KEGG   PATHWAY: sara05200
Entry
sara05200                   Pathway                                
Name
Pathways in cancer - Sorex araneus (European shrew)
Class
Human Diseases; Cancer: overview
Pathway map
sara05200  Pathways in cancer
sara05200

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101552747  DCC; netrin receptor DCC [KO:K06765]
101539340  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101537803  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101546914  APPL1; DCC-interacting protein 13-alpha [KO:K08733]
101547461  CDH1; cadherin-1 [KO:K05689]
101538379  CTNNB1; catenin beta-1 [KO:K02105]
101545580  CTNNA1; catenin alpha-1 isoform X1 [KO:K05691]
101552254  protein humpback-1-like [KO:K05691]
101541202  CTNNA3; catenin alpha-3 [KO:K05691]
101549290  CTNNA2; catenin alpha-2 [KO:K05691]
101552077  AXIN1; axin-1 [KO:K02157]
101542438  AXIN2; axin-2 [KO:K04385]
101536960  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101550252  APC; adenomatous polyposis coli protein [KO:K02085]
101536841  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101540913  TCF7; transcription factor 7 [KO:K02620]
101550691  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101546297  TCF7L2; transcription factor 7-like 2 isoform X2 [KO:K04491]
101547696  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
101543114  BIRC5; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5 [KO:K08731]
101541387  MYC; myc proto-oncogene protein [KO:K04377]
101555422  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101557092  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101542782  WNT2B; protein Wnt-2b [KO:K00182]
101551266  WNT2; protein Wnt-2 [KO:K00182]
101557532  WNT3A; protein Wnt-3a [KO:K00312]
101538754  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101541062  WNT4; protein Wnt-4 [KO:K00408]
101545125  WNT5B; protein Wnt-5b [KO:K00444]
101544811  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101552930  WNT6; protein Wnt-6 [KO:K00445]
101551490  WNT7B; protein Wnt-7b [KO:K00572]
101557455  WNT7A; protein Wnt-7a [KO:K00572]
101544351  WNT8A; protein Wnt-8a [KO:K00714]
101537855  WNT8B; protein Wnt-8b [KO:K00714]
101548323  WNT9A; protein Wnt-9a [KO:K01064]
101550368  WNT9B; protein Wnt-9b [KO:K01064]
101557372  WNT10B; protein Wnt-10b [KO:K01357]
101540942  WNT10A; protein Wnt-10a [KO:K01357]
101537834  WNT11; protein Wnt-11 [KO:K01384]
101549154  WNT16; protein Wnt-16 [KO:K01558]
101544647  FZD7; frizzled-7 [KO:K02432]
101547645  FZD1; frizzled-1 [KO:K02432]
101545544  FZD2; frizzled-2 [KO:K02235]
101556188  FZD3; frizzled-3 [KO:K02329]
101539988  FZD4; frizzled-4 [KO:K02354]
101546854  FZD5; frizzled-5 [KO:K02375]
101548121  FZD6; frizzled-6 [KO:K02376]
101544648  FZD9; frizzled-9 [KO:K02842]
101556629  FZD10; frizzled-10 [KO:K02842]
101555586  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101545951  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101549958  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
101544146  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101541600  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101546501  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101553203  AGT; angiotensinogen [KO:K09821]
101544230  F2R; proteinase-activated receptor 1 [KO:K03914]
101559345  F2RL3; proteinase-activated receptor 4 [KO:K04236]
101548706  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101543935  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101538328  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101552106  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101543906  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105942807  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101537266  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101539799  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101539190  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
101550666  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
101541648  ARHGEF11; rho guanine nucleotide exchange factor 11 [KO:K12331]
101542367  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101545662  PLEKHG5; pleckstrin homology domain-containing family G member 5 [KO:K19464]
101544191  transforming protein RhoA [KO:K04513]
101557527  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
101540987  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
101539253  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101548656  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101547089  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101544375  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101538556  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101545200  guanine nucleotide-binding protein G(i) subunit alpha-like [KO:K04630]
101545636  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101557003  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101553999  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101547928  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101542741  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101539470  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
101557843  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101539413  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101547055  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101539776  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101551819  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101549131  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101543858  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101550559  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101551730  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101539926  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101555578  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101546696  cAMP-dependent protein kinase catalytic subunit-like [KO:K04345] [EC:2.7.11.11]
101554719  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
101542668  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101556740  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101547419  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101556046  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101542101  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101537346  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101539394  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101558836  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101548469  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101558565  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101551980  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101543392  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101540808  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101541335  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101552244  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101543125  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101537837  LAMA1; laminin subunit alpha-1 [KO:K05637]
101555992  LAMA2; laminin subunit alpha-2 [KO:K05637]
101550991  LAMA5; laminin subunit alpha-5 [KO:K06240]
101543985  LAMA3; laminin subunit alpha-3 [KO:K06240]
101537541  LAMA4; laminin subunit alpha-4 [KO:K06241]
101537613  LAMB1; laminin subunit beta-1 [KO:K05636]
101537850  LAMB2; laminin subunit beta-2 [KO:K06243]
101551415  LAMB3; laminin subunit beta-3 [KO:K06244]
101559369  LAMB4; laminin subunit beta-4 [KO:K06245]
101547700  laminin subunit gamma-1 [KO:K05635]
101538549  LAMC3; laminin subunit gamma-3 [KO:K06247]
101549777  FN1; fibronectin [KO:K05717]
101551216  ITGA2; integrin alpha-2 [KO:K06481]
