KEGG   PATHWAY: mna05200
Entry
mna05200                    Pathway                                
Name
Pathways in cancer - Miniopterus natalensis (Natal long-fingered bat)
Class
Human Diseases; Cancer: overview
Pathway map
mna05200  Pathways in cancer
mna05200

Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107546643  DCC; netrin receptor DCC [KO:K06765]
107535740  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107531542  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107531462  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
107527895  CDH1; cadherin-1 [KO:K05689]
107524266  CTNNB1; catenin beta-1 [KO:K02105]
107529240  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
107526073  catenin alpha-3 [KO:K05691]
107530128  CTNNA1; catenin alpha-1 [KO:K05691]
107539654  AXIN1; axin-1 isoform X1 [KO:K02157]
107538303  AXIN2; axin-2 isoform X1 [KO:K04385]
107546495  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107534581  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
107527219  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107525397  TCF7; transcription factor 7 isoform X1 [KO:K02620]
107528616  TCF7L1; transcription factor 7-like 1 [KO:K04490]
107536455  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
107538292  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
107532046  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
107539494  MYC; myc proto-oncogene protein [KO:K04377]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107528239  WNT1; proto-oncogene Wnt-1 [KO:K03209]
107545293  WNT2B; protein Wnt-2b [KO:K00182]
107524863  WNT2; protein Wnt-2 [KO:K00182]
107529919  WNT3A; protein Wnt-3a [KO:K00312]
107530219  WNT3; proto-oncogene Wnt-3 [KO:K00312]
107538446  WNT4; protein Wnt-4 [KO:K00408]
107546464  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
107530635  WNT5A; protein Wnt-5a [KO:K00444]
107524769  WNT6; protein Wnt-6 [KO:K00445]
107537987  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
107534839  WNT7B; protein Wnt-7b [KO:K00572]
107542524  WNT8B; protein Wnt-8b [KO:K00714]
107530103  WNT8A; protein Wnt-8a [KO:K00714]
107529865  WNT9A; protein Wnt-9a [KO:K01064]
107530990  WNT9B; protein Wnt-9b [KO:K01064]
107528238  WNT10B; protein Wnt-10b [KO:K01357]
107524821  WNT10A; protein Wnt-10a [KO:K01357]
107524451  WNT11; protein Wnt-11 [KO:K01384]
107537386  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
107541653  FZD1; frizzled-1 [KO:K02432]
107533927  FZD7; frizzled-7 [KO:K02432]
107528834  FZD2; frizzled-2 [KO:K02235]
107537768  FZD3; frizzled-3 isoform X1 [KO:K02329]
107532452  FZD4; frizzled-4 isoform X1 [KO:K02354]
107525076  FZD8; frizzled-8 [KO:K02375]
107524716  FZD5; frizzled-5 [KO:K02375]
107546030  FZD6; frizzled-6 isoform X1 [KO:K02376]
107526557  FZD9; frizzled-9 [KO:K02842]
107529641  FZD10; frizzled-10 [KO:K02842]
107537408  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
107537433  LRP5L; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein [KO:K03068]
107525309  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
107541116  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
107543696  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
107544485  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
107542516  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
107530315  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
107524243  AGT; angiotensinogen [KO:K09821]
107531201  F2R; proteinase-activated receptor 1 [KO:K03914]
107534297  F2RL3; proteinase-activated receptor 4 [KO:K04236]
107537650  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107535357  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
107543205  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
107537244  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
107544026  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
107531401  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
107544042  AGTR1; type-1 angiotensin II receptor [KO:K04166]
107541162  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107538305  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
107533084  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
107543803  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
107534237  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
107538432  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
107529450  RHOA; transforming protein RhoA [KO:K04513]
107535907  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107542396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
107532553  CXCL12; stromal cell-derived factor 1 [KO:K10031]
107531145  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107545320  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107540752  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107545079  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107542363  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
107525947  PTGER2; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP2 subtype [KO:K04259]
107540123  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
107545909  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  neuroendocrine secretory protein 55-like [KO:K04632]
107526004  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107540528  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107534062  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107531740  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107527242  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
107528232  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107531029  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
107539500  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107535777  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107540160  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
107540939  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
107544078  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
107541113  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
107546541  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
107525867  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
107543109  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
107527185  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
107543194  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
107534609  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
107536795  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
107541861  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
107537622  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
107541673  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
107541527  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
107533406  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107533363  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
107541750  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
107539173  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
107530382  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107530384  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107526032  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107526046  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
107525529  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107525530  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
107530937  LAMA2; laminin subunit alpha-2 [KO:K05637]
