
PCOQ: 105810783(MAP2K1)
OGA: 100959926(MAP2K1)
MMU: 26395(Map2k1)
MCAL: 110301502(Map2k1)
MPAH: 110327244(Map2k1)
RNO: 170851(Map2k1)
MCOC: 116073764(Map2k1)
ANU: 117699009(Map2k1)
MUN: 110559000(Map2k1)
CGE: 100689403(Map2k1) 103158537 113835540
MAUA: 101831139(Map2k1)
PROB: 127231875(Map2k1)
PLEU: 114691497(Map2k1)
MORG: 121466018(Map2k1)
MFOT: 126507499
AAMP: 119809903(Map2k1)
NGI: 103736801(Map2k1)
HGL: 101715628(Map2k1)
CPOC: 100712888(Map2k1)
CCAN: 109687824(Map2k1)
DORD: 105981136(Map2k1)
DSP: 122114391(Map2k1)
PLOP: 125340362(Map2k1)
NCAR: 124977990
MMMA: 107138000(Map2k1)
OCU: 100009316(MAP2K1) 127489461
OPI: 101533612(MAP2K1)
TUP: 102476496(MAP2K1)
GVR: 103596129(MAP2K1)
CFA: 478347(MAP2K1)
CLUD: 112675721(MAP2K1)
VLG: 121484067(MAP2K1)
NPO: 129506345(MAP2K1)
AML: 100478039(MAP2K1)
UMR: 103679064(MAP2K1)
UAH: 113240885(MAP2K1)
UAR: 123800861(MAP2K1)
ELK: 111153158
LLV: 125105594
MPUF: 101680975(MAP2K1)
MNP: 131999543(MAP2K1)
MLK: 131835957(MAP2K1)
NVS: 122892965(MAP2K1)
ORO: 101365373(MAP2K1)
EJU: 114206298(MAP2K1)
ZCA: 113908979(MAP2K1)
MLX: 118003336(MAP2K1)
NSU: 110584045(MAP2K1)
LWW: 102750302(MAP2K1)
FCA: 101081387(MAP2K1)
PYU: 121041863(MAP2K1)
PCOO: 112855545(MAP2K1)
PBG: 122468485(MAP2K1)
PVIV: 125167652(MAP2K1)
LRUF: 124508471
PTG: 102969757(MAP2K1)
PPAD: 109262816(MAP2K1)
PUC: 125910082
AJU: 106980282
HHV: 120221655(MAP2K1)
BTA: 101905399 533199(MAP2K1)
BOM: 102280670(MAP2K1)
BIU: 109564697(MAP2K1)
BBUB: 102396842(MAP2K1)
BBIS: 104984678(MAP2K1)
CHX: 102190520(MAP2K1)
OAS: 101123635(MAP2K1)
BTAX: 128054045(MAP2K1)
ODA: 120852527(MAP2K1) 120860906
CCAD: 122443062(MAP2K1)
MBEZ: 129562372(MAP2K1)
SSC: 100233191(MAP2K1)
CFR: 102515937(MAP2K1)
CBAI: 105069422(MAP2K1)
CDK: 105093267(MAP2K1)
VPC: 102530118(MAP2K1)
BACU: 103017381(MAP2K1)
BMUS: 118891063(MAP2K1)
LVE: 103082805(MAP2K1)
OOR: 101286388(MAP2K1)
DLE: 111177745(MAP2K1)
PCAD: 102992191(MAP2K1)
PSIU: 116747589(MAP2K1)
NASI: 112393112(MAP2K1)
ECB: 100065996(MAP2K1)
EPZ: 103549630(MAP2K1)
EAI: 106840602(MAP2K1)
MYB: 102240696(MAP2K1)
MYD: 102763997(MAP2K1)
MMYO: 118654213(MAP2K1)
MLF: 102417411(MAP2K1)
MDT: 132235370(MAP2K1)
PKL: 118719104(MAP2K1)
EFUS: 103283794(MAP2K1)
MNA: 107533801(MAP2K1)
DRO: 112311345(MAP2K1)
SHON: 118992336(MAP2K1)
AJM: 119057101(MAP2K1)
PDIC: 114491735(MAP2K1)
PHAS: 123808110(MAP2K1)
MMF: 118628434(MAP2K1)
PPAM: 129064157(MAP2K1)
HAI: 109385252(MAP2K1)
RFQ: 117022968(MAP2K1)
PALE: 102897122(MAP2K1)
PGIG: 120604492(MAP2K1)
PVP: 105309827(MAP2K1)
RAY: 107508942(MAP2K1)
MJV: 108392139(MAP2K1)
TOD: 119238768(MAP2K1)
SARA: 101550720(MAP2K1)
SETR: 126021920(MAP2K1)
LAV: 100667623(MAP2K1)
TMU: 101343332
ETF: 101650474(MAP2K1)
DNM: 101435268(MAP2K1)
MDO: 100018410(MAP2K1)
GAS: 123238040(MAP2K1)
SHR: 100921899(MAP2K1)
AFZ: 127551242
PCW: 110205943(MAP2K1)
TVP: 118829086(MAP2K1)
OAA: 100080362(MAP2K1)
GGA: 415549(MAP2K1)
PCOC: 116225470(MAP2K1)
MGP: 100543421(MAP2K1)
CJO: 107318921(MAP2K1)
TPAI: 128075267(MAP2K1)
LMUT: 125698355(MAP2K1)
NMEL: 110404031(MAP2K1)
APLA: 101791037(MAP2K1)
ACYG: 106043651(MAP2K1)
CATA: 118252022(MAP2K1)
AFUL: 116493377(MAP2K1)
TGU: 105760975(MAP2K1)
LSR: 110482957(MAP2K1)
SCAN: 103816115(MAP2K1)
PMOA: 120508953(MAP2K1)
OTC: 121343563(MAP2K1)
PRUF: 121354353(MAP2K1)
GFR: 102031727(MAP2K1)
FAB: 101816905(MAP2K1)
OMA: 130257462(MAP2K1)
PHI: 102110075(MAP2K1)
PMAJ: 107209483(MAP2K1)
CCAE: 111933966(MAP2K1)
CCW: 104683880(MAP2K1)
CBRC: 103619915(MAP2K1)
ETL: 114055284(MAP2K1)
ZAB: 102061434(MAP2K1)
ZLE: 135452097(MAP2K1)
ACHL: 103809856
SVG: 106852168(MAP2K1)
MMEA: 130577141(MAP2K1)
HRT: 120758598(MAP2K1)
SATI: 136366905(MAP2K1)
FPG: 101924998(MAP2K1)
FCH: 102053397(MAP2K1)
CCRI: 104158875
NNT: 104408199(MAP2K1)
SHAB: 115612648(MAP2K1)
ACUN: 113484193(MAP2K1)
TALA: 104368504(MAP2K1)
ACHC: 115342153(MAP2K1)
HALD: 104322861(MAP2K1)
HLE: 104834611(MAP2K1)
AGEN: 126043484
GCL: 127020580
CSTI: 104560517(MAP2K1)
LDI: 104344158
MNB: 103778610(MAP2K1)
DPUB: 104303271(MAP2K1)
AVIT: 104270203(MAP2K1)
BRHI: 104490724(MAP2K1)
EGZ: 104133527(MAP2K1)
NNI: 104017047(MAP2K1)
