KEGG   PATHWAY: cclu04144
Entry
cclu04144                   Pathway                                
Name
Endocytosis - Coregonus clupeaformis (lake whitefish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cclu04144  Endocytosis
cclu04144

Other DBs
GO: 0006897
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530669  [KO:K12185]
121530728  [KO:K12490]
121530841  [KO:K12186]
121530870  [KO:K15053]
121530878  [KO:K07897]
121530890  [KO:K12484]
121531504  [KO:K07904]
121531534  [KO:K12958]
121531536  [KO:K06278]
121531538  [KO:K10364]
121531676  cav2; caveolin-2 [KO:K12958]
121531677  cav1; caveolin-1 [KO:K06278]
121531680  [KO:K10364]
121531807  [KO:K12197]
121531847  [KO:K17918]
121531872  [KO:K06093]
121531890  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121531937  [KO:K07939]
121531961  [KO:K12495]
121531963  wash1; WASH complex subunit 1 [KO:K18461]
121531987  tsg101a; tumor susceptibility 101a [KO:K12183]
121532037  [KO:K23612]
121532083  snx1a; sorting nexin-1a isoform X1 [KO:K17917]
121532188  [KO:K02833]
121532225  sh3gl3b; endophilin-A3b [KO:K11247]
121532249  [KO:K12478]
121532523  [KO:K12486]
121532527  [KO:K12486]
121532550  [KO:K12485]
121532567  [KO:K12471]
121532616  [KO:K12486]
121532838  [KO:K12486]
121533061  [KO:K12482]
121533101  [KO:K12486]
121533184  [KO:K17260]
121533190  [KO:K12485]
121533219  [KO:K23484]
121533339  [KO:K01528] [EC:3.6.5.5]
121533404  eps15; epidermal growth factor receptor substrate 15 isoform X3 [KO:K12472]
121533445  [KO:K12196]
121533479  [KO:K12483]
121533486  [KO:K11247]
121533582  [KO:K00889] [EC:2.7.1.68]
121533583  [KO:K07905]
121533585  [KO:K07905]
121533601  [KO:K07901]
121533612  [KO:K12472]
121533733  [KO:K04679]
121533770  [KO:K12489]
121533813  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
121533963  [KO:K04363] [EC:2.7.10.1]
121534070  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
121534318  zfyve27; protrudin isoform X1 [KO:K19368]
121534725  [KO:K04189]
121534839  [KO:K12484]
121534876  amph; amphiphysin isoform X6 [KO:K12562]
121534922  [KO:K06503]
121534934  [KO:K00909] [EC:2.7.11.14]
121535065  [KO:K07905]
121535072  [KO:K11826]
121535087  [KO:K05754]
121535112  [KO:K12472]
121535161  [KO:K04237]
121535182  [KO:K18442]
121535276  [KO:K04674] [EC:2.7.11.30]
121535294  [KO:K12196]
121535350  [KO:K12491]
121535360  [KO:K07937]
121535405  [KO:K06069] [EC:2.7.11.13]
121535424  [KO:K12472]
121535427  [KO:K07901]
121535449  [KO:K10396] [EC:5.6.1.3]
121535512  [KO:K11247]
121535557  [KO:K04361] [EC:2.7.10.1]
121535570  [KO:K01528] [EC:3.6.5.5]
121535671  [KO:K00889] [EC:2.7.1.68]
121535760  clta; LOW QUALITY PROTEIN: clathrin light chain A [KO:K04644]
121535768  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
121536199  [KO:K12484]
121536227  [KO:K04189]
121536413  si:ch211-168k14.2; LOW QUALITY PROTEIN: phospholipase D1 [KO:K01115] [EC:3.1.4.4]
121536442  [KO:K12562]
121536557  [KO:K00909] [EC:2.7.11.14]
121536638  [KO:K18584]
121536708  kif5c; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
121536935  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
121536986  [KO:K04388] [EC:2.7.11.30]
121536987  snx4; sorting nexin-4 [KO:K17919]
121537024  [KO:K04705]
121537056  [KO:K07888]
121537218  iqsec2b; IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
121537318  wipf1b; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
