KEGG   PATHWAY: bta05200
Entry
bta05200                    Pathway                                
Name
Pathways in cancer - Bos taurus (cow)
Class
Human Diseases; Cancer: overview
Pathway map
bta05200  Pathways in cancer
bta05200

Organism
Bos taurus (cow) [GN:bta]
Gene
537176  DCC; netrin receptor DCC isoform X1 [KO:K06765]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
517850  APPL1; DCC-interacting protein 13-alpha [KO:K08733]
282637  CDH1; cadherin-1 precursor [KO:K05689]
539003  CTNNB1; catenin beta-1 [KO:K02105]
526848  CTNNA1; catenin alpha-1 [KO:K05691]
780777  CTNNA3; catenin alpha-3 [KO:K05691]
527492  CTNNA2; catenin alpha-2 [KO:K05691]
504357  AXIN1; axin-1 [KO:K02157]
511619  AXIN2; axin-2 [KO:K04385]
526572  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
533233  APC; adenomatous polyposis coli protein [KO:K02085]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
782690  TCF7; transcription factor 7 [KO:K02620]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
414925  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
511077  MYC; myc proto-oncogene protein [KO:K04377]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
540662  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
445420  WNT2B; protein Wnt-2b [KO:K00182]
493729  WNT2; protein Wnt-2 precursor [KO:K00182]
540753  WNT3; proto-oncogene Wnt-3 precursor [KO:K00312]
522467  WNT3A; protein Wnt-3a [KO:K00312]
789600  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
530005  WNT5A; protein Wnt-5a [KO:K00444]
508008  WNT5B; protein Wnt-5b precursor [KO:K00444]
505075  WNT6; protein Wnt-6 precursor [KO:K00445]
533782  WNT7A; protein Wnt-7a [KO:K00572]
100337066  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
540199  WNT8A; protein Wnt-8a [KO:K00714]
538720  WNT8B; protein Wnt-8b [KO:K00714]
511308  WNT9A; protein Wnt-9a [KO:K01064]
541243  WNT9B; protein Wnt-9b [KO:K01064]
539337  WNT10B; protein Wnt-10b [KO:K01357]
537330  WNT10A; protein Wnt-10a precursor [KO:K01357]
613288  WNT11; protein Wnt-11 [KO:K01384]
538627  WNT16; protein Wnt-16 precursor [KO:K01558]
445417  FZD1; frizzled-1 [KO:K02432]
524255  FZD7; frizzled-7 precursor [KO:K02432]
538507  FZD2; frizzled-2 [KO:K02235]
445419  FZD3; frizzled-3 precursor [KO:K02329]
445416  FZD4; frizzled-4 precursor [KO:K02354]
538536  FZD5; frizzled-5 [KO:K02375]
616913  FZD8; frizzled-8 [KO:K02375]
445418  FZD6; frizzled-6 [KO:K02376]
515323  FZD10; frizzled-10 precursor [KO:K02842]
521364  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
536328  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
534450  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
523325  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
539203  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
614312  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
505664  FRAT1; proto-oncogene FRAT1 [KO:K03069]
539144  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
280685  F2; prothrombin precursor [KO:K01313] [EC:3.4.21.5]
527114  AGT; angiotensinogen precursor [KO:K09821]
526585  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
538963  F2RL3; proteinase-activated receptor 4 precursor [KO:K04236]
281136  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
509748  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
532829  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
539738  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
507598  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
782518  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
281607  AGTR1; type-1 angiotensin II receptor [KO:K04166]
515159  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
505611  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
503575  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
511220  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X5 [KO:K12331]
513377  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
615910  PLEKHG5; pleckstrin homology domain-containing family G member 5 isoform X1 [KO:K19464]
338049  RHOA; transforming protein RhoA [KO:K04513]
785911  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
613811  CXCL12; stromal cell-derived factor 1 precursor [KO:K10031]
281736  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
281790  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
281791  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
539521  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
507437  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
282329  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
282330  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
282331  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
281793  GNAS; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
281601  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
510708  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
535603  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
788151  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
505740  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
509936  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
281603  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
535017  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
525482  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104968964  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
282191  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
508632  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
523526  COL4A6; collagen alpha-6(IV) chain isoform X3 [KO:K06237]
511602  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
407107  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
317711  COL4A3; collagen alpha-3(IV) chain precursor [KO:K06237]
506387  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
100138434  LAMA2; laminin subunit alpha-2 [KO:K05637]
506751  LAMA5; laminin subunit alpha-5 [KO:K06240]
100336873  LAMA3; laminin subunit alpha-3 isoform X4 [KO:K06240]
529670  LAMA4; laminin subunit alpha-4 precursor [KO:K06241]
520030  LAMB1; laminin subunit beta-1 precursor [KO:K05636]
530599  laminin subunit beta-2 isoform X1 [KO:K06243]
520167  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
529939  LAMB3; laminin subunit beta-3 precursor [KO:K06244]
532572  LAMC1; laminin subunit gamma-1 precursor [KO:K05635]
511043  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
518914  LAMC3; laminin subunit gamma-3 [KO:K06247]
280794  FN1; fibronectin precursor [KO:K05717]
281872  ITGA2; integrin alpha-2 precursor [KO:K06481]
515011  ITGA2B; integrin alpha-IIb [KO:K06476]
508490  ITGA3; integrin alpha-3 precursor [KO:K06482]
535043  ITGA6; integrin alpha-6 precursor [KO:K06485]
281875  ITGAV; integrin alpha-V precursor [KO:K06487]