PCRI: 104025495(MAP2K1)
PCAO: 104052467(MAP2K1)
PADL: 103914812(MAP2K1)
AFOR: 103899919(MAP2K1)
FGA: 104081857(MAP2K1)
GSTE: 104257768(MAP2K1)
CLV: 102096091(MAP2K1)
MUI: 104546901(MAP2K1)
PGUU: 104459398
PLET: 104615077
EHS: 104504125
CMAC: 104484433(MAP2K1)
CUCA: 104065161(MAP2K1)
TEO: 104376605(MAP2K1)
BREG: 104639949
OHA: 104339270(MAP2K1)
ACAR: 104522175
CPEA: 104386653(MAP2K1)
CVF: 104288536(MAP2K1)
RTD: 128914576(MAP2K1)
AAM: 106487663(MAP2K1)
AROW: 112970007(MAP2K1)
NPD: 112948263(MAP2K1)
TGT: 104568332(MAP2K1)
DNE: 112996257(MAP2K1)
SCAM: 104139226(MAP2K1)
ASN: 102373880(MAP2K1)
AMJ: 102563228(MAP2K1)
CPOO: 109309197(MAP2K1)
GGN: 109288426(MAP2K1)
PSS: 102443595(MAP2K1)
CMY: 102945547(MAP2K1)
CCAY: 125644013(MAP2K1)
DCC: 119862496(MAP2K1)
CPIC: 101949355(MAP2K1)
TST: 117883780(MAP2K1)
CABI: 116816669(MAP2K1)
MRV: 120373628(MAP2K1)
ACS: 100558982
ASAO: 132762408(MAP2K1)
PVT: 110085468(MAP2K1)
SUND: 121934449(MAP2K1)
PBI: 103051071(MAP2K1)
PMUR: 107283932(MAP2K1)
CTIG: 120320137(MAP2K1)
TSR: 106549118(MAP2K1)
PGUT: 117676177(MAP2K1)
APRI: 131184910(MAP2K1)
PTEX: 113442026(MAP2K1)
NSS: 113415615(MAP2K1)
VKO: 123030795(MAP2K1)
PMUA: 114584876(MAP2K1)
PRAF: 128401265(MAP2K1)
ZVI: 118092724(MAP2K1)
HCG: 128334828(MAP2K1)
GJA: 107121194(MAP2K1)
EMC: 129345582(MAP2K1)
XLA: 108712802(map2k1.S) 379991(map2k1.L)
XTR: 493420(map2k1)
NPR: 108784101(MAP2K1)
RTEM: 120931107(MAP2K1)
BBUF: 120986019(MAP2K1)
BGAR: 122929542(MAP2K1)
MUO: 115459940(MAP2K1)
GSH: 117348007(MAP2K1)
DRE: 406728(map2k1)
SRX: 107738719(map2k1)
SANH: 107672217 107686295
SGH: 107583767 107596971
CCAR: 109092233 109092234
CAUA: 113061451 113118360(map2k1)
CGIB: 127934302 127977545
PTET: 122323040(map2k1)
LROH: 127180735(map2k1)
OMC: 131524475(map2k1)
PPRM: 120487665(map2k1)
RKG: 130087752(map2k1)
MAMB: 125253954(map2k1)
CIDE: 127499431
CERY: 137023351(map2k1)
MASI: 127417241 127456003
TROS: 130562953(map2k1)
TDW: 130435775(map2k1)
MANU: 129419265(map2k1)
IPU: 124627985
IFU: 128606701(map2k1)
PHYP: 113534784(map2k1)
SMEO: 124396002(map2k1)
TFD: 113652659(map2k1)
TVC: 132851235(map2k1)
TRN: 134322800(map2k1)
AMEX: 103028644(map2k1)
CMAO: 118818240(map2k1)
EEE: 113588584(map2k1)
CHAR: 105892387(map2k1) 116219257
TRU: 101063584(map2k1)
TFS: 130535835(map2k1)
TNG: GSTEN00016020G001
LCO: 104922316(map2k1)
NCC: 104967860(map2k1)
TBEN: 117491463(map2k1)
CGOB: 115009830(map2k1)
PGEO: 117447861(map2k1)
GACU: 117538865(map2k1)
EMAC: 134879440(map2k1)
ELY: 117262356(map2k1)
EFO: 125888135(map2k1)
PLEP: 121950008(map2k1)
SLUC: 116038429(map2k1)
ECRA: 117949315(map2k1)
ESP: 116694773(map2k1)
PFLV: 114559598(map2k1)
GAT: 120808861(map2k1)
PPUG: 119195764(map2k1)
AFB: 129108367(map2k1)
CLUM: 117732847(map2k1)
PSWI: 130194985(map2k1)
MSAM: 119893612(map2k1)
SCHU: 122875138(map2k1)
CUD: 121515443(map2k1)
ALAT: 119024934(map2k1)
MZE: 101465184(map2k1)
ONL: 100694033(map2k1)
OAU: 116326184(map2k1)
OLA: 101162677(map2k1)
OML: 112152131(map2k1)
CSAI: 133444196(map2k1)
XMA: 102217036(map2k1)
XCO: 114157072(map2k1)
XHE: 116732473(map2k1)
PRET: 103466546(map2k1)
PFOR: 103141267(map2k1)
PLAI: 106956367(map2k1)
PMEI: 106924888(map2k1)
GAF: 122835026(map2k1)
PPRL: 129363942(map2k1)
CVG: 107102008(map2k1)
CTUL: 119772490(map2k1)
GMU: 124856513(map2k1)
NFU: 107388720(map2k1)
KMR: 108230045(map2k1)
ALIM: 106521211(map2k1)
NWH: 119416306(map2k1)
AOCE: 111573164(map2k1)
MCEP: 125015166(map2k1)
CSEM: 103380238(map2k1)
POV: 109624327(map2k1)
SSEN: 122775740(map2k1)
HHIP: 117763104(map2k1)
HSP: 118109512(map2k1)
PPLT: 128443868(map2k1)
SMAU: 118314932(map2k1)
LCF: 108886445
SDU: 111228471(map2k1)
SLAL: 111667016(map2k1)
XGL: 120793562(map2k1)
HCQ: 109519419(map2k1)
SSCV: 125971154
SBIA: 133501715(map2k1)
PEE: 133402354(map2k1)
PTAO: 133478460(map2k1)
BPEC: 110160811(map2k1)
MALB: 109971216(map2k1)
BSPL: 114857278(map2k1)
SJO: 128359279(map2k1)
SASA: 106584829(map2k1)
STRU: 115192967(map2k1)
OTW: 112262497(map2k1)
OMY: 110522687(map2k1)
OGO: 124037367(map2k1) 124037445
OKI: 109883542(map2k1)
SNH: 120042460
ELS: 105006978(map2k1)
SFM: 108926724(map2k1)