121537342  [KO:K04513]
121537486  [KO:K06093]
121537646  [KO:K18584]
121537681  [KO:K18952] [EC:2.7.11.13]
121537714  [KO:K03283]
121537898  [KO:K07938]
121537935  [KO:K17848]
121537961  [KO:K05704] [EC:2.7.10.2]
121537985  [KO:K12489]
121538032  [KO:K11981] [EC:2.3.2.27]
121538114  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396] [EC:5.6.1.3]
121538117  [KO:K12495]
121538123  [KO:K12194]
121538165  [KO:K04513]
121538324  [KO:K18442]
121538399  [KO:K04513]
121538457  [KO:K05632] [EC:2.3.2.26]
121538497  [KO:K04393]
121538564  [KO:K12495]
121538586  [KO:K12481]
121538634  [KO:K12490]
121539003  [KO:K12488]
121539199  [KO:K12474]
121539292  [KO:K12482]
121539309  [KO:K07941]
121539334  [KO:K12193]
121539399  [KO:K12488]
121539498  [KO:K12477]
121539517  [KO:K17920]
121539853  [KO:K12494]
121540023  [KO:K07904]
121540157  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121540243  [KO:K12472]
121540277  [KO:K12196]
121540320  [KO:K11247]
121540451  [KO:K09526]
121540547  [KO:K23612]
121540591  washc4; WASH complex subunit 4 [KO:K18465]
121540889  [KO:K10591] [EC:2.3.2.26]
121540903  [KO:K12484]
121541100  [KO:K05754]
121541103  [KO:K13712] [EC:2.7.1.68]
121541236  [KO:K11839] [EC:3.4.19.12]
121541304  [KO:K05070]
121541305  [KO:K05070]
121541454  [KO:K04679]
121541507  [KO:K12185]
121541513  [KO:K00910] [EC:2.7.11.15]
121541536  zgc:100918; ras-related protein rab7-like [KO:K07897]
121541616  [KO:K18467]
121541617  [KO:K05756]
121541642  [KO:K00889] [EC:2.7.1.68]
121541659  [KO:K12494]
121541675  [KO:K01528] [EC:3.6.5.5]
121541848  [KO:K12483]
121541898  ehd2a; EH domain-containing protein 2 isoform X1 [KO:K12469]
121542046  sparta; spartin a isoform X1 [KO:K19366]
121542060  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
121542114  [KO:K17918]
121542136  [KO:K18439]
121542365  [KO:K06093]
121542570  [KO:K18464]
121542581  [KO:K04388] [EC:2.7.11.30]
121542694  [KO:K00889] [EC:2.7.1.68]
121542760  rab10; ras-related protein Rab-10 [KO:K07903]
121542781  [KO:K17918]
121542894  cyth2; cytohesin-2 isoform X1 [KO:K18441]
121542937  [KO:K12471]
121542996  [KO:K04393]
121543102  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
121543214  [KO:K00889] [EC:2.7.1.68]
121543398  [KO:K12495]
121543438  [KO:K12493]
121543709  [KO:K07939]
121544705  [KO:K17920]
121544722  [KO:K12477]
121544859  [KO:K12193]
121544882  [KO:K07941]
121544996  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
121545092  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
121545101  [KO:K12191]
121545130  [KO:K12488]
121545275  [KO:K04513]
121545330  [KO:K12188]
121545382  [KO:K12481]
121545403  [KO:K12495]
121545456  [KO:K10396] [EC:5.6.1.3]
121545469  [KO:K12194]
121545495  [KO:K04513]
121545542  [KO:K04513]
121545593  [KO:K05632] [EC:2.3.2.26]
121545645  [KO:K04393]
121545667  [KO:K12495]
121545720  [KO:K11981] [EC:2.3.2.27]
121545760  [KO:K12489]
121545784  [KO:K05704] [EC:2.7.10.2]
121545815  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
121545856  [KO:K07938]
121545924  [KO:K12483]
121545929  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121546023  [KO:K18442]
121546082  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
121546170  [KO:K12495]
121546282  [KO:K07939]
121546312  mvb12a; multivesicular body subunit 12A [KO:K12186]
121546368  [KO:K07904]
