Entry
Name
Pathways in cancer - Marmota marmota marmota (Alpine marmot)
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
Ortholog table
Organism
Marmota marmota marmota (Alpine marmot) [GN:
mmma ]
Gene
107157407 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
125610369 Birc5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731 ]
107152668 Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
107157026 Lrp5; low-density lipoprotein receptor-related protein 5 isoform X2 [KO:K03068 ]
107155457 Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
107154316 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
107157968 Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
107158364 Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639 ]
107156669 Arhgef11; rho guanine nucleotide exchange factor 11 isoform X7 [KO:K12331 ]
107151403 Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330 ]
107155550 Plekhg5; pleckstrin homology domain-containing family G member 5 isoform X2 [KO:K19464 ]
107143459 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
107144582 Gnai1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
107158616 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
107138275 Ptger2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259 ]
107146416 Ptger3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260 ]
107137583 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
107155582 Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
107147087 Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
107154943 Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825 ]
107149461 Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538 ]
107137620 Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
107143498 Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
107135927 Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
107157965 Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
107158288 Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
107143532 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
107157268 Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
107151728 Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
107141225 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
107144757 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
107149406 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
107151942 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545 ]
107145232 Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
107146407 Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
107146761 Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
107134493 guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548 ]
107150476 Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
107143149 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107149519 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107155522 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107139438 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
107141811 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
107145061 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
107141352 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
107149833 Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469 ]
107145910 Birc3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060 ]
107148893 Birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061 ]
107150571 Stat5a; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
107150572 signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
107148216 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
107157430 Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
107135966 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107138232 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
107139886 Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
107146879 Il4r; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071 ]
107151121 Il7r; LOW QUALITY PROTEIN: interleukin-7 receptor subunit alpha [KO:K05072 ]
107141672 Il12rb2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064 ]
107150213 Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
107137329 Eml4; echinoderm microtubule-associated protein-like 4 isoform X2 [KO:K15420 ]
107150570 Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
107138551 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
107140168 Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
107138552 Stat4; signal transducer and activator of transcription 4 [KO:K11222 ]
107140146 Stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
107143955 Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
107135964 Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858 ]
107141390 Egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
107151249 Flt3lg; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454 ]
107143448 Rassf1; ras association domain-containing protein 1 isoform X2 [KO:K09850 ]
107140609 Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
107150868 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
107137985 Calml4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
107141405 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515 ] [EC:2.7.11.17 ]
107142680 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107146068 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107158156 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
107151971 Ralgds; ral guanine nucleotide dissociation stimulator isoform X6 [KO:K08732 ]
107142153 Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
107155970 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
107150087 Pparg; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530 ]
107143792 Rxrb; LOW QUALITY PROTEIN: retinoic acid receptor RXR-beta [KO:K08525 ]
107143827 Ppard; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504 ]
107145845 Zbtb16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055 ]
107136457 Runx1; runt-related transcription factor 1 isoform X2 [KO:K08367 ]
107160206 granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
107160207 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
107141944 Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
107142205 Zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500 ]
125612843 LOW QUALITY PROTEIN: cyclin-dependent kinases regulatory subunit 2-like [KO:K02219 ]
107146405 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
107157267 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
107157608 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
107150120 Mitf; microphthalmia-associated transcription factor isoform X3 [KO:K09455 ]
107140543 Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
107139517 Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500 ]
107137992 Smad3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605 ]
107139501 Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
107140779 Brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775 ]
107147374 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
107153328 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
125617707 Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
125618140 LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738 ]
107139684 Apaf1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084 ]
107145182 Keap1; kelch-like ECH-associated protein 1 isoform X1 [KO:K10456 ]
107136946 Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638 ]
107137310 Epas1; endothelial PAS domain-containing protein 1 isoform X2 [KO:K09095 ]
107156832 Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097 ]
107148324 Arnt2; aryl hydrocarbon receptor nuclear translocator 2 isoform X7 [KO:K15589 ]
107141876 Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
107143763 Notch4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996 ]
107142464 Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091 ]
107141493 Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091 ]
107155148 Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
107145218 Bmp2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283 ]
Compound
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Reference
Authors
Weinberg RA.
Title
The biology of cancer
Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
Authors
Hanahan D, Weinberg RA
Title
The hallmarks of cancer.
Journal
Reference
Authors
Grady WM.
Title
Genomic instability and colon cancer.
Journal
Reference
Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
Title
Microsatellite instability in colorectal cancer.
Journal
Reference
Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
Title
Hereditary non-polyposis colorectal cancer: an updated review.
Journal
Reference
Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
Title
Colorectal cancer: genetics of development and metastasis.
Journal
Reference
Authors
Lynch HT, de la Chapelle A.
