KEGG   ORTHOLOGY: K04850
Entry
K04850                      KO                                     

Name
CACNA1C, CAV1.2
Definition
voltage-dependent calcium channel L type alpha-1C
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04713  Circadian entrainment
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04742  Taste transduction
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04929  GnRH secretion
map04930  Type II diabetes mellitus
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05031  Amphetamine addiction
map05207  Chemical carcinogenesis - receptor activation
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H00720  Long QT syndrome
H00728  Brugada syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04020 Calcium signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04024 cAMP signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04022 cGMP-PKG signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04929 GnRH secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04912 GnRH signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04921 Oxytocin signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04935 Growth hormone synthesis, secretion and action
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04924 Renin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04925 Aldosterone synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04927 Cortisol synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04261 Adrenergic signaling in cardiomyocytes
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04270 Vascular smooth muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09156 Nervous system
   04724 Glutamatergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04727 GABAergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04725 Cholinergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04728 Dopaminergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04726 Serotonergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04720 Long-term potentiation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04723 Retrograde endocannabinoid signaling
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09157 Sensory system
   04742 Taste transduction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05020 Prion disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05022 Pathways of neurodegeneration - multiple diseases
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09165 Substance dependence
   05031 Amphetamine addiction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05414 Dilated cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04934 Cushing syndrome
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Other DBs
GO: 0005245
TC: 1.A.1.11.4 1.A.1.11.6
Genes
HSA: 775(CACNA1C)
PTR: 466915(CACNA1C)
PPS: 100971701(CACNA1C)
GGO: 101134060(CACNA1C)
PON: 100442085(CACNA1C)
NLE: 100580437(CACNA1C)
MCC: 721721(CACNA1C)
MCF: 101865175
CSAB: 103218385(CACNA1C)
CATY: 105582968(CACNA1C)
PANU: 101026237(CACNA1C)
RRO: 104659017(CACNA1C)
RBB: 108522695(CACNA1C)
TFN: 117090701
PTEH: 111520328(CACNA1C)
CJC: 100406735(CACNA1C)
SBQ: 101040048(CACNA1C)
MMUR: 105861596(CACNA1C)
MMU: 12288(Cacna1c)
MCAL: 110295755(Cacna1c)
MPAH: 110317086(Cacna1c)
RNO: 24239(Cacna1c)
MCOC: 116099482(Cacna1c)
CGE: 100754788(Cacna1c)
PLEU: 114700762(Cacna1c)
NGI: 103739378(Cacna1c)
HGL: 101717129(Cacna1c)
OCU: 100101555(CACNA1C)
CFA: 403516(CACNA1C)
VVP: 112917426(CACNA1C)
VLG: 121479835(CACNA1C)
AML: 100479715(CACNA1C)