281876  ITGB1; integrin beta-1 precursor [KO:K05719]
506270  PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
540786  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
782252  NKX3-1; homeobox protein Nkx-3.1 [KO:K09348]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
526392  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
508233  RELA; transcription factor p65 [KO:K04735]
282023  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
282876  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
539314  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
514386  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101905053  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
281647  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
514508  BIRC7; baculoviral IAP repeat-containing protein 7 [KO:K16061]
282152  BCL2L1; bcl-2-like protein 1 [KO:K04570]
540944  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
512355  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
506182  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
781568  TRAF4; TNF receptor-associated factor 4 [KO:K09848]
507234  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
782032  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
506618  FOXO1; forkhead box protein O1 [KO:K07201]
540378  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
512613  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
513497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
789892  BCR; breakpoint cluster region protein isoform X1 [KO:K08878] [EC:2.7.11.1]
540876  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
512841  CRK; adapter molecule crk [KO:K04438]
518180  CRKL; crk-like protein [KO:K04438]
527418  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
282375  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
282376  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
281402  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
508424  PIM2; serine/threonine-protein kinase pim-2 [KO:K08806] [EC:2.7.11.1]
280833  KNG1; kininogen-1 isoform II precursor [KO:K03898]
281137  EDN1; endothelin-1 precursor [KO:K16366]
532119  BDKRB1; B1 bradykinin receptor [KO:K03915]
538896  BDKRB2; B2 bradykinin receptor [KO:K03916]
281749  EDNRA; endothelin-1 receptor precursor [KO:K04197]
281750  EDNRB; endothelin receptor type B precursor [KO:K04198]
536654  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
281788  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
280822  IL2; interleukin-2 precursor [KO:K05429]
280823  IL3; interleukin-3 precursor [KO:K04736]
280824  IL4; interleukin-4 precursor [KO:K05430]
280825  IL5; interleukin-5 precursor [KO:K05428]
280826  IL6; interleukin-6 precursor [KO:K05405]
280827  IL7; interleukin-7 precursor [KO:K05431]
281856  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
281857  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
281247  IL13; interleukin-13 precursor [KO:K05435]
281248  IL15; interleukin-15 precursor [KO:K05433]
511022  IL23A; interleukin-23 subunit alpha precursor [KO:K05426]
280784  EPO; erythropoietin precursor [KO:K05437]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
510726  IFNA16; interferon alpha-H [KO:K05414]
523244  interferon alpha-B-like [KO:K05414]
517108  interferon alpha-2 [KO:K05414]
618947  interferon alpha-B-like [KO:K05414]
787343  interferon alpha-2 [KO:K05414]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100335490  interferon alpha-G-like [KO:K05414]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
783912  interferon alpha-H [KO:K05414]
617556  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
132345931  interferon alpha-H-like [KO:K05414]
281237  IFNG; interferon gamma precursor [KO:K04687]
281861  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
510185  interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104968644  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
281862  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
100299249  IL3RA; interleukin-3 receptor subunit alpha isoform X3 [KO:K04737]
132342083  interleukin-3 receptor subunit alpha-like isoform X1 [KO:K04737]
404154  IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071]
528530  CSF2RB; cytokine receptor common subunit beta precursor [KO:K04738]
615848  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
507359  IL6R; interleukin-6 receptor subunit alpha precursor [KO:K05055]
522155  IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060]
521554  IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072]
524299  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
282452  IL12RB2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064]
407110  IL13RA1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076]
615030  IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074]
614367  IL23R; interleukin-23 receptor precursor [KO:K05065]
281144  EPOR; erythropoietin receptor precursor [KO:K05079]
282257  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
282258  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
508619  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
514889  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
540187  EML4; echinoderm microtubule-associated protein-like 4 [KO:K15420]
536642  ALK; ALK tyrosine kinase receptor isoform X2 [KO:K05119] [EC:2.7.10.1]
533125  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
512056  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
523745  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
529375  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
537201  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
538276  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
515988  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
353105  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
280894  PGF; placenta growth factor precursor [KO:K16859]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
540388  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
281239  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
281240  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
281848  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
281885  KITLG; kit ligand precursor [KO:K05461]
280832  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
282233  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
512700  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
280831  JUN; transcription factor Jun [KO:K04448]
280795  FOS; protein c-Fos [KO:K04379]
540313  ETS1; protein C-ets-1 [KO:K02678]
281308  MMP1; interstitial collagenase precursor [KO:K01388] [EC:3.4.24.7]
112441463  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