PKI: 111845607(map2k1)
AANG: 118214767(map2k1)
LOC: 102691532(map2k1)
PSPA: 121294557 121298929(map2k1) 121304127
ARUT: 117428255 117964269
PSEX: 120541670(map2k1)
LCM: 102358560(MAP2K1)
CMK: 103186399(map2k1)
RTP: 109922810(map2k1)
CPLA: 122540870(map2k1)
HOC: 132834257(map2k1)
LERI: 129712705(map2k1)
PMRN: 116953551
LRJ: 133355212
BFO: 118408739
BBEL: 109466296
CIN: 778923(mapkk1/2)
SCLV: 120334253
SPU: 576066
APLC: 110982925
ARUN: 117296124
AJC: 117120283
SKO: 100370801
DME: Dmel_CG15793(Dsor1)
DER: 6549818
DSE: 6620447
DSI: Dsimw501_GD16945(Dsim_Dsor1)
DYA: Dyak_GE17784
DAN: 6492918
DSR: 110184291
DPO: 4815680
DPE: 6597716
DMN: 108164991 117191703
DWI: 6648268
DGR: 6565443
DMO: Dmoj_GI15238
DAZ: 108618224
DNV: 115564869
DHE: 111598354
DVI: 6631656
CCAT: 101451721
BOD: 106616301
BDR: 105224141
RZE: 108373264 108373733
AOQ: 129237218
TDA: 119671905
MDE: 101901485
SCAC: 106083022
LCQ: 111685490
LSQ: 119608188
GFS: 119638140
ECOE: 129947540
CLON: 129611365
HIS: 119654220
AGA: 1282062
ACOZ: 120947396
AARA: 120902005
AMER: 121589954
ASTE: 118507761 118517187
AFUN: 125762868
AMOU: 128305964
AALI: 118468867
AAG: 5576696
AALB: 109419297 109426103 109431812 115264449
ASUA: 134219234
CQU: CpipJ_CPIJ015801
CPII: 120413685
CNS: 116340771 116342246 116347451 116348270
BCOO: 119077584
AME: 409925
ACER: 108002559
ALAB: 122712800
ADR: 102672193
AFLR: 100867069
BIM: 100742289
BBIF: 117213930
BVK: 117236396
BVAN: 117161448
BTER: 100649968
BAFF: 126917747
BPYO: 122573067
BPAS: 132906665
FVI: 122537895
CCAL: 108623277
OBB: 114879602
OLG: 117607756
MGEN: 117223562
NMEA: 116435010
CGIG: 122403860
SOC: 105204688
MPHA: 105834200
AEC: 105151971
ACEP: 105625005
PBAR: 105423551
VEM: 105565878
HST: 105189689
DQU: 106745029
CFO: 105255739
FEX: 115240360
LHU: 105668080(Dsor1)
PGC: 109856723
OBO: 105286168
PCF: 106790392
PFUC: 122523136
VPS: 122629831
VCRB: 124425412
VVE: 124949166
NVI: 103318128
CSOL: 105367539
TPRE: 106654915
LHT: 122498850
LBD: 127285676
MDL: 103575004
CGLO: 123259268
FAS: 105267793
DAM: 107046891
AGIF: 122859778
CINS: 118066801
VCAN: 122408913 122412584 122414907
CCIN: 107273912
DSM: 124408582
NPT: 124217156
NFB: 124180753
NLO: 107221664
NVG: 124303057
AROA: 105686666
TCA: 661995
DPA: 109540984
SOY: 115882547
AGRG: 126748510
ATD: 109595060 109609505
CSET: 123318986 123321858
AGB: 108914693
LDC: 111509423
DVV: 114343473
NVL: 108558925 108567966
APLN: 108735268
PPYR: 116166034
OTU: 111419628
BMOR: 692467(Mek)
BMAN: 114252971
MSEX: 115446913
DPL: KGM_206256
BANY: 112055733
MJU: 123874657
NIQ: 126773379
VCD: 124534606
MCIX: 123658974
PMAC: 106716354
PPOT: 106104858
PXU: 106119435
PRAP: 111004260
PBX: 123707320
PNAP: 125050204
ZCE: 119839600
CCRC: 123698495
LSIN: 126967015
AAGE: 121734107
HZE: 124636901
TNL: 113503523
SLIU: 111354994
OFU: 114362094
ATRA: 106129720
GMW: 113510599
PXY: 119693116
PGW: 126370973
LGLY: 125233870
CFEL: 113366234
CCRN: 123293365
API: 100159396
DNX: 107171279
AGS: 114126955
RMD: 113560464
ACOO: 126837924
DVT: 126903061
BTAB: 109034101
DCI: 103512077
CLEC: 106663880
HHAL: 106686382(Dsor1)
NLU: 111058821 120353160
HVI: 124365977
MQU: 129002106 129002503
PHU: Phum_PHUM413460
FOC: 113212512
TPAL: 117645021
ZNE: 110829818
CSEC: 111868600 111874579
SGRE: 126281223
BROR: 134535384
IEL: 124166391
FCD: 110856140
DPX: DAPPUDRAFT_46211
DMK: 116936587
DPZ: 124313106
PVM: 113829534
PJA: 122257335
PCHN: 125031453
PMOO: 119593844
HAME: 121866369
PCLA: 123764886 123772113
CQD: 128688153
PTRU: 123498495
ESN: 126999959
MNZ: 135200149
HAZT: 108681758
EAF: 111714877
LSM: 121115813
TCF: 131878944
PPOI: 119095029 119095643
ISC: 8051907
DSV: 119440714 119442680
RSAN: 119387467
RMP: 119188276
VDE: 111248407 111249660
VJA: 111261252 111265854
TUT: 107366172
DPTE: 113796565
DFR: 124494243
CSCU: 111628403
CVS: 136979224(Dsor1)
PTEP: 107441316 107443359
ABRU: 129961800 129963425
UDV: 129221477 129224730
SDM: 118199164
LPOL: 106468591 106474636
PMEO: 129589242 129592733
CEL: CELE_Y54E10BL.6(mek-2)
CBR: CBG_04190(Cbr-mek-2)
CRQ: GCK72_000914
NAI: NECAME_05191
BMY: BM_BM6799(Bma-mek-2)