101552061  ITGA2B; integrin alpha-IIb [KO:K06476]
101539335  ITGA3; integrin alpha-3 [KO:K06482]
101557845  ITGA6; integrin alpha-6 [KO:K06485]
101553309  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
101540720  ITGB1; integrin beta-1 [KO:K05719]
101540332  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101558235  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101538807  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101537233  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101543163  RELA; transcription factor p65 [KO:K04735]
101543763  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101548820  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101545820  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101546184  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101546443  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101549358  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101542397  bcl-2-like protein 1 isoform X1 [KO:K04570]
101558524  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101558533  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
101550002  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101538970  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101551642  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
101543216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101554656  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101553684  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101550456  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101549930  BAD; bcl2-associated agonist of cell death [KO:K02158]
101557018  FOXO1; forkhead box protein O1 [KO:K07201]
101546351  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101558045  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
101544887  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101543917  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101555682  BCR; breakpoint cluster region protein [KO:K08878] [EC:2.7.11.1]
101539877  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
101543637  CRK; adapter molecule crk isoform X1 [KO:K04438]
101547306  CRKL; crk-like protein [KO:K04438]
101548296  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101552631  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101552185  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101548795  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
101555372  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
101541147  KNG1; kininogen-1 [KO:K03898]
101538407  EDN1; endothelin-1 [KO:K16366]
101539989  BDKRB1; B1 bradykinin receptor [KO:K03915]
101539723  BDKRB2; B2 bradykinin receptor [KO:K03916]
101546450  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101538515  EDNRB; endothelin B receptor [KO:K04198]
101557809  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101544809  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
101551223  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101546811  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101547690  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101559179  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101547658  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
101539279  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101556429  IL2; interleukin-2 [KO:K05429]
101539338  IL4; interleukin-4 [KO:K05430]
101538806  IL5; interleukin-5 [KO:K05428]
101540363  IL6; interleukin-6 [KO:K05405]
101540970  IL7; interleukin-7 [KO:K05431]
101539403  IL12A; interleukin-12 subunit alpha [KO:K05406]
101542768  IL12B; interleukin-12 subunit beta [KO:K05425]
101539069  IL13; interleukin-13 [KO:K05435]
101547946  IL15; interleukin-15 [KO:K05433]
101548978  IL23A; interleukin-23 subunit alpha [KO:K05426]
101546751  EPO; erythropoietin [KO:K05437]
101549593  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
101540972  IFNG; interferon gamma [KO:K04687]
101546623  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101540128  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101545374  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101557640  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101538809  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
101555492  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101551921  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101554650  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101552662  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
101540292  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
101542064  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101546365  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101540550  IL23R; interleukin-23 receptor [KO:K05065]
101545876  EPOR; erythropoietin receptor [KO:K05079]
101558656  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101559190  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101546718  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101558386  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101537319  EML4; echinoderm microtubule-associated protein-like 4 [KO:K15420]
101552411  ALK; ALK tyrosine kinase receptor [KO:K05119] [EC:2.7.10.1]
101549191  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
101552845  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101544723  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
101550382  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101556525  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101550196  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101553455  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101552896  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101554357  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101550386  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101554621  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
101554096  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101548477  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
101549227  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101557525  PGF; placenta growth factor [KO:K16859]
101539272  VEGFC; vascular endothelial growth factor C [KO:K05449]
101552026  FIGF; vascular endothelial growth factor D [KO:K05449]
101553872  TGFA; protransforming growth factor alpha [KO:K08774]
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101540816  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101545086  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101547238  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101539850  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101540263  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101554190  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
101545641  IGF2; insulin-like growth factor II [KO:K13769]
101549049  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101540449  KITLG; kit ligand isoform X2 [KO:K05461]
101547411  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
101541560  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101545300  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101546946  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101552331  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101548050  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101555369  FGF2; fibroblast growth factor 2 [KO:K18497]
101545481  FGF10; fibroblast growth factor 10 [KO:K04358]
101552920  FGF5; fibroblast growth factor 5 [KO:K04358]
101537046  FGF22; fibroblast growth factor 22 [KO:K04358]
101546702  FGF9; fibroblast growth factor 9 [KO:K04358]