282872  MMP2; 72 kDa type IV collagenase precursor [KO:K01398] [EC:3.4.24.24]
282871  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
280828  CXCL8; interleukin-8 precursor [KO:K10030]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
504408  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
515924  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
522998  CCDC6; coiled-coil domain-containing protein 6 [KO:K09288]
525329  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
353111  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
497019  TPM3; tropomyosin alpha-3 chain [KO:K09290]
101904481  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
104970173  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
101906472  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
507869  TPR; nucleoprotein TPR [KO:K09291]
505171  TFG; protein TFG [KO:K09292]
510276  RASSF1; ras association domain-containing protein 1 [KO:K09850]
539767  RASSF5; ras association domain-containing protein 5 [KO:K08015]
514886  STK4; serine/threonine-protein kinase 4 [KO:K04411]
525506  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
529131  DAPK2; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
540873  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
786886  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
326597  CALM; calmodulin [KO:K02183]
520277  CALM3; calmodulin-3 [KO:K02183]
617095  CALM1; calmodulin-1 [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
100297344  CALM2; calmodulin-2 [KO:K02183]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
104973792  uncharacterized protein LOC104973792 [KO:K02183]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
513723  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
538477  RALA; ras-related protein Ral-A [KO:K07834]
505238  RALB; ras-related protein Ral-B [KO:K07835]
523324  RALBP1; ralA-binding protein 1 [KO:K08773]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
522159  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
514554  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
534661  PAX8; paired box protein Pax-8 isoform X2 [KO:K09293]
281993  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
507554  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
504943  RXRB; retinoic acid receptor RXR-beta [KO:K08525]
509500  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
616895  RARB; retinoic acid receptor beta isoform X2 [KO:K08528]
407238  ESR1; estrogen receptor [KO:K08550]
281146  ESR2; estrogen receptor beta [KO:K08551]
525346  NCOA1; nuclear receptor coactivator 1 [KO:K09101] [EC:2.3.1.48]
523707  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
540741  SP1; transcription factor Sp1 [KO:K04684]
353106  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
445543  JUP; junction plakoglobin [KO:K10056]
534401  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
534280  RARA; retinoic acid receptor alpha [KO:K08527]
281667  CCNA2; cyclin-A2 [KO:K06627]
521939  CCNA1; cyclin-A1 [KO:K06627]
100138545  PML; protein PML [KO:K10054] [EC:2.3.2.-]
529631  RUNX1; runt-related transcription factor 1 [KO:K08367]
538628  RUNX1T1; protein CBFA2T1 [KO:K10053]
507100  SPI1; transcription factor PU.1 [KO:K09438]
281677  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
100336606  CSF2RA; uncharacterized protein CSF2RA isoform X1 [KO:K05066]
132344945  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
509418  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
616369  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X2 [KO:K06621]
535369  E2F1; transcription factor E2F1 [KO:K17454]
617024  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
541184  E2F3; transcription factor E2F3 [KO:K06620]
540616  MAX; protein max [KO:K04453]
512915  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
527124  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
511754  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
615827  CKS1B; cyclin-dependent kinases regulatory subunit 1 [KO:K02219]
767985  CKS2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219]
615427  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
407228  CUL1; cullin-1 [KO:K03347]
112446327  cullin-1-like [KO:K03347]
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
780968  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
519018  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
785617  LOW QUALITY PROTEIN: S-phase kinase-associated protein 2-like [KO:K03875]
519217  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
533526  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
538436  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
534712  RB1; retinoblastoma-associated protein [KO:K06618]
504939  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
618405  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
505463  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
280730  BAX; apoptosis regulator BAX [KO:K02159]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
519357  DDB2; DNA damage-binding protein 2 [KO:K10140]
541218  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
518884  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
379035  TERC; telomerase RNA component [KO:K22183]
407219  MITF; microphthalmia-associated transcription factor isoform M- [KO:K09455]
282089  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
534069  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
538957  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
282382  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
535376  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
516010  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
515125  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
540248  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
532209  MECOM; histone-lysine N-methyltransferase MECOM isoform X8 [KO:K04462] [EC:2.1.1.367]
281730  CTBP2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
513131  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
404126  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
407223  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
533652  MLH1; DNA mismatch repair protein Mlh1 [KO:K08734]
533115  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
616744  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
540526  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
507069  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
514749  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493720  FADD; FAS-associated death domain protein [KO:K02373]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
510373  BID; BH3-interacting domain death agonist [KO:K04726]
100296226  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
