Entry
Name
Pathways in cancer - Rattus norvegicus (rat)
Class
Human Diseases; Cancer: overview
BRITE hierarchy
Pathway map
Organism
Rattus norvegicus (rat) [GN:
rno ]
Gene
100362620 Cks2l1; cyclin-dependent kinases regulatory subunit 2-like [KO:K02219 ]
103691134 Flt3lg; fms-related tyrosine kinase 3 ligand precursor [KO:K05454 ]
114103 Il5ra; interleukin-5 receptor subunit alpha precursor [KO:K05067 ]
114111 Vegfc; vascular endothelial growth factor C precursor [KO:K05449 ]
114117 Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
114118 Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
114119 Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
114120 Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
114851 Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
116465 Ifngr1; interferon gamma receptor 1 precursor [KO:K05132 ]
116499 Fgf4; fibroblast growth factor 4 precursor [KO:K04358 ]
117519 Keap1; kelch-like ECH-associated protein 1 [KO:K10456 ]
117557 Tpm3; tropomyosin alpha-3 chain isoform Tpm3.3cy [KO:K09290 ]
140924 Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070 ]
155140 Il23a; interleukin-23 subunit alpha precursor [KO:K05426 ]
155430 Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091 ]
155437 Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091 ]
170579 Fgf22; fibroblast growth factor 22 precursor [KO:K04358 ]
170580 Fgf21; fibroblast growth factor 21 precursor [KO:K22429 ]
170582 Fgf19; fibroblast growth factor 19 precursor [KO:K22603 ]
170583 Fgf23; fibroblast growth factor 23 precursor [KO:K22428 ]
170633 Fgf3; fibroblast growth factor 3 precursor [KO:K04358 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
171081 Csf2rb; cytokine receptor common subunit beta precursor [KO:K04738 ]
171140 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
171333 Il12rb1; interleukin-12 receptor subunit beta-1 precursor [KO:K05063 ]
171334 Il12rb2; interleukin-12 receptor subunit beta-2 precursor [KO:K05064 ]
24180 Agtr1a; type-1 angiotensin II receptor A [KO:K04166 ]
24205 Apc; adenomatous polyposis coli protein [KO:K02085 ]
24245 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515 ] [EC:2.7.11.17 ]
24246 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
24252 Cebpa; CCAAT/enhancer-binding protein alpha isoform a [KO:K09055 ]
24326 Ednra; endothelin-1 receptor precursor [KO:K04197 ]
24336 Epor; erythropoietin receptor precursor [KO:K05079 ]
24400 Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
24446 Hgf; hepatocyte growth factor preproprotein [KO:K05460 ]
24482 Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459 ]
24483 Igf2; insulin-like growth factor II isoform 2 preproprotein [KO:K13769 ]
24499 Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055 ]
245986 Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
246144 Il3ra; interleukin-3 receptor subunit alpha precursor [KO:K04737 ]
24628 Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
24708 Rb1; retinoblastoma-associated protein [KO:K06618 ]
24716 Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126 ] [EC:2.7.10.1 ]
24772 Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031 ]
24778 Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
24827 Tgfa; protransforming growth factor alpha preproprotein [KO:K08774 ]
24874 Vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871 ]
24888 Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570 ]
24896 Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632 ]
24918 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
24929 Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
25084 Il4r; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
25087 Kng2l1; kininogen-1 isoform 1 precursor [KO:K03898 ]
25094 Mitf; microphthalmia-associated transcription factor isoform 1 [KO:K09455 ]
25112 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
25124 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220 ]
25125 Stat3; signal transducer and activator of transcription 3 [KO:K04692 ]
25126 Stat5b; signal transducer and activator of transcription 5B [KO:K11224 ]
25163 Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621 ]
25164 Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685 ]
25205 Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
25242 Arnt; aryl hydrocarbon receptor nuclear translocator isoform 1 [KO:K09097 ]
25243 Arnt2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589 ]
25245 Bdkrb2; B2 bradykinin receptor isoform 2 [KO:K03916 ]
25266 Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359 ]
25267 Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363 ] [EC:2.7.10.1 ]
25271 Rxra; retinoic acid receptor RXR-alpha [KO:K08524 ]
25296 Bmp4; bone morphogenetic protein 4 precursor [KO:K04662 ]
252963 Il13ra1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076 ]
