KEGG   PATHWAY: mlf05200
Entry
mlf05200                    Pathway                                
Name
Pathways in cancer - Myotis lucifugus (little brown bat)
Class
Human Diseases; Cancer: overview
Pathway map
mlf05200  Pathways in cancer
mlf05200

Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102438419  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
102428235  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
102438518  APPL1; DCC-interacting protein 13-alpha isoform X1 [KO:K08733]
102430843  CDH1; cadherin-1 isoform X2 [KO:K05689]
102441147  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102438484  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
102439453  CTNNA2; catenin alpha-2 isoform X4 [KO:K05691]
102420650  CTNNA3; catenin alpha-3 [KO:K05691]
102421524  AXIN1; axin-1 isoform X1 [KO:K02157]
102432404  AXIN2; axin-2 [KO:K04385]
102438347  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
102420488  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
102428794  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
102433022  TCF7; transcription factor 7 isoform X4 [KO:K02620]
102417756  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102428683  TCF7L2; transcription factor 7-like 2 isoform X5 [KO:K04491]
102439262  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
102439527  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
102427260  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
102426511  MYC; myc proto-oncogene protein [KO:K04377]
102441858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
102433775  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102417121  WNT2; protein Wnt-2 [KO:K00182]
102440610  WNT2B; LOW QUALITY PROTEIN: protein Wnt-2b [KO:K00182]
102429304  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102422483  WNT5A; protein Wnt-5a [KO:K00444]
102436468  WNT5B; protein Wnt-5b [KO:K00444]
102420490  WNT6; protein Wnt-6 [KO:K00445]
102440256  WNT7A; protein Wnt-7a [KO:K00572]
102417803  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
102427177  WNT8B; protein Wnt-8b [KO:K00714]
102427165  WNT9A; protein Wnt-9a [KO:K01064]
102417616  WNT9B; protein Wnt-9b [KO:K01064]
102425605  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
102436360  WNT10B; protein Wnt-10b [KO:K01357]
102429600  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102440107  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
102438581  FZD1; frizzled-1 [KO:K02432]
102433622  FZD7; frizzled-7 [KO:K02432]
102437539  FZD3; frizzled-3 isoform X1 [KO:K02329]
102432960  FZD4; frizzled-4 isoform X1 [KO:K02354]
102429852  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102420951  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
102442257  FZD6; frizzled-6 [KO:K02376]
102435819  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
102427391  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102423336  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
102424701  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102419260  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
102425438  proto-oncogene FRAT1 [KO:K03069]
102428075  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
102429375  AGT; angiotensinogen [KO:K09821]
102421923  F2R; proteinase-activated receptor 1 [KO:K03914]
102427056  F2RL3; LOW QUALITY PROTEIN: proteinase-activated receptor 4 [KO:K04236]
102418229  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
102420275  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102417048  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
102443146  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102423544  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102435690  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102418550  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102436989  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X2 [KO:K04639]
102438169  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102432130  ARHGEF11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
102440463  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
102435919  PLEKHG5; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family G member 5 [KO:K19464]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102430746  transforming protein RhoA-like isoform X1 [KO:K04513]
102419225  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102431516  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102416999  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102427675  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102427230  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102429580  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102431273  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102420060  PTGER1; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP1 subtype [KO:K04258]
102442700  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
102442487  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
102437889  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102428502  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X11 [KO:K04632]
102433989  neuroendocrine secretory protein 55-like [KO:K04632]
102430354  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
102442682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102417969  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102425254  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102433159  ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102423495  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102422477  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102437773  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102417960  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102420431  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102420482  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102428334  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
102431535  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
102420203  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
102441805  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102442437  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102428001  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
102422498  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106697041  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102432910  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102431853  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102432692  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
102420164  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
102419751  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102428769  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
