KEGG   PATHWAY: biu05200
Entry
biu05200                    Pathway                                
Name
Pathways in cancer - Bos indicus (zebu cattle)
Class
Human Diseases; Cancer: overview
Pathway map
biu05200  Pathways in cancer
biu05200

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109577700  DCC; netrin receptor DCC [KO:K06765]
109553316  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
109570433  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109575959  APPL1; DCC-interacting protein 13-alpha [KO:K08733]
109572856  cadherin-1 [KO:K05689]
109576112  CTNNB1; catenin beta-1 [KO:K02105]
109566189  CTNNA2; catenin alpha-2 [KO:K05691]
109562070  CTNNA1; catenin alpha-1 [KO:K05691]
109553763  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
109562114  catenin alpha-1 [KO:K05691]
109578518  AXIN1; axin-1 isoform X1 [KO:K02157]
109561990  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
109564604  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
109562015  TCF7; transcription factor 7 isoform X1 [KO:K02620]
109565564  TCF7L1; transcription factor 7-like 1 [KO:K04490]
109553057  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
109560266  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
109574440  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
109568594  MYC; myc proto-oncogene protein [KO:K04377]
109554439  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109558697  WNT1; proto-oncogene Wnt-1 [KO:K03209]
109555924  WNT2B; protein Wnt-2b [KO:K00182]
109557407  WNT2; protein Wnt-2 [KO:K00182]
109561352  WNT3A; protein Wnt-3a [KO:K00312]
109573450  WNT3; proto-oncogene Wnt-3 [KO:K00312]
109576138  WNT4; protein Wnt-4 [KO:K00408]
109576252  WNT5A; protein Wnt-5a [KO:K00444]
109559776  WNT5B; protein Wnt-5b [KO:K00444]
109570782  WNT6; protein Wnt-6 [KO:K00445]
109558644  WNT7B; protein Wnt-7b [KO:K00572]
109576501  WNT7A; protein Wnt-7a [KO:K00572]
109578990  WNT8B; protein Wnt-8b [KO:K00714]
109561268  WNT8A; protein Wnt-8a [KO:K00714]
109560806  WNT9A; protein Wnt-9a [KO:K01064]
109570791  WNT10A; protein Wnt-10a [KO:K01357]
109559150  WNT10B; protein Wnt-10b [KO:K01357]
109569843  WNT11; protein Wnt-11 [KO:K01384]
109558182  FZD1; frizzled-1 [KO:K02432]
109569613  FZD7; frizzled-7 [KO:K02432]
109574394  FZD2; frizzled-2 [KO:K02235]
109575114  LOW QUALITY PROTEIN: frizzled-3-like [KO:K02329]
109562801  FZD3; frizzled-3 [KO:K02329]
109554353  FZD4; frizzled-4 [KO:K02354]
109570198  FZD5; frizzled-5 [KO:K02375]
109567602  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
109568539  FZD6; frizzled-6 [KO:K02376]
109571551  FZD10; frizzled-10 [KO:K02842]
109578168  FZD9; frizzled-9 [KO:K02842]
109554405  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
109559652  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
109573933  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
109570328  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
109562775  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
109553209  FRAT1; proto-oncogene FRAT1 [KO:K03069]
109553193  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
109569554  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
109553744  AGT; angiotensinogen [KO:K09821]
109564649  F2R; proteinase-activated receptor 1 [KO:K03914]
109561166  F2RL3; proteinase-activated receptor 4 [KO:K04236]
109563336  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109563337  lysophosphatidic acid receptor 1-like [KO:K04289]
109561368  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109556129  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
109558930  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109566714  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
109559421  AGTR1; type-1 angiotensin II receptor [KO:K04166]
109578204  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
109573379  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
109569536  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109553002  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
109572733  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
109570637  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
109576171  RHOA; transforming protein RhoA [KO:K04513]
109577829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109566382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109553743  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109568167  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109557337  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
109576257  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
109555970  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
109560893  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
109564679  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
109556168  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
109574951  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
109567291  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
109567292  neuroendocrine secretory protein 55 [KO:K04632]
109557525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109574822  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109566330  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
109564199  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109555842  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
109559159  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109572478  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109568647  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
109578364  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
109556827  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109561498  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109570386  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109578415  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
109558919  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
109557856  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109565125  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
109554309  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109553666  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
109556134  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109561787  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109573005  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109558211  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109556958  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109561546  LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog [KO:K04347]
109556175  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109578787  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109558062  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109574071  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109567101  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109555345  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109575895  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109571374  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109566959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109555197  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
109577666  LAMA1; laminin subunit alpha-1 [KO:K05637]
109563534  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
109567659  LAMA5; laminin subunit alpha-5 [KO:K06240]
109577653  laminin subunit alpha-3-like [KO:K06240]
109577655  laminin subunit alpha-3-like [KO:K06240]
109563807  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109557393  LAMB1; laminin subunit beta-1 [KO:K05636]
109575927  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
109575885  laminin subunit beta-2-like [KO:K06243]