25313 Egf; pro-epidermal growth factor precursor [KO:K04357 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
25400 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
25439 F2r; proteinase-activated receptor 1 precursor [KO:K03914 ]
25443 Fgf10; fibroblast growth factor 10 precursor [KO:K04358 ]
25473 Lamb2; laminin subunit beta-2 precursor [KO:K06243 ]
25496 Notch1; neurogenic locus notch homolog protein 1 precursor [KO:K02599 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
25631 Smad3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
25637 Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258 ]
25643 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
25664 Pparg; peroxisome proliferator-activated receptor gamma isoform 1 [KO:K08530 ]
25682 Ppard; peroxisome proliferator-activated receptor delta [KO:K04504 ]
25686 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
25704 Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
25717 Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377 ]
25718 Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087 ] [EC:2.7.10.1 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
25746 Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
266610 Fadd; FAS-associated death domain protein [KO:K02373 ]
287280 Skp1; S-phase kinase-associated protein 1 [KO:K03094 ]
288264 Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130 ]
288774 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
290905 Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237 ]
291005 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
291936 Hhip; hedgehog-interacting protein precursor [KO:K06231 ]
293047 Kif7; kinesin-like protein KIF7 isoform X2 [KO:K18806 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
29348 Fgf7; fibroblast growth factor 7 precursor [KO:K04358 ]
29349 Fgf8; fibroblast growth factor 8 isoform 1 precursor [KO:K04358 ]
29357 Smad2; mothers against decapentaplegic homolog 2 [KO:K04500 ]
293649 Lrp5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068 ]
293656 Gstp3; Glutathione S-transferase P-like isoform 2 [KO:K23790 ]
29368 Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358 ]
29369 Fgf18; fibroblast growth factor 18 precursor [KO:K04358 ]
29373 Bmp2; bone morphogenetic protein 2 precursor [KO:K21283 ]
29434 Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350 ]
29452 Epas1; endothelial PAS domain-containing protein 1 [KO:K09095 ]
294790 Skp2; S-phase kinase-associated protein 2 [KO:K03875 ]
294797 Il7r; interleukin-7 receptor subunit alpha precursor [KO:K05072 ]
29492 Notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994 ]
294962 Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
29499 Shh; sonic hedgehog protein precursor [KO:K11988 ]
29560 Hif1a; hypoxia-inducible factor 1-alpha [KO:K08268 ]
29622 Ralgds; ral guanine nucleotide dissociation stimulator isoform 1 [KO:K08732 ]
296456 Itgav; integrin alpha-V isoform 1 precursor [KO:K06487 ]
296468 Birc7; baculoviral IAP repeat-containing protein 7 [KO:K16061 ]
297173 RSA-14-44; ras homolog gene family, member A [KO:K04513 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
298213 Ifna2; interferon alpha family, gene 2 precursor [KO:K05414 ]
298518 Csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061 ]
299331 Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079 ]
299611 Apc2; adenomatous polyposis coli protein 2 [KO:K02085 ]
299626 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
303251 Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
303634 Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639 ]
303811 Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
306628 Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237 ]
307582 Lama3; laminin subunit alpha-3 isoform B precursor [KO:K06240 ]
309452 Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
310999 Plekhg5; pleckstrin homology domain-containing family G member 5 isoform 3 [KO:K19464 ]
312781 Lrp6; low-density lipoprotein receptor-related protein 6 isoform 2 precursor [KO:K03068 ]
313575 Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091 ]
313666 Zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500 ]
313861 Eml4; echinoderm microtubule-associated protein-like 4 [KO:K15420 ]
314436 Elk1; ETS domain-containing protein Elk-1 [KO:K04375 ]
315713 Pml; PML nuclear body scaffold [KO:K10054 ] [EC:2.3.2.-]
353227 Zbtb16; zinc finger and BTB domain-containing protein 16 [KO:K10055 ]
360254 Brca2; breast cancer type 2 susceptibility protein homolog [KO:K08775 ]
360457 Vegfd; vascular endothelial growth factor D precursor [KO:K05449 ]
360697 Ifngr2; interferon gamma receptor 2 precursor [KO:K05133 ]
362896 Stat6; signal transducer and activator of transcription 6 [KO:K11225 ]
