KEGG DRUG: Pharmacogenomic Biomarkers

Drug	KEGG	ATC	Product	Target	Biomarker	KEGG VARIANT	KEGG NETWORK
Maralixibat	D10952	A05AX04	Livmarli	SLC10A2	ABCB11 mutation	8647v1
Mecasermin	D03297	H01AC03	Increlex	IGF1R GHR	GH1 deletion (developed neutralizing antibodies to GH)
Tegafur, gimeracil and oteracil potassium	D06399	L01BC53	Ts-1		ESR1 positive HER2 negative	2099v1
Imatinib	D01441	L01EA01	Gleevec	BCR-ABL FIP1L1-PDGFRA KIT PDGFR	Philadelphia chromosome (BCR-ABL fusion gene) FIP1L1-PDGFRA fusion gene KIT mutation D816V negative PDGFR rearrangement	25v1	nt06276
Dasatinib	D06414	L01EA02	Sprycel	BCR-ABL	Philadelphia chromosome, BCR-ABL T315I mutation
Nilotinib	D06413	L01EA03	Tasigna	BCR-ABL	Philadelphia chromosome (BCR-ABL fusion gene) UGT1A1*28 allele homozygotes	54658v1	nt06276
Bosutinib	D09728	L01EA04	Bosulif	BCR-ABL	Philadelphia chromosome (BCR-ABL fusion gene)
Ponatinib	D09951	L01EA05	Iclusig	BCR-ABL	Philadelphia chromosome, (BCR-ABL fusion gene) T315I mutation
Asciminib	D11404	L01EA06	Scemblix	BCR-ABL	Philadelphia chromosome, (BCR-ABL fusion gene) T315I mutation	25v1	nt06276
Gefitinib	D01977	L01EB01	Iressa	EGFR	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2	nt06266
Erlotinib	D04023	L01EB02	Tarceva	EGFR	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2	nt06266
Afatinib	D09733	L01EB03	Giotrif	EGFR	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2	nt06266
Osimertinib	D10766	L01EB04	Tagrisso	EGFR	EGFR T790M mutation	1956v3	nt06266
Dacomitinib	D10514	L01EB07	Vizimpro	EGFR	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2	nt06266
Lazertinib	D12245	L01EB09	Lazcluze	EGFR	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2	nt06266
Mobocertinib	D11969	L01EB10	Exkivity	EGFR	EGFR exon 20 insertion mutation	1956v2	nt06266
Sunvozertinib	D12506		Zegfrovy	EGFR	EGFR exon 20 insertion mutation	1956v2	nt06266
Vemurafenib	D09996	L01EC01	Zelboraf	BRAF	BRAF V600E mutation NRAS mutation	673v1	nt06268
Dabrafenib	D10104	L01EC02	Tafinlar	BRAF	BRAF V600E mutation G6PD deficiency	673v1	nt06268
Encorafenib	D11053	L01EC03	Braftovi	BRAF	BRAF V600E/K mutation	673v1	nt06268
Tovorafenib	D12291	(L01EC04)	Ojemda	BRAF RAF1	BRAF fusion or BRAF rearrangement or BRAF V600 mutation	673v1 673v2	nt06273
Crizotinib	D09731	L01ED01	Xalkori	EML4-ALK ROS1	EML4-ALK fusion gene ROS1 fusion gene	238v1 6098v1	nt06266
Ceritinib	D10551	L01ED02	Zykadia	EML4-ALK	ALK gene rearrangement	238v2	nt06266
Alectinib	D10450	L01ED03	Alecensa	EML4-ALK	ALK gene rearrangement	238v2	nt06266
Brigatinib	D10866	L01ED04	Alunbrig	EML4-ALK	ALK gene rearrangement	238v2	nt06266
Lorlatinib	D11012	L01ED05	Lorbrena	EML4-ALK	ALK gene rearrangement	238v2	nt06266
Trametinib	D10176	L01EE01	Mekinist	MEK	BRAF V600E/K mutation	673v1	nt06268
Cobimetinib	D10615	L01EE02	Cotellic	MEK	BRAF V600E/K mutation	673v1	nt06268
Binimetinib	D10604	L01EE03	Mektovi	MEK	BRAF V600E/K mutation	673v1	nt06268
Palbociclib	D10372	L01EF01	Ibrance	CDK4/6	ESR1 positive HER2 negative	2099v1
