KEGG   PATHWAY: pbg05200
Entry
pbg05200                    Pathway                                
Name
Pathways in cancer - Prionailurus bengalensis (leopard cat)
Class
Human Diseases; Cancer: overview
Pathway map
pbg05200  Pathways in cancer
pbg05200

Organism
Prionailurus bengalensis (leopard cat) [GN:pbg]
Gene
122470779  DCC; netrin receptor DCC isoform X1 [KO:K06765]
122470647  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122479964  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
122487350  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
122495148  CDH1; cadherin-1 [KO:K05689]
122492117  CTNNB1; catenin beta-1 [KO:K02105]
122487957  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
122492803  CTNNA3; catenin alpha-3 [KO:K05691]
122497083  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
122471934  AXIN1; axin-1 isoform X1 [KO:K02157]
122485808  AXIN2; axin-2 [KO:K04385]
122491978  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
122488602  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
122491479  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122487396  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
122497097  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
122493255  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122477660  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
122486155  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
122495809  MYC; myc proto-oncogene protein [KO:K04377]
122484101  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122472345  WNT1; proto-oncogene Wnt-1 [KO:K03209]
122488137  WNT2; protein Wnt-2 [KO:K00182]
122480945  WNT2B; protein Wnt-2b [KO:K00182]
122485662  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
122485726  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
122480068  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
122487341  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
122473283  WNT5B; protein Wnt-5b [KO:K00444]
122481782  WNT6; protein Wnt-6 [KO:K00445]
122487553  WNT7A; protein Wnt-7a [KO:K00572]
122472908  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
122473140  WNT8A; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
122492627  WNT8B; protein Wnt-8b [KO:K00714]
122485671  WNT9A; protein Wnt-9a [KO:K01064]
122484683  WNT9B; protein Wnt-9b [KO:K01064]
122481783  WNT10A; protein Wnt-10a [KO:K01357]
122472343  WNT10B; protein Wnt-10b [KO:K01357]
122483317  WNT11; protein Wnt-11 [KO:K01384]
122488147  WNT16; protein Wnt-16 [KO:K01558]
122487862  FZD1; frizzled-1 [KO:K02432]
122481650  FZD7; frizzled-7 [KO:K02432]
122485689  FZD2; frizzled-2 [KO:K02235]
122474036  FZD3; frizzled-3 [KO:K02329]
122483240  FZD4; frizzled-4 isoform X1 [KO:K02354]
122481701  FZD5; frizzled-5 [KO:K02375]
122472158  FZD8; frizzled-8 [KO:K02375]
122495693  FZD6; frizzled-6 [KO:K02376]
122470117  FZD10; frizzled-10 [KO:K02842]
122471360  FZD9; frizzled-9 [KO:K02842]
122484082  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
122472429  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
122479781  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
122484851  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
122491668  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
122493080  FRAT1; proto-oncogene FRAT1 [KO:K03069]
122493081  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
122484430  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
122492757  AGT; angiotensinogen [KO:K09821]
122489994  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
122487046  F2RL3; proteinase-activated receptor 4 [KO:K04236]
122474974  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
122487153  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
122480711  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
122478023  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
122472367  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
122482120  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
122491879  AGTR1; type-1 angiotensin II receptor [KO:K04166]
122471226  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
122485811  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
122483076  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
122476594  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
122493965  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
122479865  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
122488710  RHOA; transforming protein RhoA [KO:K04513]
122470622  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
122497462  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
122492994  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
122481291  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
122487249  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
122487816  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
122480896  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
122486992  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
122469091  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
122480633  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
122494350  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
122467218  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
122467219  neuroendocrine secretory protein 55 [KO:K04632]
122487650  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
122495529  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122497386  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
122468944  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
122491521  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122472335  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
122494184  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122495819  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122471737  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122480698  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122486980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122479805  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122471298  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
122472382  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
122491707  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122468635  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
122469086  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122482482  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
122483904  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122480706  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122486655  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122494951  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122475050  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122487888  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122480621  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122486926  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
122471900  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
122487887  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122485401  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122481853  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
122481854  collagen alpha-3(IV) chain-like isoform X1 [KO:K06237]
122480338  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122479647  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
122477549  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
122477664  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122489971  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
122470575  LAMA1; laminin subunit alpha-1 [KO:K05637]
122470645  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
122467189  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
122489882  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
122487737  LAMB1; laminin subunit beta-1 [KO:K05636]
122488689  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
122476346  LAMB3; laminin subunit beta-3 [KO:K06244]
122487736  LAMB4; laminin subunit beta-4 [KO:K06245]
122476097  LAMC1; laminin subunit gamma-1 [KO:K05635]
122475881  LAMC2; laminin subunit gamma-2 [KO:K06246]
122475400  LAMC3; laminin subunit gamma-3 [KO:K06247]
122481737  FN1; fibronectin isoform X1 [KO:K05717]
122493943  ITGA2; integrin alpha-2 [KO:K06481]
122485686  ITGA2B; integrin alpha-IIb [KO:K06476]
