KEGG   PATHWAY: hmh05200
Entry
hmh05200                    Pathway                                
Name
Pathways in cancer - Hylobates moloch (silvery gibbon)
Class
Human Diseases; Cancer: overview
Pathway map
hmh05200  Pathways in cancer
hmh05200

Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456094  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116456139  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
116456166  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116456218  FOS; protein c-Fos [KO:K04379]
116456558  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X2 [KO:K04261]
116456568  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
116456610  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
116456615  FRAT1; proto-oncogene FRAT1 [KO:K03069]
116456636  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
116456678  FGF10; fibroblast growth factor 10 [KO:K04358]
116456707  FGFR3; fibroblast growth factor receptor 3 isoform X5 [KO:K05094] [EC:2.7.10.1]
116456830  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
116456910  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
116457087  [KO:K03872]
116457100  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
116457270  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116457363  JUN; transcription factor Jun [KO:K04448]
116457403  LAMB3; laminin subunit beta-3 [KO:K06244]
116457529  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
116457552  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
116457634  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116457708  LAMC1; laminin subunit gamma-1 [KO:K05635]
116457725  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116457822  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
116457829  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116457859  AGT; angiotensinogen [KO:K09821]
116457866  [KO:K04542]
116457894  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
116457897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116457929  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
116457985  LAMC2; laminin subunit gamma-2 [KO:K06246]
116458042  EGLN1; egl nine homolog 1 isoform X3 [KO:K09592] [EC:1.14.11.29]
116458095  WNT3A; protein Wnt-3a [KO:K00312]
116458096  WNT9A; protein Wnt-9a [KO:K01064]
116458283  CRK; adapter molecule crk isoform X1 [KO:K04438]
116458301  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
116458314  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
116458330  [KO:K05414]
116458331  [KO:K05414]
116458332  [KO:K05414]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116458431  [KO:K06621]
116458432  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
116458453  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
116458477  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
116458484  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
116458527  [KO:K05414]
116458544  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
116458550  CTNNA3; catenin alpha-3 [KO:K05691]
116458566  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116458611  [KO:K05414]
116458660  [KO:K05414]
116458708  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116458855  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
116458915  CRKL; crk-like protein [KO:K04438]
116458970  WNT7B; protein Wnt-7b [KO:K00572]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116459068  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116459144  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
116459168  [KO:K00799] [EC:2.5.1.18]
116459172  [KO:K00799] [EC:2.5.1.18]
116459174  [KO:K00799] [EC:2.5.1.18]
116459240  [KO:K08732]
116459316  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
116459453  BID; BH3-interacting domain death agonist [KO:K04726]
116459675  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116459750  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
116459822  [KO:K03873]
116459823  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
116459845  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
116459964  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
116459971  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
116460133  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116460172  EDN1; endothelin-1 isoform X2 [KO:K16366]
116460213  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
116460324  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
116460446  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
116460475  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116460497  [KO:K00799] [EC:2.5.1.18]
116460498  [KO:K00799] [EC:2.5.1.18]
116460501  [KO:K00799] [EC:2.5.1.18]
116460769  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116460817  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
116460867  STK4; serine/threonine-protein kinase 4 [KO:K04411]
116460929  JAG1; protein jagged-1 [KO:K06052]
116460963  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
116461010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461210  BMP2; bone morphogenetic protein 2 [KO:K21283]
116461227  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
116461322  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
116461332  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116461334  MMP9; matrix metalloproteinase-9 isoform X2 [KO:K01403] [EC:3.4.24.35]
116461337  E2F1; transcription factor E2F1 [KO:K17454]
116461353  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116461395  LAMA5; laminin subunit alpha-5 [KO:K06240]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116461732  CUL2; cullin-2 [KO:K03870]
116461764  FZD3; frizzled-3 [KO:K02329]
116461805  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116461858  ITGB1; integrin beta-1 [KO:K05719]
116461936  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116461941  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
116462013  WNT10B; protein Wnt-10b [KO:K01357]
116462014  WNT1; proto-oncogene Wnt-1 [KO:K03209]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116462129  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116462272  ITGA2; integrin alpha-2 [KO:K06481]
