Entry
Name
Pathways in cancer - Bos taurus (cow)
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
Ortholog table
Organism
Bos taurus (cow) [GN:
bta ]
Gene
526572 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
515303 TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490 ]
414925 BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731 ]
536328 LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068 ]
534450 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
523325 DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
539203 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353 ]
614312 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
526585 F2R; proteinase-activated receptor 1 precursor [KO:K03914 ]
538963 F2RL3; proteinase-activated receptor 4 precursor [KO:K04236 ]
515159 GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
505611 GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639 ]
503575 ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532 ]
511220 ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X5 [KO:K12331 ]
513377 ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330 ]
615910 PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464 ]
613811 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
281790 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
281791 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
539521 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
507437 PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258 ]
282329 PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259 ]
282330 PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260 ]
282331 PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261 ]
281793 GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
281201 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
281202 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
513340 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
525962 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
535365 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
281203 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
281204 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
100125276 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
287018 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
104968964 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
618399 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
618470 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
613930 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
511812 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
286850 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
529425 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
517006 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
281796 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
281797 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
282191 COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237 ]
508632 COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237 ]
523526 COL4A6; collagen alpha-6(IV) chain isoform X3 [KO:K06237 ]
407107 COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237 ]
317711 COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237 ]
506387 LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637 ]
511043 LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246 ]
282306 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
517948 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
504531 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
282308 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
286865 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
282307 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
616115 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
526392 NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
539314 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060 ]
514386 BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060 ]
101905053 LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060 ]
514508 BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061 ]
615013 BAD; bcl2-associated agonist of cell death [KO:K02158 ]
512613 CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
513497 CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
282375 STAT5A; signal transducer and activator of transcription 5A [KO:K11223 ]
282376 STAT5B; signal transducer and activator of transcription 5B [KO:K11224 ]
281750 EDNRB; endothelin receptor type B precursor [KO:K04198 ]
536654 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
281788 GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
287026 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
281985 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
515669 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
508888 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
281856 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
281857 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
511022 IL23A; interleukin-23 subunit alpha precursor [KO:K05426 ]
617556 LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414 ]
281861 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
510185 interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
281862 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
100299249 IL3RA; interleukin-3 receptor subunit alpha isoform X3 [KO:K04737 ]
404154 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
528530 CSF2RB; cytokine receptor common subunit beta precursor [KO:K04738 ]
615848 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
507359 IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
522155 IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060 ]
521554 IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072 ]
524299 IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063 ]
282452 IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
407110 IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
615030 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
282257 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
282258 IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131 ]
508619 IFNGR1; interferon gamma receptor 1 precursor [KO:K05132 ]
514889 IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133 ]
540187 EML4; echinoderm microtubule-associated protein-like 4 [KO:K15420 ]
508541 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
510814 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
511023 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
515988 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
353105 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
281572 VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448 ]
282121 VEGFB; vascular endothelial growth factor B precursor [KO:K16858 ]
286799 VEGFD; vascular endothelial growth factor D precursor [KO:K05449 ]
282122 VEGFC; vascular endothelial growth factor C precursor [KO:K05449 ]
540388 TGFA; protransforming growth factor alpha isoform X1 [KO:K08774 ]
530315 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
505908 PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359 ]
540106 PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386 ]
281239 IGF1; insulin-like growth factor I preproprotein [KO:K05459 ]
281240 IGF2; insulin-like growth factor II preproprotein [KO:K13769 ]
282233 FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454 ]
281161 FGF2; fibroblast growth factor 2 precursor [KO:K18497 ]
326284 FGF8; fibroblast growth factor 8 precursor [KO:K04358 ]
326285 FGF10; fibroblast growth factor 10 precursor [KO:K04358 ]
616885 FGF7; fibroblast growth factor 7 precursor [KO:K04358 ]
618474 FGF4; fibroblast growth factor 4 precursor [KO:K04358 ]
533929 FGF18; fibroblast growth factor 18 precursor [KO:K04358 ]
519657 FGF22; fibroblast growth factor 22 precursor [KO:K04358 ]
536771 FGF5; fibroblast growth factor 5 precursor [KO:K04358 ]
535298 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
537682 SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099 ]
101905399 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368 ] [EC:2.7.12.2 ]
522998 CCDC6; coiled-coil domain-containing protein 6 [KO:K09288 ]
510276 RASSF1; ras association domain-containing protein 1 [KO:K09850 ]
539767 RASSF5; ras association domain-containing protein 5 [KO:K08015 ]
281987 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
786886 ELK1; ETS domain-containing protein Elk-1 [KO:K04375 ]
617412 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
282162 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
525416 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
530719 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
532713 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
513723 RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732 ]
532712 CDC42; cell division control protein 42 homolog [KO:K04393 ]
281440 RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
327671 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
619066 RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
534661 PAX8; paired box protein Pax-8 isoform X2 [KO:K09293 ]
281993 PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530 ]
616895 RARB; retinoic acid receptor beta isoform X2 [KO:K08528 ]
353106 PPARD; peroxisome proliferator-activated receptor delta [KO:K04504 ]
534401 ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055 ]
529631 RUNX1; runt-related transcription factor 1 [KO:K08367 ]
281677 CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055 ]
132344945 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
616369 CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X2 [KO:K06621 ]
617024 E2F2; transcription factor E2F2 isoform X2 [KO:K09389 ]
512915 ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500 ]
527124 CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685 ]
615827 CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219 ]
767985 CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219 ]
615427 SKP1; S-phase kinase-associated protein 1 [KO:K03094 ]
519018 SKP2; S-phase kinase-associated protein 2 [KO:K03875 ]
785617 LOW QUALITY PROTEIN: S-phase kinase-associated protein 2-like [KO:K03875 ]
504939 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
618405 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
505463 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
407219 MITF; microphthalmia-associated transcription factor isoform M- [KO:K09455 ]
282089 TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
534069 TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
538957 TGFB3; transforming growth factor beta-3 proprotein [KO:K13377 ]
516010 SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500 ]
515125 SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
540248 SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
507069 BRCA2; breast cancer type 2 susceptibility protein [KO:K08775 ]
514749 RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482 ]
407111 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
282488 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
493720 FADD; FAS-associated death domain protein [KO:K02373 ]
510373 BID; BH3-interacting domain death agonist [KO:K04726 ]
100296226 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
782359 BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132 ]
537782 APAF1; apoptotic protease-activating factor 1 [KO:K02084 ]
532791 KEAP1; kelch-like ECH-associated protein 1 [KO:K10456 ]
497024 NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638 ]
540957 VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871 ]
282711 EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095 ]
281010 ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097 ]
533445 ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589 ]
282356 SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
767866 NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599 ]
513730 NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994 ]
789485 NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995 ]
536128 NOTCH4; neurogenic locus notch homolog protein 4 precursor [KO:K20996 ]
538609 HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091 ]
408005 HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091 ]
538619 HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
538808 KIF7; kinesin-like protein KIF7 isoform X4 [KO:K18806 ]
785371 GLI3; transcriptional activator GLI3 isoform X3 [KO:K06230 ]
615037 BMP2; bone morphogenetic protein 2 precursor [KO:K21283 ]
407216 BMP4; bone morphogenetic protein 4 precursor [KO:K04662 ]
540830 HHIP; hedgehog-interacting protein precursor [KO:K06231 ]
507948 PTCH2; protein patched homolog 2 isoform X2 [KO:K11101 ]
281832 HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079 ]
Compound
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
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bta04060 Cytokine-cytokine receptor interaction
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