KEGG   PATHWAY: otw04510
Entry
otw04510                    Pathway                                
Name
Focal adhesion - Oncorhynchus tshawytscha (Chinook salmon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
otw04510  Focal adhesion
otw04510

Other DBs
GO: 0005925
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112214179  [KO:K06270]
112214206  [KO:K05459]
112214224  [KO:K10151]
112214243  [KO:K12755]
112214511  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112214774  [KO:K06269] [EC:3.1.3.16]
112214996  hgfa; hepatocyte growth factor a [KO:K05460]
112215023  [KO:K12959]
112215049  [KO:K05636]
112215073  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
112215221  [KO:K06484]
112215524  [KO:K05730]
112215535  [KO:K10351]
112215542  [KO:K05760]
112215587  [KO:K05719]
112215590  [KO:K05719]
112215662  [KO:K12757]
112215764  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
112215778  [KO:K08131]
112215806  [KO:K19719]
112215853  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
112216009  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
112216010  lamb2l; laminin subunit beta-2 isoform X1 [KO:K06243]
112216060  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112216138  [KO:K12329]
112216155  [KO:K04393]
112216212  [KO:K04353]
112216306  [KO:K05704] [EC:2.7.10.2]
112216380  [KO:K06590]
112216422  [KO:K26255]
112216475  [KO:K05637]
112216488  [KO:K05096] [EC:2.7.10.1]
112216685  col4a3; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
112216718  vtnb; LOW QUALITY PROTEIN: vitronectin b [KO:K06251]
112216823  [KO:K05636]
112216983  [KO:K10151]
112217005  [KO:K05459]
112217080  cav3; caveolin-3 [KO:K12959]
112217395  [KO:K17388] [EC:2.7.11.1]
112217524  [KO:K06241]
112217528  [KO:K05703] [EC:2.7.10.2]
112217557  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
112217662  [KO:K04456] [EC:2.7.11.1]
112217664  itgb7; integrin beta-7 isoform X1 [KO:K06590]
112217670  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
112217822  [KO:K05736] [EC:2.7.11.1]
112217890  [KO:K06269] [EC:3.1.3.16]
112217958  [KO:K16857]
112218162  parvb; beta-parvin isoform X1 [KO:K06275]
112218163  parvg; gamma-parvin [KO:K06275]
112218284  [KO:K04393]
112218294  itga11b; integrin alpha-11 isoform X1 [KO:K06587]
112218531  [KO:K05726]
112218557  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112218574  tln2b; talin-2 [KO:K06271]
112218594  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
112218668  [KO:K02833]
112218786  ccnd2a; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
112218806  parvaa; LOW QUALITY PROTEIN: parvin, alpha a [KO:K06275]
112218852  cav1; caveolin-1 [KO:K06278]
112218853  cav2; caveolin-2 [KO:K12958]
112218887  [KO:K04503]
112219023  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112219051  [KO:K06249] [EC:3.4.21.-]
112219159  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
112219242  [KO:K05460]
112219368  [KO:K05730]
112219617  [KO:K04440] [EC:2.7.11.24]
112219683  [KO:K06480]
112219685  [KO:K06481]
112219784  [KO:K04448]
112219921  [KO:K06247]
112219996  tln1; talin-1 isoform X1 [KO:K06271]
112220187  [KO:K06483]
112220256  rapgef1b; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1b [KO:K06277]
112220314  tnca; tenascin isoform X1 [KO:K06252]
112220315  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112220384  [KO:K04438]
112220399  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
112220540  [KO:K06485]
112220751  [KO:K04440] [EC:2.7.11.24]
112220770  [KO:K05089] [EC:2.7.10.1]
112220893  [KO:K05096] [EC:2.7.10.1]
112221054  [KO:K05450]
112221097  [KO:K04353]
112221165  vegfba; vascular endothelial growth factor A [KO:K05448]
112221344  [KO:K06243]