LOA: LOAG_12861 LOAG_16946
TSP: Tsp_10801
HRO: HELRODRAFT_155691
LGI: LOTGIDRAFT_132393
PVUL: 126828385
PCAN: 112554538
BGT: 106070384
GAE: 121385651
HRF: 124145034
HRJ: 124256521
CRG: 105339480
CANU: 128175496
CVN: 111128693 111128744
OED: 125650565
MYI: 110462626
PMAX: 117335235
MCAF: 127735535
MMER: 123523160
RPHI: 132724823 132749167
DPOL: 127876878
MAEA: 128226805
OBI: 106880850
OSN: 115220569
LJP: 135473793
LAK: 106152593
SMM: Smp_026510 Smp_151670
SHX: MS3_00001402(MAP2K1_1) MS3_00004657(MAP2K1_2)
OVI: T265_12118
EGL: EGR_07687
NVE: 5517613
ADF: 107334270
AMIL: 114958686
PDAM: 113672696
SPIS: 111340758
DGT: 114534537
HSY: 130632013
AQU: 100638124
ATH: AT5G56580(MKK6)
ALY: 9300546
CRB: 17875895
CSAT: 104726204 104733393 104761719 109128719
EUS: EUTSA_v10013956mg
BRP: 103845091 103856810
BNA: 106370322 106385249 106432808 106443279
BOE: 106332241
RSZ: 108825599 108845509 130504554
THJ: 104811725 104817739
CPAP: 110812440
CIT: 102625904
CIC: CICLE_v10008771mg
PVY: 116130583 116130622
MINC: 123194507
TCC: 18588491
GRA: 105784362 105790320
GHI: 107893314 107932005 107932209 107940146
GAB: 108462937 108484586
HSYR: 120117872 120166329 120167821
DZI: 111300352 111303155
EGR: 104438209
GMX: 100786284 100792457
GSJ: 114369761 114393081
PVU: PHAVU_004G174500g
VRA: 106763728
VAR: 108344747
VUN: 114181467
VUM: 124836079
CCAJ: 109816106
APRC: 113867854
MTR: 11437265
TPRA: 123884708
CAM: 101494029
PSAT: 127117960
VVO: 131598679
LJA: 130739053
ADU: 107479175
AIP: 107630442
AHF: 112738363 112790542
LANG: 109342960
PCIN: 129308627
QSA: O6P43_003950 O6P43_007852
FVE: 101299988
RCN: 112189155
PPER: 18771831
PMUM: 103340802
PAVI: 110751155
PDUL: 117635782
MDM: 103410520 103449823
MSYL: 126596685 126601429
PXB: 103943916
ZJU: 107432800
MNT: 21390400
CSAV: 115704245 115704458
CSV: 101218848
CMO: 103498246
BHJ: 120080172
MCHA: 111021852
CMAX: 111465588 111493846
CMOS: 111443886 111450244
CPEP: 111798228 111805644
RCU: 8265133
MEAN: 126666855
JCU: 105637830
HBR: 110633998 110656012
MESC: 110610612
POP: 18107672
PEU: 105114862
PALZ: 118054162
JRE: 109002837 109018692
CILL: 122304429 122306706
CAVE: 132166003
QSU: 111995051
QLO: 115975619
TWL: 120006166
VVI: 100252603
VRI: 117924885
SLY: 543947(MKK3)
SPEN: 107012802
SOT: 102594623(MKK6)
SSTN: 125858114
SDUL: 129896786
CANN: 107865874
LBB: 132633142 132633281
NTA: 107806359 107818136(mek1)
NSY: 104246534
NTO: 104092097
NAU: 109210505
INI: 109193026
ITR: 115999747
SIND: 105173561
EGT: 105969317
SSPL: 121779501 121780890
SMIL: 131014567
APAN: 127255744
HAN: 110877101 110886928
ECAD: 122605581
LSV: 111888070
CCAV: 112500594 112516979
DCR: 108213025
CSIN: 114285325
RVL: 131327031
AEW: 130756263 130790339
BVG: 104902319
SOE: 110791517
CQI: 110690921 110707675
ATRI: 130814208
MOF: 131157311
NNU: 104592034
MING: 122088633
TSS: 122669948
PSOM: 113296283 113319200
OSA: 4324023(MAPKK1)
OBR: 102711840
OGL: 127783166
BDI: 100826178(MKK6.1)
ATS: 109783679
TDC: 119287637 119291785
TAES: 123088151 123093521 123098798
TUA: 125552914
LPER: 127296707
LRD: 124701439 124701443
SBI: 8059201
ZMA: 542356
MFLO: 136450384 136517166 136533930
SITA: 101762126 101777602
SVS: 117849628 117857006
PVIR: 120664042 120673684 120697241 120707877
PHAI: 112885006 112894649
PDA: 103711214 103714344
EGU: 105040189 105047288
MUS: 103996546
ZOF: 121979194 121983843 122011962
DCT: 110096934 110097283
PEQ: 110024088 110039158
AOF: 109829965
MSIN: 131222908
NCOL: 116256456
ATR: 18443463
SMO: SELMODRAFT_272204(NQK-2) SELMODRAFT_450110(NQK-1)
PPP: 112277391 112287228 112293702
VCN: VOLCADRAFT_73333
OLU: OSTLU_4731
MBR: MONBRDRAFT_18821
SRE: PTSG_04378 PTSG_04559
DDI: DDB_G0269152(mekA)
DPP: DICPUDRAFT_98833
TET: TTHERM_00697080
AAF: AURANDRAFT_4099
EHX: EMIHUDRAFT_67969
TBR: Tb927.8.5950
TBG: TbgDal_VIII5950
TCR: 511075.60
LIF: LINJ_24_2410
LDO: LDBPK_242410
LMI: LMXM_24_2320
LBZ: LBRM_24_2400
LPAN: LPMP_242290
NGR: NAEGRDRAFT_50497 NAEGRDRAFT_55909
TVA: TVAG_2v0250790
GLA: GL50803_0022165
BZG: C4H11_07370
 » show all
Reference
PMID:1281467
  Authors
Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM, Krebs EG