UMR: 103675706(CACNA1C)
UAH: 113258052(CACNA1C)
ORO: 101365624(CACNA1C)
ELK: 111159674
MPUF: 101679746(CACNA1C)
EJU: 114222521(CACNA1C)
MLX: 118025809(CACNA1C)
FCA: 101082923(CACNA1C)
PTG: 102956322(CACNA1C)
PPAD: 109276255(CACNA1C)
AJU: 106965473(CACNA1C)
HHV: 120243774(CACNA1C)
BTA: 408015(CACNA1C)
BOM: 102277590(CACNA1C)
BIU: 109558615(CACNA1C)
BBUB: 102407190(CACNA1C)
CHX: 100861292(CACNA1C)
OAS: 101116562(CACNA1C)
ODA: 120857839(CACNA1C)
SSC: 100518733(CACNA1C)
CFR: 102524149(CACNA1C)
CDK: 105100748(CACNA1C)
BACU: 103019389(CACNA1C)
LVE: 103087340(CACNA1C)
OOR: 101272740(CACNA1C)
DLE: 111176594(CACNA1C)
PCAD: 102989784(CACNA1C)
ECB: 100049924(CACNA1C)
EAI: 106839455(CACNA1C)
MYB: 102240225(CACNA1C)
MYD: 102753812(CACNA1C)
MMYO: 118652154(CACNA1C)
MNA: 107546425(CACNA1C)
HAI: 109388950(CACNA1C)
DRO: 112309331(CACNA1C)
SHON: 118999983(CACNA1C)
AJM: 119051688(CACNA1C)
MMF: 118624255(CACNA1C)
PALE: 102882682(CACNA1C)
RAY: 107500540(CACNA1C)
MJV: 108387253(CACNA1C)
TOD: 119247058(CACNA1C)
TMU: 101360945
MDO: 100021421(CACNA1C)
SHR: 100926503
PCW: 110218748(CACNA1C)
OAA: 100082618(CACNA1C)
GGA: 395891(CACNA1C)
PCOC: 116226870(CACNA1C)
CJO: 107315213(CACNA1C)
NMEL: 110395457(CACNA1C)
APLA: 101790062(CACNA1C)
ACYG: 106030933(CACNA1C)
TGU: 100218244(CACNA1C)
LSR: 110472925(CACNA1C)
SCAN: 103820462(CACNA1C)
PMOA: 120501729(CACNA1C)
GFR: 102031898
FAB: 101815051(CACNA1C)
PHI: 102106069(CACNA1C)
PMAJ: 107204397(CACNA1C)
CCAE: 111928486
CCW: 104692245(CACNA1C)
ETL: 114069083(CACNA1C)
FPG: 101916694(CACNA1C)
FCH: 102048150(CACNA1C)
CLV: 102095010(CACNA1C)
EGZ: 104134399(CACNA1C)
NNI: 104020209(CACNA1C)
ACUN: 113475961(CACNA1C)
PADL: 103924366(CACNA1C)
AAM: 106488364(CACNA1C)
ASN: 102377475(CACNA1C)
AMJ: 102575519(CACNA1C)
CPOO: 109316457(CACNA1C)
GGN: 109296233(CACNA1C)
PSS: 102451554(CACNA1C)
CMY: 102940198(CACNA1C)
CPIC: 101946823(CACNA1C)
TST: 117882551(CACNA1C)
CABI: 116834346
ACS: 100553244(cacna1c)
PVT: 110076659(CACNA1C)
PMUR: 107288329(CACNA1C)
PGUT: 117655788(CACNA1C)
PMUA: 114605885
ZVI: 118090932(CACNA1C)
GJA: 107120231(CACNA1C)
XLA: 100462911(cacna1c.S) 108704565(cacna1c.L)
XTR: 100488055(cacna1c)
NPR: 108791575
DRE: 170581(cacna1c)
SRX: 107732972
SANH: 107694143
CCAR: 109104295
IPU: 108279829
PHYP: 113544629
AMEX: 103041474
EEE: 113576556
TRU: 101064574(cacna1c)
LCO: 104940547
ELY: 117249155(cacna1c)
PLEP: 121961140
SLUC: 116059999(cacna1c)
ECRA: 117938808(cacna1c)
PFLV: 114549894
GAT: 120818340(cacna1c)
MSAM: 119918210(cacna1c)
CUD: 121505730(cacna1c)
MZE: 101471946(cacna1c)
ONL: 100711294(cacna1c)
OAU: 116309817(cacna1c)
OLA: 101173517
OML: 112156742(cacna1c)
XMA: 102230290(cacna1c)
XCO: 114161254
XHE: 116736851
PRET: 103459268
CVG: 107095494
CTUL: 119786207(cacna1c)
NFU: 107385235(cacna1c)
KMR: 108235074(cacna1c)
ALIM: 106515158
AOCE: 111571438
CSEM: 103382787(cacna1c)
POV: 109632862
LCF: 108879625
SDU: 111224579(cacna1c)
SLAL: 111658797(cacna1c)
XGL: 120800940(cacna1c)
HCQ: 109520063
BPEC: 110162494
MALB: 109959866
ELS: 105023097(cacna1c)
SFM: 108920904(cacna1c)
PKI: 111843125(cacna1c)
LOC: 102684408(cacna1c)
LCM: 102357941(CACNA1C)
CMK: 103179419
SCLV: 120345351
BGT: 106052266
 » show all
Reference
  Authors
Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM
  Title
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.
  Journal
Proc Natl Acad Sci U S A 103:17024-9 (2006)
DOI:10.1073/pnas.0606539103
  Sequence
[hsa:775]
Reference
PMID:1316612
  Authors
Soldatov NM
  Title
Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.