121546384  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X2 [KO:K11839] [EC:3.4.19.12]
121546390  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
121546400  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121546787  [KO:K06093]
121546988  [KO:K12494]
121547132  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
121547179  [KO:K07889]
121547208  [KO:K12485]
121547253  [KO:K12494]
121547271  [KO:K12188]
121547530  [KO:K18441]
121547594  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
121547609  rab4a; ras-related protein Rab-4A [KO:K07879]
121547694  [KO:K18466]
121547699  [KO:K12482]
121547705  [KO:K18441]
121547731  [KO:K12195]
121547752  [KO:K17920]
121547956  [KO:K12191]
121548237  [KO:K17917]
121548245  [KO:K05050]
121548293  [KO:K10591] [EC:2.3.2.26]
121548318  [KO:K18468]
121548658  [KO:K07941]
121548758  snx3; sorting nexin-3 [KO:K17918]
121548906  [KO:K12476]
121548915  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
121548934  [KO:K06564]
121549179  [KO:K12488]
121549203  [KO:K12474]
121549395  [KO:K12493]
121549465  [KO:K07937]
121549572  [KO:K12198]
121549646  [KO:K04361] [EC:2.7.10.1]
121549724  [KO:K04674] [EC:2.7.11.30]
121549792  [KO:K01115] [EC:3.1.4.4]
121549819  tfr1b; transferrin receptor 1b [KO:K06503]
121549822  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
121549858  [KO:K12495]
121549861  [KO:K18442]
121549935  [KO:K05633] [EC:2.3.2.26]
121549961  [KO:K04237]
121549974  [KO:K10396] [EC:5.6.1.3]
121550036  [KO:K12488]
121550089  sh3glb1a; endophilin-B1a [KO:K11248]
121550174  [KO:K12487]
121550213  [KO:K04500]
121550231  rab35b; ras-related protein Rab-35b [KO:K07876]
121550259  [KO:K05095] [EC:2.7.10.1]
121550286  [KO:K13712] [EC:2.7.1.68]
121550287  [KO:K21269]
121550296  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
121550329  [KO:K07876]
121550344  [KO:K03283]
121550389  [KO:K12485]
121550500  [KO:K18584]
121550536  [KO:K07889]
121550595  [KO:K07937]
121550913  [KO:K04707] [EC:2.3.2.27]
121551043  [KO:K12473]
121551066  [KO:K04678] [EC:2.3.2.26]
121551181  [KO:K12185]
121551200  [KO:K18441]
121551263  [KO:K18441]
121551311  [KO:K23484]
121551380  [KO:K18441]
121551451  [KO:K05757]
121551478  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
121551480  [KO:K11825]
121551488  [KO:K12471]
121551513  [KO:K12195]
121551619  [KO:K05069]
121551943  [KO:K08291] [EC:2.7.11.16]
121551994  [KO:K12480]
121552068  ehd3; EH domain-containing protein 3 isoform X1 [KO:K12476]
121552083  [KO:K07903]
121552268  [KO:K17918]
121552348  [KO:K12488]
121552795  [KO:K06564]
121552922  [KO:K12199]
121552932  [KO:K07941]
121553175  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
121553272  [KO:K18462]
121553384  [KO:K18443]
121553451  [KO:K05093] [EC:2.7.10.1]
121553581  [KO:K12494]
121553824  ldlrb; low-density lipoprotein receptor [KO:K12473]
121553870  [KO:K06643] [EC:2.3.2.27]
121554180  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
121554310  si:dkey-19b23.8; uncharacterized protein si:dkey-19b23.8 [KO:K12474]
121554437  [KO:K11247]
121554600  [KO:K04439]
121554837  [KO:K04705]
121554966  [KO:K12562]
121554988  [KO:K17919]
121555017  [KO:K04388] [EC:2.7.11.30]
121555029  rab5b; ras-related protein Rab-5B [KO:K07888]
121555314  [KO:K18463]
121555326  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
121555384  [KO:K12195]
121555414  [KO:K06643] [EC:2.3.2.27]