782359  BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132]
507390  BCL2L11; bcl-2-like protein 11 [KO:K16341]
510767  CYCS; cytochrome c [KO:K08738]
781996  CYCT; cytochrome c 2 [KO:K08738]
100847700  cytochrome c [KO:K08738]
100847304  cytochrome c-like [KO:K08738]
112447733  cytochrome c-like [KO:K08738]
537782  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
526279  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
532791  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
497024  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
513221  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
519632  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
281805  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
327709  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
493719  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
533917  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
507346  MGST3; glutathione S-transferase 3, mitochondrial [KO:K00799] [EC:2.5.1.18]
517724  GSTT1; glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
615514  glutathione S-transferase mu 1-like [KO:K00799] [EC:2.5.1.18]
615552  MGST2; microsomal glutathione S-transferase 2 precursor [KO:K00799] [EC:2.5.1.18]
615507  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
777644  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
768055  GSTA3; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
505642  GSTO1; glutathione-S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
785216  glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
783879  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
521685  GSTA5; glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
613905  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
516190  GSTT2; glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
615537  GSTM2; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100295687  glutathione S-transferase Mu 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
506093  GSTT4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
132342556  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
281806  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
525938  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
282388  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
282389  TXNRD2; thioredoxin reductase 2, mitochondrial precursor [KO:K22182] [EC:1.8.1.9]
319097  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
540957  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
540859  ELOC; elongin-C [KO:K03872]
617277  ELOB; elongin-B [KO:K03873]
132343864  elongin-B-like [KO:K03873]
535219  CUL2; cullin-2 [KO:K03870]
535578  EGLN3; prolyl hydroxylase EGLN3 [KO:K09592] [EC:1.14.11.29]
534075  EGLN1; egl nine homolog 1 [KO:K09592] [EC:1.14.11.29]
536763  EGLN2; prolyl hydroxylase EGLN2 [KO:K09592] [EC:1.14.11.29]
520260  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
281814  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
282711  EPAS1; endothelial PAS domain-containing protein 1 [KO:K09095]
281010  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
533445  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
505453  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
112446776  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
282356  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
783681  JAG1; protein jagged-1 precursor [KO:K06052]
517405  JAG2; protein jagged-2 isoform X1 [KO:K21635]
505993  DLL3; delta-like protein 3 precursor [KO:K06051]
518746  DLL4; delta-like protein 4 precursor [KO:K06051]
788775  DLL1; delta-like protein 1 [KO:K06051]
767866  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
513730  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
789485  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
536128  NOTCH4; neurogenic locus notch homolog protein 4 precursor [KO:K20996]
539547  HES1; transcription factor HES-1 [KO:K06054]
787633  HES5; transcription factor HES-5 [KO:K06055]
538609  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
408005  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
538619  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
286821  SHH; sonic hedgehog protein [KO:K11988]
520994  PTCH1; protein patched homolog 1 [KO:K06225]
539308  SMO; protein smoothened precursor [KO:K06226]
538808  KIF7; kinesin-like protein KIF7 isoform X4 [KO:K18806]
535067  SUFU; suppressor of fused homolog [KO:K06229]
517588  GLI1; zinc finger protein GLI1 [KO:K16797]
510255  GLI2; zinc finger protein GLI2 [KO:K16798]
785371  GLI3; transcriptional activator GLI3 isoform X3 [KO:K06230]
615037  BMP2; bone morphogenetic protein 2 precursor [KO:K21283]
407216  BMP4; bone morphogenetic protein 4 precursor [KO:K04662]
540830  HHIP; hedgehog-interacting protein precursor [KO:K06231]
507948  PTCH2; protein patched homolog 2 isoform X2 [KO:K11101]
280675  AR; androgen receptor [KO:K08557]
767874  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
281832  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
282646  HSP90B1; endoplasmin precursor [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00122  Fumarate
C00149  (S)-Malate
C00165  Diacylglycerol
C00187  Cholesterol
C00280  Androstenedione
C00410  Progesterone
C00416  Phosphatidate
C00533  Nitric oxide
C00535  Testosterone
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00681  1-Acyl-sn-glycerol 3-phosphate
C00704  Superoxide
C00735  Cortisol
C00762  Cortisone
C00777  Retinoate
C00951  Estradiol-17beta
C01227  Dehydroepiandrosterone
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C03917  Dihydrotestosterone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07653  Flutamide
C15493  9-cis-Retinoic acid
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
  Authors
Weinberg RA.
  Title
The biology of cancer
  Journal
Garland Science, Taylor & Francis Group, LLC (2007)
Reference
  Authors
Hanahan D, Weinberg RA
  Title
The hallmarks of cancer.
  Journal
Cell 100:57-70 (2000)
DOI:10.1016/S0092-8674(00)81683-9
Reference
  Authors
Grady WM.
  Title
Genomic instability and colon cancer.
  Journal
Cancer Metastasis Rev 23:11-27 (2004)
DOI:10.1023/A:1025861527711
Reference
  Authors
Soreide K, Janssen EA, Soiland H, Korner H, Baak JP.
  Title
Microsatellite instability in colorectal cancer.
  Journal
Br J Surg 93:395-406 (2006)
DOI:10.1002/bjs.5328
Reference
  Authors
Anwar S, Hall C, White J, Deakin M, Farrell W, Elder JB.
  Title
Hereditary non-polyposis colorectal cancer: an updated review.
  Journal
Eur J Surg Oncol 26:635-45 (2000)
DOI:10.1053/ejso.2000.0974
Reference
  Authors
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
  Title
Colorectal cancer: genetics of development and metastasis.