102428453  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102420284  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102443143  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102416916  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102436659  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102426930  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102421945  LAMA5; laminin subunit alpha-5 [KO:K06240]
106694687  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
102434140  LAMA3; laminin subunit alpha-3 [KO:K06240]
102434037  LAMA4; laminin subunit alpha-4 [KO:K06241]
102438476  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102420016  LAMB3; laminin subunit beta-3 [KO:K06244]
102438166  LAMB4; laminin subunit beta-4 [KO:K06245]
102419814  LAMC1; laminin subunit gamma-1 [KO:K05635]
102438305  LAMC2; laminin subunit gamma-2 [KO:K06246]
102434681  LAMC3; laminin subunit gamma-3 [KO:K06247]
102433247  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102428304  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102435750  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102422347  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102426307  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
102424236  RELA; transcription factor p65 [KO:K04735]
102423775  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102424107  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102432611  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
102424628  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102424316  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102436922  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102443091  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102441839  TRAF1; TNF receptor-associated factor 1 isoform X3 [KO:K03172]
102420724  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102432859  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
102436664  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102436804  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102434974  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102429245  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
102433676  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102432268  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
102416898  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102431418  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102429961  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102439094  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
102433845  ABL1; LOW QUALITY PROTEIN: tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
102440736  CRK; adapter molecule crk isoform X1 [KO:K04438]
102420269  CRKL; crk-like protein isoform X1 [KO:K04438]
102420957  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
102423996  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
102424720  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102438580  PIM1; LOW QUALITY PROTEIN: serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
102429522  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
102431641  KNG1; kininogen-1 [KO:K03898]
102432691  kininogen-1-like [KO:K03898]
111825105  kininogen-1-like [KO:K03898]
102433011  kininogen-1 [KO:K03898]
102442936  kininogen-2-like [KO:K03898]
102441373  kininogen-1-like [KO:K03898]
102432377  kininogen-1-like [KO:K03898]
102429917  EDN1; endothelin-1 [KO:K16366]
102425270  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
102424220  BDKRB2; B2 bradykinin receptor [KO:K03916]
102437634  EDNRA; endothelin-1 receptor [KO:K04197]
102436123  EDNRB; endothelin receptor type B [KO:K04198]
102424688  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102424028  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102432706  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102438291  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102432440  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102429686  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102441813  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102433200  IL2; interleukin-2 [KO:K05429]
106699073  interleukin-3-like [KO:K04736]
102437928  IL4; interleukin-4 [KO:K05430]
102430773  IL5; interleukin-5 [KO:K05428]
102431882  IL6; interleukin-6 [KO:K05405]
102418120  IL7; interleukin-7 isoform X1 [KO:K05431]
102431058  IL12A; interleukin-12 subunit alpha [KO:K05406]
102435627  IL12B; interleukin-12 subunit beta [KO:K05425]
102437628  IL13; LOW QUALITY PROTEIN: interleukin-13 [KO:K05435]
102425482  IL15; interleukin-15 isoform X1 [KO:K05433]
102431172  IL23A; interleukin-23 subunit alpha [KO:K05426]
102419335  EPO; erythropoietin isoform X1 [KO:K05437]
102438946  IFNG; interferon gamma [KO:K04687]
102427118  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102420320  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
102441989  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102423070  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
102436222  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102424341  IL5RA; LOW QUALITY PROTEIN: interleukin-5 receptor subunit alpha [KO:K05067]
102438125  IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
102441934  interleukin-6 receptor subunit beta-like [KO:K05060]
102443066  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
102426075  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102421801  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
102425026  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
102435881  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
102443288  IL15RA; interleukin-15 receptor subunit alpha isoform X7 [KO:K05074]
102424709  IL23R; interleukin-23 receptor [KO:K05065]
102441273  EPOR; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
102427197  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
102419381  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
102440031  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
102422535  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102416924  EML4; echinoderm microtubule-associated protein-like 4 isoform X2 [KO:K15420]
102423499  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
102440792  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102427498  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
102420246  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102439442  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
102442353  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102420466  JAK2; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102428976  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102422489  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102424662  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
102430852  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102424971  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