  Journal
Proc Natl Acad Sci U S A 89:4628-32 (1992)
DOI:10.1073/pnas.89.10.4628
  Sequence
[hsa:775]
LinkDB

KEGG   ORTHOLOGY: K04851
Entry
K04851                      KO                                     

Name
CACNA1D, CAV1.3
Definition
voltage-dependent calcium channel L type alpha-1D
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04218  Cellular senescence
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04361  Axon regeneration
map04530  Tight junction
map04713  Circadian entrainment
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04929  GnRH secretion
map04930  Type II diabetes mellitus
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04973  Carbohydrate digestion and absorption
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05031  Amphetamine addiction
map05207  Chemical carcinogenesis - receptor activation
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H01603  Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04020 Calcium signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04024 cAMP signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04022 cGMP-PKG signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04929 GnRH secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04912 GnRH signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04921 Oxytocin signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04935 Growth hormone synthesis, secretion and action
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04924 Renin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04925 Aldosterone synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04927 Cortisol synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04261 Adrenergic signaling in cardiomyocytes
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04270 Vascular smooth muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09156 Nervous system
   04724 Glutamatergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04727 GABAergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04725 Cholinergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04728 Dopaminergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04726 Serotonergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04723 Retrograde endocannabinoid signaling
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09158 Development and regeneration
   04361 Axon regeneration
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05020 Prion disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05022 Pathways of neurodegeneration - multiple diseases
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09165 Substance dependence
   05031 Amphetamine addiction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05414 Dilated cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04934 Cushing syndrome
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Other DBs
GO: 0005245
TC: 1.A.1.11.1 1.A.1.11.20 1.A.1.11.21
Genes
HSA: 776(CACNA1D)
PTR: 460447(CACNA1D)
PPS: 100975108(CACNA1D)
GGO: 101140987(CACNA1D)
PON: 100453904(CACNA1D)
NLE: 100600997(CACNA1D)
MCC: 693924(CACNA1D)
MCF: 102138213(CACNA1D)
CSAB: 103227762(CACNA1D)
CATY: 105585586(CACNA1D)
PANU: 101002070(CACNA1D)
RRO: 104672388(CACNA1D)
RBB: 108515198(CACNA1D)
TFN: 117083004(CACNA1D)
PTEH: 111524370(CACNA1D)
CJC: 100397940(CACNA1D)
SBQ: 101043152(CACNA1D)
MMUR: 105875072(CACNA1D)
MMU: 12289(Cacna1d)
MCAL: 110309492(Cacna1d)
MPAH: 110325961(Cacna1d)
RNO: 29716(Cacna1d)
MCOC: 116084337(Cacna1d)
MUN: 110547567(Cacna1d)
CGE: 100772497(Cacna1d)
PLEU: 114686204(Cacna1d)
NGI: 103749025(Cacna1d)
HGL: 101714832(Cacna1d)
CCAN: 109674812(Cacna1d)
OCU: 100327259(CACNA1D)
TUP: 102484770(CACNA1D)
CFA: 484724(CACNA1D)
VVP: 112910069(CACNA1D)
VLG: 121494863(CACNA1D)
AML: 100467700(CACNA1D)