112221781  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112221831  [KO:K06484]
112221873  [KO:K04353]
112221931  [KO:K04393]
112221953  [KO:K12329]
112222049  [KO:K04513]
112222068  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112222098  [KO:K04513]
112222151  [KO:K19719]
112222169  col9a3; collagen alpha-3(IX) chain [KO:K08131]
112222214  [KO:K04366] [EC:2.7.11.1]
112222342  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
112222449  [KO:K04437]
112222506  [KO:K06273]
112222541  [KO:K06584]
112222547  zgc:113232; collagen alpha-1(I) chain [KO:K08131]
112222667  shc1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
112222669  [KO:K06238]
112222725  [KO:K04393]
112222833  thbs3a; thrombospondin-3a [KO:K04659]
112223176  [KO:K12958]
112223181  [KO:K05448]
112223208  [KO:K03853] [EC:3.4.22.53]
112223442  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112223506  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112223616  [KO:K06248]
112223646  itga3b; integrin alpha-3b isoform X1 [KO:K06482]
112223683  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112223770  itgb3b; integrin beta-3 isoform X1 [KO:K06493]
112223791  [KO:K00907] [EC:2.7.11.18]
112223856  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
112223872  mylpfb; myosin regulatory light chain 2, skeletal muscle isoform isoform X2 [KO:K12758]
112223875  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112223950  [KO:K03853] [EC:3.4.22.53]
112224117  [KO:K06276] [EC:2.7.11.1]
112224134  [KO:K06248]
112224208  [KO:K04440] [EC:2.7.11.24]
112224277  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112224481  [KO:K04392]
112224482  rac3b; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112224508  col1a1b; collagen, type I, alpha 1b isoform X1 [KO:K06236]
112224566  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112224592  itga9; integrin alpha-9 isoform X1 [KO:K06585]
112224605  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
112224778  [KO:K06525]
112224852  itga4; integrin alpha-4 [KO:K06483]
112224871  [KO:K05087] [EC:2.7.10.1]
112224903  [KO:K06238]
112225026  [KO:K06237]
112225082  [KO:K06238]
112225150  [KO:K04456] [EC:2.7.11.1]
112225163  [KO:K00907] [EC:2.7.11.18]
112225238  [KO:K06485]
112225415  [KO:K06237]
112225427  [KO:K03083] [EC:2.7.11.26]
112225600  [KO:K06588]
112225680  fn1a; fibronectin 1a [KO:K05717]
112225772  [KO:K02677] [EC:2.7.11.13]
112225909  [KO:K06236]
112225975  [KO:K06493]
112225996  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112226431  col6a2; collagen alpha-2(VI) chain [KO:K06238]
112226503  [KO:K06237]
112226662  [KO:K06485]
112226747  [KO:K02649]
112226753  [KO:K04448]
112226767  [KO:K04361] [EC:2.7.10.1]
112226775  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112226830  [KO:K00907] [EC:2.7.11.18]
112226859  [KO:K02161]
112226951  tnn; tenascin-N isoform X1 [KO:K06252]
112226953  tnr; tenascin-R isoform X1 [KO:K06252]
112226965  [KO:K05635]
112226966  lamc2; laminin subunit gamma-2 [KO:K06246]
112227000  [KO:K05719]
112227144  [KO:K00922] [EC:2.7.1.153]
112227214  [KO:K06237]
112227340  [KO:K00889] [EC:2.7.1.68]
112227373  [KO:K06240]
112227507  lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
112227702  [KO:K05096] [EC:2.7.10.1]
112227752  [KO:K02161]
112227760  [KO:K04361] [EC:2.7.10.1]
112227962  myl12.1; myosin regulatory light polypeptide 9 [KO:K12757]
112228042  [KO:K05719]
112228218  [KO:K06274]
112228388  [KO:K04438]
112228464  [KO:K04659]
112228530  [KO:K12756]
112228809  bada; bcl2-associated agonist of cell death [KO:K02158]
112228863  [KO:K05733] [EC:2.7.11.1]
112229039  [KO:K05449]
112229041  [KO:K05089] [EC:2.7.10.1]
112229210  [KO:K06591]