107535878  LAMA1; laminin subunit alpha-1 [KO:K05637]
107529572  LAMA5; laminin subunit alpha-5 [KO:K06240]
107535921  laminin subunit alpha-3-like [KO:K06240]
107535922  laminin subunit alpha-3-like [KO:K06240]
107540693  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
107526620  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
107529446  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
107529447  laminin subunit beta-2-like [KO:K06243]
107532931  LAMB3; laminin subunit beta-3 [KO:K06244]
107526629  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
107546271  LAMC1; laminin subunit gamma-1 [KO:K05635]
107546249  LAMC2; laminin subunit gamma-2 [KO:K06246]
107524677  LAMC3; laminin subunit gamma-3 [KO:K06247]
107524737  FN1; fibronectin isoform X1 [KO:K05717]
107527140  ITGA2; integrin alpha-2 [KO:K06481]
107528854  ITGA2B; integrin alpha-IIb [KO:K06476]
107539175  ITGA3; integrin alpha-3 [KO:K06482]
107530895  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107536679  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107533206  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107543303  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107536081  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107542599  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107523913  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107544156  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107526117  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
107545508  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107542628  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
107533544  RELA; transcription factor p65 [KO:K04735]
107546245  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
107533063  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
107545431  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
107532417  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
107532418  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
107524984  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
107529527  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
107527777  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107537677  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
107536208  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107538601  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
107528737  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
107538857  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
107531990  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107530082  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107537414  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107537551  FOXO1; forkhead box protein O1 [KO:K07201]
107526860  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107538830  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
107544572  TP53; cellular tumor antigen p53 [KO:K04451]
107525363  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
107545578  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107530446  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
107524646  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107530545  CRKL; crk-like protein [KO:K04438]
107533071  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
107528939  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
107528845  signal transducer and activator of transcription 5B-like [KO:K11224]
107545640  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
107541347  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
107527424  KNG1; kininogen-1 isoform X1 [KO:K03898]
107530403  EDN1; endothelin-1 [KO:K16366]
107528072  BDKRB1; B1 bradykinin receptor [KO:K03915]
107528081  BDKRB2; B2 bradykinin receptor [KO:K03916]
107532511  EDNRA; endothelin-1 receptor [KO:K04197]
107539876  EDNRB; endothelin B receptor [KO:K04198]
107544926  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107544328  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107542967  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
107536366  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107536369  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
107539797  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107529760  IL2; interleukin-2 [KO:K05429]
107525027  IL4; interleukin-4 [KO:K05430]
107525025  IL5; interleukin-5 [KO:K05428]
107540295  IL6; interleukin-6 [KO:K05405]
107539481  IL7; interleukin-7 [KO:K05431]
107539273  IL12A; interleukin-12 subunit alpha [KO:K05406]
107537877  IL12B; interleukin-12 subunit beta [KO:K05425]
107525052  IL13; interleukin-13 [KO:K05435]
107532491  IL15; interleukin-15 [KO:K05433]
107546155  IL23A; interleukin-23 subunit alpha [KO:K05426]
107540896  EPO; erythropoietin isoform X1 [KO:K05437]
107527227  IFNG; interferon gamma [KO:K04687]
107542420  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
107545294  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
107532895  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
107543962  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
107539670  interleukin-4 receptor subunit alpha-like [KO:K05071]
107544754  interleukin-4 receptor subunit alpha-like [KO:K05071]
107545322  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
107529138  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
107543721  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
107527134  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
107546370  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
107535370  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
107533449  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
107529345  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
107542422  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
107533896  IL23R; interleukin-23 receptor [KO:K05065]
107533235  EPOR; erythropoietin receptor [KO:K05079]
107537477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107530983  IFNGR1; interferon gamma receptor 1 [KO:K05132]
107537453  IFNGR2; interferon gamma receptor 2 [KO:K05133]
107539758  EML4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
107534860  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
107542952  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
107542784  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
107541820  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
107532208  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
107533604  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
107538122  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
107535380  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
107528938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107540521  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
107546189  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
107540906  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
107546227  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
107536886  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107539800  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107533829  PGF; placenta growth factor isoform X1 [KO:K16859]
107541939  VEGFC; vascular endothelial growth factor C [KO:K05449]
107529497  FIGF; vascular endothelial growth factor D [KO:K05449]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107529006  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107545147  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107539909  IGF2; insulin-like growth factor II [KO:K13769]
