KEGG   ORTHOLOGY: K03175Help
Entry
K03175                      KO                                     

Name
TRAF6
Definition
TNF receptor-associated factor 6 [EC:2.3.2.27]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04064  NF-kappa B signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04214  Apoptosis - fly
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04722  Neurotrophin signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05133  Pertussis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04013 MAPK signaling pathway - fly
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
   04140 Autophagy - animal
    K03175  TRAF6; TNF receptor-associated factor 6
  09143 Cell growth and death
   04214 Apoptosis - fly
    K03175  TRAF6; TNF receptor-associated factor 6
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04657 IL-17 signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05131 Shigellosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05135 Yersinia infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05161 Hepatitis B
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease (American trypanosomiasis)
    K03175  TRAF6; TNF receptor-associated factor 6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03175  TRAF6; TNF receptor-associated factor 6
   04121 Ubiquitin system
    K03175  TRAF6; TNF receptor-associated factor 6
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03175  TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6
BRITE hierarchy
Genes
HSA: 7189(TRAF6)
PTR: 451702(TRAF6)
PPS: 100983960(TRAF6)
GGO: 101152087(TRAF6)
PON: 100449432(TRAF6)
NLE: 100595327(TRAF6)
MCC: 716907(TRAF6)
MCF: 102128596(TRAF6)
CSAB: 103237554(TRAF6)
RRO: 104658364(TRAF6)
RBB: 108535559(TRAF6)
CJC: 100395364(TRAF6)
SBQ: 101033308(TRAF6)
MMU: 22034(Traf6)
MCAL: 110290132(Traf6)
MPAH: 110318382(Traf6)
RNO: 311245(Traf6)
MUN: 110557497(Traf6)
CGE: 100753700(Traf6)
NGI: 103749513(Traf6)
HGL: 101697126(Traf6)
CCAN: 109693564(Traf6)
OCU: 100343190(TRAF6)
TUP: 102482652(TRAF6)
CFA: 100688110(TRAF6)
VVP: 112930471(TRAF6)
AML: 100483216(TRAF6)
UMR: 103659308(TRAF6)
UAH: 113265029(TRAF6)
ORO: 101362953(TRAF6)
ELK: 111150027
FCA: 101099750(TRAF6)
PTG: 102960157(TRAF6)
PPAD: 109279193(TRAF6)
AJU: 106976941(TRAF6)
BTA: 539124(TRAF6)
BOM: 102285891(TRAF6)
BIU: 109565970
BBUB: 102399580(TRAF6)
CHX: 102172830(TRAF6)
OAS: 101107132(TRAF6)
SSC: 396629(TRAF6)
CFR: 102520181(TRAF6)
CDK: 105106823(TRAF6)
BACU: 103018592(TRAF6)
OOR: 101277553(TRAF6)
DLE: 111179772(TRAF6)
PCAD: 102993207(TRAF6)
ECB: 100052296(TRAF6)
EPZ: 103560236(TRAF6)
EAI: 106837480(TRAF6)
MYB: 102250946(TRAF6)
MYD: 102765934(TRAF6)
MNA: 107531990(TRAF6)
HAI: 109381153(TRAF6)
DRO: 112303407(TRAF6)
PALE: 102886476(TRAF6)
RAY: 107499247(TRAF6)
MJV: 108390300(TRAF6)
LAV: 100671471(TRAF6)
TMU: 101345331
MDO: 100010055(TRAF6)
SHR: 100922331(TRAF6)
PCW: 110192620(TRAF6)
OAA: 100077058(TRAF6)
