Entry
Name
Herpes simplex virus 1 infection - Salmo trutta (river trout)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Salmo trutta (river trout) [GN:
stru ]
Gene
115147760 tumor necrosis factor ligand superfamily member 14-like isoform X1 [KO:K05477 ]
115171573 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
115204269 tumor necrosis factor ligand superfamily member 14-like [KO:K05477 ]
115165379 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115165381 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115165383 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165388 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115165389 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165390 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165406 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165375 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115165378 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115165380 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152 ]
115165382 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152 ]
115165384 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165385 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165386 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165391 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165392 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
115165405 tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152 ]
115173310 nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580 ]
115205318 nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580 ]
115204697 baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060 ]
115164876 caspase recruitment domain-containing protein 9-like isoform X1 [KO:K12794 ]
115195308 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
115178837 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
115147443 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
115194003 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404 ]
115174890 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404 ]
115156064 ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647 ] [EC:5.6.2.6 ]
115198169 serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
115155450 interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
115162042 eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
115172304 eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237 ]
115164491 translation initiation factor eIF-2B subunit alpha-like isoform X1 [KO:K03239 ]
115149293 translation initiation factor eIF-2B subunit alpha-like [KO:K03239 ]
115200149 translation initiation factor eIF-2B subunit alpha-like [KO:K03239 ]
115151293 translation initiation factor eIF-2B subunit beta-like isoform X1 [KO:K03754 ]
115169770 translation initiation factor eIF-2B subunit gamma-like [KO:K03241 ]
115157001 translation initiation factor eIF-2B subunit gamma-like [KO:K03241 ]
115175171 translation initiation factor eIF-2B subunit delta-like [KO:K03680 ]
115150359 translation initiation factor eIF-2B subunit delta-like [KO:K03680 ]
115157579 eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
115173530 POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364 ]
115175938 POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364 ]
115176611 POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364 ]
115155893 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
115179450 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
115161280 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
115148605 POU domain, class 2, transcription factor 3-like isoform X1 [KO:K09364 ]
115196377 POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364 ]
115156118 signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220 ]
115160666 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220 ]
115195984 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220 ]
115207827 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221 ]
115167702 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115170885 zinc finger and SCAN domain-containing protein 31-like [KO:K09228 ]
115183597 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115183642 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115183663 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115177515 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115160036 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115172793 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
115206141 gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228 ]
115206150 gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228 ]
115176556 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
115177271 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
115184256 gastrula zinc finger protein XlCGF48.2-like isoform X1 [KO:K09228 ]
115208116 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
115175916 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
115175919 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
115175920 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
115206560 major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751 ]
115155518 major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751 ]
115175918 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
115175905 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
115182842 H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752 ]
115182843 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
115176236 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
115176237 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
115177484 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
115147540 H-2 class II histocompatibility antigen, A-Q alpha chain-like isoform X1 [KO:K06752 ]
115148613 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
115147539 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
115148612 H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752 ]
115177064 rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752 ]
115184166 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
115174315 H-2 class II histocompatibility antigen gamma chain-like isoform X1 [KO:K06505 ]
115205394 HLA class II histocompatibility antigen gamma chain-like [KO:K06505 ]
115170061 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
115158422 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
115165908 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
115156658 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
115206538 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
115192204 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
115169527 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
115158103 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
115169950 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
115158753 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
115159695 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
115156743 phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649 ]
115167650 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
115157257 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
115151679 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
115203963 phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649 ]
115164452 eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205 ]
115200186 eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205 ]
115204692 serine/arginine-rich splicing factor 1B-like isoform X1 [KO:K12890 ]
115171417 serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891 ]
115202364 srsf2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891 ]
115150350 serine/arginine-rich splicing factor 3-like isoform X1 [KO:K12892 ]
115161890 serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893 ]
115175132 serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893 ]
115155913 serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893 ]
115154147 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
115163174 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
115177733 srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
115208485 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
115206121 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
115192444 tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389 ]
115158458 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
115153220 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
115193754 tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390 ]
115187990 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
115176742 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
115167216 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
115203119 tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171 ]
115180292 apoptotic protease-activating factor 1-like isoform X1 [KO:K02084 ]
115199073 apoptotic protease-activating factor 1-like isoform X1 [KO:K02084 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
stru04620 Toll-like receptor signaling pathway
stru04622 RIG-I-like receptor signaling pathway
KO pathway
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