Ribociclib	D10979	L01EF02	Kisqali	CDK4/6	ESR1 positive HER2 negative	2099v1
Abemaciclib	D10688	L01EF03	Verzenio	CDK4/6	ESR1 positive HER2 negative MKI67 score
Everolimus	D02714	L01EG02 L04AH02	Afinitor Zortress	MTOR	ESR1 positive HER2 negative	2099v1
Lapatinib	D04024	L01EH01	Tykerb	EGFR HER2	HER2 positive ESR1, PGR positive HLA-DQA10201 or HLA-DRB10701 allele carrier	2064v1	nt06270
Neratinib	D10898	L01EH02	Nerlynx	EGFR HER2 HER4	HER2 positive	2064v1 2064v3	nt06270
Tucatinib	D11141	L01EH03	Tukysa	HER2 HER3	HER2 positive RAS wild type	2064v1 2064v3	nt06270
Momelotinib	D10889	L01EJ04	Ojjaara	JAK1 JAK2 ACVR1	JAK2 mutation	3717v1
Fruquintinib	D11977	L01EK04	Fruzaqla	VEGFR1 VEGFR2 VEGFR3	RAS wild type
Ibrutinib	D10223	L01EL01	Imbruvica	BTK	Chromosome 17p deletion Chromosome 11q deletion
Alpelisib	D11011	L01EM03	Piqray	PIK3CA	PIK3CA mutation ESR1 positive HER2 negative	5290v1 2099v1	nt06270
Erdafitinib	D10927	L01EN01	Balversa	FGFR3 FGFR2	FGFR3,2 genetic alterations	2261v2 2263v2	nt06265
Pemigatinib	D11417	L01EN02	Pemazyre	FGFR2	FGFR2 fusion gene	2263v2
Infigratinib	D11611	L01EN03	Truseltiq	FGFR2 FGFR1 FGFR3	FGFR2 mutation	2263v2 2263v1
Futibatinib	D11725	L01EN04	Lytgobi	FGFR2	FGFR2 fusion gene	2263v2
Midostaurin	D05029	L01EX10	Rydapt	FLT3 (CD135)	FLT3 mutation	2322v1 2322v2
Quizartinib	D09956	L01EX11	Vanflyta	FLT3 (CD135)	FLT3 mutation	2322v2
Larotrectinib	D11138	L01EX12	Vitrakvi	TRKA	TRK positive
Gilteritinib	D10800	L01EX13	Xospata	FLT3 (CD135)	FLT3 mutation	2322v1 2322v2
Entrectinib	D10926	L01EX14	Rozlytrek	NTRK1 ROS1	NTRK1 fusion gene ROS1 fusion gene	4914v1 6098v1
Capmatinib	D10891	L01EX17	Tabrecta	MET	MET exon 14 skipping	4233v4	nt06266
Avapritinib	D11279	L01EX18	Ayvakit	KIT PDGFRA	KIT mutation PDGFRA mutation	3815v1 5156v2
Tepotinib	D11073	L01EX21	Tepmetko	MET	MET exon 14 skipping	4233v4	nt06266
Selpercatinib	D11713	L01EX22	Retevmo	RET	RET fusion positive	5979v1 5979v2	nt06274 nt06266
Pralsetinib	D11712	L01EX23	Gavreto	RET	RET fusion positive	5979v1	nt06266
Capivasertib	D11371	L01EX27	Truqap	AKT	HER2 negative ESR1 positive PIK3CA/AKT1/PTEN mutations	207v1 2099v1	nt06530
Repotrectinib	D11454	L01EX28	Augtyro	ROS1 NTRK1 NTRK2 NTRK3	ROS1 fusion gene	6098v1
Taletrectinib	D12364		Ibtrozi	ROS1 NTRK1 NTRK2 NTRK3	ROS1 fusion gene	6098v1
Rituximab	D02994	L01FA01	Rituxan	CD20	CD20 positive
Ofatumumab	D09314	L01FA02	Arzerra	CD20	CD20 positive
Obinutuzumab	D09321	L01FA03	Gazyva	CD20	CD20 positive
Inotuzumab ozogamicin	D08933	L01FB01	Besponsa	CD22	CD22 positive
Trastuzumab	D03257	L01FD01	Herceptin	HER2	HER2 overexpression	2064v1	nt06270 nt06261
Pertuzumab	D05446	L01FD02	Perjeta	HER2	HER2 positive	2064v1 2064v3	nt06270
Trastuzumab emtansine	D09980	L01FD03	Kadcyla	HER2	HER2 positive	2064v1 2064v3	nt06270
Trastuzumab deruxtecan	D11529	L01FD04	Enhertu	HER2	HER2 positive	2064v1 2064v3	nt06270
Margetuximab	D10446	L01FD06	Margenza	HER2	HER2 positive	2064v1 2064v3
Cetuximab	D03455	L01FE01	Erbitux	EGFR	EGFR expression KRAS wild type BRAF V600E mutation	673v1
