KEGG   PATHWAY: hsa05132
Entry
hsa05132                    Pathway                                
Name
Salmonella infection - Homo sapiens (human)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
hsa05132  Salmonella infection
hsa05132

Network
nt06181  Salmonella
nt06505  WNT signaling
nt06516  TNF signaling
nt06521  NLR signaling
  Element
N01112  Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01113  Salmonella SseK1 to TNF-NFKB signaling pathway
N01114  Salmonella SseK3 to TNF-NFKB signaling pathway
N01116  Salmonella SseL to TNF-NFKB signaling pathway
N01117  Salmonella GogB to TNF-NFKB signaling pathway
N01118  Salmonella SpvD to TNF-NFKB signaling pathway
N01120  Salmonella SptP to RAC/CDC42-PAK-ERK signaling pathway
N01121  Salmonella SpvC to ERK signaling pathway
N01122  Salmonella PipA/GogA/GtgA to TNF-NFKB signaling pathway
N01123  Salmonella AvrA to TNF-NFKB signaling pathway
N01124  Salmonella AvrA to beta-catenin signaling pathway
N01125  Salmonella AvrA to TNF-JNK signaling pathway
N01126  Salmonella SipB to Inflammasome signaling pathway
N01127  Salmonella SopE to Inflammasome signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01130  Salmonella SopB to RhoA signaling pathway
N01131  Salmonella SopE/E2 to RhoA signaling pathway
N01132  Salmonella SopE/E2 to RhoG signaling pathway
N01133  Salmonella SopB to RhoG signaling pathway
N01134  Salmonella SopB to CDC42 signaling pathway
N01296  Salmonella SopD2 to Rab7-regulated microtubule minus-end directed transport
N01298  Salmonella SifA to microtubule plus-end directed transport
N01299  Salmonella PipB2 to microtubule plus-end directed transport
N01301  Salmonella SifA to Tethering of late endosomes and lysosomes
N01303  Salmonella SopB to Early endosomal fusion
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
Disease
H00111  Typhoid fever
Organism
Homo sapiens (human) [GN:hsa]
Gene
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
10006  ABI1; abl interactor 1 [KO:K23649]
10092  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
10093  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
10094  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
10095  ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
10096  ACTR3; actin related protein 3 [KO:K18584]
10097  ACTR2; actin related protein 2 [KO:K17260]
10109  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
10120  ACTR1B; actin related protein 1B [KO:K16575]
10121  ACTR1A; actin related protein 1A [KO:K16575]
10333  TLR6; toll like receptor 6 [KO:K10169]
10376  TUBA1B; tubulin alpha 1b [KO:K07374]
10381  TUBB3; tubulin beta 3 class III [KO:K07375]
10382  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
10383  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
103910  MYL12B; myosin light chain 12B [KO:K12757]
10392  NOD1; nucleotide binding oligomerization domain containing 1 [KO:K08727]
10398  MYL9; myosin light chain 9 [KO:K12755]
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
10540  DCTN2; dynactin subunit 2 [KO:K10424]
10552  ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
10627  MYL12A; myosin light chain 12A [KO:K12757]
10640  EXOC5; exocyst complex component 5 [KO:K19984]
10671  DCTN6; dynactin subunit 6 [KO:K10428]
10787  NCKAP1; NCK associated protein 1 [KO:K05750]
10810  WASF3; WASP family member 3 [KO:K06083]
11035  RIPK3; receptor interacting serine/threonine kinase 3 [KO:K08847] [EC:2.7.11.1]
112574  SNX18; sorting nexin 18 [KO:K17923]
11258  DCTN3; dynactin subunit 3 [KO:K10425]
112714  TUBA3E; tubulin alpha 3e [KO:K07374]
113146  AHNAK2; AHNAK nucleoprotein 2 [KO:K23934]
113457  TUBA3D; tubulin alpha 3d [KO:K07374]
114548  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
114609  TIRAP; TIR domain containing adaptor protein [KO:K05403]
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467] [EC:2.7.11.10]
124908013  [KO:K07375]
124908015  [KO:K07375]
124908041  [KO:K07375]
127829  ARL8A; ADP ribosylation factor like GTPase 8A [KO:K07955]
140735  DYNLL2; dynein light chain LC8-type 2 [KO:K10418]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
1434  CSE1L; chromosome segregation 1 like [KO:K18423]
147700  KLC3; kinesin light chain 3 [KO:K10407]
1499  CTNNB1; catenin beta 1 [KO:K02105]
1639  DCTN1; dynactin subunit 1 [KO:K04648]
1778  DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
1780  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
1781  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
1783  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
1785  DNM2; dynamin 2 [KO:K23484]
197259  MLKL; mixed lineage kinase domain like pseudokinase [KO:K08849] [EC:2.7.11.1]
203068  TUBB; tubulin beta class I [KO:K07375]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [KO:K04404]
2316  FLNA; filamin A [KO:K04437]
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
23207  PLEKHM2; pleckstrin homology and RUN domain containing M2 [KO:K15348]
23265  EXOC7; exocyst complex component 7 [KO:K07195]
23339  VPS39; VPS39 subunit of HOPS complex [KO:K20183]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
23643  LY96; lymphocyte antigen 96 [KO:K05400]
257364  SNX33; sorting nexin 33 [KO:K17923]
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [KO:K12793]
