KEGG   ORTHOLOGY: K04526Help
Entry
K04526                      KO                                     

Name
INS
Definition
insulin
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04911  Insulin secretion
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04917  Prolactin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04940  Type I diabetes mellitus
ko04950  Maturity onset diabetes of the young
ko04960  Aldosterone-regulated sodium reabsorption
ko05215  Prostate cancer
Disease
H00408  Type 1 diabetes mellitus
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04010 MAPK signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP-PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04526  INS; insulin
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocytes
    K04526  INS; insulin
   04913 Ovarian steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  09149 Aging
   04211 Longevity regulating pathway
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
 09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K04526  INS; insulin
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin
BRITE hierarchy
Genes
HSA: 3630(INS)
PTR: 449570(INS)
PPS: 100969387(INS)
GGO: 101132604(INS)
PON: 100453978(INS)
NLE: 100586809(INS)
MCC: 704534(INS)
MCF: 102133184(INS)
CSAB: 103239029(INS)
RRO: 104677102(INS)
RBB: 108539226(INS)
CJC: 100393089(INS)
SBQ: 101038116(INS)
MMU: 16333(Ins1) 16334(Ins2)
RNO: 24505(Ins1) 24506(Ins2)
MUN: 110547298
CGE: 100760716(Ins)
NGI: 103738986(Ins)
HGL: 101719971(Ins)
CCAN: 109689794
OCU: 100009181(INS)
TUP: 102481191(INS)
CFA: 483665(INS)
VVP: 112924140(INS)
AML: 100483432(INS)
UMR: 103671056
UAH: 113243960
ORO: 101383590(INS)
FCA: 493804(INS)
AJU: 113595531(INS)
BTA: 280829(INS)
BOM: 102274400(INS)
BIU: 109554336(INS)
BBUB: 102396436(INS)
CHX: 108634241(INS)
OAS: 114110121(INS)
SSC: 397415(INS)
CDK: 105106405
BACU: 103021022(INS)
LVE: 103085742(INS)
OOR: 101278494(INS)
DLE: 111183606(INS)
PCAD: 112062628(INS)
ECB: 111776000(INS)
EPZ: 103567614(INS)
EAI: 106824100(INS)
MYB: 102254396
MYD: 102753598(INS)
HAI: 109395936(INS)
RSS: 109435670(INS)
DRO: 112317432
PALE: 102881117
RAY: 107513269(INS)
LAV: 100661112(INS)
TMU: 101346705
PCW: 110197190(INS)
OAA: 114810063(INS)
GGA: 396145(INS-IGF2)
MGP: 100540225(INS)
CJO: 107314531(INS)
NMEL: 110400779(INS)
APLA: 101794427(INS)
ACYG: 106042601(INS)
TGU: 100231606(INS)
LSR: 110468670(INS)
SCAN: 103826754(INS)
GFR: 102044590(INS)
FAB: 101812165(INS)
PHI: 102111203(INS)
PMAJ: 107205419(INS)
CCAE: 111930707(INS)
CCW: 104687554(INS)
ETL: 114059852(INS)
FPG: 101915745(INS)
FCH: 102054961(INS)
CLV: 102092033(INS)
EGZ: 104124907
NNI: 104010412
ACUN: 113481160
PADL: 103920695(INS)
AAM: 106497062(INS)
ASN: 102378642(INS)
AMJ: 102565762(INS)
PSS: 102445198(INS)
CMY: 102935680(INS)
CPIC: 101937524(INS)
ACS: 100565615(ins)
PVT: 110076559(INS)
PBI: 103061255(INS)
PMUR: 107294042(INS)
GJA: 107123376(INS)
XLA: 108696734 378695(ins.L) 378696(ins.S)
XTR: 100101718(ins)
NPR: 108792002(INS)
DRE: 30262(ins) 566735(insb)
PHYP: 113525002 113531241(ins)
EEE: 113591428(ins)
TRU: 101065226
NCC: 104961913(ins)
MZE: 101468103(ins) 101469513
XMA: 102225241(ins) 102229304
XCO: 114139621 114153755(ins)
CSEM: 103395680(ins)
SASA: 106567474(INS) 106603941(INS) 106612054
SFM: 108934283(ins)
PKI: 111850821(ins)
LCM: 102348278(INS)
CMK: 103186003(ins)
DME: Dmel_CG14167(Ilp3) Dmel_CG14173(Ilp1) Dmel_CG33273(Ilp5) Dmel_CG6736(Ilp4) Dmel_CG8167(Ilp2)
DSI: Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)
BIM: 112211977
BTER: 100646077
SOC: 105200753
MPHA: 105832901
AEC: 105147653
ACEP: 105625577
PBAR: 105432563
VEM: 105559845
HST: 105188195
DQU: 106750697
LHU: 105670049
PGC: 109860861
OBO: 105278524
PCF: 106791661
NVI: 100117514
MDL: 103569964
TCA: 100142381
BMOR: 100146109(Bbx-e1) 100146110(Bbx-f1) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169726(Bbx-g1) 100653512(BmILP) 101741759
CLEC: 112127432
FCD: 110851216
TSP: Tsp_10902
OBI: 106870869
LAK: 106180359
EGL: EGR_08330
SPIS: 111326395
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lizcano JM, Alessi DR
  Title
The insulin signalling pathway.
  Journal
Curr Biol 12:R236-8 (2002)
DOI:10.1016/S0960-9822(02)00777-7
Reference
PMID:2397023
  Authors
Sawa T, Ohgaku S, Morioka H, Yano S
  Title
Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.
  Journal
J Mol Endocrinol 5:61-7 (1990)
DOI:10.1677/jme.0.0050061
  Sequence
[mmu:16333 16334]
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