KEGG   PATHWAY: mcoc05200
Entry
mcoc05200                   Pathway                                
Name
Pathways in cancer - Mastomys coucha (southern multimammate mouse)
Class
Human Diseases; Cancer: overview
Pathway map
mcoc05200  Pathways in cancer
mcoc05200

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116087326  Dcc; netrin receptor DCC isoform X1 [KO:K06765]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116096967  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116085385  Appl1; DCC-interacting protein 13-alpha [KO:K08733]
116070104  Cdh1; cadherin-1 [KO:K05689]
116073724  Ctnnb1; catenin beta-1 [KO:K02105]
116099100  Ctnna2; catenin alpha-2 isoform X1 [KO:K05691]
116074727  Ctnna3; catenin alpha-3 isoform X1 [KO:K05691]
116086989  Ctnna1; catenin alpha-1 [KO:K05691]
116076684  Axin1; axin-1 isoform X1 [KO:K02157]
116076714  Axin2; axin-2 [KO:K04385]
116075850  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
116086966  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116077224  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
116099088  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
116104020  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
116093789  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
116078576  Birc5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
116082253  Myc; myc proto-oncogene protein [KO:K04377]
116103285  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116082044  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
116098605  Wnt2; protein Wnt-2 [KO:K00182]
116093560  Wnt2b; protein Wnt-2b isoform X1 [KO:K00182]
116077475  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
116078862  Wnt3a; protein Wnt-3a [KO:K00312]
116096876  Wnt4; protein Wnt-4 [KO:K00408]
116099495  Wnt5b; protein Wnt-5b [KO:K00444]
116084455  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
116088584  Wnt6; protein Wnt-6 [KO:K00445]
116099270  Wnt7a; protein Wnt-7a [KO:K00572]
116077324  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
116103897  Wnt8b; protein Wnt-8b [KO:K00714]
116087814  Wnt8a; protein Wnt-8a [KO:K00714]
116078860  Wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
116088586  Wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
116079174  Wnt10b; protein Wnt-10b [KO:K01357]
116102613  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
116098622  Wnt16; protein Wnt-16 [KO:K01558]
116097454  Fzd1; frizzled-1 [KO:K02432]
116088479  Fzd7; frizzled-7 [KO:K02432]
116078405  Fzd2; frizzled-2 isoform X1 [KO:K02235]
116085420  Fzd3; frizzled-3 isoform X1 [KO:K02329]
116102539  Fzd4; frizzled-4 [KO:K02354]
116086824  Fzd8; frizzled-8 [KO:K02375]
116088518  Fzd5; frizzled-5 [KO:K02375]
116081996  Fzd6; frizzled-6 [KO:K02376]
116068468  Fzd10; frizzled-10 [KO:K02842]
116070947  Fzd9; frizzled-9 [KO:K02842]
116103296  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
116099693  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
116097159  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
116085718  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
116079062  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
116103835  Frat1; proto-oncogene FRAT1 [KO:K03069]
116100551  proto-oncogene FRAT1-like [KO:K03069]
116103836  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
116092238  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
116070395  Agt; angiotensinogen [KO:K09821]
116083372  F2r; proteinase-activated receptor 1 [KO:K03914]
116069565  F2rl3; proteinase-activated receptor 4 isoform X1 [KO:K04236]
116096072  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
116069430  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
116093916  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
116088074  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
116099597  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
116085076  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
116094994  Agtr1; type-1 angiotensin II receptor [KO:K04166]
116082258  type-1A angiotensin II receptor [KO:K04166]
116068678  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116076843  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
116072951  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116093089  Arhgef11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
116101825  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
116097088  Plekhg5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116076329  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116080601  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116099458  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
116098629  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116097497  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116093617  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116072321  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116069690  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116084940  Ptger2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
116093986  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116083366  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
116091495  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
116091496  neuroendocrine secretory protein 55 [KO:K04632]
116069116  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116083593  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116079663  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116084111  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116085856  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116079067  Adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116069817  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116082049  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116084214  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116097142  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116068597  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
116099581  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
116095064  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
116073026  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116085348  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
116103521  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116082206  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116093923  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116076327  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116101712  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116096080  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116098540  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116078416  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116097985  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116078231  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116096167  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
116068903  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
116068904  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
116088649  Col4a4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116088650  Col4a3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