Panitumumab	D05350	L01FE02	Vectibix	EGFR	EGFR expression, KRAS wild type	nt06270
Nivolumab	D10316	L01FF01	Opdivo	PD1	PDL1 positive BRAF V600 mutation Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Pembrolizumab	D10574	L01FF02	Keytruda	PD1	PDL1 positive Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR) HER2 negative ESR1, PGR negative
Durvalumab	D10808	L01FF03	Imfinzi	PDL1	PDL1 positive Mismatch repair deficiency (dMMR)
Avelumab	D10817	L01FF04	Bavencio	PDL1	PDL1 positive
Atezolizumab	D10773	L01FF05	Tecentriq	PDL1	PDL1 positive HER2 negative ESR1, PGR negative BRAF V600E/K mutation	673v1
Cemiplimab	D11108	L01FF06	Libtayo	PD1	PDL1 positive
Dostarlimab	D11366	L01FF07	Jemperli	PDCD1	Mismatch repair deficiency (dMMR)
Ramucirumab	D09371	L01FG02	Cyramza	VEGFR2	EGFR exon 19 deletion or exon 21 L858R mutation	1956v2
Gemtuzumab ozogamicin	D03259	L01FX02	Mylotarg	CD33	CD33 positive
Ipilimumab	D04603	L01FX04	Yervoy	CTLA4	Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Brentuximab vedotin	D09587	L01FX05	Adcetris	CD30	CD30 positive
Dinutuximab	D10559	L01FX06	Unituxin	GD2	MYCN amplification
Blinatumomab	D09325	L01FX07	Blincyto	CD19	Philadelphia chromosome (BCR-ABL fusion gene) negative
Mogamulizumab	D09761	L01FX09	Poteligeo	CCR4	CCR4 positive
Tafasitamab	D11601	L01FX12	Monjuvi	CD19	CD19 positive
Sacituzumab govitecan	D10985	L01FX17	Trodelvy	TOP1 TACSTD2	HER2 negative ESR1 positive	2099v1
Amivantamab	D11894	L01FX18	Rybrevant	EGFR MET	EGFR exon 20 insertion mutation	1956v2
Olaparib	D09730	L01XK01	Lynparza	PARP1	BRCA1,2 mutation HER2 negative	672v1 675v1
Niraparib	D11895	L01XK02	Zejula	PARP1	BRCA1,2 mutation or wild type	672v1 675v1
Rucaparib	D10982	L01XK03	Rubraca	PARP1	BRCA1,2 mutation	672v1 675v1
Talazoparib	D10733	L01XK04	Talzenna	PARP1/2	BRCA1,2 mutation HER2 negative Homologous recombination repair gene (HRR) mutations	672v1 675v1
Tisagenlecleucel-T	D11386	L01XL04	Kymriah	CD19	CD19 positive
Omacetaxine	D08956	L01XX40	Synribo	CCND1	Philadelphia chromosome (BCR-ABL fusion gene) negative
Venetoclax	D10679	L01XX52	Venclexta	BCL2	Chromosome 17p deletion
Enasidenib	D11044	L01XM01	Idhifa	IDH2	IDH2 mutation	3418v1
Ivosidenib	D11090	L01XM02	Tibsovo	IDH1	IDH1 mutation	3417v1
Olutasidenib	D12483	(L01XM03)	Rezlidhia	IDH1	IDH1 mutation	3417v1
Tazemetostat	D11485	L01XX72	Tazverik	EZH2	EZH2 mutation positive	2146v1
Sotorasib	D12055	L01XX73	Lumakras	KRAS	KRAS mutation	3845v1	nt06266
Tebentafusp	D12296	L01XX75	Kimmtrak	CD3D CD3E CD3G	HLA-A*0201 positive
Adagrasib	D12301	L01XX77	Krazati	KRAS	KRAS mutation	3845v1
Mirvetuximab soravtansine	D10954	L01FX26	Elahere	FOLR1 TUBB	FOLR1 positive
Tamoxifen	D00966	L02BA01	Nolvadex	NR3A (ESR)	ESR1, PGR positive Factor V Leiden negative Prothrombin G20210A negative	2099v1 2153v1 2147v1
Fulvestrant	D01161	L02BA03	Faslodex	NR3A (ESR)	ESR1, PGR positive HER2 negative
Elacestrant	D11672	L02BA04	Orserdu	NR3A1 (ESR1)	ER positive ESR1 mutation HER2 negative	2099v1 2099v2
Anastrozole	D00960	L02BG03	Arimidex	CYP19A1 (ARO)	ESR1, PGR positive	2099v1