UMR: 103674739(CACNA1D)
UAH: 113256986(CACNA1D)
ORO: 101383514(CACNA1D)
ELK: 111143738
MPUF: 101669870(CACNA1D)
EJU: 114225091(CACNA1D)
MLX: 118006050(CACNA1D)
FCA: 101088394(CACNA1D)
PTG: 102958456(CACNA1D)
PPAD: 109247930(CACNA1D)
AJU: 106986998(CACNA1D)
HHV: 120239388(CACNA1D)
BTA: 408013(CACNA1D)
BOM: 102271623(CACNA1D)
BIU: 109576190(CACNA1D)
BBUB: 102405249(CACNA1D)
CHX: 102174706(CACNA1D)
OAS: 101106371(CACNA1D)
ODA: 120868392(CACNA1D)
SSC: 100511102(CACNA1D)
CFR: 102504854(CACNA1D)
CDK: 105093176(CACNA1D)
BACU: 103001906(CACNA1D)
LVE: 103074544(CACNA1D)
OOR: 101276749(CACNA1D)
DLE: 111174277(CACNA1D)
PCAD: 102976068(CACNA1D)
ECB: 100051186(CACNA1D)
EPZ: 103560754
EAI: 106822066(CACNA1D)
MYB: 102259218(CACNA1D)
MYD: 102761441(CACNA1D)
MMYO: 118667975(CACNA1D)
MNA: 107534931(CACNA1D)
HAI: 109395944(CACNA1D)
DRO: 112301160(CACNA1D)
SHON: 118983345(CACNA1D)
AJM: 119041393(CACNA1D)
MMF: 118632910(CACNA1D)
PALE: 102888351(CACNA1D)
RAY: 107516535(CACNA1D)
MJV: 108402355(CACNA1D)
TOD: 119237589
LAV: 100659992(CACNA1D)
TMU: 101357085
MDO: 100014450(CACNA1D)
SHR: 100919750(CACNA1D)
PCW: 110197022(CACNA1D)
OAA: 100077296(CACNA1D)
GGA: 395895(CACNA1D)
PCOC: 116238597(CACNA1D)
MGP: 100545748(CACNA1D)
CJO: 107319871(CACNA1D)
NMEL: 110404743(CACNA1D)
APLA: 101803307(CACNA1D)
ACYG: 106048937(CACNA1D)
TGU: 100226925(CACNA1D)
LSR: 110471933(CACNA1D)
SCAN: 103816992(CACNA1D)
PMOA: 120514084(CACNA1D)
GFR: 102035179(CACNA1D)
FAB: 101819434(CACNA1D)
PHI: 102103301(CACNA1D)
PMAJ: 107210294(CACNA1D)
CCAE: 111935128(CACNA1D)
CCW: 104683258(CACNA1D)
ETL: 114058704(CACNA1D)
FPG: 101912795(CACNA1D)
FCH: 102054190(CACNA1D)
CLV: 102091108(CACNA1D)
EGZ: 104126731(CACNA1D)
NNI: 104009116 104010825(CACNA1D)
ACUN: 113484825(CACNA1D)
PADL: 103925489(CACNA1D)
AAM: 106488627(CACNA1D)
ASN: 102373960(CACNA1D)
AMJ: 102576817(CACNA1D)
CPOO: 109311400(CACNA1D)
GGN: 109288857(CACNA1D)
PSS: 102447276(CACNA1D)
CMY: 102934282(CACNA1D)
CPIC: 101951786(CACNA1D)
TST: 117880097(CACNA1D)
CABI: 116838746
ACS: 100554865(cacna1d)
PVT: 110084495(CACNA1D)
PBI: 103056075(CACNA1D)
PMUR: 107287678(CACNA1D)
PGUT: 117677102(CACNA1D)
PMUA: 114591684(CACNA1D)
ZVI: 118080704(CACNA1D)
GJA: 107116832(CACNA1D)
XLA: 100462912(cacna1d.L) 108704388
NPR: 108786047(CACNA1D)
DRE: 403310(cacna1da) 403311(cacna1db)
IPU: 108265454(cacna1d) 108281043
PHYP: 113533266(cacna1d) 113539515
AMEX: 103033357(cacna1d) 103043956
EEE: 113579158 113580442(cacna1d)
TRU: 101066777(cacna1d) 101070235
NCC: 104942817 104946163(cacna1d)
ELY: 117257145(cacna1da) 117258176(cacna1db)
PLEP: 121946664(cacna1db) 121959083(cacna1da)
SLUC: 116040630(cacna1db) 116041539(cacna1da)
ECRA: 117942646(cacna1da) 117947687(cacna1db)
PFLV: 114553636 114558551(cacna1d)
GAT: 120829866(cacna1db) 120835798(cacna1da)
MSAM: 119886716(cacna1da) 119905703(cacna1db)
CUD: 121506740(cacna1da) 121517267
MZE: 101474865(cacna1d) 101485620
ONL: 100693494 100712099(cacna1d)
OAU: 116324683(cacna1db) 116328943(cacna1da)
OLA: 101157531 101171831(cacna1d)
OML: 112144629(cacna1da) 112159387(cacna1db)
XMA: 102234425(cacna1d)
XCO: 114135515 114148180(cacna1d)
XHE: 116710265 116725097(cacna1d)
PRET: 103465120 103468016(cacna1d)
CVG: 107086672(cacna1d) 107094760
CTUL: 119780005 119789213(cacna1db)
NFU: 107385116 107390617(cacna1d)
KMR: 108236775(cacna1db) 108247381(cacna1da)
ALIM: 106513069(cacna1d) 106516186
LCF: 108886531 108891636(cacna1d)
XGL: 120803559(cacna1db) 120807074(cacna1da)
HCQ: 109517788(cacna1d) 109522320
BPEC: 110168588 110174734(cacna1d)
MALB: 109951925 109970859(cacna1d)
OMY: 100135991(cacna1da) 110493200(cacna1da) 110531171
ELS: 105006991 105007355(cacna1d)
SFM: 108925619(cacna1d) 108933838
PKI: 111833375(cacna1d) 111852542
LOC: 102695139(cacna1d)
LCM: 102360815(CACNA1D)
CMK: 103185068(cacna1d)
RTP: 109930589(cacna1d)
BFO: 118415799