  Journal
J Gastroenterol 41:185-92 (2006)
DOI:10.1007/s00535-006-1801-6
Reference
  Authors
Lynch HT, de la Chapelle A.
  Title
Hereditary colorectal cancer.
  Journal
N Engl J Med 348:919-32 (2003)
DOI:10.1056/NEJMra012242
Reference
  Authors
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C.
  Title
The significance of unstable chromosomes in colorectal cancer.
  Journal
Nat Rev Cancer 3:695-701 (2003)
DOI:10.1038/nrc1165
Reference
  Authors
Behrens J.
  Title
Cadherins and catenins: role in signal transduction and tumor progression.
  Journal
Cancer Metastasis Rev 18:15-30 (1999)
DOI:10.1023/A:1006200102166
Reference
  Authors
Behrens J.
  Title
The role of the Wnt signalling pathway in colorectal tumorigenesis.
  Journal
Biochem Soc Trans 33:672-5 (2005)
DOI:10.1042/BST0330672
Reference
  Authors
Behrens J, Lustig B.
  Title
The Wnt connection to tumorigenesis.
  Journal
Int J Dev Biol 48:477-87 (2004)
DOI:10.1387/ijdb.041815jb
Reference
PMID:9196022
  Authors
Polakis P.
  Title
The adenomatous polyposis coli (APC) tumor suppressor.
  Journal
Biochim Biophys Acta 1332:F127-47 (1997)
DOI:10.1016/S0304-419X(97)00008-5
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Mehlen P, Fearon ER.
  Title
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
  Journal
J Clin Oncol 22:3420-8 (2004)
DOI:10.1200/JCO.2004.02.019
Reference
  Authors
Peltomaki P.
  Title
DNA mismatch repair and cancer.
  Journal
Mutat Res 488:77-85 (2001)
DOI:10.1016/S1383-5742(00)00058-2
Reference
  Authors
Li F, Cao Y, Townsend CM Jr, Ko TC.
  Title
TGF-beta signaling in colon cancer cells.
  Journal
World J Surg 29:306-11 (2005)
DOI:10.1007/s00268-004-7813-6
Reference
  Authors
Roman C, Saha D, Beauchamp R.
  Title
TGF-beta and colorectal carcinogenesis.
  Journal
Reference
  Authors
Watson AJ.
  Title
An overview of apoptosis and the prevention of colorectal cancer.
  Journal
Crit Rev Oncol Hematol 57:107-21 (2006)
DOI:10.1016/j.critrevonc.2005.06.005
Reference
  Authors
Watson AJ.
  Title
Apoptosis and colorectal cancer.
  Journal
Gut 53:1701-9 (2004)
DOI:10.1136/gut.2004.052704
Reference
  Authors
Houlston RS.
  Title
What we could do now: molecular pathology of colorectal cancer.
  Journal
Mol Pathol 54:206-14 (2001)
DOI:10.1136/mp.54.4.206
Reference
  Authors
Von Hoff D, Evans D, Hruban R (ed).
  Title
Pancreatic cancer
  Journal
Jones and Bartlett publishers (2005)
Reference
  Authors
Niitsu Y, Yokota J (ed).
  Title
[Oncogenes and Tumor Suppressor Genes for Medical Oncologist] (In Japanese)
  Journal
Nankodo (1999)
Reference
  Authors
Bardeesy N, DePinho RA.
  Title
Pancreatic cancer biology and genetics.
  Journal
Nat Rev Cancer 2:897-909 (2002)
DOI:10.1038/nrc949
Reference
  Authors
Bardeesy N, Sharpless NE, DePinho RA, Merlino G.
  Title
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
  Journal
Semin Cancer Biol 11:201-18 (2001)
DOI:10.1006/scbi.2000.0371
Reference
  Authors
Cowgill SM, Muscarella P.
  Title
The genetics of pancreatic cancer.
  Journal
Am J Surg 186:279-86 (2003)
DOI:10.1016/S0002-9610(03)00226-5
Reference
  Authors
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.
  Title
Genetics and biology of pancreatic ductal adenocarcinoma.
  Journal
Genes Dev 20:1218-49 (2006)
DOI:10.1101/gad.1415606
Reference
  Authors
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ.
  Title
Understanding Ras: 'it ain't over 'til it's over'.
  Journal
Trends Cell Biol 10:147-54 (2000)
DOI:10.1016/S0962-8924(00)01740-2
Reference
  Authors
Holbro T, Civenni G, Hynes NE.
  Title
The ErbB receptors and their role in cancer progression.
  Journal
Exp Cell Res 284:99-110 (2003)
DOI:10.1016/S0014-4827(02)00099-X
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
DeArmond D, Brattain MG, Jessup JM, Kreisberg J, Malik S, Zhao S, Freeman JW.
  Title
Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines.
  Journal
Oncogene 22:7781-95 (2003)
DOI:10.1038/sj.onc.1206966
Reference
  Authors
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K.
  Title
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
  Journal
Oncogene 22:319-29 (2003)
DOI:10.1038/sj.onc.1206122
Reference
  Authors
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M.