116089039  Col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116097932  Lama2; laminin subunit alpha-2 [KO:K05637]
116088869  Lama1; laminin subunit alpha-1 [KO:K05637]
116086852  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116091524  Lama5; laminin subunit alpha-5 [KO:K06240]
116075456  Lama4; laminin subunit alpha-4 [KO:K06241]
116080788  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
116072107  Lamb2; laminin subunit beta-2 [KO:K06243]
116069150  Lamb3; laminin subunit beta-3 [KO:K06244]
116101239  Lamc1; laminin subunit gamma-1 [KO:K05635]
116101229  Lamc2; laminin subunit gamma-2 [KO:K06246]
116089980  Lamc3; laminin subunit gamma-3 [KO:K06247]
116088545  Fn1; fibronectin isoform X1 [KO:K05717]
116083244  Itga2; integrin alpha-2 [KO:K06481]
116078214  Itga2b; integrin alpha-IIb [KO:K06476]
116078986  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116103746  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116084616  Nkx3-1; homeobox protein Nkx-3.1 [KO:K09348]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116103881  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116069014  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116086280  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116080443  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116103943  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116070506  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116076938  Nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
116072766  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
116072810  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116079101  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116091548  Birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116090053  Traf1; TNF receptor-associated factor 1 [KO:K03172]
116089826  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116080944  Traf3; TNF receptor-associated factor 3 [KO:K03174]
116078917  Traf4; TNF receptor-associated factor 4 [KO:K09848]
116069008  Traf5; TNF receptor-associated factor 5 [KO:K09849]
116090551  Traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116103319  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116079205  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116094452  Foxo1; forkhead box protein O1 [KO:K07201]
116075923  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
116077116  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
116099702  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116075178  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116075452  Bcr; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
116089976  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
116085656  Crkl; crk-like protein [KO:K04438]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116073545  Cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
116078736  signal transducer and activator of transcription 5A [KO:K11223]
116078734  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
116075082  Pim1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
116104252  Pim2; serine/threonine-protein kinase pim-2 isoform X1 [KO:K08806] [EC:2.7.11.1]
116086252  Kng1; kininogen-1 [KO:K03898]
116086253  T-kininogen 2-like [KO:K03898]
116081785  Edn1; endothelin-1 [KO:K16366]
116080412  Bdkrb1; B1 bradykinin receptor [KO:K03915]
116079827  Bdkrb2; B2 bradykinin receptor [KO:K03916]
116069603  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
116084570  Ednrb; endothelin receptor type B [KO:K04198]
116103624  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116075890  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116103465  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116090695  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090998  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090999  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116094798  Il2; interleukin-2 [KO:K05429]
116078664  interleukin-3-like [KO:K04736]
116078788  Il4; interleukin-4 [KO:K05430]
116078387  Il5; interleukin-5 [KO:K05428]
116097436  Il6; interleukin-6 [KO:K05405]
116094928  Il7; interleukin-7 isoform X1 [KO:K05431]
116094048  Il12a; interleukin-12 subunit alpha [KO:K05406]
116077653  Il12b; interleukin-12 subunit beta [KO:K05425]
116078552  Il13; interleukin-13 [KO:K05435]
116069657  Il15; interleukin-15 isoform X1 [KO:K05433]
116075994  Il23a; interleukin-23 subunit alpha isoform X1 [KO:K05426]
116070961  Epo; erythropoietin isoform X1 [KO:K05437]
116095401  interferon alpha-7-like [KO:K05414]
116095403  interferon alpha-1-like [KO:K05414]
116095406  interferon alpha-9-like [KO:K05414]
116095408  interferon alpha-12-like [KO:K05414]
116095410  interferon alpha-1 [KO:K05414]
116095416  interferon alpha-1-like [KO:K05414]
116095417  interferon alpha-4-like [KO:K05414]
116095418  interferon alpha-12 [KO:K05414]
116095419  interferon alpha-7-like [KO:K05414]
116095420  interferon alpha-12-like [KO:K05414]
116095421  interferon alpha-7-like [KO:K05414]
116096218  interferon alpha-11 [KO:K05414]
116076208  Ifng; interferon gamma [KO:K04687]
116082367  Il2ra; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
116075473  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
116087170  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
116078335  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
116102932  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
116082509  Csf2rb; cytokine receptor common subunit beta [KO:K04738]
116099354  Il5ra; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
116093191  Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
116083943  Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
116083490  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
116069495  Il12rb1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
116099025  Il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
116075762  Il13ra1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
116082267  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
116099026  Il23r; interleukin-23 receptor isoform X1 [KO:K05065]
116073027  Epor; erythropoietin receptor isoform X1 [KO:K05079]
116086128  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
116086124  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116097807  Ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
116086134  Ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05133]
116080363  Eml4; echinoderm microtubule-associated protein-like 4 isoform X1 [KO:K15420]
116080916  Alk; ALK tyrosine kinase receptor isoform X1 [KO:K05119] [EC:2.7.10.1]
116090682  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116103453  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116079748  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116101938  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116096295  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
116103711  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116069528  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
116076801  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116088407  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116076236  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
