KEGG   ORTHOLOGY: K17908
Entry
K17908                      KO                                     

Name
WIPI1_2, ATG18
Definition
autophagy-related protein 18
Pathway
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   04138 Autophagy - yeast
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   04136 Autophagy - other
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   05014 Amyotrophic lateral sclerosis
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   05016 Huntington disease
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   05017 Spinocerebellar ataxia
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   05022 Pathways of neurodegeneration - multiple diseases
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
   03029 Mitochondrial biogenesis
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
Membrane trafficking [BR:ko04131]
 Autophagy
  Autophagosome formation proteins
   Atg18-Atg2 complex
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Autophagy-related proteins
    K17908  WIPI1_2, ATG18; autophagy-related protein 18
Transporters [BR:ko02000]
 Other transporters
  Others
   K17908  WIPI1_2, ATG18; autophagy-related protein 18
Other DBs
COG: COG2319
TC: 9.A.15.1
Genes
HSA: 26100(WIPI2) 55062(WIPI1)
PTR: 468309(WIPI1) 737922(WIPI2)
PPS: 100968649(WIPI1) 100985903(WIPI2)
GGO: 101130514(WIPI2) 101148284(WIPI1)
PON: 100433761(WIPI2) 100446173(WIPI1)
NLE: 100588327(WIPI1) 100595693(WIPI2)
MCC: 702966(WIPI2) 718945(WIPI1)
MCF: 101865895(WIPI2) 102118159(WIPI1)
CSAB: 103243149(WIPI1) 103246841(WIPI2)
RRO: 104654030(WIPI1) 104665223(WIPI2)
RBB: 108523042(WIPI1) 108530419(WIPI2)
CJC: 100395323(WIPI1) 100408705(WIPI2)
SBQ: 101032537(WIPI1) 101035498(WIPI2)
MMU: 52639(Wipi1) 74781(Wipi2)
MCAL: 110294285(Wipi2) 110305706(Wipi1)
MPAH: 110331591(Wipi1) 110339041(Wipi2)
RNO: 288498(Wipi2) 303630(Wipi1)
MUN: 110540721(Wipi2) 110560038(Wipi1)
CGE: 100750963(Wipi1) 100759282(Wipi2)
NGI: 103742212(Wipi1) 103748663(Wipi2)
HGL: 101722436(Wipi1) 101722837(Wipi2)
OCU: 100340527(WIPI1) 100352881(WIPI2)
TUP: 102477819(WIPI2) 102491552(WIPI1)
CFA: 490899(WIPI1) 608721(WIPI2)
VVP: 112920739(WIPI1) 112929323(WIPI2)
AML: 100475501(WIPI1) 100483830(WIPI2)
UMR: 103665675(WIPI1) 103670082(WIPI2)
UAH: 113265240(WIPI1) 113267967(WIPI2)
ORO: 101373875(WIPI2) 101384528(WIPI1)
FCA: 101088378(WIPI1) 101095300(WIPI2)
PTG: 102954818(WIPI2) 102967857(WIPI1)
PPAD: 109251061(WIPI2) 109277039(WIPI1)
AJU: 106975308(WIPI1) 106984491(WIPI2)
BTA: 512685(WIPI2) 528410(WIPI1)
BOM: 102277604(WIPI1) 102285764(WIPI2)
BIU: 109573378(WIPI1) 109578618(WIPI2)