122486099  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
122481459  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122481545  ITGAV; integrin alpha-V [KO:K06487]
122473976  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122495851  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122482064  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122491710  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122491934  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122487093  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122480440  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122489641  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122493436  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122472180  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
122469592  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122494042  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122476061  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122493134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122472994  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122477442  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122469008  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122478010  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122493183  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
122484468  RELA; transcription factor p65 [KO:K04735]
122475760  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122485185  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
122470833  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
122482885  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
122482886  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
122477723  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
122467169  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
122496407  BCL2L1; bcl-2-like protein 1 [KO:K04570]
122475453  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
122474992  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122469573  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122485148  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
122476367  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
122483712  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122479919  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
122484054  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122485296  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122483950  BAD; bcl2-associated agonist of cell death [KO:K02158]
122481792  FOXO1; forkhead box protein O1 [KO:K07201]
122474007  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122484900  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
122473385  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122489448  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122470381  BCR; breakpoint cluster region protein isoform X1 [KO:K08878] [EC:2.7.11.1]
122474547  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
122485124  CRK; adapter molecule crk isoform X1 [KO:K04438]
122470502  CRKL; crk-like protein [KO:K04438]
122483059  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
122485600  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
122485599  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
122489459  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
122476857  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
122491631  KNG1; kininogen-1 isoform X1 [KO:K03898]
122489235  EDN1; endothelin-1 [KO:K16366]
122469509  B2 bradykinin receptor-like isoform X1 [KO:K03916]
122475763  EDNRA; endothelin-1 receptor [KO:K04197]
122483782  EDNRB; endothelin receptor type B [KO:K04198]
122474691  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
122486676  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
122483945  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122468783  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122496559  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122496563  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122485801  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122471545  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122494748  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122476434  IL2; interleukin-2 [KO:K05429]
122472647  IL3; interleukin-3 [KO:K04736]
122472844  IL4; interleukin-4 [KO:K05430]
122487241  IL5; interleukin-5 [KO:K05428]
122487989  IL6; interleukin-6 [KO:K05405]
122495513  IL7; interleukin-7 isoform X1 [KO:K05431]
122491789  IL12A; interleukin-12 subunit alpha [KO:K05406]
122493041  IL12B; interleukin-12 subunit beta [KO:K05425]
122487255  IL13; interleukin-13 [KO:K05435]
122476037  IL15; interleukin-15 [KO:K05433]
122473644  IL23A; interleukin-23 subunit alpha [KO:K05426]
122471301  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
122475087  interferon alpha-2-like [KO:K05414]
122474263  interferon alpha-like [KO:K05414]
122474324  interferon alpha-like [KO:K05414]
122474291  interferon alpha-like [KO:K05414]
122474338  interferon alpha-like [KO:K05414]
122474333  interferon alpha [KO:K05414]
122473187  IFNG; interferon gamma [KO:K04687]
122472215  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
122472705  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
122477318  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
122477710  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
122471527  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
122472696  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
122487451  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
122476366  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
122489075  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
122494662  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
122487088  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
122480617  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
122477898  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
122472214  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
122479413  IL23R; interleukin-23 receptor [KO:K05065]
122486896  EPOR; erythropoietin receptor [KO:K05079]
122491222  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
122491224  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
122490015  IFNGR1; interferon gamma receptor 1 [KO:K05132]
122491220  IFNGR2; interferon gamma receptor 2 [KO:K05133]
122497228  EML4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
122468800  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
122483972  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122466911  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122494101  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
122480600  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122475044  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122487079  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
122485601  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
122481579  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
122473765  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
122481580  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
122473799  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
122489562  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122483956  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122469337  PGF; placenta growth factor isoform X1 [KO:K16859]
122470391  VEGFC; vascular endothelial growth factor C [KO:K05449]
122477565  VEGFD; vascular endothelial growth factor D [KO:K05449]
122496971  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
122477450  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122487677  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122485481  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
122471191  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122472773  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122478872  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122493456  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122472604  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122484126  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
122468290  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122472441  KITLG; kit ligand isoform X1 [KO:K05461]