116088411  Stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
116076456  Stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116079820  Pgf; placenta growth factor [KO:K16859]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116099176  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116103249  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116076467  Kitlg; kit ligand isoform X1 [KO:K05461]
116071281  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116102173  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116068778  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116073820  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116096245  Jun; transcription factor AP-1 [KO:K04448]
116080518  Fos; proto-oncogene c-Fos [KO:K04379]
116073851  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
116072562  interstitial collagenase B-like [KO:K01388] [EC:3.4.24.7]
116072563  interstitial collagenase A-like [KO:K01388] [EC:3.4.24.7]
116069868  Mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
116092533  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
116104586  C-X-C motif chemokine 15-like [KO:K10030]
116075684  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116080005  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116099474  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116075520  Ccdc6; coiled-coil domain-containing protein 6 [KO:K09288]
116084790  Ncoa4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
116094433  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
116093096  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116093202  Tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
116093484  tropomyosin alpha-3 chain-like [KO:K09290]
116100741  Tpr; nucleoprotein TPR [KO:K09291]
116086002  Tfg; protein TFG isoform X1 [KO:K09292]
116072255  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
116098819  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116091355  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
116082387  Dapk1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
116076180  Dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
116072163  Dapk2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116070251  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116073994  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
116102663  calmodulin-like [KO:K02183]
116101711  Calm3; calmodulin-3 [KO:K02183]
116082411  calmodulin-4 [KO:K02183]
116069997  calmodulin-like [KO:K02183]
116079808  Calm1; calmodulin-1 [KO:K02183]
116079993  Calm2; calmodulin-2 [KO:K02183]
116073523  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116081777  calmodulin-like protein 3 [KO:K02183]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116089898  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
116081427  Rala; ras-related protein Ral-A [KO:K07834]
116097777  Ralb; ras-related protein Ral-B [KO:K07835]
116088854  Ralbp1; ralA-binding protein 1 [KO:K08773]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116095022  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
116079039  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116089785  Pax8; paired box protein Pax-8 isoform X1 [KO:K09293]
116099428  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
116089888  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116074254  Rxrb; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
116103078  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
116084258  Rarb; retinoic acid receptor beta isoform X1 [KO:K08528]
116078810  Esr1; estrogen receptor [KO:K08550]
116079837  Esr2; estrogen receptor beta [KO:K08551]
116079752  Ncoa1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
116091403  Ncoa3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
116080468  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
116074315  Ppard; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
116076915  Jup; junction plakoglobin [KO:K10056]
116071993  Zbtb16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
116076864  Rara; retinoic acid receptor alpha isoform X1 [KO:K08527]
116095103  Ccna2; cyclin-A2 [KO:K06627]
116092877  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
116072502  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
116086157  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
116088059  Runx1t1; protein CBFA2T1 isoform X1 [KO:K10053]
116090459  Spi1; transcription factor PU.1 isoform X1 [KO:K09438]
116102026  Cebpa; CCAAT/enhancer-binding protein alpha [KO:K09055]
116075238  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
116096625  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
116087228  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116096224  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
116091213  E2f1; transcription factor E2F1 [KO:K17454]
116095785  E2f2; transcription factor E2F2 [KO:K09389]
116081717  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
116079888  Max; protein max isoform X1 [KO:K04453]
116096961  Zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
116096225  Cdkn2b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
116097440  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
116099629  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
116075067  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
116082682  Cks2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
116093180  Cks1b; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
116078246  Skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
116098531  Cul1; cullin-1 [KO:K03347]
116076358  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
116083772  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
116076163  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116102054  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
116088079  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116085075  Rb1; retinoblastoma-associated protein [KO:K06618]
116099018  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116075868  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116081743  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116075029  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116090466  Ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
116083555  Polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
116083456  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
116099319  Mitf; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
116101857  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
116068447  Tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116080097  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116095983  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116073579  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
116087365  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116073193  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
116087335  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
116095046  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116101371  Ctbp2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
116069828  Ctbp1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