112229484  [KO:K06236]
112229535  ptk2aa; protein tyrosine kinase 2aa isoform X8 [KO:K05725] [EC:2.7.10.2]
112229692  [KO:K04659]
112229790  [KO:K06252]
112229837  [KO:K04393]
112230281  [KO:K04364]
112230347  [KO:K02677] [EC:2.7.11.13]
112230362  [KO:K04456] [EC:2.7.11.1]
112230419  [KO:K03099]
112230514  [KO:K00889] [EC:2.7.1.68]
112230527  [KO:K05730]
112230757  [KO:K06277]
112230790  [KO:K02649]
112230791  [KO:K06252]
112230880  [KO:K06247]
112230946  [KO:K04438]
112231122  [KO:K05449]
112231277  [KO:K05733] [EC:2.7.11.1]
112231415  [KO:K04440] [EC:2.7.11.24]
112231417  [KO:K04456] [EC:2.7.11.1]
112232479  [KO:K06249] [EC:3.4.21.-]
112232600  [KO:K04513]
112232691  [KO:K04361] [EC:2.7.10.1]
112232698  [KO:K02161]
112232894  [KO:K17388] [EC:2.7.11.1]
112233141  [KO:K16857]
112233191  [KO:K16859]
112234003  [KO:K04409] [EC:2.7.11.1]
112234040  [KO:K07860]
112234081  [KO:K05448]
112234141  [KO:K00907] [EC:2.7.11.18]
112234309  [KO:K08131]
112234531  [KO:K05449]
112234604  [KO:K04364]
112234737  [KO:K06251]
112234933  [KO:K02649]
112235378  [KO:K00889] [EC:2.7.1.68]
112235421  [KO:K17447]
112235545  [KO:K06586]
112235685  [KO:K16060]
112235885  [KO:K05740]
112236105  [KO:K04410] [EC:2.7.11.1]
112236162  [KO:K04359]
112236240  [KO:K03853] [EC:3.4.22.53]
112236328  [KO:K07861]
112236423  [KO:K04659]
112236582  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
112236612  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
112236749  [KO:K26255]
112236859  pdgfd; platelet-derived growth factor D [KO:K05450]
112237061  [KO:K06583]
112237136  [KO:K06238]
112237223  [KO:K06238]
112237229  [KO:K06487]
112237383  [KO:K06271]
112237408  [KO:K04371] [EC:2.7.11.24]
112237626  [KO:K06525]
112237840  [KO:K06237]
112237883  [KO:K04393]
112237949  badb; BCL2 associated agonist of cell death b [KO:K02158]
112238315  [KO:K06585]
112238339  [KO:K19719]
112238407  [KO:K05097] [EC:2.7.10.1]
112238437  itgb5; integrin beta-5 [KO:K06588]
112238567  [KO:K06587]
112238870  [KO:K06270]
112239140  fn1b; fibronectin 1b isoform X1 [KO:K05717]
112239204  [KO:K06483]
112239227  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
112239256  [KO:K06487]
112239349  [KO:K05700]
112239456  [KO:K05730]
112239481  [KO:K04659]
112239893  [KO:K06238]
112239905  [KO:K04513]
112239941  [KO:K19663] [EC:2.7.11.13]
112239957  [KO:K04392]
112240032  [KO:K19719]
112240142  lama5; laminin subunit alpha-5 [KO:K06240]
112240485  [KO:K07860]
112240545  [KO:K05699]
112240612  [KO:K19663] [EC:2.7.11.13]
112240645  [KO:K05692]
112240770  [KO:K06238]
112240781  [KO:K26256]
112240902  [KO:K05692]
112240903  [KO:K05692]
112240982  [KO:K17386]
112241065  [KO:K13708]
112241148  [KO:K03083] [EC:2.7.11.26]
112241368  [KO:K04359]
112241427  [KO:K05730]
112241524  [KO:K06237]
112241545  [KO:K06237]
112241769  vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
112241873  [KO:K05449]
112242268  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
112242516  [KO:K04371] [EC:2.7.11.24]
112242721  [KO:K05732]
112244527  lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112244626  [KO:K02649]
112244635  [KO:K06584]
112244792  [KO:K06244]
112244890  [KO:K04513]
112244951  [KO:K13709]
112245009  [KO:K05700]
112245139  [KO:K04410] [EC:2.7.11.1]
112245248  [KO:K05460]
112245255  [KO:K04349]
112245504  [KO:K17457]
112245575  [KO:K17457]
112245729  [KO:K08131]
112245979  [KO:K05725] [EC:2.7.10.2]
112246201  [KO:K12755]
112246216  [KO:K06484]
112246248  [KO:K04659]
112246255  [KO:K05449]
112246274  [KO:K06583]
112246336  [KO:K16060]
112247573  [KO:K05699]
112247795  [KO:K05450]
112248091  [KO:K05449]
112248224  [KO:K06277]
112248359  [KO:K06269] [EC:3.1.3.16]
112248400  [KO:K05760]
112248575  [KO:K04659]