121555650  [KO:K05087] [EC:2.7.10.1]
121555762  [KO:K04645]
121555848  [KO:K18441]
121555914  [KO:K04189]
121556153  stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
121556157  [KO:K12198]
121556225  [KO:K05050]
121556493  [KO:K12471]
121556697  [KO:K05094] [EC:2.7.10.1]
121556728  [KO:K04388] [EC:2.7.11.30]
121556788  [KO:K00909] [EC:2.7.11.14]
121556833  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1 [KO:K12488]
121556948  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
121556974  [KO:K03283]
121557112  [KO:K18441]
121557192  [KO:K12486]
121558597  [KO:K04646]
121558728  [KO:K12494]
121558982  [KO:K12562]
121559174  [KO:K06643] [EC:2.3.2.27]
121559236  [KO:K07889]
121559238  [KO:K12474]
121559310  [KO:K19476]
121559318  [KO:K03283]
121559398  [KO:K18466]
121559813  [KO:K06643] [EC:2.3.2.27]
121559965  [KO:K17260]
121560121  [KO:K07887]
121560300  [KO:K11827]
121560436  [KO:K19476]
121560742  [KO:K12184]
121560841  [KO:K04707] [EC:2.3.2.27]
121561241  [KO:K06643] [EC:2.3.2.27]
121561653  [KO:K11826]
121562346  [KO:K12471]
121562537  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
121563470  [KO:K05737]
121563733  [KO:K04679]
121564495  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
121564553  [KO:K00909] [EC:2.7.11.14]
121565135  [KO:K00909] [EC:2.7.11.14]
121565258  [KO:K05050]
121565625  [KO:K19366]
121565694  [KO:K06751]
121565900  [KO:K05050]
121566095  [KO:K12474]
121566786  [KO:K18439]
121566801  [KO:K13649]
121567288  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
121567308  [KO:K11826]
121567354  [KO:K04707] [EC:2.3.2.27]
121567387  [KO:K11827]
121567477  [KO:K05737]
121567685  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
121567817  [KO:K13649]
121567824  [KO:K18439]
121567849  ehd2b; EH domain-containing protein 2b [KO:K12469]
121567867  [KO:K19366]
121567997  [KO:K03283]
121568030  [KO:K05093] [EC:2.7.10.1]
121568035  [KO:K04646]
121568348  [KO:K06751]
121568396  [KO:K18466]
121568703  [KO:K18441]
121568924  [KO:K18441]
121568947  [KO:K12484]
121568980  [KO:K04678] [EC:2.3.2.26]
121569133  [KO:K04674] [EC:2.7.11.30]
121569195  [KO:K04361] [EC:2.7.10.1]
121569208  actr3b; actin-related protein 3B [KO:K18584]
121569230  [KO:K18442]
121569274  [KO:K12470]
121569276  [KO:K06503]
121569456  [KO:K12473]
121569469  [KO:K19475]
121569556  [KO:K07937]
121569587  [KO:K03283]
121569655  [KO:K19475]
121569692  [KO:K12494]
121569811  [KO:K10396] [EC:5.6.1.3]
121569888  [KO:K12198]
121569904  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
121569976  [KO:K12485]
121569984  [KO:K05757]
121570000  [KO:K12182]
121570066  [KO:K18443]
121570067  [KO:K04180]
121570152  [KO:K05757]
121570153  [KO:K05757]
121570291  epn3a; epsin-3 isoform X2 [KO:K12471]
121570585  [KO:K05069]
121570617  chmp4c; charged multivesicular body protein 4c [KO:K24782]
121570994  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
121571214  [KO:K17260]
121571284  arrb2b; arrestin, beta 2b [KO:K04439]
121571445  [KO:K04388] [EC:2.7.11.30]
121571554  [KO:K04393]
121571574  [KO:K06751]
121571730  [KO:K12192]
121571790  [KO:K12479]
121571967  [KO:K06093]
121572074  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
121572106  [KO:K12489]
121572262  [KO:K12200]
121572307  [KO:K10396] [EC:5.6.1.3]
121572313  [KO:K11824]
121572410  [KO:K17260]
121573316  [KO:K04646]