  Title
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
  Journal
Cancer Lett 201:107-16 (2003)
DOI:10.1016/S0304-3835(03)00482-8
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Elliott RL, Blobe GC.
  Title
Role of transforming growth factor Beta in human cancer.
  Journal
J Clin Oncol 23:2078-93 (2005)
DOI:10.1200/JCO.2005.02.047
Reference
  Authors
Rudkin TM, Foulkes WD.
  Title
BRCA2: breaks, mistakes and failed separations.
  Journal
Trends Mol Med 11:145-8 (2005)
DOI:10.1016/j.molmed.2005.02.003
Reference
  Authors
Venkitaraman AR.
  Title
Functions of BRCA1 and BRCA2 in the biological response to DNA damage.
  Journal
J Cell Sci 114:3591-8 (2001)
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bansal K, Liang ML, Rutka JT.
  Title
Molecular biology of human gliomas.
  Journal
Technol Cancer Res Treat 5:185-94 (2006)
DOI:10.1177/153303460600500302
Reference
  Authors
Tabuchi K (ed).
  Title
[Gliomas: Research and therapy] (In Japanese)
  Journal
Springer-Verlag Tokyo (2006)
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Hulleman E, Helin K.
  Title
Molecular mechanisms in gliomagenesis.
  Journal
Adv Cancer Res 94:1-27 (2005)
DOI:10.1016/S0065-230X(05)94001-3
Reference
  Authors
Schlessinger J.
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 103:211-25 (2000)
DOI:10.1016/S0092-8674(00)00114-8
Reference
PMID:9643506
  Authors
Ng HK, Lam PY.
  Title
The molecular genetics of central nervous system tumors.
  Journal
Pathology 30:196-202 (1998)
DOI:10.1080/00313029800169236
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Reference
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
  Authors
Tenen DG.
  Title
Disruption of differentiation in human cancer: AML shows the way.
  Journal
Nat Rev Cancer 3:89-101 (2003)
DOI:10.1038/nrc989
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R.
  Title
Normal and oncogenic forms of the receptor tyrosine kinase kit.
  Journal
Stem Cells 23:16-43 (2005)
DOI:10.1634/stemcells.2004-0117
Reference
  Authors
Lorsbach RB, Downing JR.
  Title
The role of the AML1 transcription factor in leukemogenesis.
  Journal
Int J Hematol 74:258-65 (2001)
DOI:10.1007/BF02982058
Reference
  Authors
Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B, Steffen B, Matsumura I, Kanakura Y, Bohmer FD, Muller-Tidow C, Berdel WE, Serve H.
  Title
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
  Journal
Blood 101:3164-73 (2003)
DOI:10.1182/blood-2002-06-1677
Reference
  Authors
Mikesch JH, Steffen B, Berdel WE, Serve H, Muller-Tidow C.
  Title
The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
  Journal
Leukemia 21:1638-47 (2007)
DOI:10.1038/sj.leu.2404732
Reference
  Authors
Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.
  Title
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.
  Journal
Blood 107:3330-8 (2006)
DOI:10.1182/blood-2005-07-3068
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Deininger MW, Goldman JM, Melo JV.
  Title
The molecular biology of chronic myeloid leukemia.
  Journal
Blood 96:3343-56 (2000)
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Mitani K.
  Title
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
  Journal
Oncogene 23:4263-9 (2004)
DOI:10.1038/sj.onc.1207777
Reference
  Authors
Dong M, Blobe GC.
  Title
Role of transforming growth factor-beta in hematologic malignancies.
  Journal
Blood 107:4589-96 (2006)
DOI:10.1182/blood-2005-10-4169
Reference
PMID:9834202
  Authors
Kurokawa M, Mitani K, Imai Y, Ogawa S, Yazaki Y, Hirai H.
  Title
The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-beta-mediated growth inhibition of myeloid cells.
  Journal
Blood 92:4003-12 (1998)
Reference
  Authors
Brusa G, Benvenuti M, Mazzacurati L, Mancini M, Pattacini L, Martinelli G, Barbieri E, Greenberger JS, Baccarani M, Santucci MA.
  Title
p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase.
  Journal
Haematologica 88:622-30 (2003)
Reference
  Authors
Baldwin AS.
  Title
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.
  Journal
J Clin Invest 107:241-6 (2001)
DOI:10.1172/JCI11991
Reference
  Authors
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL.
  Title
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Journal
Nat Med 8:1145-52 (2002)
DOI:10.1038/nm759
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
  Authors
Takata M, Saida T.
  Title
Genetic alterations in melanocytic tumors.
  Journal
J Dermatol Sci 43:1-10 (2006)
DOI:10.1016/j.jdermsci.2006.05.002
Reference
  Authors
Chudnovsky Y, Khavari PA, Adams AE.
  Title
Melanoma genetics and the development of rational therapeutics.
  Journal
J Clin Invest 115:813-24 (2005)
DOI:10.1172/JCI24808
Reference
  Authors
Merlino G.
  Title
Cancer biology: the weakest link?
  Journal
Nature 436:33-5 (2005)
DOI:10.1038/436033a
Reference
  Authors
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.