Letrozole	D00964	L02BG04	Femara	CYP19A1 (ARO)	ESR1, PGR positive	2099v1
Exemestane	D00963	L02BG06	Aromasin	CYP19A1 (ARO)	ESR1, PGR positive	2099v1
Satralizumab	D11079	L04AC19	Enspryng	IL6R	anti-AQP4 antibody positive
Inebilizumab	D11757	L04AG10	Uplizna	CD19	anti-AQP4 antibody positive
Rozanolixizumab	D12182	L04AG16	Rystiggo	FCGRT	anti-ACHR antibody positive anti-MUSK antibody positive
Eculizumab	D03940	L04AJ01	Soliris	C5	anti-ACHR antibody positive anti-AQP4 antibody positive
Ravulizumab	D11054	L04AJ02	Ultomiris	C5	anti-ACHR antibody positive
Zilucoplan	D12356	L04AJ06	Zilbrysq	C5	anti-ACHR antibody positive
Ibritumomab tiuxetan	D04489	V10XX02	Zevalin	CD20	CD20 positive
Lutetium (177Lu) dotatate	D11033	V10XX04	Lutathera	SSTR2	somatostatin receptor (SSTR) positive
Lutetium Lu 177 vipivotide tetraxetan	D12335	V10XX05	Pluvicto	FOLH1	PSMA positive
Letrozole and ribociclib	D11068		Kisqali femara		ESR1, PGR positive HER2 negative	2099v1
Gumarontinib	D12705		Haiyitan	MET	MET exon 14 skipping	4233v4	nt06266
Zenocutuzumab	D11991		Bizengri	HER2 HER3	NRG1 fusion gene	3084v1	nt06543

Germline mutations in genetic disorder treatments

Drug	KEGG	ATC	Product	KEGG DISEASE	Biomarker	KEGG VARIANT	KEGG NETWORK
Setmelanotide	D11928	A08AA12	Imcivree	H02106 H02060 H02105	LEPR, PCSK1, POMC deficiency
Carglumic acid	D07130	A16AA05	Carbaglu	H01032	NAGS deficiency (CPS1 activator)	162417v1	nt06010
Imiglucerase	D03020	A16AB02	Cerezyme	H00126	GBA deficiency (enzyme replacement)	2629v1	nt06014
Agalsidase alpha	D02784	A16AB03	Replagal	H00125	GLA deficiency (enzyme replacement)	2717v1	nt06014
Agalsidase beta	D03228	A16AB04	Fabrazyme	H00125	GLA deficiency (enzyme replacement)	2717v1	nt06014
Laronidase	D04670	A16AB05	Aldurazyme	H00128	IDUA deficiency (enzyme replacement)	3425v1	nt06012
Sacrosidase	D05782	A16AB06	Sucraid	H00115	SI deficiency (enzyme replacement)	6476v1
Alglucosidase alfa	D03207	A16AB07	Lumizyme	H01940	GAA deficiency (enzyme replacement)	2548v1	nt06017
Galsulfase	D06565	A16AB08	Naglazyme	H00131	ARSB deficiency (enzyme replacement)	411v1	nt06012
Idursulfase	D04499	A16AB09	Elaprase	H00129	IDS deficiency (enzyme replacement)	3423v1	nt06012
Velaglucerase alfa	D09029	A16AB10	Vpriv	H00126	GBA deficiency (enzyme replacement)	2629v1	nt06014
Taliglucerase alfa	D09675	A16AB11	Elelyso	H00126	GBA deficiency (enzyme replacement)	2629v1	nt06014
Elosulfase	D10333	A16AB12	Vimizim	H00123	GALNS deficiency (enzyme replacement)	2588v1	nt06012
Asfotase alfa	D10595	A16AB13	Strensiq	H00213	ALPL deficiency (enzyme replacement)	249v1
Sebelipase alfa	D10377	A16AB14	Kanuma	H00148	LIPA deficiency (enzyme replacement)	3988v1
Velmanase alfa	D11024	A16AB15	Lamzede	H00139	MAN2B1 deficiency (enzyme replacement)	4125v1
Idursulfase beta	D11025	A16AB16	Hunterase	H00129	IDS deficiency (enzyme replacement)	3423v1	nt06012
Cerliponase alfa	D10813	A16AB17	Brineura	H00149	TPP1 deficiency (enzyme replacement)	1200v1
Vestronidase alfa	D11004	A16AB18	MepseVII	H00132	GUSB deficiency (enzyme replacement)	2990v1	nt06012