112248588  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
112248681  jun; transcription factor AP-1 isoform X1 [KO:K04448]
112248937  [KO:K02649]
112249039  [KO:K04503]
112249079  [KO:K00907] [EC:2.7.11.18]
112249110  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112249135  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
112249152  [KO:K06275]
112249374  [KO:K06271]
112249514  [KO:K06252]
112249819  thbs1b; thrombospondin-1 [KO:K16857]
112249908  [KO:K05735] [EC:2.7.11.1]
112249925  [KO:K17388] [EC:2.7.11.1]
112250058  [KO:K06241]
112250060  [KO:K05703] [EC:2.7.10.2]
112250079  [KO:K00907] [EC:2.7.11.18]
112250387  [KO:K04456] [EC:2.7.11.1]
112250395  [KO:K05448]
112250506  [KO:K06269] [EC:3.1.3.16]
112250555  [KO:K16859]
112250569  [KO:K05736] [EC:2.7.11.1]
112250738  [KO:K02649]
112250823  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
112250872  [KO:K02649]
112250883  [KO:K17447]
112250960  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
112251044  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112251077  [KO:K04448]
112251129  [KO:K04363] [EC:2.7.10.1]
112251200  [KO:K05636]
112251545  [KO:K04659]
112251616  [KO:K00907] [EC:2.7.11.18]
112251950  mapk3; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112251959  [KO:K04371] [EC:2.7.11.24]
112252131  [KO:K02649]
112252223  [KO:K00889] [EC:2.7.1.68]
112252351  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
112252352  [KO:K04440] [EC:2.7.11.24]
112252377  [KO:K05087] [EC:2.7.10.1]
112252395  [KO:K06271]
112252501  [KO:K02833]
112252585  [KO:K10151]
112252602  [KO:K06275]
112252623  lamb4; laminin subunit beta-4 [KO:K06245]
112252624  [KO:K05636]
112252650  [KO:K05099] [EC:2.7.10.1]
112252651  [KO:K06278]
112252652  [KO:K12958]
112252678  [KO:K04503]
112252764  [KO:K04440] [EC:2.7.11.24]
112253032  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112253319  comp; cartilage oligomeric matrix protein [KO:K04659]
112253980  [KO:K03083] [EC:2.7.11.26]
112254024  [KO:K04410] [EC:2.7.11.1]
112254214  [KO:K04513]
112254221  [KO:K04353]
112254527  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112254533  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112254562  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
112254586  [KO:K06590]
112254785  [KO:K05760]
112254822  [KO:K12958]
112254824  [KO:K12959]
112254873  lamb3; laminin subunit beta-3 [KO:K06244]
112254897  [KO:K04513]
112255022  [KO:K06586]
112255048  [KO:K05704] [EC:2.7.10.2]
112255105  [KO:K27392]
112255167  [KO:K06589]
112255282  [KO:K12958]
112255301  [KO:K10351]
112255496  [KO:K12959]
112255751  [KO:K05735] [EC:2.7.11.1]
112255836  [KO:K03099]
112255900  [KO:K04725] [EC:2.3.2.27]
112255929  [KO:K05448]
112256098  [KO:K05089] [EC:2.7.10.1]
112256125  [KO:K05740]
112256198  [KO:K05096] [EC:2.7.10.1]
112256330  egf; pro-epidermal growth factor [KO:K04357]
112256335  pdgfc; platelet-derived growth factor C [KO:K05450]
112256640  [KO:K04456] [EC:2.7.11.1]
112256663  [KO:K16857]
112256717  pgfb; placenta growth factor [KO:K16859]
112256837  [KO:K13709]
112257296  [KO:K06481]
112257314  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
112257338  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112257355  shc3; SHC-transforming protein 3 [KO:K17448]
112257427  [KO:K04659]
112257727  [KO:K05732]
112257917  [KO:K12756]
112257962  vclb; vinculin isoform X1 [KO:K05700]
112258044  [KO:K04438]
112258495  itga2b; integrin alpha-IIb [KO:K06476]
112258519  [KO:K06482]
112258533  [KO:K06236]
112258603  [KO:K06493]
112258667  [KO:K00907] [EC:2.7.11.18]
112258739  [KO:K26255]
112258867  [KO:K04364]
112258954  [KO:K07860]
112258967  [KO:K12758]
112258985  [KO:K06269] [EC:3.1.3.16]