  Title
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.
  Journal
Nature 436:117-22 (2005)
DOI:10.1038/nature03664
Reference
  Authors
Levy C, Khaled M, Fisher DE.
  Title
MITF: master regulator of melanocyte development and melanoma oncogene.
  Journal
Trends Mol Med 12:406-14 (2006)
DOI:10.1016/j.molmed.2006.07.008
Reference
  Authors
Tsao H, Goel V, Wu H, Yang G, Haluska FG.
  Title
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
  Journal
J Invest Dermatol 122:337-41 (2004)
DOI:10.1046/j.0022-202X.2004.22243.x
Reference
  Authors
Gruss C, Herlyn M.
  Title
Role of cadherins and matrixins in melanoma.
  Journal
Curr Opin Oncol 13:117-23 (2001)
DOI:10.1097/00001622-200103000-00006
Reference
  Authors
Thompson JF, Scolyer RA, Kefford RF.
  Title
Cutaneous melanoma.
  Journal
Lancet 365:687-701 (2005)
DOI:10.1016/S0140-6736(05)17951-3
Reference
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
  Authors
Hussein MR.
  Title
The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
  Journal
Tumour Biol 25:200-7 (2004)
DOI:10.1159/000081103
Reference
  Authors
Lazar-Molnar E, Hegyesi H, Toth S, Falus A.
  Title
Autocrine and paracrine regulation by cytokines and growth factors in melanoma.
  Journal
Cytokine 12:547-54 (2000)
DOI:10.1006/cyto.1999.0614
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364
Reference
  Authors
Linehan WM, Walther MM, Zbar B.
  Title
The genetic basis of cancer of the kidney.
  Journal
J Urol 170:2163-72 (2003)
DOI:10.1097/01.ju.0000096060.92397.ed
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Kim WY, Kaelin WG.
  Title
Role of VHL gene mutation in human cancer.
  Journal
J Clin Oncol 22:4991-5004 (2004)
DOI:10.1200/JCO.2004.05.061
Reference
  Authors
Sudarshan S, Linehan WM, Neckers L.
  Title
HIF and fumarate hydratase in renal cancer.
  Journal
Br J Cancer 96:403-7 (2007)
DOI:10.1038/sj.bjc.6603547
Reference
  Authors
Sudarshan S, Pinto PA, Neckers L, Linehan WM.
  Title
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer.
  Journal
Nat Clin Pract Urol 4:104-10 (2007)
DOI:10.1038/ncpuro0711
Reference
  Authors
Bodmer D, van den Hurk W, van Groningen JJ, Eleveld MJ, Martens GJ, Weterman MA, van Kessel AG.
  Title
Understanding familial and non-familial renal cell cancer.
  Journal
Hum Mol Genet 11:2489-98 (2002)
DOI:10.1093/hmg/11.20.2489
Reference
  Authors
Mitra AP, Datar RH, Cote RJ.
  Title
Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification.
  Journal
J Clin Oncol 24:5552-64 (2006)
DOI:10.1200/JCO.2006.08.2073
Reference
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
  Authors
Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R.
  Title
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
  Journal
Cancer Res 60:6298-302 (2000)
Reference
  Authors
Bellmunt J, Hussain M, Dinney CP.
  Title
Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family.
  Journal
Crit Rev Oncol Hematol 46 Suppl:S85-104 (2003)
DOI:10.1016/S1040-8428(03)00067-2
Reference
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
  Authors
Dunn KL, Espino PS, Drobic B, He S, Davie JR.
  Title
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling.
  Journal
Biochem Cell Biol 83:1-14 (2005)
DOI:10.1139/o04-121
Reference
  Authors
Williams SG, Stein JP.
  Title
Molecular pathways in bladder cancer.
  Journal
Urol Res 32:373-85 (2004)
DOI:10.1007/s00240-003-0345-y
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
  Authors
Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC.
  Title
The emerging role of the PI3-K-Akt pathway in prostate cancer progression.
  Journal
Prostate Cancer Prostatic Dis 8:108-18 (2005)
DOI:10.1038/sj.pcan.4500776
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
  Authors
Heinlein CA, Chang C.
  Title
Androgen receptor in prostate cancer.
  Journal
Endocr Rev 25:276-308 (2004)
DOI:10.1210/er.2002-0032
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
Reference
  Authors
Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D.
  Title
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Journal
Nat Med 6:703-6 (2000)
DOI:10.1038/76287
Reference
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
  Authors
Steers WD.
  Title
5alpha-reductase activity in the prostate.
  Journal
Urology 58:17-24; discussion 24 (2001)
DOI:10.1016/S0090-4295(01)01299-7
Reference
PMID:8069858
  Authors
Lin D, Meyer DJ, Ketterer B, Lang NP, Kadlubar FF.
  Title
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
  Journal
Cancer Res 54:4920-6 (1994)
Reference
  Authors
Grimes CA, Jope RS.
  Title
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
  Journal
Prog Neurobiol 65:391-426 (2001)
DOI:10.1016/S0301-0082(01)00011-9
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Sanchez-Cespedes M.
