ORTHOLOGY: K03175
Entry
K03175 KO
Name
TRAF6
Definition
TNF receptor-associated factor 6 [EC:
2.3.2.27
]
Pathway
ko04010
MAPK signaling pathway
ko04013
MAPK signaling pathway - fly
ko04064
NF-kappa B signaling pathway
ko04120
Ubiquitin mediated proteolysis
ko04140
Autophagy - animal
ko04144
Endocytosis
ko04214
Apoptosis - fly
ko04380
Osteoclast differentiation
ko04620
Toll-like receptor signaling pathway
ko04621
NOD-like receptor signaling pathway
ko04622
RIG-I-like receptor signaling pathway
ko04657
IL-17 signaling pathway
ko04722
Neurotrophin signaling pathway
ko05130
Pathogenic Escherichia coli infection
ko05131
Shigellosis
ko05133
Pertussis
ko05135
Yersinia infection
ko05140
Leishmaniasis
ko05142
Chagas disease (American trypanosomiasis)
ko05145
Toxoplasmosis
ko05152
Tuberculosis
ko05160
Hepatitis C
ko05161
Hepatitis B
ko05162
Measles
ko05168
Herpes simplex virus 1 infection
ko05169
Epstein-Barr virus infection
ko05170
Human immunodeficiency virus 1 infection
ko05200
Pathways in cancer
ko05222
Small cell lung cancer
ko05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K03175 TRAF6; TNF receptor-associated factor 6
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
04013 MAPK signaling pathway - fly
K03175 TRAF6; TNF receptor-associated factor 6
04064 NF-kappa B signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K03175 TRAF6; TNF receptor-associated factor 6
04140 Autophagy - animal
K03175 TRAF6; TNF receptor-associated factor 6
09143 Cell growth and death
04214 Apoptosis - fly
K03175 TRAF6; TNF receptor-associated factor 6
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
04621 NOD-like receptor signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
04622 RIG-I-like receptor signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
04657 IL-17 signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
09156 Nervous system
04722 Neurotrophin signaling pathway
K03175 TRAF6; TNF receptor-associated factor 6
09158 Development and regeneration
04380 Osteoclast differentiation
K03175 TRAF6; TNF receptor-associated factor 6
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K03175 TRAF6; TNF receptor-associated factor 6
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
K03175 TRAF6; TNF receptor-associated factor 6
09162 Cancer: specific types
05222 Small cell lung cancer
K03175 TRAF6; TNF receptor-associated factor 6
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K03175 TRAF6; TNF receptor-associated factor 6
05131 Shigellosis
K03175 TRAF6; TNF receptor-associated factor 6
05135 Yersinia infection
K03175 TRAF6; TNF receptor-associated factor 6
05133 Pertussis
K03175 TRAF6; TNF receptor-associated factor 6
05152 Tuberculosis
K03175 TRAF6; TNF receptor-associated factor 6
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
K03175 TRAF6; TNF receptor-associated factor 6
05162 Measles
K03175 TRAF6; TNF receptor-associated factor 6
05161 Hepatitis B
K03175 TRAF6; TNF receptor-associated factor 6
05160 Hepatitis C
K03175 TRAF6; TNF receptor-associated factor 6
05168 Herpes simplex virus 1 infection
K03175 TRAF6; TNF receptor-associated factor 6
05169 Epstein-Barr virus infection
K03175 TRAF6; TNF receptor-associated factor 6
09174 Infectious disease: parasitic
05145 Toxoplasmosis