25828  TXN2; thioredoxin 2 [KO:K03671]
2597  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
260334  TUBB8B; tubulin beta 8B [KO:K07375]
26084  ARHGEF26; Rho guanine nucleotide exchange factor 26 [KO:K13744]
26263  FBXO22; F-box protein 22 [KO:K10302]
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
27072  VPS41; VPS41 subunit of HOPS complex [KO:K20184]
27128  CYTH4; cytohesin 4 [KO:K18441]
29108  PYCARD; PYD and CARD domain containing [KO:K12799]
29109  FHOD1; formin homology 2 domain containing 1 [KO:K23938]
29895  MYL11; myosin light chain 11 [KO:K12758]
302  ANXA2; annexin A2 [KO:K17092]
3071  NCKAP1L; NCK associated protein 1 like [KO:K05750]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
329  BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
330  BIRC3; baculoviral IAP repeat containing 3 [KO:K16060]
3320  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
3326  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
338382  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
345456  PFN3; profilin 3 [KO:K05759]
347688  TUBB8; tubulin beta 8 class VIII [KO:K07375]
347733  TUBB2B; tubulin beta 2B class IIb [KO:K07375]
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
3553  IL1B; interleukin 1 beta [KO:K04519]
3569  IL6; interleukin 6 [KO:K05405]
3576  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
3606  IL18; interleukin 18 [KO:K05482]
3654  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
375  ARF1; ADP ribosylation factor 1 [KO:K07937]
375189  PFN4; profilin family member 4 [KO:K05759]
3798  KIF5A; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
3799  KIF5B; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
3800  KIF5C; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
382  ARF6; ADP ribosylation factor 6 [KO:K07941]
3831  KLC1; kinesin light chain 1 [KO:K10407]
3836  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
3839  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
3840  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
387  RHOA; ras homolog family member A [KO:K04513]
388  RHOB; ras homolog family member B [KO:K07856]
391  RHOG; ras homolog family member G [KO:K07863]
399  RHOH; ras homolog family member H [KO:K07873]
4074  M6PR; mannose-6-phosphate receptor, cation dependent [KO:K10089]
4609  MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377]
4615  MYD88; MYD88 innate immune signal transduction adaptor [KO:K04729]
4633  MYL2; myosin light chain 2 [KO:K10351]
4636  MYL5; myosin light chain 5 [KO:K12753]
4646  MYO6; myosin VI [KO:K10358]
4671  NAIP; NLR family apoptosis inhibitory protein [KO:K12807]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
5058  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
5063  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
51135  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
51143  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
51164  DCTN4; dynactin subunit 4 [KO:K10426]
51176  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
51209  RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
51429  SNX9; sorting nexin 9 [KO:K17923]
51626  DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417]
51807  TUBA8; tubulin alpha 8 [KO:K07374]
5216  PFN1; profilin 1 [KO:K05759]
5217  PFN2; profilin 2 [KO:K05759]
5286  PIK3C2A; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
5287  PIK3C2B; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
5288  PIK3C2G; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5294  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
54106  TLR9; toll like receptor 9 [KO:K10161]
5420  PODXL; podocalyxin like [KO:K06817]
54205  CYCS; cytochrome c, somatic [KO:K08738]
55207  ARL8B; ADP ribosylation factor like GTPase 8B [KO:K07955]
55770  EXOC2; exocyst complex component 2 [KO:K17637]
55823  VPS11; VPS11 core subunit of CORVET and HOPS complexes [KO:K20179]
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex [KO:K05752]
5585  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
55860  ACTR10; actin related protein 10 [KO:K16576]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5606  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
5608  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
5609  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
57180  ACTR3B; actin related protein 3B [KO:K18584]
57381  RHOJ; ras homolog family member J [KO:K07864]
57617  VPS18; VPS18 core subunit of CORVET and HOPS complexes [KO:K20181]
578  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
5788  PTPRC; protein tyrosine phosphatase receptor type C [KO:K06478] [EC:3.1.3.48]
581  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
58484  NLRC4; NLR family CARD domain containing 4 [KO:K12805]
58498  MYL7; myosin light chain 7 [KO:K12754]
5868  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
5869  RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
5878  RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5898  RALA; RAS like proto-oncogene A [KO:K07834]
596  BCL2; BCL2 apoptosis regulator [KO:K02161]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
60  ACTB; actin beta [KO:K05692]
60412  EXOC4; exocyst complex component 4 [KO:K06111]
6188  RPS3; ribosomal protein S3 [KO:K02985]