GGA: 423163(TRAF6)
MGP: 100544809(TRAF6)
CJO: 107314700(TRAF6)
NMEL: 110401104(TRAF6)
APLA: 101802411(TRAF6)
ACYG: 106044346(TRAF6)
TGU: 100229606(TRAF6)
LSR: 110484454(TRAF6)
SCAN: 103826724(TRAF6)
GFR: 102040197(TRAF6)
FAB: 101817601(TRAF6)
PHI: 102105183(TRAF6)
PMAJ: 107206210(TRAF6)
CCAE: 111930105(TRAF6)
CCW: 104693976(TRAF6)
ETL: 114056738(TRAF6)
FPG: 101912003(TRAF6)
FCH: 102058044(TRAF6)
CLV: 102083770(TRAF6)
EGZ: 104134046(TRAF6)
ACUN: 113481145(TRAF6)
PADL: 103921676(TRAF6)
AAM: 106498355(TRAF6)
ASN: 102368234(TRAF6)
AMJ: 102572036(TRAF6)
PSS: 102463398(TRAF6)
CMY: 102938959(TRAF6)
CPIC: 101953645(TRAF6)
ACS: 100561211(traf6)
PVT: 110090250(TRAF6)
PBI: 103052063(TRAF6)
PMUR: 107293338(TRAF6) 107301648
TSR: 106556967(TRAF6)
PMUA: 114600173(TRAF6)
GJA: 107116985(TRAF6)
XLA: 444777(traf6.L) 734929(traf6.S)
XTR: 493524(traf6)
NPR: 108787821(TRAF6)
DRE: 554561(traf6)
CCAR: 109065463 109093401(traf6)
IPU: 108259200(traf6)
PHYP: 113540966(traf6)
AMEX: 103021325(traf6)
EEE: 113579696(traf6)
TRU: 101071368(traf6)
LCO: 104920634(traf6)
NCC: 104948752(traf6)
MZE: 101469001(traf6)
ONL: 100703551(traf6)
OLA: 101161132(traf6)
XMA: 102220826(traf6)
XCO: 114142760(traf6)
PRET: 103462724(traf6)
CVG: 107099447(traf6)
NFU: 107383589(traf6)
KMR: 108234801(traf6)
ALIM: 106523547(traf6)
AOCE: 111571002(traf6)
CSEM: 103378810(traf6)
POV: 109637261(traf6)
LCF: 108887802(traf6)
SDU: 111223588(traf6)
SLAL: 111644323(traf6)
HCQ: 109525774(traf6)
BPEC: 110162549(traf6)
MALB: 109965061(traf6)
SALP: 112077783(traf6)
ELS: 105025313(traf6)
SFM: 108934700 108942315(traf6)
LCM: 102353931(TRAF6)
CMK: 103186026(traf6)
RTP: 109936672(traf6)
CIN: 778949(zf(traf/ring)-3)
DME: Dmel_CG10961(Traf6)
DER: 6550517
DSI: Dsimw501_GD16124(Dsim_GD16124)
DSR: 110179707
DPE: 6598159
DMN: 108164693
DWI: 6641099
DAZ: 108617878
DNV: 108655545
DHE: 111594992
MDE: 101890213
LCQ: 111674929
AME: 551819
BIM: 100744070
BTER: 100647374
CCAL: 108622235
OBB: 114881674
SOC: 105198280
MPHA: 105833603
AEC: 105149418
ACEP: 105625455
PBAR: 105422477
VEM: 105567281
HST: 105190721
DQU: 106742594
CFO: 105257286
LHU: 105676050
PGC: 109851970
OBO: 105280100
PCF: 106788531
MDL: 103569690
TCA: 661716(Traf2)
DPA: 109541363
ATD: 109597958
BMOR: 100862757
BMAN: 114241799
PMAC: 106715656
PRAP: 111001407
HAW: 110371014
TNL: 113507105
API: 100575177
DNX: 107165263
AGS: 114120558
RMD: 113560984
BTAB: 109044603
CLEC: 106670044
ZNE: 110826527
FCD: 110850863
PVM: 113823573
DPTE: 113797525
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
  Title
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
  Journal
Science 325:1134-8 (2009)
DOI:10.1126/science.1175065
  Sequence
[hsa:7189]
Reference
PMID:8837778
  Authors
Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV
  Title
TRAF6 is a signal transducer for interleukin-1.
  Journal
Nature 383:443-6 (1996)
DOI:10.1038/383443a0
  Sequence
[hsa:7189]
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