CIN: 100184376
APLC: 110974142
SKO: 100371433
DME: Dmel_CG4894(Ca-alpha1D)
DER: 6543266
DSE: 6613668
DSI: Dsimw501_GD24041(Dsim_GD24041)
DSR: 110186075
DPE: 6598125
DMN: 108161670
DWI: 6643675
DAZ: 108611419
DNV: 115564037
DHE: 111594149
MDE: 101899996
LCQ: 111687187
AAG: 5574639
AALB: 109415132
AME: 100578899
ACER: 107992486
BIM: 100746891
BTER: 100649439
CCAL: 108624459
OBB: 114871919
MGEN: 117217820
NMEA: 116427354
CGIG: 122397899
SOC: 105195131
MPHA: 105827888
AEC: 105144165
PBAR: 105427526
VEM: 105568891
HST: 105183370
DQU: 106749620
CFO: 105255351
FEX: 115245961
LHU: 105672748
PGC: 109853346
OBO: 105280692
PCF: 106788672
NVI: 100119154
CSOL: 105365750
MDL: 103575476
TCA: 659557
DPA: 109541068
ATD: 109601172
AGB: 108907478
NVL: 108568734
APLN: 108737961
PPYR: 116166136
OTU: 111425584
PXY: 105386242
API: 100160955
DNX: 107169074
AGS: 114121007
RMD: 113559335
BTAB: 109041122
CLEC: 106672043
ZNE: 110839478
CSEC: 111864093
PVM: 113811306
HAME: 121853601
DSV: 119466573
RSAN: 119372441
RMP: 119162950
VDE: 111245386
VJA: 111271292
TUT: 107359653
DPTE: 113792829
SDM: 118200226
CEL: CELE_C48A7.1(egl-19)
CBR: CBG05858(Cbr-egl-19)
BMY: BM_BM2825(Bma-egl-19)
PCAN: 112571409
GAE: 121369269
CRG: 105345994
MYI: 110461243
PMAX: 117330515
OBI: 106872359
LAK: 106176729
ATEN: 116298733
DGT: 114521657
 » show all
Reference
  Authors
Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ
  Title
Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.
  Journal
Nat Neurosci 14:77-84 (2011)
DOI:10.1038/nn.2694
Reference
PMID:1309948
  Authors
Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI
  Title
Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.
  Journal
Proc Natl Acad Sci U S A 89:584-8 (1992)
DOI:10.1073/pnas.89.2.584
  Sequence
[hsa:776]
LinkDB

KEGG   ORTHOLOGY: K04853
Entry
K04853                      KO                                     

Name
CACNA1F, CAV1.4
Definition
voltage-dependent calcium channel L type alpha-1F
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04723  Retrograde endocannabinoid signaling
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05207  Chemical carcinogenesis - receptor activation
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H00481  Cone-rod dystrophy and cone dystrophy
H00690  Aland Island eye disease
H00787  Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04020 Calcium signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04024 cAMP signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04022 cGMP-PKG signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04929 GnRH secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04912 GnRH signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04921 Oxytocin signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04935 Growth hormone synthesis, secretion and action
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04924 Renin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04925 Aldosterone synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04927 Cortisol synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04261 Adrenergic signaling in cardiomyocytes
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04270 Vascular smooth muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09156 Nervous system
   04727 GABAergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04725 Cholinergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04726 Serotonergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04723 Retrograde endocannabinoid signaling
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05020 Prion disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05022 Pathways of neurodegeneration - multiple diseases
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05414 Dilated cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