Pegvaliase	D11077	A16AB19	Palynziq	H00167	PAH deficiency (substitution by PAL activity)	5053v1
Pegunigalsidase alfa	D11685	A16AB20	Elfabrio	H00125	GLA deficiency (enzyme replacement)	2717v1
Avalglucosidase alfa	D11744	A16AB22	Nexviazyme	H01940	GAA deficiency (enzyme replacement)	2548v1	nt06017
Cipaglucosidase alfa	D11798	A16AB23	Pombiliti	H01940	GAA deficiency (enzyme replacement)	2548v1	nt06017
Olipudase alfa	D10820	A16AB25	Xenpozyme	H00137	SMPD1 deficiency (enzyme replacement)	6609v1
Eladocagene exuparvovec	D12407	A16AB26	Upstaza	H01161	DDC deficiency (gene therapy)	1644v1	nt06028
Sodium phenylbutyrate	D05868	A16AX03	Buphenyl	H01398	ASS1, CPS1, OTC deficiency	445v1 1373v1 5009v1
Nitisinone	D05177	A16AX04	Orfadin	H00165	FAH deficiency (HPD inhibitor)	2184v1	nt06016
Miglustat	D05032	A16AX06	Zavesca	H00126	GBA deficiency (UGCG inhibitor)	2629v1	nt06014
Sapropterin	D01798	A16AX07	Kuvan	H00167	QDPR deficiency (cofactor replacement)	5860v1	nt06016
Glycerol phenylbutyrate	D10127	A16AX09	Ravicti	H01398	ASS1, CPS1, OTC deficiency	445v1 1373v1 5009v1
Eliglustat	D09894	A16AX10	Cerdelga	H00126	GBA deficiency (UGCG inhibitor) CYP2D6 polymorphism	2629v1	nt06014
Migalastat	D05031	A16AX14	Galafold	H00125	GLA variant (migalastat amenable)	2717v2	nt06014
Triheptanoin	D11465	A16AX17	Dojolvi		ACADVL, CPT2, HADHA, HADHB mutation (fatty acid supplement)
Lumasiran	D11926	A16AX18	Oxlumo	H00117	AGXT mutation
Fosdenopterin	D11780	A16AX19	Nulibry	H02311	MOCS1 deficiency (cofactor replacement)	4337v1	nt06025
Lonafarnib	D04768	A16AX20	Zokinvy	H00601	LMNA mutation ZMPSTE24 mutation
Elapegademase	D11017	L03AX21	Revcovi	H02309	ADA deficiency (enzyme replacement)	100v1
Efgartigimod alfa	D11876	L04AA58	Vyvgart	H01594	anti-ACHR antibody positive
Eteplirsen	D09900	M09AX06	Exondys 51	H01963	DMD mutation (exon 51 skipping amenable)	1756v1
Golodirsen	D11707	M09AX08	Vyondys 53	H01963	DMD mutation (exon 53 skipping amenable)	1756v1
Onasemnogene abeparvovec	D11559	M09AX09	Zolgensma	H00455	bi-allelic SMN1 mutations
Viltolarsen	D11528	M09AX12	Viltepso	H01963	DMD mutation (exon 53 skipping amenable)	1756v1
Casimersen	D11988	M09AX13	Amondys 45	H01963	DMD mutation (exon 45 skipping amenable)	1756v1
Ganaxolone	D04300	N03AX27	Ztalmy	H01819	CDKL5 mutation
Tofersen	D11811	N07XX22	Qalsody	H00058	SOD1 mutation	6647v1
Ivacaftor	D09916	R07AX02	Kalydeco	H00218	CFTR mutation	1080v1
Lumacaftor and ivacaftor	D10685	R07AX30	Orkambi	H00218	CFTR mutation	1080v1
Tezacaftor and ivacaftor	D11042	R07AX31	Symdeko	H00218	CFTR mutation	1080v1
Elexacaftor, ivacaftor and tezacaftor	D11700	R07AX32	Trikafta	H00218	CFTR mutation	1080v1
Vanzacaftor, tezacaftor and deutivacaftor	D13024	R07AX33	Alyftrek	H00218	CFTR mutation	1080v1
Apadamtase alfa and cinaxadamtase alfa	D12835	(B01AD13)	Adzynma	H00225	ADAMTS13 mutation (enzyme replacement)

Pathogen genome variants in infectious disease treatments

Drug	KEGG	ATC	Product	Target	Biomarker
Maraviroc	D06670	J05AX09	Selzentry	CCR5	CCR5-tropic HIV-1 (R5 variant)