116462297  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
116462301  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116462417  AXIN1; axin-1 isoform X1 [KO:K02157]
116462469  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
116462586  ELOB; elongin-B [KO:K03873]
116462715  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116462901  RALB; ras-related protein Ral-B [KO:K07835]
116462920  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116462932  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116462943  GLI2; zinc finger protein GLI2 [KO:K16798]
116463099  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
116463128  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116463161  [KO:K08550]
116463211  [KO:K08550]
116463273  [KO:K04632]
116463274  [KO:K04632]
116463360  [KO:K04632]
116463361  [KO:K04632]
116463392  [KO:K05406]
116463424  [KO:K05406]
116463537  CCNA2; cyclin-A2 [KO:K06627]
116463600  FGF2; fibroblast growth factor 2 [KO:K18497]
116463710  [KO:K07299]
116463723  [KO:K07299]
116463760  [KO:K04385]
116463765  [KO:K04385]
116463853  [KO:K04537]
116463856  [KO:K05437]
116463857  [KO:K04537]
116463860  [KO:K05437]
116463892  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
116464070  [KO:K00510] [EC:1.14.14.18]
116464072  [KO:K00510] [EC:1.14.14.18]
116464221  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
116464223  [KO:K04630]
116464225  [KO:K04630]
116464494  [KO:K12330]
116464499  HHIP; hedgehog-interacting protein [KO:K06231]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116464897  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
116465188  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
116465956  [KO:K03870]
116466046  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116466067  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
116466288  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
116466374  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116466652  MITF; microphthalmia-associated transcription factor isoform X6 [KO:K09455]
116466732  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
116466751  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116466764  WNT7A; protein Wnt-7a [KO:K00572]
116466817  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
116466852  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116466871  [KO:K02183]
116466882  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116467002  CXCL8; interleukin-8 [KO:K10030]
116467007  TFG; protein TFG isoform X1 [KO:K09292]
116467081  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
116467095  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
116467123  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116467157  FGF9; fibroblast growth factor 9 [KO:K04358]
116467163  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
116467191  FOXO1; forkhead box protein O1 [KO:K07201]
116467261  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
116467262  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
116467343  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116467366  EDNRB; endothelin receptor type B [KO:K04198]
116467516  [KO:K02183]
116467540  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116467559  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
116467560  COL4A1; collagen alpha-1(IV) chain isoform X5 [KO:K06237]
116467918  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116467995  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
116468256  FGF19; fibroblast growth factor 19 [KO:K22603]
116468258  FGF4; fibroblast growth factor 4 [KO:K04358]
116468259  FGF3; fibroblast growth factor 3 [KO:K04358]
116468348  [KO:K03872]
116468390  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
116468409  IL23R; interleukin-23 receptor [KO:K05065]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116468506  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X1 [KO:K10131]
116468532  DCC; netrin receptor DCC isoform X1 [KO:K06765]
116468535  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
116468563  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116468664  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116468684  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116468730  LAMA1; laminin subunit alpha-1 [KO:K05637]
116468744  RALBP1; ralA-binding protein 1 [KO:K08773]
116468899  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116468948  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116468962  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116469076  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116469088  GSTP1; glutathione S-transferase P [KO:K23790]
116469103  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116469121  FADD; FAS-associated death domain protein [KO:K02373]
116469151  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
116469192  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
116469255  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
116469279  [KO:K04513]
116469349  CKS1B; cyclin-dependent kinases regulatory subunit 1 isoform X2 [KO:K02219]
116469359  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
116469370  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
116469474  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
116469568  NRAS; GTPase NRas [KO:K07828]
116469600  WNT2B; protein Wnt-2b [KO:K00182]
116469643  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
116469644  [KO:K00799] [EC:2.5.1.18]
116469646  [KO:K00799] [EC:2.5.1.18]
116469652  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
116469780  [KO:K09487]
116469841  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116469897  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116469917  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116469918  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116469921  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116470325  IL3; interleukin-3 [KO:K04736]
116470472  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
116470627  [KO:K09848]
116470775  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116470836  IL4; interleukin-4 isoform X1 [KO:K05430]
116470838  IL13; interleukin-13 isoform X3 [KO:K05435]