  Title
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.
  Journal
J Biol Chem 267:25628-31 (1992)
  Sequence
[hsa:5604]
LinkDB

KEGG   ORTHOLOGY: K04369
Entry
K04369                      KO                                     
Symbol
MAP2K2, MEK2
Name
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04140  Autophagy - animal
map04148  Efferocytosis
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05135  Yersinia infection
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05216  Thyroid cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00523  Noonan syndrome and related disorders
H01745  Cardiofaciocutaneous syndrome
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04012 ErbB signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04014 Ras signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04015 Rap1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04370 VEGF signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04371 Apelin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04066 HIF-1 signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04068 FoxO signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04072 Phospholipase D signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04071 Sphingolipid signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04024 cAMP signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04022 cGMP-PKG signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04151 PI3K-Akt signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04150 mTOR signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04148 Efferocytosis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09143 Cell growth and death
   04210 Apoptosis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04218 Cellular senescence
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04620 Toll-like receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04650 Natural killer cell mediated cytotoxicity
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04660 T cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04662 B cell receptor signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04664 Fc epsilon RI signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04929 GnRH secretion
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04912 GnRH signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04915 Estrogen signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04917 Prolactin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04921 Oxytocin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04926 Relaxin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04935 Growth hormone synthesis, secretion and action
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04919 Thyroid hormone signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04916 Melanogenesis
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09156 Nervous system
   04720 Long-term potentiation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04730 Long-term depression
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   04722 Neurotrophin signaling pathway
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05206 MicroRNAs in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05205 Proteoglycans in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05207 Chemical carcinogenesis - receptor activation
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05208 Chemical carcinogenesis - reactive oxygen species
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05230 Central carbon metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05231 Choline metabolism in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05225 Hepatocellular carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05226 Gastric cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05214 Glioma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05216 Thyroid cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05221 Acute myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05220 Chronic myeloid leukemia