121573413  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121573452  [KO:K00889] [EC:2.7.1.68]
121573506  [KO:K12475]
121573560  [KO:K04646]
121573616  [KO:K04439]
121573633  [KO:K01115] [EC:3.1.4.4]
121573661  [KO:K18439]
121573707  [KO:K12197]
121573829  [KO:K12487]
121573955  [KO:K03283]
121573958  [KO:K03283]
121574232  [KO:K18466]
121574522  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
121574795  kif5ab; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
121574899  [KO:K10364]
121574970  [KO:K07897]
121574973  [KO:K05755]
121575057  [KO:K12958]
121575116  [KO:K12492]
121575125  [KO:K11981] [EC:2.3.2.27]
121575166  [KO:K17848]
121575215  [KO:K12959]
121575218  [KO:K12958]
121575233  [KO:K05755]
121575235  [KO:K07897]
121575299  [KO:K10365]
121575328  [KO:K04393]
121575341  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
121575372  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
121575429  [KO:K18441]
121575450  [KO:K04513]
121575574  [KO:K05632] [EC:2.3.2.26]
121575593  [KO:K05704] [EC:2.7.10.2]
121575595  [KO:K07891]
121575600  [KO:K12194]
121575656  agap1; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
121575662  [KO:K17919]
121575877  [KO:K12959]
121576347  snx5; sorting nexin-5 [KO:K17920]
121576390  [KO:K02833]
121576418  [KO:K07939]
121576428  [KO:K07939]
121576430  [KO:K04679]
121576441  [KO:K07939]
121576511  [KO:K12489]
121576567  [KO:K18461]
121576596  [KO:K07939]
121576630  [KO:K05087] [EC:2.7.10.1]
121576646  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
121576702  [KO:K12197]
121576703  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
121576787  [KO:K00889] [EC:2.7.1.68]
121576788  [KO:K07905]
121576790  [KO:K07905]
121576806  [KO:K07901]
121576812  [KO:K12472]
121577000  [KO:K12478]
121577316  [KO:K18441]
121577440  [KO:K12495]
121577559  si:dkey-28n18.9; sorting nexin-6 [KO:K17920]
121577578  [KO:K12959]
121577594  [KO:K05755]
121577595  [KO:K07897]
121577656  [KO:K10365]
121577683  cdc42; cell division control protein 42 homolog [KO:K04393]
121577788  [KO:K12492]
121577801  [KO:K11981] [EC:2.3.2.27]
121577845  [KO:K17848]
121577893  [KO:K12489]
121577958  [KO:K07891]
121577962  [KO:K05704] [EC:2.7.10.2]
121577977  [KO:K07879]
121577985  [KO:K05632] [EC:2.3.2.26]
121578110  [KO:K04513]
121578167  [KO:K12958]
121578211  [KO:K07897]
121578307  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
121578315  [KO:K10396] [EC:5.6.1.3]
121578369  [KO:K04513]
121578371  [KO:K10364]
121578516  [KO:K12958]
121578753  [KO:K12495]
121578938  [KO:K18439]
121579300  [KO:K03283]
121579301  [KO:K03283]
121579317  [KO:K18466]
121579363  [KO:K12185]
121579366  [KO:K12480]
121579371  [KO:K04707] [EC:2.3.2.27]
121579374  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
121579400  [KO:K05095] [EC:2.7.10.1]
121579409  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
121579495  [KO:K12483]
121579626  [KO:K17918]
121579738  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
121579762  [KO:K04646]
121579815  [KO:K04439]
121579832  [KO:K01115] [EC:3.1.4.4]
121579954  chmp1b; charged multivesicular body protein 1b [KO:K12197]
121579991  [KO:K18439]
121580278  [KO:K12474]
121580563  [KO:K07891]
121580603  [KO:K06503]
121580623  [KO:K00909] [EC:2.7.11.14]
121580776  [KO:K07905]
121580788  [KO:K11826]
121580825  [KO:K12472]
121580868  [KO:K04237]
121580872  [KO:K11247]