102419724  STAT6; signal transducer and activator of transcription 6 isoform X2 [KO:K11225]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102421300  PGF; placenta growth factor isoform X1 [KO:K16859]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102434624  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102427788  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102416825  KITLG; kit ligand isoform X6 [KO:K05461]
102442787  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
102420687  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102439118  fibroblast growth factor 21-like [KO:K22429]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102420799  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
102435241  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102437415  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102417433  FOS; proto-oncogene c-Fos [KO:K04379]
102437429  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
102426724  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
102432629  LOW QUALITY PROTEIN: interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
102418715  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
102417294  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102428495  CXCL8; interleukin-8 [KO:K10030]
102431798  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102431961  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102420377  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102429398  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
102420999  NCOA4; nuclear receptor coactivator 4 isoform X1 [KO:K09289]
102431497  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102439438  TPM3; tropomyosin alpha-3 chain isoform X3 [KO:K09290]
102423081  TPR; nucleoprotein TPR [KO:K09291]
102422309  TFG; protein TFG isoform X2 [KO:K09292]
102422877  RASSF1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
102442160  RASSF5; ras association domain-containing protein 5 [KO:K08015]
102429707  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102434407  DAPK2; death-associated protein kinase 2 isoform X2 [KO:K08803] [EC:2.7.11.1]
102422068  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
102420311  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
102421330  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102420000  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
102419846  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102430787  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102417912  calmodulin-A-like isoform X1 [KO:K02183]
102419493  calmodulin-like protein 3 [KO:K02183]
102419808  calmodulin-like protein 5 [KO:K02183]
102426645  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102434863  CALM1; calmodulin-1 [KO:K02183]
102440407  calmodulin-like [KO:K02183]
102443136  calmodulin-like [KO:K02183]
102428043  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
102427134  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
102440347  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102418938  ral guanine nucleotide dissociation stimulator [KO:K08732]
102432493  RALA; ras-related protein Ral-A [KO:K07834]
102417752  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
102425126  RALBP1; LOW QUALITY PROTEIN: ralA-binding protein 1 [KO:K08773]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102443088  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
102423031  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
102430582  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102418507  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102429550  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
102435787  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
102430829  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102442015  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
102437396  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
102425322  RARB; retinoic acid receptor beta isoform X1 [KO:K08528]
102440234  ESR1; estrogen receptor [KO:K08550]
102427484  ESR2; estrogen receptor beta isoform X1 [KO:K08551]
102443319  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
102432954  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
102419937  SP1; transcription factor Sp1 [KO:K04684]
102434857  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
102421982  JUP; junction plakoglobin isoform X1 [KO:K10056]
102442374  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
102429033  RARA; retinoic acid receptor alpha [KO:K08527]
102442533  CCNA2; cyclin-A2 [KO:K06627]
102427709  CCNA1; cyclin-A1 [KO:K06627]
102430294  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102436751  RUNX1; runt-related transcription factor 1 [KO:K08367]
102429918  RUNX1T1; protein CBFA2T1 [KO:K10053]
102427246  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102442629  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102419422  cyclin-dependent kinase inhibitor 2A [KO:K06621]
102421766  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
102418995  E2F2; transcription factor E2F2 [KO:K09389]
102422093  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102422986  MAX; protein max isoform X1 [KO:K04453]
102430174  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X8 [KO:K10500]
102442800  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
102430068  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102422703  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102435083  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102430026  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
102434766  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
102432509  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102421559  CUL1; cullin-1 isoform X1 [KO:K03347]
102431403  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102429293  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
102440300  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102431579  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102429544  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102436007  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
102428736  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102427327  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
102429644  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102417074  BAX; apoptosis regulator BAX [KO:K02159]
102437326  BAK1; LOW QUALITY PROTEIN: bcl-2 homologous antagonist/killer [KO:K14021]
102422583  DDB2; DNA damage-binding protein 2 [KO:K10140]
102435990  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
102424129  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
102428391  MITF; microphthalmia-associated transcription factor isoform X2 [KO:K09455]
102435068  TGFB1; transforming growth factor beta-1 [KO:K13375]
102431488  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