109570638  LAMB3; laminin subunit beta-3 [KO:K06244]
109570361  LAMC1; laminin subunit gamma-1 [KO:K05635]
109570495  LAMC2; laminin subunit gamma-2 [KO:K06246]
109566555  LAMC3; laminin subunit gamma-3 [KO:K06247]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109568429  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109556345  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109552991  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109563136  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109553086  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109553353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109575581  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109553030  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
109554392  RELA; transcription factor p65 [KO:K04735]
109570734  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109574459  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
109577782  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109555878  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
109568764  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109569840  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109567657  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
109567345  BCL2L1; bcl-2-like protein 1 [KO:K04570]
109565507  bcl-2-like protein 1 [KO:K04570]
109563408  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
109566626  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109575564  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109573977  TNF receptor-associated factor 4 [KO:K09848]
109573194  TNF receptor-associated factor 4-like [KO:K09848]
109570606  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
109565970  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
109570401  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109554358  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
109573726  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
109554386  BAD; bcl2-associated agonist of cell death [KO:K02158]
109566997  FOXO1; forkhead box protein O1 [KO:K07201]
109558399  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109574238  TP53; cellular tumor antigen p53 [KO:K04451]
109559641  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109577247  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
109571416  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
109566554  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
109570977  CRKL; crk-like protein [KO:K04438]
109573847  CRK; adapter molecule crk isoform X1 [KO:K04438]
109568806  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
109574089  signal transducer and activator of transcription 5A-like [KO:K11223]
109573773  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
109577351  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
109555183  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
109562726  kininogen-1-like [KO:K03898]
109577403  EDN1; endothelin-1 [KO:K16366]
109575240  BDKRB1; B1 bradykinin receptor [KO:K03915]
109575666  BDKRB2; B2 bradykinin receptor [KO:K03916]
109571433  EDNRA; endothelin-1 receptor [KO:K04197]
109566890  EDNRB; endothelin B receptor [KO:K04198]
109562978  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
109561778  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
109554384  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109567852  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109567854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109564927  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109571028  IL2; interleukin-2 [KO:K05429]
109561219  interleukin-3 [KO:K04736]
109561213  IL4; interleukin-4 [KO:K05430]
109561216  IL5; interleukin-5 [KO:K05428]
109558077  IL6; interleukin-6 [KO:K05405]
109568650  IL7; interleukin-7 [KO:K05431]
109564477  IL12A; interleukin-12 subunit alpha [KO:K05406]
109561305  IL12B; interleukin-12 subunit beta [KO:K05425]
109561215  IL13; interleukin-13 [KO:K05435]
109571474  IL15; interleukin-15 [KO:K05433]
109559359  IL23A; interleukin-23 subunit alpha [KO:K05426]
109578290  EPO; erythropoietin [KO:K05437]
109562847  interferon alpha-H [KO:K05414]
109562638  interferon alpha-G-like [KO:K05414]
109562641  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
109562644  interferon alpha-F [KO:K05414]
109562652  interferon alpha-A [KO:K05414]
109562656  interferon alpha-H-like [KO:K05414]
109562659  interferon alpha-H-like [KO:K05414]
109562660  interferon alpha-H-like [KO:K05414]
109562665  interferon alpha-B-like [KO:K05414]
109562668  interferon alpha-2-like [KO:K05414]
109562670  interferon alpha-2-like [KO:K05414]
109562673  interferon alpha-3-like [KO:K05414]
109558719  IFNG; interferon gamma [KO:K04687]
109567961  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
109559534  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
109555190  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
109578521  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
109559524  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
109575848  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
109554138  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
109574817  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
109575020  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
109561420  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
109556179  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
109567895  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
109556180  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
109561621  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109572614  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109563984  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109569763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109566017  EML4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
109565582  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
109564913  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
109554073  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
109554125  LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2-like [KO:K12361]
109565967  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
109571998  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
109556202  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109562906  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109561426  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109573817  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
109568771  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109559357  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
109575487  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
109559334  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
109576576  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
109554117  VEGFB; vascular endothelial growth factor B [KO:K16858]
109565356  PGF; placenta growth factor isoform X1 [KO:K16859]
109555471  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109553526  VEGFC; vascular endothelial growth factor C [KO:K05449]
109565956  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109559983  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109573971  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109578611  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109558630  LOW QUALITY PROTEIN: platelet-derived growth factor subunit B-like [KO:K17386]
109559825  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109560475  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109562197  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109559448  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109554335  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109575129  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109558333  KITLG; kit ligand [KO:K05461]