107527774  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107526843  KITLG; kit ligand isoform X1 [KO:K05461]
107532733  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
107531799  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
107534352  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
107527167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107528536  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107531500  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107529795  FGF2; fibroblast growth factor 2 [KO:K18497]
107536980  FGF9; fibroblast growth factor 9 [KO:K04358]
107542543  FGF8; fibroblast growth factor 8 [KO:K04358]
107543550  FGF17; fibroblast growth factor 17 [KO:K04358]
107540349  FGF18; fibroblast growth factor 18 [KO:K04358]
107526261  FGF10; fibroblast growth factor 10 [KO:K04358]
107537102  FGF5; fibroblast growth factor 5 [KO:K04358]
107538886  FGF6; fibroblast growth factor 6 [KO:K04358]
107532758  FGF16; fibroblast growth factor 16 [KO:K04358]
107534875  FGF7; fibroblast growth factor 7 [KO:K04358]
107538572  FGF22; fibroblast growth factor 22 [KO:K04358]
107542168  fibroblast growth factor 3-like [KO:K04358]
107534042  FGF20; fibroblast growth factor 20 [KO:K04358]
107542172  FGF19; fibroblast growth factor 19 [KO:K22603]
107531851  FGF21; fibroblast growth factor 21 [KO:K22429]
107538868  FGF23; fibroblast growth factor 23 [KO:K22428]
107535065  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107532684  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107524118  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
107529769  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107525258  KRAS; GTPase KRas [KO:K07827]
107545303  NRAS; GTPase NRas [KO:K07828]
107541381  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107533821  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
107530603  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
107532387  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
107543503  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
107530893  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
107534494  CXCL8; interleukin-8 [KO:K10030]
107546223  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107531586  RPS6KA5; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
107532547  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107543314  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
107527966  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
107543738  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107543812  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
107546270  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
107527078  TFG; protein TFG isoform X1 [KO:K09292]
107545083  ras association domain-containing protein 1-like [KO:K09850]
107539119  RASSF5; ras association domain-containing protein 5 [KO:K08015]
107530916  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
107525638  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
107544922  DAPK1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
107533767  DAPK2; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
107542131  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
107524904  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107541393  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
107542429  CALML3; calmodulin-like protein 3 [KO:K02183]
107542435  CALML5; calmodulin-like protein 5 [KO:K02183]
107536794  CALM3; calmodulin [KO:K02183]
107540147  CALML6; calmodulin-like protein 6 [KO:K02183]
107544318  CALM2; calmodulin isoform X1 [KO:K02183]
107531584  CALM1; calmodulin [KO:K02183]
107525969  CALML4; calmodulin-like protein 4 [KO:K02183]
107545830  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107542053  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
107535228  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
107527851  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
107524673  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
107532781  RALA; ras-related protein Ral-A [KO:K07834]
107534635  RALB; ras-related protein Ral-B [KO:K07835]
107533986  RALBP1; ralA-binding protein 1 [KO:K08773]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107540891  cell division control protein 42 homolog [KO:K04393]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107539040  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107528068  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
107529520  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
107533526  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528648  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
107534765  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
107524613  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
107542678  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
107537950  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
107526367  RARB; retinoic acid receptor beta isoform X1 [KO:K08528]
107535956  ESR1; estrogen receptor [KO:K08550]
107545662  ESR2; estrogen receptor beta [KO:K08551]
107534051  NCOA1; nuclear receptor coactivator 1 [KO:K09101] [EC:2.3.1.48]
107530884  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
107528307  SP1; transcription factor Sp1 [KO:K04684]
107545624  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
107538780  JUP; junction plakoglobin isoform X1 [KO:K10056]
107534004  ZBTB16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055]
107528992  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
107525165  CCNA1; cyclin-A1 [KO:K06627]
107528451  CCNA2; cyclin-A2 [KO:K06627]
107528565  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
107533502  RUNX1; runt-related transcription factor 1 [KO:K08367]
107534139  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
107530287  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
107543384  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
107543958  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
107543956  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
107542574  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
107535231  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107527747  E2F1; transcription factor E2F1 [KO:K17454]
107538329  E2F2; transcription factor E2F2 [KO:K09389]
107539632  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
107545703  MAX; protein max isoform X1 [KO:K04453]
107541905  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
107541193  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
107541691  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107538904  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107536896  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107529177  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
107543754  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
107525395  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
107523767  CUL1; cullin-1 isoform X1 [KO:K03347]
107531277  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107546230  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
107538223  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
107535865  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
107534117  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
107531399  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