6237  RRAS; RAS related [KO:K07829]
6281  S100A10; S100 calcium binding protein A10 [KO:K17274]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
63916  ELMO2; engulfment and cell motility 2 [KO:K18985]
6416  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
64601  VPS16; VPS16 core subunit of CORVET and HOPS complexes [KO:K20180]
64746  ACBD3; acyl-CoA binding domain containing 3 [KO:K23935]
64837  KLC2; kinesin light chain 2 [KO:K10407]
6500  SKP1; S-phase kinase associated protein 1 [KO:K03094]
65082  VPS33A; VPS33A core subunit of CORVET and HOPS complexes [KO:K20182]
653857  ACTR3C; actin related protein 3C [KO:K18584]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
6932  TCF7; transcription factor 7 [KO:K02620]
6934  TCF7L2; transcription factor 7 like 2 [KO:K04491]
6990  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
6993  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
7097  TLR2; toll like receptor 2 [KO:K10159]
7099  TLR4; toll like receptor 4 [KO:K10160]
71  ACTG1; actin gamma 1 [KO:K05692]
7100  TLR5; toll like receptor 5 [KO:K10168]
7124  TNF; tumor necrosis factor [KO:K03156]
7132  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
7184  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
7186  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
7277  TUBA4A; tubulin alpha 4a [KO:K07374]
7278  TUBA3C; tubulin alpha 3c [KO:K07374]
7280  TUBB2A; tubulin beta 2A class IIa [KO:K07375]
7295  TXN; thioredoxin [KO:K03671]
7846  TUBA1A; tubulin alpha 1a [KO:K07374]
7879  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
79026  AHNAK; AHNAK nucleoprotein [KO:K23934]
79443  FYCO1; FYVE and coiled-coil domain autophagy adaptor 1 [KO:K21954]
79659  DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
79792  GSDMD; gasdermin D [KO:K20917]
79861  TUBAL3; tubulin alpha like 3 [KO:K07374]
81027  TUBB1; tubulin beta 1 class VI [KO:K07375]
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
834  CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
83439  TCF7L1; transcription factor 7 like 1 [KO:K04490]
83547  RILP; Rab interacting lysosomal protein [KO:K13883]
836  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
83657  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
83658  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
837  CASP4; caspase 4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
838  CASP5; caspase 5 [KO:K04395] [EC:3.4.22.58]
840  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
841  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
84516  DCTN5; dynactin subunit 5 [KO:K10427]
84617  TUBB6; tubulin beta 6 class V [KO:K07375]
84790  TUBA1C; tubulin alpha 1c [KO:K07374]
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210]
8655  DYNLL1; dynein light chain LC8-type 1 [KO:K10418]
8677  STX10; syntaxin 10 [KO:K23937]
8717  TRADD; TNFRSF1A associated via death domain [KO:K03171]
8737  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
8743  TNFSF10; TNF superfamily member 10 [KO:K04721]
8767  RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
8772  FADD; Fas associated via death domain [KO:K02373]
8795  TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722]
8797  TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
8976  WASL; WASP like actin nucleation promoting factor [KO:K23612]
89953  KLC4; kinesin light chain 4 [KO:K10407]
9265  CYTH3; cytohesin 3 [KO:K18441]
9266  CYTH2; cytohesin 2 [KO:K18441]
9267  CYTH1; cytohesin 1 [KO:K18441]
929  CD14; CD14 molecule [KO:K04391]
93408  MYL10; myosin light chain 10 [KO:K12756]
9367  RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
9648  GCC2; GRIP and coiled-coil domain containing 2 [KO:K20282]
9842  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
9844  ELMO1; engulfment and cell motility 1 [KO:K12366]
998  CDC42; cell division cycle 42 [KO:K04393]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
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Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
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van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
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Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
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Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
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Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
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McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
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Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
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Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
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J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
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Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
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Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
hsa04010  MAPK signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
KO pathway
ko05132   

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