109560477  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109572992  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109567013  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109557878  HGF; hepatocyte growth factor [KO:K05460]
109557411  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109562156  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109570879  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
109565142  FGF7; fibroblast growth factor 7 [KO:K04358]
109554256  fibroblast growth factor 4-like [KO:K04358]
109553379  FGF20; fibroblast growth factor 20 [KO:K04358]
109579084  FGF8; fibroblast growth factor 8 [KO:K04358]
109567047  FGF9; fibroblast growth factor 9 [KO:K04358]
109575026  FGF18; fibroblast growth factor 18 [KO:K04358]
109575038  FGF10; fibroblast growth factor 10 [KO:K04358]
109555562  FGF16; fibroblast growth factor 16 [KO:K04358]
109559742  FGF6; fibroblast growth factor 6 [KO:K04358]
109561058  FGF22; fibroblast growth factor 22 [KO:K04358]
109554150  FGF19; fibroblast growth factor 19 [KO:K22603]
109572074  FGF21; fibroblast growth factor 21 [KO:K22429]
109559743  FGF23; fibroblast growth factor 23 [KO:K22428]
109553304  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109553142  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109560724  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109561893  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109574040  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109566002  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109564346  SOS2; son of sevenless homolog 2 [KO:K03099]
109560940  GTPase HRas-like [KO:K02833]
109559581  KRAS; GTPase KRas isoform X1 [KO:K07827]
109555890  NRAS; GTPase NRas [KO:K07828]
109555027  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
109557698  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109556235  JUN; transcription factor AP-1 [KO:K04448]
109565363  FOS; proto-oncogene c-Fos [KO:K04379]
109554352  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
109569224  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
109569225  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
109572595  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
109567506  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
109560575  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
109560570  CXCL8; interleukin-8 [KO:K10030]
109559308  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109565420  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
109553788  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109553746  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
109553707  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
109556725  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109554330  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
109570337  TPR; nucleoprotein TPR [KO:K09291]
109567003  TFG; protein TFG isoform X1 [KO:K09292]
109576291  RASSF1; ras association domain-containing protein 1 [KO:K09850]
109570657  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
109567475  STK4; serine/threonine-protein kinase 4 [KO:K04411]
109565051  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
109561757  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
109563229  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
109567698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
109572707  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
109555031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
109565417  CALM1; calmodulin [KO:K02183]
109575003  calmodulin-alpha-like [KO:K02183]
109566056  CALM2; calmodulin [KO:K02183]
109568081  calmodulin-like [KO:K02183]
109570679  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
109572535  CALM3; calmodulin isoform X1 [KO:K02183]
109564712  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
109553698  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109560236  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109557541  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109562200  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
109565671  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
109565672  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
109557564  RALA; ras-related protein Ral-A [KO:K07834]
109568603  RALB; ras-related protein Ral-B [KO:K07835]
109577855  RALBP1; ralA-binding protein 1 [KO:K08773]
109574100  CDC42; cell division control protein 42 homolog [KO:K04393]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109574290  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109574235  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
109558091  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109566138  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
109576385  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
109566619  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
109576548  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
109577828  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
109565239  ESR2; estrogen receptor beta [KO:K08551]
109566334  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
109567523  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
109559035  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
109577192  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
109574086  JUP; junction plakoglobin [KO:K10056]
109569240  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
109574115  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
109560207  CCNA2; cyclin-A2 [KO:K06627]
109566776  CCNA1; cyclin-A1 [KO:K06627]
109575524  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109561422  RUNX1; runt-related transcription factor 1 [KO:K08367]
109568483  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
109569922  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
109568669  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
109556495  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109562194  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109562627  tumor suppressor ARF-like isoform X1 [KO:K06621]
109567683  E2F1; transcription factor E2F1 [KO:K17454]
109576116  E2F2; transcription factor E2F2 [KO:K09389]
109577245  E2F3; transcription factor E2F3 [KO:K06620]
109565255  MAX; protein max isoform X1 [KO:K04453]
109570298  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
109562837  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
109558203  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109559745  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109577151  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109553981  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
109563287  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
109562016  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
109557757  CUL1; LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
109559850  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
109574865  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
109579088  S-phase kinase-associated protein 2-like [KO:K03875]
109559386  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109568476  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
109572914  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
109566987  RB1; retinoblastoma-associated protein [KO:K06618]
109561788  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109556176  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109563283  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109571977  apoptosis regulator BAX [KO:K02159]