BBUB: 102391221(WIPI1) 102411428(WIPI2)
CHX: 102179237(WIPI1) 102180716(WIPI2)
OAS: 101109028(WIPI1) 101109238(WIPI2)
SSC: 100462758(WIPI1) 100462759(WIPI2)
CFR: 102503459(WIPI1) 102515887(WIPI2)
CDK: 105085704(WIPI1) 105104243(WIPI2)
BACU: 103001233(WIPI2) 103008082(WIPI1)
LVE: 103074872(WIPI1) 103078314(WIPI2)
OOR: 101278800(WIPI2) 101279066(WIPI1)
DLE: 111170348(WIPI2) 111182905(WIPI1)
PCAD: 102977297(WIPI1) 102989465(WIPI2) 114487831
ECB: 100053194(WIPI1) 100060823(WIPI2)
EPZ: 103558474(WIPI1) 103567550(WIPI2)
EAI: 106835357(WIPI1) 106846343(WIPI2)
MYB: 102255438(WIPI2) 102260137(WIPI1)
MYD: 102762786(WIPI1) 102772683(WIPI2)
MNA: 107528402(WIPI1) 107537602(WIPI2)
HAI: 109380230(WIPI2) 109380286(WIPI1)
DRO: 112316590(WIPI1) 112319592(WIPI2)
PALE: 102884976(WIPI2) 102890320(WIPI1)
RAY: 107505308(WIPI2) 107510293(WIPI1)
MJV: 108392402(WIPI1) 108408316(WIPI2)
LAV: 100653866(WIPI2) 100663073(WIPI1)
MDO: 100011149(WIPI2) 100024500(WIPI1)
SHR: 100920269(WIPI2) 100931931(WIPI1)
PCW: 110218293(WIPI1) 110223111(WIPI2)
OAA: 100078638(WIPI1) 100082003(WIPI2)
GGA: 416481(WIPI2) 417437(WIPI1)
MGP: 100538905(WIPI2) 100546057(WIPI1)
CJO: 107320704(WIPI2) 107322108(WIPI1)
NMEL: 110406157(WIPI2) 110407200(WIPI1)
APLA: 101790231(WIPI2)
ACYG: 106032174(WIPI2) 106034789(WIPI1)
TGU: 100225065(WIPI2) 100230726(WIPI1)
LSR: 110473952(WIPI1) 110481050(WIPI2)
SCAN: 103817852(WIPI2) 103819969(WIPI1)
GFR: 102040126(WIPI1) 102041955(WIPI2)
FAB: 101814556(WIPI2) 101818403(WIPI1)
PHI: 102106867(WIPI2) 102114741(WIPI1)
PMAJ: 107211238(WIPI2) 107212470(WIPI1)
CCAE: 111936108(WIPI2) 111937442
CCW: 104684803(WIPI2) 104696028(WIPI1)
ETL: 114060164(WIPI2) 114060696(WIPI1)
FPG: 101914177(WIPI1) 101917783(WIPI2)
FCH: 102052403(WIPI1) 102057342(WIPI2)
CLV: 102083868(WIPI1) 102087454(WIPI2)
EGZ: 104132625(WIPI2) 104132824(WIPI1)
NNI: 104014356(WIPI1) 104015222(WIPI2)
ACUN: 113485555(WIPI2) 113486701(WIPI1)
PADL: 103913578(WIPI2) 103916713(WIPI1)
AAM: 106485983(WIPI1) 106497878(WIPI2)
ASN: 102372972(WIPI2) 102386150(WIPI1)
AMJ: 102569555(WIPI2) 102570428(WIPI1)
PSS: 102449560(WIPI2) 102458634(WIPI1)
CMY: 102936050(WIPI2) 102939770(WIPI1)
CPIC: 101943547(WIPI2) 101954042(WIPI1)
ACS: 100555432(wipi2) 100555875(wipi1)
PVT: 110077812(WIPI1) 110083723(WIPI2)
PBI: 103057870(WIPI1) 103065993(WIPI2)
PMUR: 107282574(WIPI1) 107290606(WIPI2)
TSR: 106547888(WIPI1) 106550794
PMUA: 114584121(WIPI2) 114588294(WIPI1)
GJA: 107112906(WIPI1) 107123504(WIPI2)
XLA: 380011(wipi2.L) 446709(wipi1.L) 446901(wipi1.S)
XTR: 100497399(wipi2) 496656(wipi1)
NPR: 108791508(WIPI2)
DRE: 100332293 393362(wipi1) 437002(wipi2)