121580888  [KO:K18442]
121580966  [KO:K04674] [EC:2.7.11.30]
121580985  [KO:K12196]
121581035  [KO:K12491]
121581046  arf1; ADP-ribosylation factor 1 [KO:K07937]
121581068  [KO:K04361] [EC:2.7.10.1]
121581079  [KO:K01528] [EC:3.6.5.5]
121581162  [KO:K00889] [EC:2.7.1.68]
121581189  [KO:K11247]
121581268  [KO:K07901]
121581280  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121581295  [KO:K10396] [EC:5.6.1.3]
121581477  [KO:K05754]
121581543  [KO:K12494]
121581552  [KO:K12494]
121581559  [KO:K04189]
121581869  [KO:K08291] [EC:2.7.11.16]
121581926  mvb12ba; multivesicular body subunit 12Ba isoform X1 [KO:K12186]
121581979  psd3l; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
121582053  [KO:K05754]
121582078  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
121582135  [KO:K04679]
121582331  [KO:K18468]
121582340  [KO:K12487]
121582382  [KO:K12484]
121582498  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
121582522  [KO:K12494]
121582535  [KO:K00889] [EC:2.7.1.68]
121582577  [KO:K05756]
121582581  [KO:K18467]
121582665  [KO:K07897]
121582681  [KO:K00910] [EC:2.7.11.15]
121582688  [KO:K12185]
121582697  [KO:K08291] [EC:2.7.11.16]
121582732  [KO:K13305] [EC:2.3.2.26]
121582824  [KO:K12475]
121582966  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
121582975  [KO:K19367]
121583197  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
121584129  [KO:K13712] [EC:2.7.1.68]
121584165  [KO:K15053]
121584210  [KO:K12185]
121584311  chmp6b; charged multivesicular body protein 6 [KO:K12195]
121584320  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
121584533  [KO:K12487]
121584607  [KO:K12189]
121584620  snx2; sorting nexin-2 isoform X1 [KO:K17917]
121584646  [KO:K04500]
121584713  [KO:K21269]
121584743  [KO:K07876]
121584840  [KO:K12484]
121584931  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
121584955  [KO:K00889] [EC:2.7.1.68]
121584982  [KO:K04646]
121585095  [KO:K08291] [EC:2.7.11.16]
121585479  [KO:K06093]
121585682  [KO:K12474]
121585685  [KO:K12486]
121585832  [KO:K00889] [EC:2.7.1.68]
121585944  [KO:K18464]
121586107  [KO:K03283]
121586159  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
121586201  [KO:K04393]
121586243  [KO:K04180]
121586289  [KO:K00889] [EC:2.7.1.68]
121586338  [KO:K04388] [EC:2.7.11.30]
121586369  [KO:K07937]
121586431  [KO:K04393]
121586457  [KO:K06751]
121586510  [KO:K06093]
121586622  [KO:K12200]
121586705  [KO:K07887]
121586891  [KO:K12479]
121587431  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
121587489  cltb; clathrin light chain B isoform X1 [KO:K04645]
123481068  [KO:K07939]
123483336  [KO:K17260]
123484180  [KO:K23484]
123484216  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
123484477  [KO:K12474]
123484744  [KO:K18463]
123488289  [KO:K12486]
123489416  [KO:K09526]
123490290  [KO:K11866] [EC:3.4.19.12]
123491232  [KO:K11824]
123491402  [KO:K06751]
123491404  [KO:K06751]
123492056  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
123492613  [KO:K19367]
123492872  [KO:K06751]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cclu04060  Cytokine-cytokine receptor interaction
cclu04070  Phosphatidylinositol signaling system
cclu04130  SNARE interactions in vesicular transport
cclu04142  Lysosome
cclu04350  TGF-beta signaling pathway
KO pathway
ko04144   

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