Other DBs
GO: 0005245
TC: 1.A.1.11.11
Genes
HSA: 778(CACNA1F)
PTR: 740711(CACNA1F)
PPS: 100988624(CACNA1F)
GGO: 101131714(CACNA1F)
PON: 100431752(CACNA1F)
NLE: 100590475(CACNA1F)
MCC: 715787(CACNA1F)
MCF: 102119841(CACNA1F)
CSAB: 103231971(CACNA1F)
CATY: 105573107(CACNA1F)
PANU: 101019865(CACNA1F)
RRO: 104661816(CACNA1F)
RBB: 108521361
TFN: 117077518(CACNA1F)
CJC: 100386041(CACNA1F)
SBQ: 101034685(CACNA1F)
MMUR: 105856433(CACNA1F)
MMU: 54652(Cacna1f)
MCAL: 110286673(Cacna1f)
MPAH: 110313596(Cacna1f)
RNO: 114493(Cacna1f)
MCOC: 116102419(Cacna1f)
MUN: 110561910(Cacna1f)
CGE: 100757994(Cacna1f)
PLEU: 114701281(Cacna1f)
NGI: 103741673(Cacna1f)
HGL: 101722090(Cacna1f)
CCAN: 109697195(Cacna1f)
OCU: 100357261(CACNA1F)
TUP: 102482779(CACNA1F)
CFA: 480915(CACNA1F)
VVP: 112907237(CACNA1F)
VLG: 121483414(CACNA1F)
AML: 100468661(CACNA1F)
UMR: 103667625(CACNA1F)
UAH: 113265950(CACNA1F)
ORO: 101364481(CACNA1F)
ELK: 111150407
MPUF: 101689134(CACNA1F)
EJU: 114216787(CACNA1F)
MLX: 118008972(CACNA1F)
FCA: 101080870(CACNA1F)
PTG: 102950547(CACNA1F)
PPAD: 109248097(CACNA1F)
AJU: 106988999(CACNA1F)
HHV: 120221013(CACNA1F)
BTA: 509779(CACNA1F)
BOM: 102286805(CACNA1F)
BIU: 109554975(CACNA1F)
BBUB: 102407399(CACNA1F)
CHX: 102189746(CACNA1F)
OAS: 101104552(CACNA1F)
ODA: 120881638(CACNA1F)
SSC: 100514745(CACNA1F)
CFR: 102504151(CACNA1F)
CDK: 105103284(CACNA1F)
BACU: 102998540(CACNA1F)
LVE: 103082192(CACNA1F)
OOR: 101281199(CACNA1F)
DLE: 111169490(CACNA1F)
PCAD: 102992313(CACNA1F)
ECB: 100062861(CACNA1F)
EPZ: 103543955(CACNA1F)
EAI: 106826963(CACNA1F)
MYB: 102260789(CACNA1F)
MYD: 102771414(CACNA1F)
MMYO: 118654729(CACNA1F)
MNA: 107541372(CACNA1F)
HAI: 109374806(CACNA1F)
DRO: 112322357(CACNA1F)
SHON: 118998346(CACNA1F)
AJM: 119059521(CACNA1F)
MMF: 118635608(CACNA1F)
PALE: 102893611(CACNA1F)
RAY: 107514999(CACNA1F)
MJV: 108404213(CACNA1F)
TOD: 119246715(CACNA1F)
LAV: 100674649(CACNA1F)
TMU: 101340818
MDO: 100019531(CACNA1F)
SHR: 100927554(CACNA1F)
PCW: 110201034(CACNA1F)
OAA: 100075939(CACNA1F)
PCOC: 116240105(CACNA1F)
LSR: 110482322
PMOA: 120506954(CACNA1F)
FAB: 101817703
PHI: 102111116(CACNA1F)
CCW: 120412196(CACNA1F)
FPG: 101922071
FCH: 102046341
CLV: 102089966
AAM: 106493905(CACNA1F)
ASN: 102368804(CACNA1F)
AMJ: 102563169(CACNA1F)
CPIC: 101934179(CACNA1F)
CABI: 116823939
ACS: 100565753(cacna1f)
PVT: 110078615(CACNA1F)
PBI: 103051695(CACNA1F)
PMUR: 107284195(CACNA1F)
PGUT: 117675658(CACNA1F)
PMUA: 114587594(CACNA1F)
ZVI: 118097569(CACNA1F)
GJA: 107117359
XLA: 100462913(cacna1f.L)
XTR: 100485906(cacna1f)
NPR: 108788491
DRE: 559964(cacna1fb) 793708(cacna1fa)
IPU: 108265065 108265094(cacna1f)
EEE: 113578747(cacna1f) 113579098
TRU: 101077620(cacna1f) 101079199
ELY: 117257982(cacna1fb) 117258407(cacna1fa)
PLEP: 121946427
SLUC: 116043571(cacna1fa) 116045489(cacna1fb)
ECRA: 117947003(cacna1fa)
PFLV: 114558250
GAT: 120814961(cacna1fb) 120828763(cacna1fa)
MSAM: 119905055(cacna1fb) 119905094(cacna1fa)
CUD: 121516935(cacna1fa) 121517368(cacna1fb)
MZE: 101480057
OAU: 116319501(cacna1fa) 116335447(cacna1fb)
OML: 112158663(cacna1fb) 112158801(cacna1fa)
CVG: 107095949(cacna1f) 107099706
CTUL: 119792002(cacna1fb) 119799513(cacna1fa)
NFU: 107390498(cacna1f) 107391407
ALIM: 106519282(cacna1f) 106523414 106533880
AOCE: 111580242
CSEM: 103384398 103385395(cacna1f)
XGL: 120803456(cacna1fa) 120804054(cacna1fb)
HCQ: 109510493 109512986(cacna1f)
BPEC: 110154433 110164475(cacna1f)
MALB: 109953071
SASA: 106572493
OTW: 112221526
OMY: 110512770(cacna1fb) 110531219
SALP: 111966955
PSPA: 121305498
ARUT: 117967960
LCM: 102353236(CACNA1F)
 » show all
Reference
  Authors
Lee A, Wang S, Williams B, Hagen J, Scheetz TE, Haeseleer F
  Title
Characterization of Cav1.4 complexes (alpha11.4, beta2, and alpha2delta4) in HEK293T cells and in the retina.
