KEGG   PATHWAY: lroh04510
Entry
lroh04510                   Pathway                                
Name
Focal adhesion - Labeo rohita (rohu)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
lroh04510  Focal adhesion
lroh04510

Other DBs
GO: 0005925
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127173943  col1a1b; collagen, type I, alpha 1b isoform X1 [KO:K06236]
127161719  col1a1a; collagen, type I, alpha 1a isoform X1 [KO:K06236]
127181701  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
127170094  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
127172797  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
127170610  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
127170611  col4a1; collagen alpha-1(IV) chain [KO:K06237]
127177168  col4a3; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
127177169  col4a4; collagen alpha-4(IV) chain [KO:K06237]
127168880  col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
127168881  col4a5; collagen alpha-5(IV) chain [KO:K06237]
127171385  col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238]
127177929  col6a4a; collagen alpha-6(VI) chain [KO:K06238]
127172976  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
127173493  col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
127175221  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
127181930  col9a2; collagen alpha-2(IX) chain [KO:K08131]
127172647  col9a1a; LOW QUALITY PROTEIN: collagen, type IX, alpha 1a [KO:K08131]
127162203  col9a3; collagen alpha-3(IX) chain [KO:K08131]
127175022  col9a1b; collagen, type IX, alpha 1b isoform X1 [KO:K08131]
127181485  collagen alpha-1(IX) chain [KO:K08131]
127155761  lama1; laminin subunit alpha-1 [KO:K05637]
127182900  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
127154454  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
127176443  si:ch211-241e1.3; laminin subunit alpha-3 [KO:K06240]
127162021  laminin subunit alpha-4-like [KO:K06241]
127163997  lamb1b; LOW QUALITY PROTEIN: laminin subunit beta-1b [KO:K05636]
127156916  lamb1a; LOW QUALITY PROTEIN: laminin subunit beta-1a [KO:K05636]
127154701  lamb2l; laminin subunit beta-2 [KO:K06243]
127154793  lamb2; laminin subunit beta-2 [KO:K06243]
127162518  lamb3; laminin subunit beta-3 [KO:K06244]
127156291  lamb4; laminin subunit beta-4 [KO:K06245]
127177999  lamc1; laminin subunit gamma-1 [KO:K05635]
127177749  lamc2; laminin subunit gamma-2 [KO:K06246]
127165653  lamc3; laminin subunit gamma-3 [KO:K06247]
127174051  chad; chondroadherin [KO:K06248]
127180406  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
127179534  thbs1a; thrombospondin-1 [KO:K16857]
127182985  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
127165336  thbs4a; thrombospondin-4a [KO:K04659]
127173074  comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
127178869  thbs3a; thrombospondin-3a [KO:K04659]
127173991  thbs2b; thrombospondin-2 [KO:K04659]
127152079  thbs4b; thrombospondin-4-B [KO:K04659]
127175131  thbs2a; thrombospondin-2 [KO:K04659]
127181629  thbs3b; thrombospondin-3b [KO:K04659]
127170881  fn1a; LOW QUALITY PROTEIN: fibronectin 1a [KO:K05717]
127177289  vtna; vitronectin a [KO:K06251]
127152992  vtnb; vitronectin b [KO:K06251]
127154617  tnn; tenascin-N isoform X1 [KO:K06252]
127165301  tnca; tenascin isoform X1 [KO:K06252]
127165368  tncb; tenascin [KO:K06252]
127180394  tnr; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
127180844  vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
127160000  itga1; integrin alpha-1 [KO:K06480]
127172447  itga2.2; integrin alpha-2 [KO:K06481]
127155505  itga2b; integrin alpha-IIb [KO:K06476]
127173940  itga3b; integrin alpha-3b isoform X1 [KO:K06482]
127163042  itga3a; integrin alpha-3 [KO:K06482]
127170405  itga4; integrin alpha-4 [KO:K06483]
127154577  itga5; integrin alpha-5 [KO:K06484]
127170731  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
127176579  itga6l; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
127168635  itga6b; integrin alpha-6b [KO:K06485]
127173364  itga7; integrin alpha-7 isoform X1 [KO:K06583]
127178218  itga8; integrin alpha-8 [KO:K06584]
127175258  itga9; integrin alpha-9 [KO:K06585]
127178896  itga10; integrin alpha-10 [KO:K06586]
127157132  itga11b; integrin alpha-11 [KO:K06587]
127169002  itga11a; LOW QUALITY PROTEIN: integrin alpha-11a [KO:K06587]
127170570  itgav; integrin alpha-V [KO:K06487]
127175891  integrin beta-1 isoform X1 [KO:K05719]
127155652  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
127173872  itgb3b; LOW QUALITY PROTEIN: integrin beta-3b [KO:K06493]
127163361  itgb3a; integrin beta-3a [KO:K06493]
127169510  itgb4; integrin beta-4 isoform X1 [KO:K06525]
127170828  itgb5; integrin beta-5 [KO:K06588]
127173525  itgb6; integrin beta-6 [KO:K06589]
127167365  itgb7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
127182080  itgb8; integrin beta-8 isoform X1 [KO:K06591]
127162988  emp2; epithelial membrane protein 2 [KO:K26256]
127162991  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
127153154  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
127163317  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
127153680  si:ch211-79m20.1; uncharacterized protein si:ch211-79m20.1 [KO:K17386]
127176608  pdgfc; platelet-derived growth factor C [KO:K05450]
127177739  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
127175864  egf; pro-epidermal growth factor [KO:K04357]
127164105  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
127163886  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
127178380  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
127179376  pgfb; placenta growth factor [KO:K16859]
127183387  pgfa; snake venom vascular endothelial growth factor toxin HF [KO:K16859]
127172427  vegfc; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
127173537  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
127163750  hgfa; hepatocyte growth factor a [KO:K05460]
127180854  hepatocyte growth factor [KO:K05460]
127183147  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