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05218 Melanoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05211 Renal cell carcinoma
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05219 Bladder cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05215 Prostate cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05213 Endometrial cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05224 Breast cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05223 Non-small cell lung cancer
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05170 Human immunodeficiency virus 1 infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05161 Hepatitis B
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05160 Hepatitis C
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05164 Influenza A
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05163 Human cytomegalovirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05165 Human papillomavirus infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05135 Yersinia infection
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
   01522 Endocrine resistance
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2
Other DBs
GO: 0004708
Genes
HSA: 5605(MAP2K2)
PTR: 100611792 456390(MAP2K2)
PPS: 100977025(MAP2K2) 100988437
GGO: 101126885(MAP2K2)
PON: 100450988(MAP2K2)
PPYG: 129020439(MAP2K2)
NLE: 100591827(MAP2K2)
HMH: 116483548(MAP2K2) 116814342
SSYN: 129466637(MAP2K2)
MCC: 721821(MAP2K2)
MCF: 102140855(MAP2K2)
MTHB: 126942673
MNI: 105485357(MAP2K2)
CSAB: 103233717(MAP2K2)
CATY: 105591800(MAP2K2)
PANU: 101004074(MAP2K2)
TGE: 112612394(MAP2K2)
MLEU: 105530027(MAP2K2)
RRO: 104665487(MAP2K2)
RBB: 108512087(MAP2K2)
TFN: 117076490(MAP2K2)
PTEH: 111521954(MAP2K2)
CANG: 105512832(MAP2K2)
CJC: 100393991(MAP2K2)
SBQ: 101036151(MAP2K2)
CIMI: 108288453(MAP2K2)
ANAN: 105706136(MAP2K2)
CSYR: 103251709
MMUR: 105873938(MAP2K2)
LCAT: 123633879(MAP2K2)
PCOQ: 105811965(MAP2K2)
OGA: 100956072(MAP2K2)
MMU: 26396(Map2k2)
MCAL: 110303196(Map2k2)
MPAH: 110326321(Map2k2)
RNO: 58960(Map2k2)
MCOC: 116076013(Map2k2)
ANU: 117696143(Map2k2)
MUN: 110555605(Map2k2)
CGE: 100774204(Map2k2)
MAUA: 101822879(Map2k2)
PROB: 127216563(Map2k2)
PLEU: 114688121(Map2k2)
MORG: 121459389(Map2k2)
MFOT: 126489299
AAMP: 119827491(Map2k2)
NGI: 103737276(Map2k2)
HGL: 101707562(Map2k2)
CPOC: 100728923(Map2k2)
CCAN: 109687808(Map2k2)
DORD: 105990471(Map2k2)
DSP: 122099331(Map2k2)
PLOP: 125348606(Map2k2)
NCAR: 124969568
MMMA: 107157283(Map2k2)
OPI: 101529486(MAP2K2) 105942099
TUP: 102483700(MAP2K2)
GVR: 103600170(MAP2K2)
CFA: 611939(MAP2K2)
CLUD: 112666294(MAP2K2)
VVP: 112935545(MAP2K2)
VLG: 121495470(MAP2K2)
NPO: 129522322(MAP2K2)
AML: 100465700(MAP2K2)
UMR: 103681834(MAP2K2)
UAH: 113242822(MAP2K2)
UAR: 123796818(MAP2K2)
ELK: 111161815
LLV: 125086704
MPUF: 101678743(MAP2K2)
MNP: 132010799(MAP2K2)
MLK: 131823312(MAP2K2)
NVS: 122909871(MAP2K2)
ORO: 101376586(MAP2K2)
EJU: 114226331(MAP2K2)
ZCA: 113917006(MAP2K2)
MLX: 118004882(MAP2K2)
NSU: 110593734(MAP2K2)
LWW: 102745982(MAP2K2)
FCA: 101100281(MAP2K2)
PYU: 121021465(MAP2K2)
PCOO: 112852828(MAP2K2)
PBG: 122486708(MAP2K2)
PVIV: 125149335(MAP2K2)
LRUF: 124524782
PTG: 102956808(MAP2K2)
PPAD: 109255967(MAP2K2)
PUC: 125918032 125918034
AJU: 106975474
HHV: 120242086(MAP2K2)
BTA: 510434(MAP2K2)
BOM: 102271710(MAP2K2)
BIU: 109561751(MAP2K2)
BBUB: 102401744(MAP2K2)
BBIS: 104979900(MAP2K2)
CHX: 102175285(MAP2K2)
OAS: 101113846(MAP2K2)
BTAX: 128050664(MAP2K2)
ODA: 120864821(MAP2K2)
CCAD: 122440231 122440910 122446062
MBEZ: 129558523(MAP2K2)
SSC: 100525505(MAP2K2)
CFR: 102511209(MAP2K2)
CBAI: 105078209(MAP2K2)
CDK: 105105302(MAP2K2)
VPC: 102534668(MAP2K2)
BACU: 103018627(MAP2K2)
BMUS: 118892655(MAP2K2)
LVE: 103090769(MAP2K2)
OOR: 101287162(MAP2K2)
DLE: 111165994(MAP2K2)
PCAD: 102994150(MAP2K2)
PSIU: 116751189(MAP2K2)
NASI: 112400165(MAP2K2)
ECB: 100063190(MAP2K2)
EPZ: 103543290
EAI: 106832322(MAP2K2)
MYB: 102245571(MAP2K2)
MYD: 102757282(MAP2K2)
MMYO: 118657986(MAP2K2)
MLF: 102423748(MAP2K2)