Polymorphisms and mutations affecting drug response

Drug	KEGG	ATC	Biomarker	KEGG VARIANT
Omeprazole	D00455 D05259	A02BC01	CYP2C19 polymorphism	1557v1
Pantoprazole	D02593	A02BC02	CYP2C19 polymorphism	1557v1
Lansoprazole	D00355	A02BC03	CYP2C19 polymorphism	1557v1
Rabeprazole	D00724	A02BC04	CYP2C19 polymorphism	1557v1
Esomeprazole	D01984 D04056 D10120	A02BC05	CYP2C19 polymorphism	1557v1
Dexlansoprazole	D08903	A02BC06	CYP2C19 polymorphism	1557v1
Metoclopramide	D05008	A03FA01	CYB5R deficiency G6PD deficiency	2539v1
Palonosetron	D05343	A04AA05	CYP2D6 polymorphism	1565v1
Dronabinol	D00306	A04AD10	CYP2C9 polymorphism	1559v1
Odevixibat	D13092	A05AX05	ABCB11 mutation	8647v1
Dextromethorphan and bupropion	D12493	N06AX62 N07XX59	CYP2D6 polymorphism	1565v1
Sulfasalazine	D00448	A07EC01	G6PD deficiency	2539v1
Glibenclamide (Glyburide)	D00336	A10BB01	G6PD deficiency	2539v1
Chlorpropamide	D00271	A10BB02	G6PD deficiency	2539v1
Glipizide	D00335	A10BB07	G6PD deficiency	2539v1
Glimepiride	D00593	A10BB12	G6PD deficiency	2539v1
Nateglinide	D01111	A10BX03	CYP2C9 polymorphism	1559v1
Warfarin	D00564	B01AA03	VKORC1 rs9923231 CYP2C9 polymorphism PROC deficiency PROS deficiency	79001v1 1559v1
Clopidogrel	D00769	B01AC04	CYP2C19 polymorphism	1557v1
Ticagrelor	D09017	B01AC24	CYP2C19 polymorphism	1557v1
Eltrombopag	D03978	B02BX05	Factor V Leiden ATIII deficiency	2153v1
Lusutrombopag	D10476	B02BX07	Factor V Leiden Prothrombin 20210A ATIII deficiency PROC deficiency PROS deficiency	2153v1 2147v1
Avatrombopag	D10307	B02BX08	Factor V Leiden Prothrombin 20210A ATIII deficiency PROC deficiency PROS deficiency	2153v1 2147v1
Quinidine	D00642 D02272	C01BA01	CYP2D6 polymorphism	1565v1
Procainamide	D08421 D00477	C01BA02	NAT polymorphism	9v1 10v1
Propafenone	D00640	C01BC03	CYP2D6 polymorphism	1565v1
Isosorbide dinitrate	D00516	C01DA08	CYB5R deficiency
Isosorbide mononitrate	D00630	C01DA14	CYB5R deficiency
Mavacamten	D12265	C01EB24	CYP2C19 polymorphism	1557v1
Hydralazine and isosorbide	D10209		NAT polymorphism	9v1 10v1
Propranolol	D00483	C07AA05	CYP2D6 polymorphism	1565v1
Metoprolol	D00601 D00635	C07AB02	CYP2D6 polymorphism	1565v1
Carvedilol	D00255 D03415	C07AG02	CYP2D6 polymorphism	1565v1
Rosuvastatin	D01915	C10AA07	SLCO1B1 polymorphism
Doxepin	D00814	D04AX01 N06AA12	CYP2C19 polymorphism CYP2D6 polymorphism	1557v1 1565v1
Amikacin	D00865	D06AX12	MT-RNR1 (m.1555A>G)	4549v1
Mafenide	D01166	D06BA03	G6PD deficiency	2539v1
Dapsone	D00592	D10AX05 J04BA02	G6PD deficiency	2539v1
Abrocitinib	D11400	D11AH08	CYP2C19 polymorphism	1557v1
Flibanserin	D02577	G02CX02	CYP2C9 polymorphism CYP2C19 polymorphism CYP2D6 polymorphism	1559v1 1557v1 1565v1
Drospirenone and ethinylestradiol	D09741	G03AA12	CYP2C19 polymorphism	1557v1
Tolterodine	D01148	G04BD07	CYP2D6 polymorphism	1565v1
Darifenacin	D01699	G04BD10	CYP2D6 polymorphism	1565v1
Fesoterodine	D08923	G04BD11	CYP2D6 polymorphism	1565v1
Elagolix	D09336	H01CC03	SLCO1B1 polymorphism
Parathyroid hormone	D05364	H05AA03	CASR positive