116470839  IL5; interleukin-5 [KO:K05428]
116470866  [KO:K03347]
116470936  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116471049  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
116471090  F2R; proteinase-activated receptor 1 [KO:K03914]
116471121  LAMA4; laminin subunit alpha-4 [KO:K06241]
116471147  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116471149  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116471160  [KO:K08738]
116471167  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
116471246  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116471259  MMP2; 72 kDa type IV collagenase isoform X1 [KO:K01398] [EC:3.4.24.24]
116471429  CDH1; cadherin-1 [KO:K05689]
116471447  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
116471505  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
116471506  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
116471560  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
116471654  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
116471709  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116471711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116471714  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116471730  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
116471783  IL12B; interleukin-12 subunit beta [KO:K05425]
116471846  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116471901  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
116471959  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116471970  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116472213  FGF23; fibroblast growth factor 23 [KO:K22428]
116472296  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116472315  RXRG; retinoic acid receptor RXR-gamma isoform X2 [KO:K08526]
116472375  FGF20; fibroblast growth factor 20 [KO:K04358]
116472519  WNT5B; protein Wnt-5b [KO:K00444]
116472548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
116472553  FGF6; fibroblast growth factor 6 [KO:K04358]
116472587  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
116472600  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
116472692  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
116472702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116472735  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
116472739  [KO:K03094]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116472865  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
116472879  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
116472954  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
116472992  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
116473075  PTCH2; protein patched homolog 2 isoform X1 [KO:K11101]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116473303  MGST3; glutathione S-transferase 3, mitochondrial [KO:K00799] [EC:2.5.1.18]
116473363  WNT5A; protein Wnt-5a [KO:K00444]
116473443  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
116473478  RHOA; transforming protein RhoA [KO:K04513]
116473484  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
116473623  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
116473677  MLH1; DNA mismatch repair protein Mlh1 isoform X2 [KO:K08734]
116473711  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116473736  RARB; retinoic acid receptor beta isoform X2 [KO:K08528]
116474130  DLL1; delta-like protein 1 [KO:K06051]
116474162  WNT9B; protein Wnt-9b [KO:K01064]
116474164  WNT3; proto-oncogene Wnt-3 [KO:K00312]
116474442  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116474596  TRAF4; TNF receptor-associated factor 4 isoform X1 [KO:K09848]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116474634  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116474657  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
116474673  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116474780  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
116474838  JUP; junction plakoglobin [KO:K10056]
116474861  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
116474862  [KO:K11223]
116474863  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116474939  ITGA2B; integrin alpha-IIb [KO:K06476]
116474949  FZD2; frizzled-2 [KO:K02235]
116475178  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116475210  DAPK1; death-associated protein kinase 1 isoform X2 [KO:K08803] [EC:2.7.11.1]
116475224  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
116475228  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116475280  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
116475322  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116475535  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116475542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116475737  [KO:K00799] [EC:2.5.1.18]
116475772  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
116475776  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
116475810  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
116475838  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116475873  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
116475877  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
116476275  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
116476282  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
116476292  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
116476347  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116476763  [KO:K04542]
116476766  [KO:K02219]
116476785  FZD4; frizzled-4 [KO:K02354]
116476859  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
116476860  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116476864  MMP1; interstitial collagenase isoform X1 [KO:K01388] [EC:3.4.24.7]
116476907  [KO:K08738]
116476913  LAMA2; laminin subunit alpha-2 [KO:K05637]
116476958  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
116477056  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
116477072  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116477156  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
116477167  [KO:K03873]
116477213  [KO:K04542]
116477384  WNT11; protein Wnt-11 [KO:K01384]