IPU: 108256943(wipi2) 108259373(wipi1)
PHYP: 113528013(wipi1) 113536113(wipi2)
AMEX: 103028226(wipi2) 103046600(wipi1)
EEE: 113580266(wipi1) 113589656(wipi2)
TRU: 101062299(wipi1) 101073129(wipi2) 101079656
LCO: 104923262(wipi1) 104929725 104932088(wipi2)
NCC: 104944192 104956914(wipi2) 104963460(wipi1)
MZE: 101465687(wipi1) 101471896(wipi2)
ONL: 100699282(wipi2) 100710906(wipi1)
OLA: 101159269 101171782(wipi1) 101171834(wipi2)
XMA: 102219528(wipi1) 102223821(wipi2) 102232828
XCO: 114148610 114150965(wipi1) 114159766(wipi2)
PRET: 103468270 103468480(wipi2) 103481957(wipi1)
CVG: 107087197(wipi2) 107100320 107101030(wipi1)
NFU: 107376348(wipi2) 107388192(wipi1) 107391561
KMR: 108236048(wipi2) 108237178(wipi1) 108247479
ALIM: 106520660(wipi2) 106528784(wipi1)
AOCE: 111569213 111578314(wipi1) 111585315(wipi2)
CSEM: 103382375(wipi1) 103393297(wipi2) 103393541
POV: 109626866(wipi1) 109640360 109641999(wipi2)
SDU: 111219550(wipi1) 111230321(wipi2) 111236271
SLAL: 111646329(wipi2) 111667237 111672013(wipi1)
HCQ: 109508580 109516242(wipi1) 109520253(wipi2)
BPEC: 110159536(wipi1) 110161022 110162433(wipi2)
MALB: 109963655(wipi1) 109972424(wipi2)
ELS: 105005666(wipi1) 105012795 105030518(wipi2)
LCM: 102357407(WIPI2) 102366942(WIPI1)
CMK: 103175519(wipi1) 103186878(wipi2)
BFO: 118428714
SPU: 575901
APLC: 110973706
SKO: 100367633
DME: Dmel_CG7986(Atg18a) Dmel_CG8678(Atg18b)
DSI: Dsimw501_GD14059(Dsim_GD14059) Dsimw501_GD21643(Dsim_GD21643)
AME: 552201
BIM: 100741721
BTER: 100642580
CCAL: 108631592
OBB: 114875207
MPHA: 105838050
AEC: 105143025
ACEP: 105627563
PBAR: 105430958
VEM: 105563259
HST: 105180599
DQU: 106747868
CFO: 105254477
LHU: 105677017
PGC: 109853570
OBO: 105284042
PCF: 106784433
NVI: 100121906
CSOL: 105363476
MDL: 103572667
TCA: 658015
DPA: 109544481
ATD: 109594650
NVL: 108558773
BMAN: 114248126
PMAC: 106713720
PRAP: 110997974
HAW: 110382868
TNL: 113494873
PXY: 105392156
API: 100165258
AGS: 114127633
RMD: 113555232
BTAB: 109043586
CLEC: 106663706
ZNE: 110832477
PVM: 113825835
DPTE: 113798835
CSCU: 111633037
CEL: CELE_F41E6.13(atg-18)
CBR: CBG01467 CBG01469(Cbr-atgr-18)
PCAN: 112567306
MYI: 110448218
OBI: 106875830
LAK: 106172375
SHX: MS3_02217
EGL: EGR_09025
ADF: 107354996
AMIL: 114958617
PDAM: 113664643
SPIS: 111324000
DGT: 114519374
AQU: 100634321
ATH: AT4G30510(ATG18B)
ALY: 9303415
CRB: 17877744
BRP: 103861971
BOE: 106305832
RSZ: 108848848
THJ: 104803529
CPAP: 110806710
CIT: 102627141
TCC: 18589045
GRA: 105780575
GAB: 108461014
EGR: 104436009
VRA: 106769129
VAR: 108323210
VUN: 114178601
CAM: 101498211