101549380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101552994  FGF20; fibroblast growth factor 20 [KO:K04358]
101542138  FGF6; fibroblast growth factor 6 [KO:K04358]
101540672  FGF8; fibroblast growth factor 8 [KO:K04358]
101551840  FGF18; fibroblast growth factor 18 [KO:K04358]
101550339  FGF16; fibroblast growth factor 16 [KO:K04358]
101555290  FGF7; fibroblast growth factor 7 [KO:K04358]
101558816  FGF4; fibroblast growth factor 4 [KO:K04358]
101559085  FGF3; fibroblast growth factor 3 [KO:K04358]
101558545  FGF19; fibroblast growth factor 19 [KO:K22603]
101539900  FGF21; fibroblast growth factor 21 [KO:K22429]
101538903  FGF23; fibroblast growth factor 23 [KO:K22428]
101544250  FGFR1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
101555338  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101551516  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101539433  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101554406  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101541191  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
101545391  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101540694  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101545527  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101559441  CXCL8; interleukin-8 [KO:K10030]
101559274  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101545755  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101547575  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101553371  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
101548488  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
101540859  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101549588  TPM3; tropomyosin alpha-3 chain isoform X2 [KO:K09290]
101544270  TPR; nucleoprotein TPR [KO:K09291]
101550587  TFG; protein TFG isoform X1 [KO:K09292]
101559163  RASSF1; ras association domain-containing protein 1 isoform X3 [KO:K09850]
101552636  RASSF5; ras association domain-containing protein 5 [KO:K08015]
101540309  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101555849  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
101542780  DAPK2; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
101541652  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
101545860  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101554088  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101555656  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101554401  CALM1; calmodulin isoform X1 [KO:K02183]
101552535  CALML3; calmodulin-like protein 3 [KO:K02183]
101545302  CALML5; calmodulin-like protein 5 [KO:K02183]
101546941  CALML4; calmodulin-like protein 4 [KO:K02183]
101541555  CALM2; calmodulin [KO:K02183]
101543973  calmodulin-like [KO:K02183]
101559307  CALM3; calmodulin [KO:K02183]
101545625  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101542258  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101549665  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101549827  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101554760  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
101550569  ras-related protein O-RAL-like [KO:K07834]
101556703  RALA; ras-related protein Ral-A [KO:K07834]
101550413  RALB; ras-related protein Ral-B [KO:K07835]
101536860  RALBP1; ralA-binding protein 1 [KO:K08773]
101540617  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101555118  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101553997  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101538228  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101550489  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101549982  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
101544894  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101553357  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101542702  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101549211  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
101549877  RARB; retinoic acid receptor beta isoform X2 [KO:K08528]
101543178  ESR1; estrogen receptor [KO:K08550]
101555024  ESR2; estrogen receptor beta [KO:K08551]
101552369  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
101550023  NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48]
101550205  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
101556204  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
101555990  JUP; junction plakoglobin [KO:K10056]
101541682  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
101542943  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
101553498  CCNA1; cyclin-A1 [KO:K06627]
101556698  CCNA2; cyclin-A2 [KO:K06627]
101549024  PML; protein PML [KO:K10054] [EC:2.3.2.-]
101541108  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
101546348  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
101548532  SPI1; transcription factor PU.1 [KO:K09438]
101553119  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
101554763  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101544839  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101551169  LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
101555654  E2F1; transcription factor E2F1 [KO:K17454]
101544935  E2F2; transcription factor E2F2 [KO:K09389]
101554854  MAX; protein max [KO:K04453]
101551276  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
101538844  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101556590  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101541876  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101541507  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101558065  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101545316  CUL1; cullin-1 [KO:K03347]
101542238  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101554111  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
101554118  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
101544122  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101542272  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101550200  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101548470  RB1; retinoblastoma-associated protein [KO:K06618]
101542690  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101549691  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101552620  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101540951  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101538133  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101555848  DDB2; DNA damage-binding protein 2 [KO:K10140]
101539964  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
101541050  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101550863  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
101551346  TGFB1; transforming growth factor beta-1 [KO:K13375]
101549205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101546290  TGFB3; transforming growth factor beta-3 [KO:K13377]
101537676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101553495  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101547889  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101544572  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
101552483  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101556018  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
101548868  CTBP1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
101551423  CTBP2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
101555781  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101538340  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101538240  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
101546042  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