116478017  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X4 [KO:K22182] [EC:1.8.1.9]
116478026  HSP90B1; endoplasmin [KO:K09487]
116478036  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
116478137  KLK3; prostate-specific antigen isoform X2 [KO:K01351] [EC:3.4.21.77]
116478208  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116478225  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
116478291  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
116478306  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
116478308  CALM3; calmodulin-3 [KO:K02183]
116478449  KEAP1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456]
116478479  EPOR; erythropoietin receptor [KO:K05079]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116478596  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116478614  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
116478652  F2RL3; proteinase-activated receptor 4 [KO:K04236]
116478681  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
116478688  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X3 [KO:K05063]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116478752  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
116478827  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
116478857  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
116478988  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
116479044  RALA; ras-related protein Ral-A [KO:K07834]
116479070  KITLG; kit ligand isoform X1 [KO:K05461]
116479141  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
116479165  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116479176  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116479382  FZD10; frizzled-10 [KO:K02842]
116479588  [KO:K04725] [EC:2.3.2.27]
116479646  IFNG; interferon gamma [KO:K04687]
116479721  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116479726  FGF21; fibroblast growth factor 21 [KO:K22429]
116479887  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
116479942  KNG1; kininogen-1 [KO:K03898]
116479944  IL2; interleukin-2 [KO:K05429]
116479977  HES1; transcription factor HES-1 [KO:K06054]
116480086  IL15; interleukin-15 isoform X2 [KO:K05433]
116480113  [KO:K08773]
116480239  AGTR1; type-1 angiotensin II receptor [KO:K04166]
116480242  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116480287  [KO:K04392]
116480404  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
116480405  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116480519  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
116480555  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116480613  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
116480647  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
116480659  EGLN2; prolyl hydroxylase EGLN2 [KO:K09592] [EC:1.14.11.29]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116480704  DLL3; delta-like protein 3 isoform X1 [KO:K06051]
116480739  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116480865  GLI1; zinc finger protein GLI1 [KO:K16797]
116480880  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
116480910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
116480912  IL23A; interleukin-23 subunit alpha [KO:K05426]
116480936  FZD8; frizzled-8 [KO:K02375]
116480938  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116481003  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
116481217  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481481  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116481506  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
116481514  [KO:K03872]
116481623  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
116481707  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116481760  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
116481802  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
116481890  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116482110  IGF1R; insulin-like growth factor 1 receptor isoform X4 [KO:K05087] [EC:2.7.10.1]
116482118  DLL4; delta-like protein 4 [KO:K06051]
116482160  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
116482218  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116482351  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
116482540  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
116482607  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116482629  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116482637  IFNGR2; interferon gamma receptor 2 isoform X2 [KO:K05133]
116482647  FGF7; fibroblast growth factor 7 [KO:K04358]
116482912  EPAS1; endothelial PAS domain-containing protein 1 isoform X1 [KO:K09095]
116482978  MSH2; DNA mismatch repair protein Msh2 isoform X1 [KO:K08735]
116483096  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116483116  [KO:K03872]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116483152  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116483299  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116483374  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
116483378  PAX8; paired box protein Pax-8 [KO:K09293]
116483412  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
116483446  TCF7L2; transcription factor 7-like 2 isoform X12 [KO:K04491]
116483502  TGFA; protransforming growth factor alpha [KO:K08774]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116483590  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
116483640  EML4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
116483669  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
116483784  CTNNA2; catenin alpha-2 isoform X3 [KO:K05691]
116483790  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116483891  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
116483907  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
116483925  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
116483940  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
116483948  MSH6; DNA mismatch repair protein Msh6 isoform X1 [KO:K08737]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116483979  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
