KEGG   PATHWAY: fca05417
Entry
fca05417                    Pathway                                
Name
Lipid and atherosclerosis - Felis catus (domestic cat)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
fca05417  Lipid and atherosclerosis
fca05417

Disease
H02505  Atherosclerosis
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100127112  MCP-1; C-C motif chemokine 2 [KO:K14624]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100142684  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100174789  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100302540  [KO:K05408]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100502578  BID; BH3-interacting domain death agonist [KO:K04726]
101080362  LDLR; low-density lipoprotein receptor isoform X2 [KO:K12473]
101080520  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101080570  APOA4; apolipoprotein A-IV [KO:K08760]
101080710  [KO:K03283]
101081076  APOA1; apolipoprotein A-I [KO:K08757]
101081091  [KO:K05408]
101081273  RXRG; retinoic acid receptor RXR-gamma isoform X2 [KO:K08526]
101081371  [KO:K05414]
101081492  [KO:K01394] [EC:3.4.24.17]
101081534  CALM2; calmodulin-2 [KO:K02183]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101082249  HSP90B1; endoplasmin [KO:K09487]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101082454  [KO:K04393]
101082884  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101083565  SELP; P-selectin isoform X1 [KO:K06496]
101083606  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101083630  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101083728  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
101083885  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X2 [KO:K05641]
101083892  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
101083957  [KO:K01388] [EC:3.4.24.7]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101084060  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101084148  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101084185  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101084217  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084342  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084920  POU2F2; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 2 [KO:K09364]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101085488  ABCG1; ATP-binding cassette sub-family G member 1 isoform X6 [KO:K05679]
101085520  SELE; E-selectin [KO:K06494]
101085757  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101085801  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101086207  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101086238  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
101086264  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101086282  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101086376  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
101086432  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101086780  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101087306  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
101087417  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101087422  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101088003  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101088122  [KO:K08738]
101088339  [KO:K08738]
101088440  [KO:K05414]
101088449  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101088683  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
101088688  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
101088712  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101088865  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
101089421  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101090005  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101090324  [KO:K05409]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101090622  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101090623  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101090942  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101091022  [KO:K03283]
101091063  CALM3; calmodulin-3 [KO:K02183]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091745  CYBA; cytochrome b-245 light chain [KO:K08009]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101092150  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101092262  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101092579  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101092961  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101093286  [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093842  CD36; platelet glycoprotein 4 [KO:K06259]
101093854  [KO:K10030]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101094679  CALM1; calmodulin-1 [KO:K02183]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094857  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101094867  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101095161  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101095507  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101095825  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101095934  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
101095952  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101096463  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101096604  RELA; transcription factor p65 [KO:K04735]
101096633  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
101096739  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101096892  AGER; advanced glycosylation end product-specific receptor isoform X6 [KO:K19722]
101096985  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101097212  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097703  [KO:K02183]
101097746  CYP2J2; cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101097784  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101097963  [KO:K05399]
101098090  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101098172  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101098187  POU2F1; POU domain, class 2, transcription factor 1 isoform X3 [KO:K09364]
101098213  [KO:K08738]
101098221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101098615  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
101098714  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101098740  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101098812  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
101098840  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101098863  APOB; apolipoprotein B-100 [KO:K14462]
101099237  [KO:K03283]
101099307  [KO:K02183]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101100214  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101100862  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
101100947  [KO:K08738]
101101092  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101259  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
102901432  [KO:K05505]
102902667  [KO:K02183]
105260573  [KO:K03283]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105261012  [KO:K04722]
109498011  [KO:K05399]
109503558  [KO:K08738]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111557596  [KO:K05414]
111560177  [KO:K05505]
111560178  [KO:K05505]
123381775  [KO:K05414]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
493662  TLR6; toll-like receptor 6 [KO:K10169]
493687  IL6; interleukin-6 precursor [KO:K05405]
493688  IL18; interleukin-18 [KO:K05482]
493689  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
493837  BAX; apoptosis regulator BAX [KO:K02159]
493840  IFNA5; interferon alpha-5 [KO:K05414]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
493849  IFNB1; interferon beta precursor [KO:K05415]
493850  CD40LG; CD40 ligand [KO:K03161]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493935  FOS; proto-oncogene c-Fos [KO:K04379]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
554347  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768261  PLA2G12A; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
768262  CASP7; caspase-7 isoform X2 [KO:K04397] [EC:3.4.22.60]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
768274  IL1B; interleukin-1 beta [KO:K04519]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
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Related
pathway
fca04020  Calcium signaling pathway
fca04115  p53 signaling pathway
fca04141  Protein processing in endoplasmic reticulum
fca04151  PI3K-Akt signaling pathway
fca04210  Apoptosis
fca04620  Toll-like receptor signaling pathway
fca04621  NOD-like receptor signaling pathway
fca04668  TNF signaling pathway
fca04670  Leukocyte transendothelial migration
fca04975  Fat digestion and absorption
fca04979  Cholesterol metabolism
fca05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   

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