  Journal
J Biol Chem 290:1505-21 (2015)
DOI:10.1074/jbc.M114.607465
  Sequence
[hsa:778]
Reference
PMID:9662399
  Authors
Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Ruther K, Drescher B, Sauer C, Zrenner E, Meitinger T, Rosenthal A, Meindl A
  Title
An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness.
  Journal
Nat Genet 19:260-3 (1998)
DOI:10.1038/940
  Sequence
[hsa:778]
LinkDB

KEGG   ORTHOLOGY: K04857
Entry
K04857                      KO                                     

Name
CACNA1S, CAV1.1
Definition
voltage-dependent calcium channel L type alpha-1S
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04723  Retrograde endocannabinoid signaling
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04929  GnRH secretion
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05207  Chemical carcinogenesis - receptor activation
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H00215  Periodic paralysis
H00746  Hypokalemic periodic paralysis (HypoPP)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04020 Calcium signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04024 cAMP signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04022 cGMP-PKG signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04929 GnRH secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04912 GnRH signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04921 Oxytocin signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04935 Growth hormone synthesis, secretion and action
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04924 Renin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04925 Aldosterone synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04927 Cortisol synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04261 Adrenergic signaling in cardiomyocytes
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04270 Vascular smooth muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09156 Nervous system
   04727 GABAergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04725 Cholinergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04726 Serotonergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04723 Retrograde endocannabinoid signaling
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05020 Prion disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05022 Pathways of neurodegeneration - multiple diseases
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05414 Dilated cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
Other DBs
GO: 0005245
TC: 1.A.1.11.2
Genes
HSA: 779(CACNA1S)
PTR: 469635(CACNA1S)
PPS: 100982136(CACNA1S)
GGO: 101150507(CACNA1S)
PON: 100433948(CACNA1S)
NLE: 100589614(CACNA1S)
MCC: 708706(CACNA1S)
MCF: 102131553(CACNA1S)
CSAB: 103230339(CACNA1S)
CATY: 105575216(CACNA1S)
PANU: 101025213(CACNA1S)
RRO: 104661868(CACNA1S)
RBB: 108545075(CACNA1S)
TFN: 117076828(CACNA1S)
PTEH: 111550963(CACNA1S)
CJC: 100390112(CACNA1S)
SBQ: 101042219(CACNA1S)
MMUR: 105859992(CACNA1S)
MMU: 12292(Cacna1s)
MCAL: 110296075(Cacna1s)
MPAH: 110322010(Cacna1s)
RNO: 682930(Cacna1s)
MCOC: 116069682(Cacna1s)
MUN: 110548425(Cacna1s)
CGE: 100765508(Cacna1s)
PLEU: 114683299(Cacna1s)
NGI: 103731814(Cacna1s)
HGL: 101726232(Cacna1s)
CCAN: 109696593
OCU: 100009585(CACNA1S)
TUP: 102481015(CACNA1S)
CFA: 490244(CACNA1S)
VVP: 112934538(CACNA1S)
VLG: 121493117(CACNA1S)
AML: 100472835(CACNA1S)
UMR: 103657769(CACNA1S)
UAH: 113242563(CACNA1S)
ORO: 101385947(CACNA1S)
ELK: 111150995
MPUF: 101688476(CACNA1S)
EJU: 114221937(CACNA1S)
MLX: 118014221(CACNA1S)
FCA: 654399(CACNA1S)