Title
Hereditary colorectal cancer.
Journal
Reference
Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
Title
The significance of unstable chromosomes in colorectal cancer.
Journal
Reference
Authors
Behrens J.
Title
Cadherins and catenins: role in signal transduction and tumor progression.
Journal
Reference
Authors
Behrens J.
Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
Journal
Reference
Authors
Behrens J, Lustig B.
Title
The Wnt connection to tumorigenesis.
Journal
Reference
Authors
Polakis P.
Title
The adenomatous polyposis coli (APC) tumor suppressor.
Journal
Reference
Authors
Janssen KP.
Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Journal
Reference
Authors
Adjei AA.
Title
Blocking oncogenic Ras signaling for cancer therapy.
Journal
Reference
Authors
Arakawa H.
Title
Netrin-1 and its receptors in tumorigenesis.
Journal
Reference
Authors
Mehlen P, Fearon ER.
Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
Journal
Reference
Authors
Peltomaki P.
Title
DNA mismatch repair and cancer.
Journal
Reference
Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
Title
TGF-beta signaling in colon cancer cells.
Journal
Reference
Authors
Roman C, Saha D, Beauchamp R.
Title
TGF-beta and colorectal carcinogenesis.
Journal
Reference
Authors
Watson AJ.
Title
An overview of apoptosis and the prevention of colorectal cancer.
Journal
Reference
Authors
Watson AJ.
Title
Apoptosis and colorectal cancer.
Journal
Reference
Authors
Houlston RS.
Title
What we could do now: molecular pathology of colorectal cancer.
Journal
Reference
Authors
Von Hoff D, Evans D, Hruban R (ed).
Title
Pancreatic cancer
Journal
Jones and Bartlett publishers (2005)
Reference
Authors
Niitsu Y, Yokota J (ed).
Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
Journal
Nankodo (1999)
Reference
Authors
Bardeesy N, DePinho RA.
Title
Pancreatic cancer biology and genetics.
Journal
Reference
Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
Journal
Reference
Authors
Cowgill SM, Muscarella P.
Title
The genetics of pancreatic cancer.
Journal
Reference
Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
Title
Genetics and biology of pancreatic ductal adenocarcinoma.
Journal
Reference
Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
Title
Understanding Ras: 'it ain't over 'til it's over'.
Journal
Reference
Authors
Holbro T, Civenni G, Hynes NE.
Title
The ErbB receptors and their role in cancer progression.
Journal
Reference
Authors
Marmor MD, Skaria KB, Yarden Y.
Title
Signal transduction and oncogenesis by ErbB/HER receptors.
Journal
Reference
Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
Journal
Reference
Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
Journal
Reference
Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
Journal
Reference
Authors
Schmid RM.
Title
Genetic basis of pancreatic cancer.
Journal
Reference
Authors
Elliott RL, Blobe GC.
Title
Role of transforming growth factor Beta in human cancer.
Journal
Reference
Authors
Rudkin TM, Foulkes WD.
Title
BRCA2: breaks, mistakes and failed separations.
Journal
Reference
Authors
Venkitaraman AR.
Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
Journal
J Cell Sci 114:3591-8 (2001)
Reference
Authors
Soni D, King JA, Kaye AH, Hovens CM.
Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
Journal
Reference
Authors
Zhu Y, Parada LF.
Title
The molecular and genetic basis of neurological tumours.
Journal
Reference
Authors
Holland EC.
Title
Gliomagenesis: genetic alterations and mouse models.
Journal
Reference
Authors
Bansal K, Liang ML, Rutka JT.
Title
Molecular biology of human gliomas.
Journal
Reference
Authors
Tabuchi K (ed).
Title
[Gliomas: Research and therapy] (In Japanese)
Journal
Springer-Verlag Tokyo (2006)
Reference
Authors
Kapoor GS, O'Rourke DM.
Title
Mitogenic signaling cascades in glial tumors.
Journal
Reference
Authors
Hulleman E, Helin K.
Title
Molecular mechanisms in gliomagenesis.
Journal
Reference
Authors
Schlessinger J.
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Ng HK, Lam PY.
Title
The molecular genetics of central nervous system tumors.
Journal
Reference
Authors
Knobbe CB, Merlo A, Reifenberger G.
Title
Pten signaling in gliomas.
Journal
Reference
Authors
Kondo T, Ezzat S, Asa SL.
Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Journal
Reference
Authors
Chiloeches A, Marais R.
Title
Is BRAF the Achilles' Heel of thyroid cancer?
Journal
Reference
Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
Journal
Reference
Authors
Santoro M, Melillo RM, Fusco A.
Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Journal
Reference
Authors
Pierotti MA, Greco A.
Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
Journal
Reference
Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
Title
Molecular pathology of well-differentiated thyroid carcinomas.
Journal
Reference
Authors
Gimm O.
Title
Thyroid cancer.
Journal
Reference
Authors
Williams D.
Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
Journal
Reference
Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
Title
The molecular pathogenesis of acute myeloid leukemia.
Journal
Reference
Authors
Tenen DG.
Title
Disruption of differentiation in human cancer: AML shows the way.
Journal
Reference
Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
Title
Signal transduction of oncogenic Flt3.
Journal
Reference
Authors
Stirewalt DL, Radich JP.
Title
The role of FLT3 in haematopoietic malignancies.
Journal
Reference
Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
Journal
Reference
Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
Journal
Reference
Authors
Lorsbach RB, Downing JR.
Title
The role of the AML1 transcription factor in leukemogenesis.
Journal
Reference
Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
Journal
Reference
Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
Journal
Reference
Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
Journal
Reference
Authors
Ren R.
Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
Journal
Reference
Authors
Deininger MW, Goldman JM, Melo JV.
Title
The molecular biology of chronic myeloid leukemia.
Journal
Blood 96:3343-56 (2000)
Reference
Authors
Calabretta B, Perrotti D.
Title
The biology of CML blast crisis.
Journal
Reference
Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
Title
The biology of chronic myeloid leukemia.
Journal
Reference
Authors
Mitani K.
Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
Journal
Reference
Authors
Dong M, Blobe GC.
Title
Role of transforming growth factor-beta in hematologic malignancies.
Journal
Reference
Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
Journal
Blood 92:4003-12 (1998)
Reference
Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
Journal
Haematologica 88:622-30 (2003)
Reference
Authors
Baldwin AS.
Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
Journal
Reference
Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
Journal
Reference
Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
Journal
Reference
Authors
Saldanha G, Fletcher A, Slater DN.
Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
Journal
Reference
Authors
Daya-Grosjean L, Couve-Privat S.
Title
Sonic hedgehog signaling in basal cell carcinomas.
Journal
Reference
Authors
Tsai KY, Tsao H.
Title
The genetics of skin cancer.
Journal
Reference
Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
Title
Hedgehog signalling in skin development and cancer.
Journal
Reference
Authors
Rubin AI, Chen EH, Ratner D.
Title
Basal-cell carcinoma.
Journal
Reference
Authors
Saldanha G.
Title
The Hedgehog signalling pathway and cancer.
Journal
Reference
Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
Journal
Reference
Authors
Pasca di Magliano M, Hebrok M.
Title
Hedgehog signalling in cancer formation and maintenance.
Journal
Reference
Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
Journal
Reference
Authors
Cohen MM Jr.
Title
The hedgehog signaling network.
Journal
Reference
Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
Journal
Reference
Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
Journal
Reference
Authors
Toftgard R.
Title
Hedgehog signalling in cancer.
Journal
Reference
Authors
Miller AJ, Mihm MC Jr.
Title
Melanoma.
Journal
Reference
Authors
Chin L.
Title
The genetics of malignant melanoma: lessons from mouse and man.
Journal
Reference
Authors
Takata M, Saida T.
Title
Genetic alterations in melanocytic tumors.
Journal
Reference
Authors
Chudnovsky Y, Khavari PA, Adams AE.
Title
Melanoma genetics and the development of rational therapeutics.
Journal
Reference
Authors
Merlino G.
Title
Cancer biology: the weakest link?
Journal
Reference
Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
Journal
Reference
Authors
Levy C, Khaled M, Fisher DE.
Title
MITF: master regulator of melanocyte development and melanoma oncogene.
Journal
Reference
Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Journal
Reference
Authors
Gruss C, Herlyn M.
Title
Role of cadherins and matrixins in melanoma.
Journal
Reference
Authors
Thompson JF, Scolyer RA, Kefford RF.
Title
Cutaneous melanoma.
Journal
Reference
Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
Authors
Hussein MR.
Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
Journal
Reference
Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
Journal
Reference
Authors
Cohen HT, McGovern FJ.
Title
Renal-cell carcinoma.
Journal
Reference
Authors
Pavlovich CP, Schmidt LS.
Title
Searching for the hereditary causes of renal-cell carcinoma.
Journal
Reference
Authors
Linehan WM, Walther MM, Zbar B.
Title
The genetic basis of cancer of the kidney.
Journal
Reference
Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
Title
Met, metastasis, motility and more.
Journal
Reference
Authors
Kim WY, Kaelin WG.
Title
Role of VHL gene mutation in human cancer.
Journal
Reference
Authors
Sudarshan S, Linehan WM, Neckers L.