122478870  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122494815  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122480968  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122487823  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122488133  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122488446  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122469044  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122480538  FGF9; fibroblast growth factor 9 [KO:K04358]
122484103  FGF4; fibroblast growth factor 4 [KO:K04358]
122484388  FGF3; fibroblast growth factor 3 [KO:K04358]
122492387  FGF18; fibroblast growth factor 18 [KO:K04358]
122494030  FGF10; fibroblast growth factor 10 [KO:K04358]
122467573  FGF20; fibroblast growth factor 20 [KO:K04358]
122472591  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122486611  FGF22; fibroblast growth factor 22 [KO:K04358]
122478739  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
122468669  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122477434  FGF16; fibroblast growth factor 16 [KO:K04358]
122492630  FGF8; fibroblast growth factor 8 [KO:K04358]
122472551  FGF6; fibroblast growth factor 6 [KO:K04358]
122484387  FGF19; fibroblast growth factor 19 [KO:K22603]
122494859  FGF21; fibroblast growth factor 21 [KO:K22429]
122472692  FGF23; fibroblast growth factor 23 [KO:K22428]
122473425  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122493321  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122479132  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122491274  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122485897  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122469065  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122497238  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122484176  HRAS; GTPase HRas isoform X1 [KO:K02833]
122473961  KRAS; GTPase KRas [KO:K07827]
122480981  NRAS; GTPase NRas [KO:K07828]
122477714  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122488405  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122487521  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122468485  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122486708  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
122470517  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122471493  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
122480569  JUN; transcription factor AP-1 [KO:K04448]
122469346  FOS; proto-oncogene c-Fos [KO:K04379]
122483138  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
122482878  LOW QUALITY PROTEIN: interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
122482471  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
122494216  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
122467326  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
122478799  C-X-C motif chemokine 15-like [KO:K10030]
122478804  CXCL8; interleukin-8 [KO:K10030]
122473830  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
122469441  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122493003  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122492781  CCDC6; coiled-coil domain-containing protein 6 isoform X1 [KO:K09288]
122492978  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
122475682  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122475969  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
122475891  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
122491367  TFG; protein TFG isoform X1 [KO:K09292]
122487262  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
122476086  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
122496222  STK4; serine/threonine-protein kinase 4 [KO:K04411]
122486703  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
122468538  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
122474975  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
122496268  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
122494519  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
122477978  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
122479809  CALML6; calmodulin-like protein 6 [KO:K02183]
122467625  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
122469437  CALM1; calmodulin-1 [KO:K02183]
122472667  calmodulin-like [KO:K02183]
122472197  calmodulin-like protein 3 [KO:K02183]
122494943  CALM3; calmodulin-3 isoform X1 [KO:K02183]
122496816  CALM2; calmodulin-2 [KO:K02183]
122487629  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122493437  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122476883  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122493468  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122478439  uncharacterized protein LOC122478439 [KO:K08732]
122478535  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122478537  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122497556  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122497557  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122474949  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
122487712  RALA; ras-related protein Ral-A [KO:K07834]
122481248  RALB; ras-related protein Ral-B [KO:K07835]
122470561  RALBP1; ralA-binding protein 1 [KO:K08773]
122480065  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122480120  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
122471262  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122474541  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122472709  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
122485969  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
122484822  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
122491729  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
122485896  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122478691  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122492960  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122497160  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
122487517  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
122475004  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122489388  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
122476622  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
122492062  RARB; retinoic acid receptor beta isoform X1 [KO:K08528]
122490107  ESR1; estrogen receptor [KO:K08550]
122469204  ESR2; estrogen receptor beta [KO:K08551]
122497390  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
122467298  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
122473480  SP1; transcription factor Sp1 [KO:K04684]
122490329  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
122485580  junction plakoglobin [KO:K10056]
122482982  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
122485502  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
122481431  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
122476514  CCNA2; cyclin-A2 [KO:K06627]
122468444  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
122491197  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
122495592  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
122484442  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
122494136  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
122476983  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
122477816  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
122480290  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
122493494  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122475137  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
122496358  E2F1; transcription factor E2F1 [KO:K17454]
122480087  E2F2; transcription factor E2F2 [KO:K09389]
122489188  E2F3; transcription factor E2F3 [KO:K06620]
122469223  MAX; LOW QUALITY PROTEIN: protein max [KO:K04453]
122479975  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
122475138  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122487880  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122472689  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122489512  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122476586  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
122475459  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
122483174  S-phase kinase-associated protein 1 [KO:K03094]
122487406  SKP1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094]
122488471  CUL1; cullin-1 isoform X1 [KO:K03347]