116096707  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
116074400  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116072734  Mlh1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
116079775  Msh2; DNA mismatch repair protein Msh2 [KO:K08735]
116083706  Msh3; DNA mismatch repair protein Msh3 isoform X1 [KO:K08736]
116080432  Msh6; DNA mismatch repair protein Msh6 [KO:K08737]
116068815  Brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
116090710  Rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116103761  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116103283  Fadd; FAS-associated death domain protein [KO:K02373]
116088467  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
116099518  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
116087283  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
116101682  Bbc3; bcl-2-binding component 3 isoform X1 [KO:K10132]
116090896  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
116098897  cytochrome c, somatic [KO:K08738]
116090342  cytochrome c, testis-specific [KO:K08738]
116075741  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
116104023  Casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
116104574  caspase-7-like [KO:K04397] [EC:3.4.22.60]
116073905  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
116090338  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
116069585  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
116068031  Nqo1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
116103068  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
116103974  Gsto1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
116103975  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
116099738  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
116073652  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
116074573  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
116094014  Mgst2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
116094251  LOW QUALITY PROTEIN: glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
116075113  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
116075114  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
116075218  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
116093604  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
116093606  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
116093607  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
116093608  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
116093609  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
116093611  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
116093612  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
116088230  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
116088231  glutathione S-transferase alpha-5 [KO:K00799] [EC:2.5.1.18]
116088234  glutathione S-transferase A6 isoform X1 [KO:K00799] [EC:2.5.1.18]
116089092  glutathione S-transferase alpha-5-like [KO:K00799] [EC:2.5.1.18]
116089388  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
116072429  glutathione S-transferase alpha-2-like [KO:K00799] [EC:2.5.1.18]
116073113  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
116100999  glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
116101000  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
116099241  Txnrd3; thioredoxin reductase 3 isoform X1 [KO:K22182] [EC:1.8.1.9]
116075695  Txnrd1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
116085691  Txnrd2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
116099407  Vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
116088209  Eloc; elongin-C [KO:K03872]
116077726  uncharacterized protein LOC116077726 isoform X1 [KO:K03873]
116079172  Elob; elongin-B [KO:K03873]
116086793  Cul2; cullin-2 isoform X1 [KO:K03870]
116101867  Egln2; egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
116070408  Egln1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
116080173  Egln3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
116103910  Fh; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
116081194  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
116079691  Epas1; endothelial PAS domain-containing protein 1 [KO:K09095]
116093411  Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
116102523  Arnt2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
116084175  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116076368  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
116096528  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
116091010  Jag1; protein jagged-1 [KO:K06052]
116080138  Jag2; protein jagged-2 isoform X1 [KO:K21635]
116101907  Dll3; delta-like protein 3 [KO:K06051]
116078288  Dll1; delta-like protein 1 [KO:K06051]
116090720  Dll4; delta-like protein 4 [KO:K06051]
116089856  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
116093487  Notch2; neurogenic locus notch homolog protein 2 [KO:K20994]
116075773  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
116075324  Notch4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
116085780  Hes1; transcription factor HES-1 [KO:K06054]
116097131  Hes5; transcription factor HES-5 [KO:K06055]
116094931  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
116096579  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
116097880  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116097591  Shh; sonic hedgehog protein [KO:K11988]
116081424  Ptch1; protein patched homolog 1 isoform X1 [KO:K06225]
116098671  Smo; smoothened homolog isoform X1 [KO:K06226]
116102440  Kif7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
116103950  Sufu; suppressor of fused homolog isoform X1 [KO:K06229]
116076410  Gli1; zinc finger protein GLI1 isoform X1 [KO:K16797]
116097764  Gli2; zinc finger protein GLI2 isoform X1 [KO:K16798]
116081632  Gli3; transcriptional activator GLI3 isoform X1 [KO:K06230]
116090993  Bmp2; bone morphogenetic protein 2 [KO:K21283]
116084889  Bmp4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
116069635  Hhip; hedgehog-interacting protein [KO:K06231]
116096489  Ptch2; protein patched homolog 2 isoform X1 [KO:K11101]
116088782  Ar; androgen receptor [KO:K08557]
116074367  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
116081114  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
116075702  Hsp90b1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
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pathway
mcoc03320  PPAR signaling pathway
mcoc04010  MAPK signaling pathway
mcoc04020  Calcium signaling pathway
mcoc04024  cAMP signaling pathway
mcoc04060  Cytokine-cytokine receptor interaction
mcoc04066  HIF-1 signaling pathway
mcoc04110  Cell cycle
mcoc04115  p53 signaling pathway
mcoc04150  mTOR signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04210  Apoptosis
mcoc04310  Wnt signaling pathway
mcoc04330  Notch signaling pathway
mcoc04340  Hedgehog signaling pathway
mcoc04350  TGF-beta signaling pathway
mcoc04370  VEGF signaling pathway
mcoc04510  Focal adhesion
mcoc04512  ECM-receptor interaction
mcoc04520  Adherens junction
mcoc04630  JAK-STAT signaling pathway
mcoc04915  Estrogen signaling pathway
KO pathway
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