LJA: Lj4g3v2018270.1(Lj4g3v2018270.1) Lj4g3v2018270.2(Lj4g3v2018270.2)
ADU: 107459567
AIP: 107641566
LANG: 109346645
FVE: 101295294
RCN: 112196072
PPER: 18792663
PMUM: 103323374
PAVI: 110760853
MDM: 114822017
CSV: 101215606
CMO: 103493470
MCHA: 111020856
CMAX: 111493984
CMOS: 111450756
CPEP: 111784883
RCU: 8258873
HBR: 110661222
MESC: 110617778
POP: 7489417
PEU: 105121231
JRE: 108989517
VVI: 100854449
SLY: 101255009
SPEN: 107024325
SOT: 102595961
CANN: 107854256
NSY: 104242950
NTO: 104104737
NAU: 109234540
INI: 109173171
SIND: 105162962
HAN: 110877503
LSV: 111889292
CCAV: 112500968
DCR: 108193911
BVG: 104901760
SOE: 110793573
NNU: 104612306
OSA: 4330978
DOSA: Os02t0791800-01(Os02g0791800)
OBR: 102704495
BDI: 100823376
ATS: 109755763(LOC109755763)
SBI: 8082730
ZMA: 100279118
SITA: 101771001
PDA: 103710459
EGU: 105050759
MUS: 103997856
DCT: 110099684
PEQ: 110021596
AOF: 109840534
ATR: 18435324
PPP: 112284232
MNG: MNEG_2141
APRO: F751_3626
SCE: YFR021W(ATG18) YPL100W(ATG21)
KMX: KLMA_10800(ATG21) KLMA_20474(ATG18)
NCS: NCAS_0A08960(NCAS0A08960) NCAS_0C01910(NCAS0C01910) NCAS_0D00540(NCAS0D00540)
NDI: NDAI_0E02630(NDAI0E02630) NDAI_0G05990(NDAI0G05990) NDAI_0H03610(NDAI0H03610)
TPF: TPHA_0A01250(TPHA0A01250) TPHA_0O01210(TPHA0O01210)
TBL: TBLA_0D04920(TBLA0D04920) TBLA_0H03870(TBLA0H03870)
TDL: TDEL_0A05240(TDEL0A05240) TDEL_0D02290(TDEL0D02290)
KAF: KAFR_0C02420(KAFR0C02420) KAFR_0C04445(KAFR0C04445) KAFR_0E00720(KAFR0E00720)
PIC: PICST_52962(ATG18) PICST_62474(ATG21)
CAL: CAALFM_C100430WA(CaO19.6064) CAALFM_C103330CA(CaO19.3030)
SLB: AWJ20_1050(ATG18)
NCR: NCU03441
NTE: NEUTE1DRAFT65975(NEUTE1DRAFT_65975)
MGR: MGG_03139
SSCK: SPSK_01676
MAW: MAC_09129
MAJ: MAA_05300
CMT: CCM_07441
MBE: MBM_09583
ANI: AN0127.2
ANG: ANI_1_382164(An18g03070)
ABE: ARB_03108
TVE: TRV_05814
PTE: PTT_17718
SPO: SPAC589.07c(atg18)
CNE: CNE02750
CNB: CNBE2770
TASA: A1Q1_03692
ABP: AGABI1DRAFT115895(AGABI1DRAFT_115895)
ABV: AGABI2DRAFT195614(AGABI2DRAFT_195614)
MGL: MGL_3093
MRT: MRET_1389
DDI: DDB_G0285375(atg18)
DFA: DFA_03995(atg18)
SMIN: v1.2.002891.t1(symbB.v1.2.002891.t1)
SPAR: SPRG_01029
 » show all
Reference
  Authors
Krick R, Tolstrup J, Appelles A, Henke S, Thumm M
  Title
The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy.
  Journal
FEBS Lett 580:4632-8 (2006)
DOI:10.1016/j.febslet.2006.07.041
  Sequence
[sce:YFR021W]
Reference
  Authors
Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A
  Title
WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.
  Journal
Oncogene 23:9314-25 (2004)
DOI:10.1038/sj.onc.1208331
  Sequence
[hsa:55062]
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