122472803  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
122494612  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
122473734  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122494162  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
122495617  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
122482016  RB1; retinoblastoma-associated protein [KO:K06618]
122480620  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122486654  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122474523  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122494846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122489414  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
122484438  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
122489887  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
122495749  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
122487430  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
122494005  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
122476025  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122469354  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
122475250  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
122492079  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122470746  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
122468477  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
122470775  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
122491755  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122479146  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
122493360  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
122480238  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
122489890  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
122492168  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
122496821  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
122490378  MSH3; DNA mismatch repair protein Msh3 isoform X1 [KO:K08736]
122496823  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
122481231  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
122468767  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
122476073  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122492668  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122484102  FADD; FAS-associated death domain protein [KO:K02373]
122481641  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122473088  BID; BH3-interacting domain death agonist [KO:K04726]
122470816  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
122493878  BBC3; bcl-2-binding component 3 [KO:K10132]
122497194  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122488013  cytochrome c [KO:K08738]
122479500  cytochrome c, testis-specific-like [KO:K08738]
122491714  cytochrome c-like [KO:K08738]
122473077  cytochrome c-like [KO:K08738]
122472567  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122493262  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
122486862  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
122481499  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
122473294  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
122494402  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
122489625  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
122489628  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
122490469  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
122489627  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
122479440  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
122480900  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
122497156  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
122476214  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
122470921  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
122470361  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
122470362  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
122470363  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122470364  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
122493222  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122493223  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
122472537  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122484066  GSTP1; LOW QUALITY PROTEIN: glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
122488195  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
122471022  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
122472623  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
122487498  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
122490554  elongin-C-like [KO:K03872]
122467740  elongin-C-like [KO:K03872]
122495495  ELOC; elongin-C isoform X1 [KO:K03872]
122480776  elongin-B-like [KO:K03873]
122471788  ELOB; elongin-B [KO:K03873]
122473249  CUL2; cullin-2 [KO:K03870]
122468983  EGLN3; prolyl hydroxylase EGLN3 [KO:K09592] [EC:1.14.11.29]
122492747  EGLN1; egl nine homolog 1 isoform X1 [KO:K09592] [EC:1.14.11.29]
122494020  EGLN2; prolyl hydroxylase EGLN2 isoform X1 [KO:K09592] [EC:1.14.11.29]
122476578  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
122469188  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
122496798  EPAS1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K09095]
122481132  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
122467518  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
122471738  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
122472804  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122480366  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
122496572  JAG1; protein jagged-1 [KO:K06052]
122469603  JAG2; protein jagged-2 isoform X1 [KO:K21635]
122490204  DLL1; delta-like protein 1 isoform X1 [KO:K06051]
122468755  DLL4; delta-like protein 4 [KO:K06051]
122494057  DLL3; delta-like protein 3 [KO:K06051]
122474354  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
122481027  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
122487026  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
122489351  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122489356  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122489360  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
122478251  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
122491598  HES1; transcription factor HES-1 [KO:K06054]
122479827  HES5; transcription factor HES-5 [KO:K06055]
122489954  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
122482135  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
122495517  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
122485844  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122488366  SHH; sonic hedgehog protein [KO:K11988]
122475073  PTCH1; LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225]
122488252  SMO; smoothened homolog [KO:K06226]
122467572  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
122493190  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
122473812  GLI1; LOW QUALITY PROTEIN: zinc finger protein GLI1 [KO:K16797]
122481243  GLI2; zinc finger protein GLI2 isoform X1 [KO:K16798]
122487703  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
122496555  BMP2; bone morphogenetic protein 2 [KO:K21283]
122469107  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
122475958  hedgehog-interacting protein [KO:K06231]
122480414  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
122477822  AR; androgen receptor [KO:K08557]
122489573  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122469558  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122472616  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
pbg03320  PPAR signaling pathway
pbg04010  MAPK signaling pathway
pbg04020  Calcium signaling pathway
pbg04024  cAMP signaling pathway
pbg04060  Cytokine-cytokine receptor interaction
pbg04066  HIF-1 signaling pathway
pbg04110  Cell cycle
pbg04115  p53 signaling pathway
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04210  Apoptosis
pbg04310  Wnt signaling pathway
pbg04330  Notch signaling pathway
pbg04340  Hedgehog signaling pathway
pbg04350  TGF-beta signaling pathway
pbg04370  VEGF signaling pathway
pbg04510  Focal adhesion
pbg04512  ECM-receptor interaction
pbg04520  Adherens junction
pbg04630  JAK-STAT signaling pathway
pbg04915  Estrogen signaling pathway
KO pathway
ko05200   
LinkDB

DBGET integrated database retrieval system