363140 Rassf1; ras association domain-containing protein 1 isoform 2 [KO:K09850 ]
363265 Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237 ]
363457 Col4a5; collagen alpha-5(IV) chain precursor [KO:K06237 ]
363458 Col4a6; collagen type IV alpha 6 chain precursor [KO:K06237 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
367072 Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532 ]
367264 Stat4; signal transducer and activator of transcription 4 [KO:K11222 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
406162 Notch4; neurogenic locus notch homolog protein 4 precursor [KO:K20996 ]
492821 Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
498709 Cks2; cyclin-dependent kinases regulatory subunit 2 [KO:K02219 ]
499655 Cks1b; cyclin-dependent kinases regulatory subunit 1 [KO:K02219 ]
499870 Rad51; DNA repair protein RAD51 homolog 1 [KO:K04482 ]
500491 Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414 ]
502959 Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414 ]
502961 Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414 ]
50554 Smad4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
50662 Runx1; runt-related transcription factor 1 [KO:K08367 ]
50672 Ednrb; endothelin receptor type B precursor [KO:K04198 ]
54355 Rassf5; ras association domain-containing protein 5 [KO:K08015 ]
56761 Notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
58979 Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
59086 Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
60323 Arhgef1; rho guanine nucleotide exchange factor 1 [KO:K12330 ]
60371 Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060 ]
60427 Kitlg; kit ligand isoform 1 precursor [KO:K05461 ]
60449 Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
60628 Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189 ]
60662 Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
64041 Birc5; baculoviral IAP repeat-containing protein 5 [KO:K08731 ]
64199 Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
64465 Cdc42; cell division control protein 42 homolog [KO:K04393 ]
64546 Il12b; interleukin-12 subunit beta precursor [KO:K05425 ]
64625 Bid; BH3-interacting domain death agonist [KO:K04726 ]
64639 Bad; bcl2-associated agonist of cell death [KO:K02158 ]
652957 Csf2ra; granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor [KO:K05066 ]
66025 Lpar3; lysophosphatidic acid receptor 3 [KO:K04294 ]
680149 Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
681162 Cks1l; CDC28 protein kinase regulatory subunit 1-like [KO:K02219 ]
684111 E2f2; transcription factor E2F2 isoform X2 [KO:K09389 ]
685451 Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
685513 Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
686326 Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
689932 Il23r; interleukin-23 receptor isoform X1 [KO:K05065 ]
690369 Il15ra; interleukin-15 receptor subunit alpha precursor [KO:K05074 ]
690825 Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
690894 Ifna1; interferon alpha family, gene 5 precursor [KO:K05414 ]
78963 Apaf1; apoptotic protease-activating factor 1 [KO:K02084 ]
78966 Arhgef11; rho guanine nucleotide exchange factor 11 [KO:K12331 ]
78971 Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060 ]
79218 Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
80850 Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
81638 Agtr1b; type-1 angiotensin II receptor B [KO:K04166 ]
81662 Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
81663 Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
81664 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
81667 Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
81685 Mlh1; DNA mismatch repair protein Mlh1 [KO:K08734 ]
81709 Msh2; DNA mismatch repair protein Msh2 [KO:K08735 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
81752 Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259 ]
81809 Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
83571 Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624 ]
83574 Rxrg; retinoic acid receptor RXR-gamma [KO:K08526 ]
83579 Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
83619 Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform 2 [KO:K05638 ]
83721 Dvl1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
83785 Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448 ]
84023 Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
89811 Vegfb; vascular endothelial growth factor B precursor [KO:K16858 ]
89830 Ptch1; protein patched homolog 1 isoform 2 [KO:K06225 ]
94203 Pgf; placenta growth factor precursor [KO:K16859 ]
Compound
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C16038 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
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