Title
HIF and fumarate hydratase in renal cancer.
Journal
Reference
Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
Journal
Reference
Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
Title
Understanding familial and non-familial renal cell cancer.
Journal
Reference
Authors
Mitra AP, Datar RH, Cote RJ.
Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
Journal
Reference
Authors
Wolff EM, Liang G, Jones PA.
Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
Journal
Reference
Authors
Wu XR.
Title
Urothelial tumorigenesis: a tale of divergent pathways.
Journal
Reference
Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
Journal
Cancer Res 60:6298-302 (2000)
Reference
Authors
Bellmunt J, Hussain M, Dinney CP.
Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
Journal
Reference
Authors
Sugano K, Kakizoe T.
Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
Journal
Reference
Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
Journal
Reference
Authors
Williams SG, Stein JP.
Title
Molecular pathways in bladder cancer.
Journal
Reference
Authors
Nelson WG, De Marzo AM, Isaacs WB.
Title
Prostate cancer.
Journal
Reference
Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
Journal
Reference
Authors
Pienta KJ, Bradley D.
Title
Mechanisms underlying the development of androgen-independent prostate cancer.
Journal
Reference
Authors
Feldman BJ, Feldman D.
Title
The development of androgen-independent prostate cancer.
Journal
Reference
Authors
Heinlein CA, Chang C.
Title
Androgen receptor in prostate cancer.
Journal
Reference
Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
Journal
Am J Pathol 152:1-9 (1998)
Reference
Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
Journal
Reference
Authors
Macri E, Loda M.
Title
Role of p27 in prostate carcinogenesis.
Journal
Reference
Authors
Steers WD.
Title
5alpha-reductase activity in the prostate.
Journal
Reference
Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
Journal
Cancer Res 54:4920-6 (1994)
Reference
Authors
Grimes CA, Jope RS.
Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Journal
Reference
Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
Title
Endometrial cancer.
Journal
Reference
Authors
Lax SF.
Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Journal
Reference
Authors
Shiozawa T, Konishi I.
Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
Journal
Reference
Authors
Hecht JL, Mutter GL.
Title
Molecular and pathologic aspects of endometrial carcinogenesis.
Journal
Reference
Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
Title
Molecular pathology of endometrial hyperplasia and carcinoma.
Journal
Reference
Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
Journal
Reference
Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
Journal
Cancer Res 55:5693-8 (1995)
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Sanchez-Cespedes M.
Title
Dissecting the genetic alterations involved in lung carcinogenesis.
Journal
Reference
Authors
Kaye FJ.
Title
Molecular biology of lung cancer.
Journal
Reference
Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
Title
Apoptosis and lung cancer: a review.
Journal
Reference
Authors
Sartorius UA, Krammer PH.
Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
Journal
Reference
Authors
Adhikary S, Eilers M.
Title
Transcriptional regulation and transformation by Myc proteins.
Journal
Reference
Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
Journal
Reference
Authors
Buttery RC, Rintoul RC, Sethi T.
Title
Small cell lung cancer: the importance of the extracellular matrix.
Journal
Reference
Authors
Yamada KM, Araki M.
Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
Journal
J Cell Sci 114:2375-82 (2001)
Reference
Authors
Rintoul RC, Sethi T.
Title
The role of extracellular matrix in small-cell lung cancer.
Journal
Reference
Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
Journal
Reference
Authors
Osada H, Takahashi T.
Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Journal
Reference
Authors
Yokota J, Nishioka M, Tani M, Kohno T.
Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Journal
Reference
Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
Title
K-ras mutations in non-small-cell lung carcinoma: a review.
Journal
Reference
Authors
Pfeifer GP, Dammann R.
Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
Journal
Reference
Authors
Altucci L, Gronemeyer H.
Title
The promise of retinoids to fight against cancer.
Journal
Reference
Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal
Reference
Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
Journal
Reference
Authors
Panani AD, Roussos C.
Title
Cytogenetic and molecular aspects of lung cancer.
Journal
Reference
Authors
Mitsuuchi Y, Testa JR.
Title
Cytogenetics and molecular genetics of lung cancer.
Journal
Reference
Authors
Breuer RH, Postmus PE, Smit EF.
Title
Molecular pathology of non-small-cell lung cancer.
Journal
Reference
Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
Journal
Clin Cancer Res 8:734-44 (2002)
Reference
Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
Journal
Reference
Authors
Lappano R, Maggiolini M
Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
Journal
Reference
Authors
O'Hayre M, Degese MS, Gutkind JS
Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
Journal
Reference
Authors
Dorsam RT, Gutkind JS
Title
G-protein-coupled receptors and cancer.
Journal
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mmma04060 Cytokine-cytokine receptor interaction
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