112259017  [KO:K06269] [EC:3.1.3.16]
112259027  [KO:K12758]
112259175  [KO:K07861]
112259254  ccndx; LOW QUALITY PROTEIN: cyclin Dx [KO:K10151]
112259461  itga1; integrin alpha-1 isoform X1 [KO:K06480]
112259508  [KO:K04392]
112259612  [KO:K06240]
112259622  [KO:K06236]
112259641  [KO:K06485]
112259668  [KO:K05730]
112260058  [KO:K06269] [EC:3.1.3.16]
112260202  [KO:K00922] [EC:2.7.1.153]
112260235  [KO:K06237]
112260309  [KO:K02649]
112260414  [KO:K05719]
112260448  [KO:K05635]
112260449  [KO:K06246]
112260458  [KO:K06252]
112260459  [KO:K06252]
112260550  [KO:K02161]
112260620  [KO:K00907] [EC:2.7.11.18]
112260654  [KO:K04514] [EC:2.7.11.1]
112260663  [KO:K04361] [EC:2.7.10.1]
112260691  [KO:K04448]
112260699  [KO:K02649]
112260798  [KO:K00889] [EC:2.7.1.68]
112260956  [KO:K06237]
112261645  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112261841  [KO:K04456] [EC:2.7.11.1]
112262240  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
112262320  [KO:K05735] [EC:2.7.11.1]
112262493  [KO:K04371] [EC:2.7.11.24]
112262497  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112262626  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
112262828  [KO:K12958]
112263036  [KO:K05760]
112263044  [KO:K06269] [EC:3.1.3.16]
112263306  [KO:K06277]
112263547  [KO:K00907] [EC:2.7.11.18]
112263555  [KO:K26255]
112263573  [KO:K04503]
112263678  parvab; alpha-parvin [KO:K06275]
112263934  [KO:K12758]
112263935  [KO:K00889] [EC:2.7.1.68]
112264096  [KO:K04364]
112264195  [KO:K06238]
112264350  [KO:K06236]
112264428  [KO:K08131]
112264679  [KO:K04659]
112264777  [KO:K06252]
112264818  [KO:K04393]
112264997  col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
112265049  [KO:K02677] [EC:2.7.11.13]
112265084  [KO:K05732]
112265169  [KO:K04438]
112265172  [KO:K04456] [EC:2.7.11.1]
112265231  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
112265290  [KO:K05699]
112265297  [KO:K05734] [EC:2.7.11.1]
112265330  [KO:K06252]
112265600  [KO:K06274]
112265711  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112265713  [KO:K06272] [EC:2.7.11.1]
112265788  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112265822  [KO:K06591]
112265983  [KO:K03099]
112266167  [KO:K00922] [EC:2.7.1.153]
112266321  col6a1; collagen alpha-1(VI) chain [KO:K06238]
112266430  capn8; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112266436  [KO:K03853] [EC:3.4.22.53]
112266506  [KO:K06589]
112266570  [KO:K03083] [EC:2.7.11.26]
112266614  [KO:K00889] [EC:2.7.1.68]
112266677  [KO:K05732]
112266812  [KO:K04438]
112266874  actn4; alpha-actinin-4 isoform X4 [KO:K05699]
112266882  [KO:K05734] [EC:2.7.11.1]
112267001  [KO:K04409] [EC:2.7.11.1]
112267038  [KO:K05704] [EC:2.7.10.2]
112267174  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
112267269  [KO:K00922] [EC:2.7.1.153]
112267273  [KO:K04456] [EC:2.7.11.1]
112267274  [KO:K06272] [EC:2.7.11.1]
112267689  [KO:K06484]
121838626  [KO:K26256]
121838936  [KO:K08131]
121840987  [KO:K06273]
121841079  [KO:K06279]
121841453  [KO:K08131]
121842780  [KO:K07836]
121843711  [KO:K04365] [EC:2.7.11.1]
121844131  [KO:K19662] [EC:2.7.11.13]
121844290  [KO:K05692]
121844383  [KO:K05692]
121844384  [KO:K05692]
121845244  [KO:K19662] [EC:2.7.11.13]
121845253  [KO:K07836]
121845884  [KO:K05730]
121846138  [KO:K00889] [EC:2.7.1.68]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
otw04010  MAPK signaling pathway
otw04060  Cytokine-cytokine receptor interaction
otw04070  Phosphatidylinositol signaling system
otw04110  Cell cycle
otw04310  Wnt signaling pathway
otw04512  ECM-receptor interaction
otw04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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