102441450  TGFB3; transforming growth factor beta-3 [KO:K13377]
102433176  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102434274  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102429768  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102427892  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102419263  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102424289  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
102420117  CTBP1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
102432907  CTBP2; LOW QUALITY PROTEIN: C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
102428494  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102425617  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
102431806  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
102430470  MSH2; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2 [KO:K08735]
102421502  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
102429143  MSH6; DNA mismatch repair protein Msh6 isoform X2 [KO:K08737]
102430585  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
102436269  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102433075  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111824600  FADD; FAS-associated death domain protein [KO:K02373]
102439369  CASP8; LOW QUALITY PROTEIN: caspase-8 [KO:K04398] [EC:3.4.22.61]
102423950  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102427214  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
102430812  BBC3; bcl-2-binding component 3 [KO:K10132]
102420929  cytochrome c-like [KO:K08738]
102436841  cytochrome c-like [KO:K08738]
102419640  cytochrome c [KO:K08738]
102424392  cytochrome c [KO:K08738]
102422013  cytochrome c-like [KO:K08738]
102421025  cytochrome c-like [KO:K08738]
102435183  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102430193  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102432374  KEAP1; kelch-like ECH-associated protein 1 isoform X2 [KO:K10456]
102437649  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
102435645  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
102429811  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
102421114  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
102430427  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102431070  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
102432189  glutathione S-transferase theta-1 isoform X3 [KO:K00799] [EC:2.5.1.18]
102432511  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
102432817  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
102431879  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
102424733  LOW QUALITY PROTEIN: glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
102441519  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
106695855  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
102441472  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102430748  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
102438019  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102424420  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
102427201  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102429409  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
102430222  glutathione S-transferase Mu 1 isoform X4 [KO:K00799] [EC:2.5.1.18]
102426861  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
102419761  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X2 [KO:K22182] [EC:1.8.1.9]
102428206  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
102434339  TXNRD3; thioredoxin reductase 3 isoform X2 [KO:K22182] [EC:1.8.1.9]
102423240  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
102434055  ELOC; elongin-C isoform X1 [KO:K03872]
102425640  ELOB; LOW QUALITY PROTEIN: elongin-B [KO:K03873]
102441704  CUL2; cullin-2 isoform X1 [KO:K03870]
102431340  EGLN3; egl nine homolog 3 [KO:K09592] [EC:1.14.11.29]
102423938  EGLN2; LOW QUALITY PROTEIN: egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
102425029  fumarate hydratase, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
102425195  FH; fumarate hydratase, mitochondrial isoform X1 [KO:K01679] [EC:4.2.1.2]
102436791  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
102434761  EPAS1; endothelial PAS domain-containing protein 1 isoform X4 [KO:K09095]
102440721  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
102430864  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102424403  CREBBP; CREB-binding protein isoform X4 [KO:K04498] [EC:2.3.1.48]
102424587  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
102418962  JAG1; protein jagged-1 isoform X1 [KO:K06052]
102418841  DLL1; LOW QUALITY PROTEIN: delta-like protein 1 [KO:K06051]
102440726  DLL3; LOW QUALITY PROTEIN: delta-like protein 3 [KO:K06051]
102438421  DLL4; delta-like protein 4 [KO:K06051]
106695521  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
102430236  NOTCH2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
102424223  NOTCH3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
102417036  HES1; LOW QUALITY PROTEIN: transcription factor HES-1 [KO:K06054]
102440048  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
102434913  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
102438851  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102424447  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
102424802  SMO; smoothened homolog isoform X1 [KO:K06226]
102426624  SUFU; suppressor of fused homolog [KO:K06229]
102439023  GLI1; zinc finger protein GLI1 [KO:K16797]
102431015  GLI3; LOW QUALITY PROTEIN: transcriptional activator GLI3 [KO:K06230]
102427988  BMP2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283]
102436795  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
102429631  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
102442277  PTCH2; protein patched homolog 2 [KO:K11101]
102427580  AR; androgen receptor isoform X1 [KO:K08557]
102419327  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102433810  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102422639  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
mlf03320  PPAR signaling pathway
mlf04010  MAPK signaling pathway
mlf04020  Calcium signaling pathway
mlf04024  cAMP signaling pathway
mlf04060  Cytokine-cytokine receptor interaction
mlf04066  HIF-1 signaling pathway
mlf04110  Cell cycle
mlf04115  p53 signaling pathway
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04210  Apoptosis
mlf04310  Wnt signaling pathway
mlf04330  Notch signaling pathway
mlf04340  Hedgehog signaling pathway
mlf04350  TGF-beta signaling pathway
mlf04370  VEGF signaling pathway
mlf04510  Focal adhesion
mlf04512  ECM-receptor interaction
mlf04520  Adherens junction
mlf04630  JAK-STAT signaling pathway
mlf04915  Estrogen signaling pathway
KO pathway
ko05200   
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