MDT: 132235183(MAP2K2)
PKL: 118731359(MAP2K2)
EFUS: 103294231(MAP2K2)
MNA: 107525695(MAP2K2)
DRO: 112312483(MAP2K2)
SHON: 118984505(MAP2K2)
AJM: 119063754(MAP2K2)
PDIC: 114503388(MAP2K2)
PHAS: 123813640(MAP2K2)
MMF: 118615385(MAP2K2)
PPAM: 129078155(MAP2K2)
HAI: 109388626(MAP2K2)
RFQ: 117037633(MAP2K2)
PALE: 102879034(MAP2K2)
PGIG: 120615382(MAP2K2)
PVP: 105306744(MAP2K2)
RAY: 107510634(MAP2K2)
MJV: 108385046(MAP2K2)
TOD: 119240577(MAP2K2)
SARA: 101555057(MAP2K2)
SETR: 126029670(MAP2K2)
LAV: 100657587(MAP2K2)
TMU: 101341078
ETF: 101643986(MAP2K2)
DNM: 101420546
MDO: 100018044(MAP2K2)
GAS: 123243007(MAP2K2)
SHR: 100917396(MAP2K2)
AFZ: 127544950
PCW: 110197417(MAP2K2)
TVP: 118849940(MAP2K2)
OAA: 100087942(MAP2K2)
GGA: 396349(MAP2K2)
PCOC: 116235833(MAP2K2)
MGP: 100551337(MAP2K2)
CJO: 107325595(MAP2K2)
TPAI: 128090447(MAP2K2)
LMUT: 125684996(MAP2K2)
NMEL: 110388854(MAP2K2)
APLA: 119714201(MAP2K2)
ACYG: 106044951(MAP2K2)
CATA: 118258785(MAP2K2)
AFUL: 116499043(MAP2K2)
TGU: 100225195(MAP2K2)
LSR: 110478470(MAP2K2)
SCAN: 103824555(MAP2K2)
PMOA: 120499033(MAP2K2)
OTC: 121346775(MAP2K2)
PRUF: 121349910(MAP2K2)
GFR: 102041148(MAP2K2)
FAB: 101820507(MAP2K2)
OMA: 130264419(MAP2K2)
PHI: 102102285(MAP2K2)
PMAJ: 107215477(MAP2K2)
CCAE: 111940193(MAP2K2)
CCW: 104697410(MAP2K2)
CBRC: 103621207(MAP2K2)
ETL: 114068839(MAP2K2)
ZAB: 102064782(MAP2K2)
ZLE: 135458804(MAP2K2)
SVG: 106859747(MAP2K2)
MMEA: 130586756(MAP2K2)
HRT: 120763546(MAP2K2)
SATI: 136371752(MAP2K2)
FPG: 101924296(MAP2K2)
FCH: 102049695(MAP2K2)
CCRI: 104154633(MAP2K2)
NNT: 104404578(MAP2K2)
SHAB: 115618167(MAP2K2)
ACUN: 113489457(MAP2K2)
TALA: 104361599(MAP2K2)
ACHC: 115349300(MAP2K2)
HALD: 104318307(MAP2K2)
HLE: 104828537(MAP2K2)
AGEN: 126041897
GCL: 127025478
CSTI: 104554578(MAP2K2)
LDI: 104349592(MAP2K2)
MNB: 103769043(MAP2K2)
DPUB: 104303243(MAP2K2)
AVIT: 104281173(MAP2K2)
BRHI: 104494663(MAP2K2)
EGZ: 104124397(MAP2K2)
NNI: 104018809(MAP2K2)
PCRI: 104024608(MAP2K2)
PCAO: 104050091(MAP2K2)
PADL: 103916484(MAP2K2)
AFOR: 103900480(MAP2K2)
FGA: 104074202(MAP2K2)
GSTE: 104257187(MAP2K2)
CLV: 102097053(MAP2K2)
MUI: 104540075(MAP2K2)
PGUU: 104468104
PLET: 104625875(MAP2K2)
EHS: 104509254
CMAC: 104480033(MAP2K2)
CUCA: 104056230(MAP2K2)
TEO: 104376146
BREG: 104629471
OHA: 104330857(MAP2K2)
ACAR: 104518296(MAP2K2)
CPEA: 104391569
CVF: 104282773(MAP2K2)
RTD: 128900734(MAP2K2)
AAM: 106492199(MAP2K2)
AROW: 112972305(MAP2K2)
NPD: 112949088(MAP2K2)
TGT: 104576452(MAP2K2)
DNE: 112994722(MAP2K2)
SCAM: 104145759(MAP2K2)
ASN: 102375508(MAP2K2)
AMJ: 106736997(MAP2K2)
CPOO: 109324852(MAP2K2)
GGN: 109294689(MAP2K2)
PSS: 102457075(MAP2K2)
CMY: 102931357(MAP2K2)
CCAY: 125627064(MAP2K2)
DCC: 119848307(MAP2K2)
CPIC: 101938330(MAP2K2)
TST: 117868754(MAP2K2)
CABI: 116819019(MAP2K2)
MRV: 120391732(MAP2K2)
ACS: 100567176(map2k2)
ASAO: 132781741(MAP2K2)
PVT: 110072466(MAP2K2)
SUND: 121921221 121936502(MAP2K2)
PBI: 103067786(MAP2K2)
PMUR: 107295320(MAP2K2)
CTIG: 120305410(MAP2K2)
TSR: 106555305(MAP2K2)
PGUT: 117656242(MAP2K2)
APRI: 131188390(MAP2K2)
PTEX: 113450336(MAP2K2)
NSS: 113425513(MAP2K2)
VKO: 123017589(MAP2K2)
PMUA: 114588247(MAP2K2)
PRAF: 128405737(MAP2K2)
ZVI: 118086608(MAP2K2)
HCG: 128346136(MAP2K2)
GJA: 107118240(MAP2K2)
STOW: 125432678(MAP2K2)
EMC: 129330130(MAP2K2)
BBUF: 120989541(MAP2K2)
BGAR: 122929119(MAP2K2)
MUO: 115480590(MAP2K2)
GSH: 117365220(MAP2K2)
DRE: 100002225(map2k2b) 563181(map2k2a)
SRX: 107719582 107724975 107726325 107729695
SANH: 107655207 107671813 107676947 107676988 107696522
SGH: 107552672 107575785 107586388 107596877
CCAR: 109046734 109046735 109100030
CAUA: 113039644 113045154 113045216 113064928
CGIB: 127942667 127986868
PTET: 122324621(map2k2b) 122327733(map2k2a)
LROH: 127153291(map2k2b) 127153476(map2k2a)
OMC: 131530277(map2k2a) 131552281(map2k2b)
PPRM: 120471345(map2k2b) 120495436(map2k2a)
RKG: 130089196(map2k2a)
MAMB: 125250873(map2k2b) 125263787(map2k2a)
CIDE: 127502256 127519987
CERY: 137002995(map2k2b) 137029156(map2k2a)
MASI: 127438106 127439045 127441351
TROS: 130549161(map2k2a) 130553870(map2k2b)