K03175 TRAF6; TNF receptor-associated factor 6
05140 Leishmaniasis
K03175 TRAF6; TNF receptor-associated factor 6
05142 Chagas disease (American trypanosomiasis)
K03175 TRAF6; TNF receptor-associated factor 6
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K03175 TRAF6; TNF receptor-associated factor 6
04121 Ubiquitin system
K03175 TRAF6; TNF receptor-associated factor 6
Enzymes [BR:
ko01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
K03175 TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:
ko04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
K03175 TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:
ko04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
TRAF proteins
K03175 TRAF6; TNF receptor-associated factor 6
Genes
HSA:
7189
(TRAF6)
PTR:
451702
(TRAF6)
PPS:
100983960
(TRAF6)
GGO:
101152087
(TRAF6)
PON:
100449432
(TRAF6)
NLE:
100595327
(TRAF6)
MCC:
716907
(TRAF6)
MCF:
102128596
(TRAF6)
CSAB:
103237554
(TRAF6)
RRO:
104658364
(TRAF6)
RBB:
108535559
(TRAF6)
CJC:
100395364
(TRAF6)
SBQ:
101033308
(TRAF6)
MMU:
22034
(Traf6)
MCAL:
110290132
(Traf6)
MPAH:
110318382
(Traf6)
RNO:
311245
(Traf6)
MUN:
110557497
(Traf6)
CGE:
100753700
(Traf6)
NGI:
103749513
(Traf6)
HGL:
101697126
(Traf6)
CCAN:
109693564
(Traf6)
OCU:
100343190
(TRAF6)
TUP:
102482652
(TRAF6)
CFA:
100688110
(TRAF6)
VVP:
112930471
(TRAF6)
AML:
100483216
(TRAF6)
UMR:
103659308
(TRAF6)
UAH:
113265029
(TRAF6)
ORO:
101362953
(TRAF6)
ELK:
111150027
FCA:
101099750
(TRAF6)
PTG:
102960157
(TRAF6)
PPAD:
109279193
(TRAF6)
AJU:
106976941
(TRAF6)
BTA:
539124
(TRAF6)
BOM:
102285891
(TRAF6)
BIU:
109565970
BBUB:
102399580
(TRAF6)
CHX:
102172830
(TRAF6)
OAS:
101107132
(TRAF6)
SSC:
396629
(TRAF6)
CFR:
102520181
(TRAF6)
CDK:
105106823
(TRAF6)
BACU:
103018592
(TRAF6)
LVE:
103088508
103088795
OOR:
101277553
(TRAF6)
DLE:
111179772
(TRAF6)
PCAD:
102993207
(TRAF6)
ECB:
100052296
(TRAF6)
EPZ:
103560236
(TRAF6)
EAI:
106837480
(TRAF6)
MYB:
102250946
(TRAF6)
MYD:
102765934
(TRAF6)
MNA:
107531990
(TRAF6)
HAI:
109381153
(TRAF6)
DRO:
112303407
(TRAF6)
PALE:
102886476
(TRAF6)
RAY:
107499247
(TRAF6)
MJV:
108390300
(TRAF6)
LAV:
100671471
(TRAF6)
TMU:
101345331
MDO:
100010055
(TRAF6)
SHR:
100922331
(TRAF6)
PCW:
110192620
(TRAF6)
OAA:
100077058
(TRAF6)
GGA:
423163
(TRAF6)
MGP:
100544809
(TRAF6)
CJO:
107314700
(TRAF6)
NMEL:
110401104
(TRAF6)
APLA:
101802411
(TRAF6)
ACYG:
106044346
(TRAF6)
TGU:
100229606
(TRAF6)
LSR:
110484454
(TRAF6)
SCAN:
103826724
(TRAF6)
GFR:
102040197
(TRAF6)
FAB:
101817601
(TRAF6)
PHI:
102105183
(TRAF6)
PMAJ:
107206210
(TRAF6)
CCAE:
111930105
(TRAF6)
CCW:
104693976
(TRAF6)
ETL:
114056738
(TRAF6)
FPG:
101912003
(TRAF6)
FCH:
102058044
(TRAF6)
CLV:
102083770
(TRAF6)
EGZ:
104134046
(TRAF6)
NNI:
104009618
104019573
ACUN:
113481145
(TRAF6)
PADL:
103921676
(TRAF6)
AAM:
106498355
(TRAF6)
ASN:
102368234
(TRAF6)
AMJ:
102572036
(TRAF6)
PSS:
102463398
(TRAF6)
CMY:
102938959
(TRAF6)
CPIC:
101953645
(TRAF6)
ACS:
100561211
(traf6)
PVT:
110090250
(TRAF6)
PBI:
103052063
(TRAF6)
PMUR:
107293338
(TRAF6)
107301648
TSR:
106556967
(TRAF6)
PMUA:
114600173
(TRAF6)
GJA:
107116985
(TRAF6)
XLA:
444777
(traf6.L)
734929
(traf6.S)
XTR:
493524
(traf6)
NPR:
108787821
(TRAF6)
DRE:
554561
(traf6)
SRX:
107707871
107730254
SANH:
107694091
107696643
SGH:
107562521
107596425
(traf6)
107596428
CCAR:
109065463