127176102  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
127167905  igf1rb; LOW QUALITY PROTEIN: insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
127180463  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
127183136  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
127176285  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127156110  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127175981  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
127155418  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
127161708  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
127157122  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
127173720  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127163505  epithelial membrane protein 2 [KO:K26255]
127166378  emp1; epithelial membrane protein 1 [KO:K26255]
127154786  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127164967  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
127177429  arhgap35a; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
127179792  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
127154872  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
127166810  rhoca; ras homolog family member Ca [KO:K04513]
127157396  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
127169411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
127169606  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
127175882  protein diaphanous homolog 1 isoform X1 [KO:K05740]
127175390  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
127175639  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
127183479  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.1]
127170142  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
127165543  myl2a; myosin regulatory light chain 2a [KO:K10351]
127169668  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
127154432  myl9a; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
127166623  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
127172130  myl10; myosin regulatory light chain 10 [KO:K12756]
127168615  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
127183079  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
127173696  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
127163283  mylpfa; myosin regulatory light chain 11 [KO:K12758]
127165713  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
127156016  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
127179450  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127168285  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127174333  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
127163965  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
127156342  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
127154606  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
127166724  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
127155714  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
127170918  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
127155333  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
127156493  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
127167115  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
127173158  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
127168742  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
127183053  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
127169818  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
127181997  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a isoform X1 [KO:K00889] [EC:2.7.1.68]
127154013  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
127172275  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
127178390  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
127178528  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X1 [KO:K00889] [EC:2.7.1.68]
127157202  actb1; actin, cytoplasmic 1 [KO:K05692]
127158359  actb2; actin, cytoplasmic 2 [KO:K05692]
127180577  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
127153354  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
127159477  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
127159478  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127159480  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127175321  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
127175692  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
127176897  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
127172185  tln1; talin-1 isoform X1 [KO:K06271]
127156436  tln2b; talin-2 isoform X1 [KO:K06271]
127168626  tln2a; LOW QUALITY PROTEIN: talin-2a [KO:K06271]
127154838  flna; LOW QUALITY PROTEIN: filamin-B [KO:K04437]
127172805  filamin-B isoform X1 [KO:K27392]
127154839  flnb; filamin-B isoform X1 [KO:K27392]
127170116  pxnb; NAC-alpha domain-containing protein 1 isoform X1 [KO:K05760]
127172189  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
127178494  zyx; zyxin [KO:K06273]
127171831  vaspa; vasodilator stimulated phosphoprotein a isoform X1 [KO:K06274]
127180527  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
127173669  vclb; vinculin b [KO:K05700]
127174878  vcla; vinculin a isoform X1 [KO:K05700]
127156356  parvb; beta-parvin isoform X1 [KO:K06275]
127156362  parvg; gamma-parvin [KO:K06275]
127157041  parvaa; parvin, alpha a [KO:K06275]
127168078  parvab; parvin, alpha b [KO:K06275]
127155812  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
127157032  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
127171830  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127168081  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127179883  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127151836  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127180526  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127174741  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127170027  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
127170699  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127178294  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