101541291  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
101543587  MSH3; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh3 [KO:K08736]
101543430  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
101541067  BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
101552281  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
101537769  FADD; FAS-associated death domain protein [KO:K02373]
101543078  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101546492  BID; BH3-interacting domain death agonist [KO:K04726]
101547642  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
101554035  BBC3; bcl-2-binding component 3 [KO:K10132]
101546719  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101558408  cytochrome c, somatic [KO:K08738]
101538879  cytochrome c-like [KO:K08738]
101549686  cytochrome c, somatic [KO:K08738]
101543860  cytochrome c 2 [KO:K08738]
101537432  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101536946  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101540674  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101542637  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101552548  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
101542092  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
101548683  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101545361  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101545806  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101546243  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101546676  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101547102  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101547538  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101539867  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101558495  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101559037  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101559303  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101546536  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
101548751  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
101552024  GSTO1; glutathione S-transferase omega-1 isoform X3 [KO:K00799] [EC:2.5.1.18]
101551022  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101557519  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101558058  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
101543479  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101543744  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101557248  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101557792  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101553461  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
101553725  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101551013  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
101553599  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
101543540  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
101538124  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
101555774  TCEB1; transcription elongation factor B polypeptide 1 [KO:K03872]
101557326  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
101554203  CUL2; cullin-2 [KO:K03870]
101554353  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
101554704  EGLN2; egl nine homolog 2 [KO:K09592] [EC:1.14.11.29]
101555023  EGLN3; egl nine homolog 3 isoform X1 [KO:K09592] [EC:1.14.11.29]
101551698  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
101538909  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101557450  EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095]
101553552  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101550019  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
101542504  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101558222  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101542959  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101544356  JAG1; protein jagged-1 [KO:K06052]
101558136  JAG2; protein jagged-2 [KO:K21635]
101554841  DLL4; delta-like protein 4 [KO:K06051]
101546403  DLL1; delta-like protein 1 [KO:K06051]
101554874  DLL3; delta-like protein 3 [KO:K06051]
101545240  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
101554690  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
101544106  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
101551978  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
101555081  HES1; transcription factor HES-1 [KO:K06054]
101552428  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X2 [KO:K09091]
101543139  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
101551321  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
101549127  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101553644  SHH; sonic hedgehog protein [KO:K11988]
101552783  PTCH1; protein patched homolog 1 [KO:K06225]
101540551  SMO; smoothened homolog [KO:K06226]
101546664  KIF7; LOW QUALITY PROTEIN: kinesin-like protein KIF7 [KO:K18806]
101558093  SUFU; suppressor of fused homolog [KO:K06229]
101555602  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101541171  GLI2; zinc finger protein GLI2 [KO:K16798]
101559222  GLI3; transcriptional activator GLI3 [KO:K06230]
101548404  BMP2; bone morphogenetic protein 2 [KO:K21283]
101540080  BMP4; bone morphogenetic protein 4 [KO:K04662]
101549011  HHIP; hedgehog-interacting protein [KO:K06231]
101559015  PTCH2; protein patched homolog 2 [KO:K11101]
101554950  AR; androgen receptor [KO:K08557]
101538241  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
101549543  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
101555614  HSP90B1; LOW QUALITY PROTEIN: endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
PMID:10647931
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
PMID:15000146
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
PMID:16555243
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
PMID:11078609
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
PMID:16699851
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
PMID:12621137
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
PMID:12951588
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
PMID:10505543
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
PMID:16042571
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
PMID:15349822
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
PMID:12737309
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
PMID:11459867
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
PMID:15573119
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
PMID:15310786
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
PMID:11223406
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
PMID:15711891
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
PMID:11170304
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Microsc Res Tech 52:450-7 (2001)
DOI:10.1002/1097-0029(20010215)52:4<450::AID-JEMT1030>3.0.CO;2-O
Reference
PMID:16326109
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
PMID:15479695
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
PMID:11477132
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
PMID:12459728
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
PMID:11407945
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
PMID:12946833
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
PMID:16702400
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
PMID:10740269
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
PMID:12648469
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:14586404
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
PMID:12545153
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
PMID:14580692