Sulfamethoxazole and trimethoprim	D00285	J01EE01	G6PD deficiency	2539v1
Tobramycin	D00063	J01GB01	MT-RNR1 (m.1555A>G)	4549v1
Plazomicin	D10655	J01GB14	MT-RNR1 (m.1555A>G)	4549v1
Nalidixic acid	D00183	J01MB02	G6PD deficiency	2539v1
Nitrofurantoin	D00439	J01XE01	G6PD deficiency	2539v1
Voriconazole	D00578	J02AC03	CYP2C19 polymorphism	1557v1
Rifampin, isoniazid, and pyrazinamide	D10210	J04AM05	NAT polymorphism	9v1 10v1
Abacavir	D00891	J05AF06	HLA-B*5701
Efavirenz	D00896	J05AG03	CYP2B6	1555v1
Dolutegravir	D10113	J05AJ03	UGT1A1 polymorphism	54658v1
Sofosbuvir	D10366	J05AP08	IL28B rs12979860	282617v1
Dasabuvir, ombitasvir, paritaprevir and ritonavir	D10582	J05AP52	IL28B rs12979860	282617v1
Elbasvir and grazoprevir	D10778	J05AP54	IL28B allele carrier
Mercaptopurine	D00161	L01BB02	TPMT polymorphism	7172v1
Thioguanine	D06109	L01BB03	TPMT polymorphism	7172v1
Fluorouracil	D00584	L01BC02	DPYD deficiency
Capecitabine	D01223	L01BC06	DPYD deficiency
Irinotecan	D01061	L01CE02	UGT1A1 polymorphism	54658v1
Lapatinib	D04024	L01EH01	HLA-DQA10201 HLA-DRB10701
Nilotinib	D06413	L01EA03	UGT1A1 polymorphism	54658v1
Pazopanib	D05380	L01EX03	UGT1A1 polymorphism	54658v1
Sacituzumab govitecan	D10985	L01FX17	UGT1A1 polymorphism	54658v1
Cisplatin	D00275	L01XA01	TPMT polymorphism	7172v1
Belinostat	D08870	L01XH04	UGT1A1 polymorphism	54658v1
Belzutifan	D11954	L01XX74	CYP2C19 polymorphism UGT2B17 polymorphism	1557v1
Peginterferon alfa-2b	D02748	L03AB10	IL28B rs12979860
Mycophenolic acid	D00752 D05095 D05096	L04AA06	HPRT deficiency
Etrasimod	D10931	L04AE05	CYP2C9 polymorphism	1559v1
Azathioprine	D00238	L04AX01	TPMT polymorphism	7172v1
Lenalidomide	D04687	L04AX04	Chromosome 5q deletion
Piroxicam	D00127	M01AC01	CYP2C9 polymorphism	1559v1
Celecoxib	D00567	L01XX33 M01AH01	CYP2C9 polymorphism	1559v1
Flurbiprofen	D00330 D02290	M01AE09 M02AA19 R02AX01 S01BC04	CYP2C9 polymorphism	1559v1
Succinylcholine	D00766	M03AB01	BCHE deficiency
Carisoprodol	D00768	M03BA02	CYP2C19 polymorphism	1557v1
Allopurinol	D07564	M04AA01	HLA-B*5801
Lesinurad	D09921	M04AB05	CYP2C9 polymorphism	1559v1
Pegloticase	D09316	M04AX02	G6PD deficiency
Sevoflurane	D00547	N01AB08	RYR1 positive
Sodium oxybate	D05866	N01AX11 N07XX04	ALDH5A1 deficiency (Succinic semialdehyde dehydrogenase deficiency)
Prilocaine and lidocaine	D02740	N01BB52 N01BB54	CYB5R deficiency G6PD deficiency	2539v1
Tramadol and acetaminophen	D09999	N02AJ13	CYP2D6 polymorphism	1565v1
Tramadol	D01355	N02AX02	CYP2D6 polymorphism	1565v1
Oliceridine	D11214	N02AX07	CYP2D6 polymorphism	1565v1
Phenytoin	D00512 D02103	N03AB02	HLA-B*1502
Fosphenytoin	D02096	N03AB05	HLA-B*1502 CYP2C9 polymorphism	1559v1
Carbamazepine	D00252	N03AF01	HLA-B1502 HLA-A3101
Oxcarbazepine	D00533	N03AF02	HLA-B*1502
Valproic acid	D00399 D00304 D00710	N03AG01	POLG deficiency CPS1,OTC,NAGS / ASS1,ASL / ARG deficiency (Urea cycle disorders)	1373v1 5009v1 162417v1 445v1 435v1 383v1
Lacosamide	D07299	N03AX18	CYP2C19 polymorphism	1557v1
Brivaracetam	D08879	N03AX23	CYP2C19 polymorphism	1557v1