TDW: 130418373(map2k2b) 130430266(map2k2a)
MANU: 129443289(map2k2b) 129453519(map2k2a)
IPU: 100528123(map2k2b) 108271291(map2k2a)
IFU: 128613746(map2k2a) 128624239(map2k2b)
PHYP: 113530702 113533517
SMEO: 124391383(map2k2a) 124403350(map2k2b)
TFD: 113645293(map2k2b) 113657741(map2k2a)
TVC: 132845593(map2k2b) 132853123(map2k2a)
TRN: 134302311(map2k2b) 134331486(map2k2a)
AMEX: 103030512(map2k2b) 125782187(map2k2a)
CMAO: 118797185(map2k2b) 118818647(map2k2a)
EEE: 113584672 113588939
CHAR: 105905870 116219516 122132003
TRU: 101070236(map2k2)
TFS: 130528688(map2k2a)
TNG: GSTEN00004843G001
LCO: 104920827(map2k2) 104929670
NCC: 104963431(map2k2) 104965132
TBEN: 117488653(map2k2b) 117495666(map2k2a)
CGOB: 115007241(map2k2) 115022522
PGEO: 117445380(map2k2a) 117462440(map2k2b)
GACU: 117532733(map2k2b) 117546153(map2k2a)
EMAC: 134866187(map2k2b) 134869745(map2k2a)
ELY: 117254181(map2k2a) 117271479(map2k2b)
EFO: 125895747(map2k2a) 125902384(map2k2b)
PLEP: 121938842(map2k2a) 121951784(map2k2b)
SLUC: 116037337(map2k2b) 116063461(map2k2a)
ECRA: 117950204(map2k2a) 117954500(map2k2b)
ESP: 116695172(map2k2) 116699426 116699428
PFLV: 114561797 114565370
GAT: 120816299(map2k2b) 120823910(map2k2a)
PPUG: 119209642(map2k2b) 119216703(map2k2a)
AFB: 129094155(map2k2a) 129112227(map2k2b)
CLUM: 117729985(map2k2a) 117746647(map2k2b)
PSWI: 130194253(map2k2a)
MSAM: 119900881(map2k2a) 119902918(map2k2b)
SCHU: 122877476(map2k2a) 122886281(map2k2b)
CUD: 121512343(map2k2a) 121520316(map2k2b)
ALAT: 119011484(map2k2b) 119028360(map2k2a)
MZE: 101478402 101484555
ONL: 100697571 100708547
OAU: 116310020(map2k2a) 116319019(map2k2b)
OLA: 101173453(map2k2)
OML: 112136869(map2k2a)
CSAI: 133458123(map2k2a)
XMA: 102225775(map2k2)
XCO: 114151477(map2k2)
XHE: 116726343(map2k2)
PRET: 103463649(map2k2)
PFOR: 103149822(map2k2)
PLAI: 106959224(map2k2)
PMEI: 106915816(map2k2)
GAF: 122839029(map2k2a)
PPRL: 129376705(map2k2a)
CVG: 107089725(map2k2)
CTUL: 119792552(map2k2a)
GMU: 124874089(map2k2a)
NFU: 107393294(map2k2)
KMR: 108230840(map2k2a)
ALIM: 106515024(map2k2)
NWH: 119407953(map2k2a)
AOCE: 111568133(map2k2) 111572311
MCEP: 125009454(map2k2a) 125010654(map2k2b)
CSEM: 103376625(map2k2)
POV: 109625750
SSEN: 122781086(map2k2a)
HHIP: 117759678(map2k2a)
HSP: 124854736(map2k2a)
PPLT: 128447654(map2k2a)
SMAU: 118311178(map2k2b) 118318813(map2k2a)
LCF: 108877315(map2k2a) 108883596(map2k2b)
SDU: 111229041 111232170
SLAL: 111652614 111656372(map2k2)
XGL: 120791009(map2k2a) 120798627(map2k2b)
HCQ: 109532301
SSCV: 125965738
SBIA: 133503693(map2k2a)
PEE: 133406476(map2k2a)
PTAO: 133481008(map2k2a)
BPEC: 110173999(map2k2)
MALB: 109967020 109974179
BSPL: 114845208(map2k2b) 114853520(map2k2a)
SJO: 128361721(map2k2a)
SASA: 100194780(mp2k2) 106569535 106600441 106613775
STRU: 115157409 115158253 115169411 115192626
OTW: 112231367 112237794(map2k2b) 112250875(map2k2a)
OMY: 100136127(tmek) 110508416 110524297 110530696(map2k2b)
OGO: 123997082(map2k2a) 124009586(map2k2b) 124037664
ONE: 115108309 115114736 115144888
OKI: 109872320 109874662 109897850 109902503
OKE: 118359232 118389751 118401816(map2k2b)
SALP: 111956577 111972098 111975763 111978999
SNH: 120020580 120052438 120054777 120056021(map2k2b)
CCLU: 121533527 121535511(map2k2b) 121540361(map2k2a) 121581348
ELS: 105011557 105020581
SFM: 108919814 108921692(map2k2)
PKI: 111836645(map2k2) 111860367
AANG: 118226171(map2k2a) 118230058(map2k2b)
LOC: 102686784(map2k2)
PSPA: 121300828(map2k2a) 121301294
ARUT: 117401470 117966151
PSEX: 120537759(map2k2a)
LCM: 102350370(MAP2K2)
CMK: 103183530
CPLA: 122565176
HOC: 132829027(map2k2a)
LERI: 129711246
PMRN: 116939688(MAP2K1)
LRJ: 133346627(MAP2K1)
LPIC: 129261697
RSAN: 119385920
LLON: 135482793
EPA: 110245894 110250375
ATEN: 116294634
XEN: 124455037
HMG: 100213114
RES: 135686976
 » show all
Reference
PMID:8297798
  Authors
Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL
  Title
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.
  Journal
Cell Growth Differ 4:921-9 (1993)
  Sequence
[mmu:26396]
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