PTG: 102949808(CACNA1S)
PPAD: 109256096(CACNA1S)
AJU: 106974264(CACNA1S)
HHV: 120228884(CACNA1S)
BTA: 100337204(CACNA1S)
BOM: 102272241(CACNA1S)
BBUB: 102397191(CACNA1S)
CHX: 102176151(CACNA1S)
OAS: 101108767(CACNA1S)
ODA: 120880100(CACNA1S)
SSC: 100622149(CACNA1S)
CFR: 102507309(CACNA1S)
CDK: 105090835(CACNA1S)
BACU: 103014409(CACNA1S)
LVE: 103090575(CACNA1S)
OOR: 101275416(CACNA1S)
DLE: 111168340(CACNA1S)
PCAD: 102987099(CACNA1S)
ECB: 100034092(CACNA1S)
EPZ: 103565109(CACNA1S)
EAI: 106823553(CACNA1S)
MYB: 102243265(CACNA1S)
MYD: 102760374(CACNA1S)
MMYO: 118678862(CACNA1S)
MNA: 107536018(CACNA1S)
HAI: 109380439(CACNA1S)
DRO: 112318756(CACNA1S)
SHON: 119003902(CACNA1S)
AJM: 119060725(CACNA1S)
MMF: 118640543(CACNA1S)
PALE: 102896136(CACNA1S)
RAY: 107513628(CACNA1S)
MJV: 108396001(CACNA1S)
TOD: 119234060(CACNA1S)
LAV: 100673089(CACNA1S)
TMU: 101343945
MDO: 100013684(CACNA1S)
SHR: 100917433(CACNA1S)
PCW: 110219570(CACNA1S)
OAA: 100093447(CACNA1S)
GGA: 395985(CATSPER2)
PCOC: 116238729(CACNA1S)
MGP: 100547445(CACNA1S)
CJO: 107324611(CACNA1S)
NMEL: 110388201(CACNA1S)
APLA: 101801311(CACNA1S)
ACYG: 106046137(CACNA1S)
TGU: 100220193(CACNA1S)
LSR: 110469152(CACNA1S)
SCAN: 103822432(CACNA1S)
PMOA: 120503413(CACNA1S)
GFR: 102037957(CACNA1S)
FAB: 101821759(CACNA1S)
PHI: 102111358(CACNA1S)
PMAJ: 107214754(CACNA1S)
CCAE: 111939717(CACNA1S)
CCW: 104692446(CACNA1S)
ETL: 114064775(CACNA1S)
FPG: 101914764(CACNA1S)
FCH: 102058184(CACNA1S)
CLV: 102092229(CACNA1S)
EGZ: 104122032(CACNA1S)
NNI: 104011070(CACNA1S)
ACUN: 113488965(CACNA1S)
PADL: 103913818(CACNA1S)
AAM: 106500235(CACNA1S)
ASN: 102377229(CACNA1S)
AMJ: 102563699(CACNA1S)
CPOO: 109317585(CACNA1S)
PSS: 102453880
CMY: 114020321(CACNA1S)
CPIC: 101932307(CACNA1S)
CABI: 116837308(CACNA1S)
ACS: 100551605(cacna1s)
PVT: 110085291(CACNA1S)
PBI: 103055781(CACNA1S)
PMUR: 107289042(CACNA1S)
TSR: 106549619(CACNA1S)
PGUT: 117664028(CACNA1S)
PMUA: 114599194(CACNA1S)
ZVI: 118088554(CACNA1S)
GJA: 107110972(CACNA1S)
XLA: 100381134(cacna1s.S) 108707491
XTR: 100485035(cacna1s)
NPR: 108804869(CACNA1S)
DRE: 405791(cacna1sb) 570683(cacna1sa)
CCAR: 109068176
IPU: 108254927 108266034(CAC1S)
PHYP: 113526802(cacna1s)
EEE: 113581084 113586976(cacna1s)
LCO: 104932670(cacna1s)
NCC: 104956859(cacna1s)
PLEP: 121946489
ECRA: 117942791 117947748(cacna1sb)
GAT: 120829078(cacna1sb) 120835575
MZE: 101479917(cacna1s)
ONL: 100704349(cacna1s)
OAU: 116325819
XMA: 102237099(cacna1s)
XCO: 114148648(cacna1s)
XHE: 116727080(cacna1s)
PRET: 103467335(cacna1s)
CVG: 107086768(cacna1s)
CTUL: 119782227
NFU: 107390862(cacna1s)
KMR: 108244587
ALIM: 106525038(cacna1s)
AOCE: 111564440(cacna1s) 111586752
POV: 109630550(cacna1s)
BPEC: 110164965(cacna1s)
MALB: 109968827(cacna1s)
OTW: 112255319
SFM: 108931184 108933625(cacna1s)
LOC: 102684448(cacna1s)
LCM: 102356715(CACNA1S)
CMK: 103190861
RTP: 109922317
BGT: 106059778
GAE: 121384134
CRG: 105331673
PMAX: 117321880
ATEN: 116298203
 » show all
Reference
  Authors
Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher BE, Carsana A, Salvatore F, Grabner M
  Title
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.
  Journal
Am J Physiol Cell Physiol 299:C1345-54 (2010)
DOI:10.1152/ajpcell.00008.2010
  Sequence
[hsa:779]
Reference
PMID:8004673
  Authors
Ptacek LJ, Tawil R, Griggs RC, Engel AG, Layzer RB, Kwiecinski H, McManis PG, Santiago L, Moore M, Fouad G, et al.
  Title
Dihydropyridine receptor mutations cause hypokalemic periodic paralysis.
  Journal
Cell 77:863-8 (1994)
DOI:10.1016/0092-8674(94)90135-X
  Sequence
[hsa:779]
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