127181728  catenin beta-1 [KO:K02105]
127166764  prkcaa; LOW QUALITY PROTEIN: protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127163386  prkcab; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127160219  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127163312  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
127178761  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
127178815  ptk2ab; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
127181451  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
127154480  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127177108  pik3cb; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
127172737  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127162255  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127176088  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
127164849  pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
127166520  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
127179724  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127174135  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127164113  proto-oncogene vav-like isoform X1 [KO:K05730]
127155509  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
127179977  vav3b; guanine nucleotide exchange factor VAV3b isoform X1 [KO:K05730]
127153056  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
127164254  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127178200  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127158366  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127174083  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127168243  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127162984  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
127163181  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127174070  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
127163279  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
127180889  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
127153773  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
127178121  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
127162623  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
127176800  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
127183356  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
127179937  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
127182619  pak6b; serine/threonine-protein kinase PAK 6b [KO:K05735] [EC:2.7.11.1]
127154286  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
127178154  cdc42l; cell division cycle 42, like [KO:K04393]
127173196  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
127180490  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
127177264  crk; adapter molecule crk [KO:K04438]
127152559  crkl; crk-like protein [KO:K04438]
127173764  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
127152696  rapgef1b; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1b [KO:K06277]
127169554  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
127169813  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
127173149  rap1ab; ras-related protein rap1ab [KO:K04353]
127163881  rap1b; ras-related protein Rap-1b [KO:K07836]
127173973  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152220  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127174909  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152675  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127165315  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127183046  jun; transcription factor AP-1 [KO:K04448]
127163979  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
127157123  cav1; caveolin-1 [KO:K06278]
127154980  cav4b; caveolin-2 [KO:K12958]
127166884  caveolin-2-like [KO:K12958]
127157124  cav2; caveolin-2 [KO:K12958]
127173361  cav4a; caveolin-2 [KO:K12958]
127166885  cav3; caveolin-3 [KO:K12959]
127180013  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
127182733  fynb; LOW QUALITY PROTEIN: tyrosine-protein kinase fynb [KO:K05703] [EC:2.7.10.2]
127178036  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
127153208  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
127152212  shc3; SHC-transforming protein 3 [KO:K17448]
127167204  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
127160635  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
127172877  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
127174997  sos2; son of sevenless homolog 2 [KO:K03099]
127156808  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
127168650  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
127154571  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127172884  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
127180735  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127164820  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127162808  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127169677  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
127168605  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
127164391  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
127156478  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
127153789  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
127152429  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
127176082  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
127167836  badb; BCL2 associated agonist of cell death b [KO:K02158]
127153080  bada; bcl2-associated agonist of cell death [KO:K02158]
127155642  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
127182809  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
lroh04010  MAPK signaling pathway
lroh04060  Cytokine-cytokine receptor interaction
lroh04070  Phosphatidylinositol signaling system
lroh04110  Cell cycle
lroh04310  Wnt signaling pathway
lroh04512  ECM-receptor interaction
lroh04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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