Perphenazine	D00503	N05AB03	CYP2D6 polymorphism	1565v1
Thioridazine	D00798	N05AC02	CYP2D6 polymorphism	1565v1
Pimozide	D00560	N05AG02	CYP2D6 polymorphism	1565v1
Clozapine	D00283	N05AH02	CYP2D6 polymorphism	1565v1
Risperidone	D00426	N05AX08	CYP2D6 polymorphism	1565v1
Aripiprazole	D01164 D10364	N05AX12	CYP2D6 polymorphism	1565v1
Iloperidone	D02666	N05AX14	CYP2D6 polymorphism	1565v1
Brexpiprazole	D10309	N05AX16	CYP2D6 polymorphism	1565v1
Diazepam	D00293	N05BA01	CYP2C19 polymorphism	1557v1
Clobazam	D01253	N05BA09	CYP2C19 polymorphism	1557v1
Desipramine	D00812	N06AA01	CYP2D6 polymorphism	1565v1
Imipramine	D00815	N06AA02	CYP2D6 polymorphism	1565v1
Clomipramine	D00811	N06AA04	CYP2D6 polymorphism	1565v1
Amitriptyline	D00809	N06AA09	CYP2D6 polymorphism	1565v1
Trimipramine	D02408	N06AA06	CYP2D6 polymorphism	1565v1
Nortriptyline	D00816	N06AA10	CYP2D6 polymorphism	1565v1
Protriptyline	D00484	N06AA11	CYP2D6 polymorphism	1565v1
Fluoxetine	D00823	N06AB03	CYP2D6 polymorphism	1565v1
Citalopram	D00822	N06AB04	CYP2C19 polymorphism CYP2D6 polymorphism	1557v1 1565v1
Paroxetine	D02260 D05374 D05375	N06AB05	CYP2D6 polymorphism	1565v1
Fluvoxamine	D00824	N06AB08	CYP2D6 polymorphism	1565v1
Escitalopram	D02567	N06AB10	CYP2C19 polymorphism CYP2D6 polymorphism	1557v1 1565v1
Nefazodone	D00819	N06AX06	CYP2D6 polymorphism	1565v1
Venlafaxine	D00821	N06AX16	CYP2D6 polymorphism	1565v1
Duloxetine	D01179	N06AX21	CYP2D6 polymorphism	1565v1
Vortioxetine	D10185	N06AX26	CYP2D6 polymorphism	1565v1
Modafinil	D01832	N06BA07	CYP2D6 polymorphism	1565v1
Atomoxetine	D02574	N06BA09	CYP2D6 polymorphism	1565v1
Chlordiazepoxide and amitriptyline	D10207	N06CA01	CYP2D6 polymorphism	1565v1
Galantamine	D02173	N06DA04	CYP2D6 polymorphism	1565v1
Lecanemab	D11678	N06DX04	APOE epsilon4 homozygotes
Cevimeline	D00661	N07AX03	CYP2D6 polymorphism	1565v1
Lofexidine	D04765	N07BC04	CYP2D6 polymorphism	1565v1
Tetrabenazine	D08575	N07XX06	CYP2D6 polymorphism	1565v1
Valbenazine	D10999	N07XX13	CYP2D6 polymorphism	1565v1
Deutetrabenazine	D10701	N07XX16	CYP2D6 polymorphism	1565v1
Dextromethorphan and quinidine	D10208	N07XX59	CYP2D6 polymorphism	1565v1
Chloroquine	D02125	P01BA01	G6PD deficiency	2539v1
Primaquine	D02126	P01BA03	G6PD deficiency	2539v1
Tafenoquine	D10670	P01BA07	G6PD deficiency	2539v1
Quinine sulfate	D02262	P01BC01	G6PD deficiency CYP2D6 polymorphism	2539v1 1565v1
Indacaterol	D09319	R03AC18	UGT1A1 polymorphism	54658v1
Arformoterol	D02981		UGT1A1 polymorphism CYP2D6 polymorphism	54658v1 1565v1
Codeine	D03580	R05DA04	CYP2D6 polymorphism	1565v1
Sodium nitrite	D05865	V03AB08	G6PD deficiency	2539v1
Methylene blue	D02312	V03AB17	G6PD deficiency	2539v1
Rasburicase	D05704	V03AF07	G6PD deficiency CYB5R deficiency	2539v1
Succimer	D00572		G6PD deficiency	2539v1

Pharmacogenomic Biomarkers

Somatic variations in targeted cancer therapies

Germline mutations in genetic disorder treatments

Pathogen genome variants in infectious disease treatments

Polymorphisms and mutations affecting drug response