  Title
Dissecting the genetic alterations involved in lung carcinogenesis.
  Journal
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
Reference
  Authors
Kaye FJ.
  Title
Molecular biology of lung cancer.
  Journal
Lung Cancer 34 Suppl 2:S35-41 (2001)
DOI:10.1016/S0169-5002(01)00342-7
Reference
  Authors
Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
  Title
Apoptosis and lung cancer: a review.
  Journal
J Cell Biochem 88:885-98 (2003)
DOI:10.1002/jcb.10440
Reference
  Authors
Sartorius UA, Krammer PH.
  Title
Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
  Journal
Int J Cancer 97:584-92 (2002)
DOI:10.1002/ijc.10096
Reference
  Authors
Adhikary S, Eilers M.
  Title
Transcriptional regulation and transformation by Myc proteins.
  Journal
Nat Rev Mol Cell Biol 6:635-45 (2005)
DOI:10.1038/nrm1703
Reference
  Authors
Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
  Title
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
  Journal
Mol Cell 7:639-50 (2001)
DOI:10.1016/S1097-2765(01)00210-6
Reference
  Authors
Buttery RC, Rintoul RC, Sethi T.
  Title
Small cell lung cancer: the importance of the extracellular matrix.
  Journal
Int J Biochem Cell Biol 36:1154-60 (2004)
DOI:10.1016/S1357-2725(03)00261-9
Reference
  Authors
Yamada KM, Araki M.
  Title
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
  Journal
J Cell Sci 114:2375-82 (2001)
Reference
  Authors
Rintoul RC, Sethi T.
  Title
The role of extracellular matrix in small-cell lung cancer.
  Journal
Lancet Oncol 2:437-42 (2001)
DOI:10.1016/S1470-2045(00)00421-6
Reference
  Authors
Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
  Title
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
  Journal
Exp Cell Res 279:277-90 (2002)
DOI:10.1006/excr.2002.5608
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802
Reference
  Authors
Yokota J, Nishioka M, Tani M, Kohno T.
  Title
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  Journal
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)
DOI:10.1007/s10541-005-0151-y
Reference
  Authors
Altucci L, Gronemeyer H.
  Title
The promise of retinoids to fight against cancer.
  Journal
Nat Rev Cancer 1:181-93 (2001)
DOI:10.1038/35106036
Reference
  Authors
Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
  Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
  Journal
J Natl Cancer Inst 92:1303-7 (2000)
DOI:10.1093/jnci/92.16.1303
Reference
  Authors
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA.
  Title
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies.
  Journal
Lung Cancer 41 Suppl 1:S29-42 (2003)
DOI:10.1016/S0169-5002(03)00137-5
Reference
  Authors
Panani AD, Roussos C.
  Title
Cytogenetic and molecular aspects of lung cancer.
  Journal
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
Reference
  Authors
Mitsuuchi Y, Testa JR.
  Title
Cytogenetics and molecular genetics of lung cancer.
  Journal
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
Reference
  Authors
Breuer RH, Postmus PE, Smit EF.
  Title
Molecular pathology of non-small-cell lung cancer.
  Journal
Respiration 72:313-30 (2005)
DOI:10.1159/000085376
Reference
  Authors
Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, Grizzle WE.
  Title
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung.
  Journal
Clin Cancer Res 8:734-44 (2002)
Reference
  Authors
Awaya H, Takeshima Y, Furonaka O, Kohno N, Inai K.
  Title
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  Journal
J Clin Pathol 58:1076-80 (2005)
DOI:10.1136/jcp.2004.025585
Reference
  Authors
Lappano R, Maggiolini M
  Title
G protein-coupled receptors: novel targets for drug discovery in cancer.
  Journal
Nat Rev Drug Discov 10:47-60 (2011)
DOI:10.1038/nrd3320
Reference
  Authors
O'Hayre M, Degese MS, Gutkind JS
  Title
Novel insights into G protein and G protein-coupled receptor signaling in cancer.
  Journal
Curr Opin Cell Biol 27:126-35 (2014)
DOI:10.1016/j.ceb.2014.01.005
Reference
  Authors
Dorsam RT, Gutkind JS
  Title
G-protein-coupled receptors and cancer.
  Journal
Nat Rev Cancer 7:79-94 (2007)
DOI:10.1038/nrc2069
Related
pathway
bta03320  PPAR signaling pathway
bta04010  MAPK signaling pathway
bta04020  Calcium signaling pathway
bta04024  cAMP signaling pathway
bta04060  Cytokine-cytokine receptor interaction
bta04066  HIF-1 signaling pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04210  Apoptosis
bta04310  Wnt signaling pathway
bta04330  Notch signaling pathway
bta04340  Hedgehog signaling pathway
bta04350  TGF-beta signaling pathway
bta04370  VEGF signaling pathway
bta04510  Focal adhesion
bta04512  ECM-receptor interaction
bta04520  Adherens junction
bta04630  JAK-STAT signaling pathway
bta04915  Estrogen signaling pathway
KO pathway
ko05200   
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