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
PMID:12079267
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
PMID:15774796
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
PMID:15823750
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
PMID:11707511
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
PMID:15639402
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
PMID:12154354
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
PMID:11253051
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
PMID:16700615
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
PMID:12762887
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
PMID:16095998
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
PMID:11057895
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
PMID:12084351
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:16551846
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:17062879
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
PMID:16242838
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
PMID:16189702
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
PMID:11165748
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
PMID:12094241
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12563308
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
PMID:16146838
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:16642045
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
PMID:15625120
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
PMID:11721960
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
PMID:12468433
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
PMID:17554387
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
PMID:16352814
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
PMID:15719031
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
PMID:11071626
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
PMID:14982876
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
PMID:10403855
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
PMID:15156182
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
PMID:16484590
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
PMID:12801837
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
PMID:11160144
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
PMID:12244301
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
PMID:15948971
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
PMID:12588368
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
PMID:15978322
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
PMID:15468170
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
PMID:16881963
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
PMID:16306523
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
PMID:11276000
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
J Pathol 193:427-32 (2001)
DOI:10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
Reference
PMID:15270885
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
PMID:14737121
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
PMID:15656799
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
PMID:14556242
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
PMID:11736900
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
PMID:16054233
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
PMID:11130178
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16750612
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
PMID:15841168
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
PMID:16001050
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
PMID:16001072
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
PMID:16899407
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
PMID:15009714
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
PMID:11224709
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
PMID:15721476
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:15557758
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
PMID:10843728
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
PMID:16339096
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
PMID:15122209
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
PMID:14634372
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:15611513
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
PMID:17211469
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
PMID:17287871
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
PMID:12351585
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
PMID:17158541
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:11103787
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
PMID:12850530
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:15746962
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
PMID:15551095
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:15724144
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:15082523
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
PMID:10835690
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:11750244
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
PMID:11527574
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12711111
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
PMID:11720739
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
PMID:12616528
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
PMID:11807782
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
PMID:16064138
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
PMID:11463388
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
PMID:15109562
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
PMID:11559746
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
PMID:11905738
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
PMID:12243753
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
PMID:12379883
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
PMID:12741677
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
PMID:16870043
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
PMID:15948711
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
PMID:11902573
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
PMID:10944551
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
PMID:12867060
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
PMID:16112428
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
PMID:12407699
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
PMID:15942304
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
PMID:11895903
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
PMID:16189154
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
PMID:21193867
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
PMID:24508914
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
PMID:17251915
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
sara03320  PPAR signaling pathway
sara04010  MAPK signaling pathway
sara04020  Calcium signaling pathway
sara04024  cAMP signaling pathway
sara04060  Cytokine-cytokine receptor interaction
sara04066  HIF-1 signaling pathway
sara04110  Cell cycle
sara04115  p53 signaling pathway
sara04150  mTOR signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04210  Apoptosis
sara04310  Wnt signaling pathway
sara04330  Notch signaling pathway
sara04340  Hedgehog signaling pathway
sara04350  TGF-beta signaling pathway
sara04370  VEGF signaling pathway
sara04510  Focal adhesion
sara04512  ECM-receptor interaction
sara04520  Adherens junction
sara04630  JAK-STAT signaling pathway
sara04915  Estrogen signaling pathway
KO pathway
ko05200   
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