116484062  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116484153  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116484196  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116484211  SUFU; suppressor of fused homolog isoform X1 [KO:K06229]
116484246  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116484343  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116484470  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116484566  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X3 [KO:K07826]
116484577  CSF2RA; LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
116484638  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116484687  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116484828  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
116484835  JAG2; protein jagged-2 isoform X1 [KO:K21635]
116484930  MAX; protein max isoform X1 [KO:K04453]
116484980  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116485006  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
116485018  EGLN3; prolyl hydroxylase EGLN3 isoform X1 [KO:K09592] [EC:1.14.11.29]
116485021  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
116485029  BDKRB2; B2 bradykinin receptor [KO:K03916]
116485030  BDKRB1; B1 bradykinin receptor [KO:K03915]
116485057  PGF; placenta growth factor isoform X1 [KO:K16859]
116485066  WNT8B; protein Wnt-8b [KO:K00714]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485178  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
116485188  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116809362  SHH; sonic hedgehog protein isoform X1 [KO:K11988]
116809645  LAMB4; laminin subunit beta-4 [KO:K06245]
116809676  [KO:K08738]
116810136  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116810138  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
116810281  WNT10A; protein Wnt-10a [KO:K01357]
116810282  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
116810333  FN1; fibronectin isoform X1 [KO:K05717]
116810383  FZD5; frizzled-5 [KO:K02375]
116810440  FZD7; frizzled-7 [KO:K02432]
116810454  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
116810527  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
116810529  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116810565  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
116810621  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
116810655  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
116810819  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116810921  LAMB1; laminin subunit beta-1 [KO:K05636]
116811148  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
116811166  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
116811338  FGF16; fibroblast growth factor 16 [KO:K04358]
116811340  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
116811446  [KO:K08738]
116811530  VEGFD; vascular endothelial growth factor D [KO:K05449]
116811640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116811671  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
116811751  AR; androgen receptor isoform X1 [KO:K08557]
116811758  FZD9; frizzled-9 [KO:K02842]
116811947  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
116811956  GNG5B; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B [KO:K04542]
116812065  [KO:K04632]
116812436  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116812469  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116812488  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116812519  GLI3; transcriptional activator GLI3 [KO:K06230]
116812776  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
116812793  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116812811  HES5; transcription factor HES-5 isoform X1 [KO:K06055]
116812846  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812918  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116812969  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X2 [KO:K10500]
116812987  [KO:K08738]
116813045  WNT4; protein Wnt-4 [KO:K00408]
116813051  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
116813063  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116813327  ELOC; elongin-C isoform X1 [KO:K03872]
116813340  IL7; interleukin-7 [KO:K05431]
116813342  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
116813413  RUNX1T1; LOW QUALITY PROTEIN: protein CBFA2T1 [KO:K10053]
116813431  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116813496  FZD6; frizzled-6 isoform X1 [KO:K02376]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
116813595  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116813620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116813623  [KO:K14021]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116814102  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116814103  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116814109  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
116814122  FZD1; frizzled-1 [KO:K02432]
116814165  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116814273  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116814280  WNT2; protein Wnt-2 [KO:K00182]
116814291  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
116814342  [KO:K04369] [EC:2.7.12.2]
116814346  SMO; protein smoothened isoform X1 [KO:K06226]
116814428  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116814485  CUL1; cullin-1 [KO:K03347]
131384252  [KO:K03873]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
hmh03320  PPAR signaling pathway
hmh04010  MAPK signaling pathway
hmh04020  Calcium signaling pathway
hmh04024  cAMP signaling pathway
hmh04060  Cytokine-cytokine receptor interaction
hmh04066  HIF-1 signaling pathway
hmh04110  Cell cycle
hmh04115  p53 signaling pathway
hmh04150  mTOR signaling pathway
hmh04151  PI3K-Akt signaling pathway
hmh04210  Apoptosis
hmh04310  Wnt signaling pathway
hmh04330  Notch signaling pathway
hmh04340  Hedgehog signaling pathway
hmh04350  TGF-beta signaling pathway
hmh04370  VEGF signaling pathway
hmh04510  Focal adhesion
hmh04512  ECM-receptor interaction
hmh04520  Adherens junction
hmh04630  JAK-STAT signaling pathway
hmh04915  Estrogen signaling pathway
KO pathway
ko05200   

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