109571778  BAX; apoptosis regulator BAX [KO:K02159]
109577301  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109569541  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109564642  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
109575079  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
109576163  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
109572866  TGFB1; transforming growth factor beta-1 [KO:K13375]
109570509  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109565371  TGFB3; transforming growth factor beta-3 [KO:K13377]
109563078  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109576148  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109564704  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
109577834  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
109558403  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
109579110  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
109560714  CTBP1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
109572356  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
109563503  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
109575944  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
109566059  MSH2; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2 [KO:K08735]
109562288  MSH3; DNA mismatch repair protein Msh3 isoform X1 [KO:K08736]
109566061  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
109566792  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
109564943  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109554562  FADD; FAS-associated death domain protein [KO:K02373]
109569521  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109559782  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109559783  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109577992  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
109571765  BBC3; bcl-2-binding component 3 [KO:K10132]
109565710  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109566483  cytochrome c [KO:K08738]
109566484  cytochrome c [KO:K08738]
109557512  cytochrome c [KO:K08738]
109559418  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
109553157  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109561590  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
109566139  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
109559493  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
109572855  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
109577820  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
109571408  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
109553169  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
109571321  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
109571322  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
109556786  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
109570966  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109555963  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
109555964  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
109555966  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
109555967  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
109555968  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109577202  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
109577203  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
109553212  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
109553219  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
109553089  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109559614  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
109577442  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109577229  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
109577230  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
109571547  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
109554615  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
109554614  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
109559462  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
109571418  TXNRD2; LOW QUALITY PROTEIN: thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
109556625  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
109576248  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
109558726  LOW QUALITY PROTEIN: transcription elongation factor B polypeptide 1-like [KO:K03872]
109578275  ELOB; transcription elongation factor B polypeptide 2 [KO:K03873]
109567917  CUL2; cullin-2 [KO:K03870]
109572227  EGLN2; egl nine homolog 2 isoform X1 [KO:K09592] [EC:1.14.11.29]
109575537  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
109570574  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
109565231  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
109566045  EPAS1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K09095]
109555321  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
109575633  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
109578349  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
109559852  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109556419  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
109567857  JAG1; protein jagged-1 isoform X1 [KO:K06052]
109572127  DLL3; delta-like protein 3 [KO:K06051]
109564135  DLL1; delta-like protein 1 [KO:K06051]
109564955  DLL4; delta-like protein 4 [KO:K06051]
109565681  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
109555853  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
109561483  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
109577271  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
109556511  HES1; transcription factor HES-1 [KO:K06054]
109563755  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
109568625  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
109556463  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
109561327  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109563237  PTCH1; protein patched homolog 1 [KO:K06225]
109557614  SMO; smoothened homolog isoform X1 [KO:K06226]
109575162  KIF7; kinesin-like protein KIF7 [KO:K18806]
109579160  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
109559320  GLI1; zinc finger protein GLI1 [KO:K16797]
109568632  GLI2; zinc finger protein GLI2 [KO:K16798]
109557558  GLI3; transcriptional activator GLI3 [KO:K06230]
109567176  BMP2; bone morphogenetic protein 2 [KO:K21283]
109565174  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
109570862  HHIP; hedgehog-interacting protein [KO:K06231]
109556373  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
109555209  AR; androgen receptor [KO:K08557]
109575457  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109577125  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
109559454  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
biu03320  PPAR signaling pathway
biu04010  MAPK signaling pathway
biu04020  Calcium signaling pathway
biu04024  cAMP signaling pathway
biu04060  Cytokine-cytokine receptor interaction
biu04066  HIF-1 signaling pathway
biu04110  Cell cycle
biu04115  p53 signaling pathway
biu04150  mTOR signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04210  Apoptosis
biu04310  Wnt signaling pathway
biu04330  Notch signaling pathway
biu04340  Hedgehog signaling pathway
biu04350  TGF-beta signaling pathway
biu04370  VEGF signaling pathway
biu04510  Focal adhesion
biu04512  ECM-receptor interaction
biu04520  Adherens junction
biu04630  JAK-STAT signaling pathway
biu04915  Estrogen signaling pathway
KO pathway
ko05200   
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