107534560  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107533887  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
107531901  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107541604  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107530310  DDB2; DNA damage-binding protein 2 [KO:K10140]
107531215  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
107536477  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
107524046  MITF; microphthalmia-associated transcription factor [KO:K09455]
107534176  TGFB1; transforming growth factor beta-1 [KO:K13375]
107543622  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
107533843  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
107544970  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
107526381  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107546622  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
107525935  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
107546640  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
107539280  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
107524087  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
107535150  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
107540819  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
107540705  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
107526398  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
107544316  MSH2; DNA mismatch repair protein Msh2 isoform X1 [KO:K08735]
107543706  DNA mismatch repair protein Msh3-like [KO:K08736]
107544300  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
107529959  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
107543004  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107542171  FADD; FAS-associated death domain protein [KO:K02373]
107533931  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
107537702  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
107545406  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
107540044  BBC3; bcl-2-binding component 3 [KO:K10132]
107539638  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
107536673  cytochrome c-like [KO:K08738]
107540285  cytochrome c isoform X1 [KO:K08738]
107533212  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
107545129  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
107536472  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
107533297  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
107533987  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
107545379  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
107527912  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
107537949  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
107525285  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
107545231  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
107545232  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
107536433  glutathione S-transferase omega-2-like [KO:K00799] [EC:2.5.1.18]
107534914  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
107530448  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
107536478  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
107525820  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
107525824  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
107525825  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
107525831  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
107530525  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
107530526  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
107530527  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
107537398  GSTP1; LOW QUALITY PROTEIN: glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
107537399  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
107525205  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
107545137  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
107530565  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
107534686  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
107539552  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
107535817  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
107525068  CUL2; cullin-2 [KO:K03870]
107534404  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
107524237  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
107534212  EGLN2; egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
107524230  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
107525927  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
107540254  EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095]
107539126  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
107541031  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
107535781  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
107531280  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
107544367  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
107536358  JAG1; protein jagged-1 [KO:K06052]
107543523  JAG2; LOW QUALITY PROTEIN: protein jagged-2 [KO:K21635]
107542965  DLL4; delta-like protein 4 [KO:K06051]
107534146  DLL3; delta-like protein 3 [KO:K06051]
107537014  DLL1; delta-like protein 1 [KO:K06051]
107535531  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
107545296  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
107534276  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
107538942  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
107527413  HES1; transcription factor HES-1 [KO:K06054]
107537045  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
107542619  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
107539496  HEY1; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
107528437  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107524916  SHH; sonic hedgehog protein [KO:K11988]
107532314  PTCH1; protein patched homolog 1 [KO:K06225]
107537370  SMO; smoothened homolog [KO:K06226]
107540376  KIF7; kinesin-like protein KIF7 [KO:K18806]
107542579  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
107546215  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
107543207  GLI2; zinc finger protein GLI2 [KO:K16798]
107537257  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
107536373  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
107525879  BMP4; bone morphogenetic protein 4 [KO:K04662]
107532520  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
107526709  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
107530204  AR; androgen receptor isoform X1 [KO:K08557]
107536915  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
107536502  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
107545155  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
mna03320  PPAR signaling pathway
mna04010  MAPK signaling pathway
mna04020  Calcium signaling pathway
mna04024  cAMP signaling pathway
mna04060  Cytokine-cytokine receptor interaction
mna04066  HIF-1 signaling pathway
mna04110  Cell cycle
mna04115  p53 signaling pathway
mna04150  mTOR signaling pathway
mna04151  PI3K-Akt signaling pathway
mna04210  Apoptosis
mna04310  Wnt signaling pathway
mna04330  Notch signaling pathway
mna04340  Hedgehog signaling pathway
mna04350  TGF-beta signaling pathway
mna04370  VEGF signaling pathway
mna04510  Focal adhesion
mna04512  ECM-receptor interaction
mna04520  Adherens junction
mna04630  JAK-STAT signaling pathway
mna04915  Estrogen signaling pathway
KO pathway
ko05200   
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