109093401
(traf6)
IPU:
108259200
(traf6)
PHYP:
113540966
(traf6)
AMEX:
103021325
(traf6)
EEE:
113579696
(traf6)
TRU:
101071368
(traf6)
TNG:
GSTEN00018197G001
LCO:
104920634
(traf6)
NCC:
104948752
(traf6)
MZE:
101469001
(traf6)
ONL:
100703551
(traf6)
OLA:
101161132
(traf6)
XMA:
102220826
(traf6)
XCO:
114142760
(traf6)
PRET:
103462724
(traf6)
CVG:
107099447
(traf6)
NFU:
107383589
(traf6)
KMR:
108234801
(traf6)
ALIM:
106523547
(traf6)
AOCE:
111571002
(traf6)
CSEM:
103378810
(traf6)
POV:
109637261
(traf6)
LCF:
108887802
(traf6)
SDU:
111223588
(traf6)
SLAL:
111644323
(traf6)
HCQ:
109525774
(traf6)
BPEC:
110162549
(traf6)
MALB:
109965061
(traf6)
SASA:
106562580
106562692
106592035
106592685
OTW:
112247822
112263881
SALP:
112077783
(traf6)
ELS:
105025313
(traf6)
SFM:
108934700
108942315
(traf6)
PKI:
111841418
111859511
LCM:
102353931
(TRAF6)
CMK:
103186026
(traf6)
RTP:
109936672
(traf6)
CIN:
778949
(zf(traf/ring)-3)
SPU:
584052
585060
APLC:
110975424
110980832
SKO:
100372970
102804654
DME:
Dmel_CG10961
(Traf6)
DER:
6550517
DSE:
Dsec_GM11204
DSI:
Dsimw501_GD16124
(Dsim_GD16124)
DYA:
Dyak_GE17475
DAN:
Dana_GF20974
DSR:
110179707
DPO:
Dpse_GA10670
DPE:
6598159
DMN:
108164693
DWI:
6641099
DGR:
Dgri_GH24860
DMO:
Dmoj_GI14410
DAZ:
108617878
DNV:
108655545
DHE:
111594992
DVI:
Dvir_GJ18758
MDE:
101890213
LCQ:
111674929
AGA:
AgaP_AGAP003004
AME:
551819
BIM:
100744070
BTER:
100647374
CCAL:
108622235
OBB:
114881674
SOC:
105198280
MPHA:
105833603
AEC:
105149418
ACEP:
105625455
PBAR:
105422477
VEM:
105567281
HST:
105190721
DQU:
106742594
CFO:
105257286
LHU:
105676050
PGC:
109851970
OBO:
105280100
PCF:
106788531
MDL:
103569690
TCA:
661716
(Traf2)
DPA:
109541363
ATD:
109597958
NVL:
108556858
108565256
BMOR:
100862757
BMAN:
114241799
DPL:
KGM_202662
PMAC:
106715656
PRAP:
111001407
HAW:
110371014
TNL:
113507105
PXY:
105382485
105389114
API:
100575177
DNX:
107165263
AGS:
114120558
RMD:
113560984
BTAB:
109044603
CLEC:
106670044
PHU:
Phum_PHUM129280
ZNE:
110826527
FCD:
110850863
PVM:
113823573
ISC:
IscW_ISCW011773
IscW_ISCW012083
DPTE:
113797525
CSCU:
111619508
111628924
HRO:
HELRODRAFT_194130
LGI:
LOTGIDRAFT_154170
LOTGIDRAFT_208992
PCAN:
112560472
112573637
CRG:
105346921
105348659
MYI:
110449364
110453157
OBI:
106878692
106883380
LAK:
106154806
106168821
NVE:
NEMVE_v1g178259
NEMVE_v1g218900
EPA:
110238205
110238648
110251240
110254378
ADF:
107330393
107332219
107345490
107354397
107355733
107355734
107355736
107355817
107355819
AMIL:
114953101
114953110
114953111
114953112
114953114
114953204
114953216
114954099
114957717
PDAM:
113665766
113665768
113668244
113673104
113679218
113685897
SPIS:
111329931
111329938
111330715
111331827
111338243
111344690
111345112
DGT:
114526503
114527425
DPP:
DICPUDRAFT_147424
DICPUDRAFT_39824
DICPUDRAFT_99195
» show all
Reference
PMID:
19713527
Authors
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
Title
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Journal
Science 325:1134-8 (2009)
DOI:
10.1126/science.1175065
Sequence
[hsa:
7189
]
Reference
PMID:
8837778
Authors
Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV
Title
TRAF6 is a signal transducer for interleukin-1.
Journal
Nature 383:443-6 (1996)
DOI:
10.1038/383443a0
Sequence
[hsa:
7189
]
LinkDB
DBGET
integrated database retrieval system