KEGG ORTHOLOGY: K23113

ORTHOLOGY: K23113

Entry

K23113                      KO

Symbol

SMCHD1

Name

structural maintenance of chromosomes flexible hinge domain-containing protein 1

Disease

H00591

Facioscapulohumeral muscular dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K23113  SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
   03400 DNA repair and recombination proteins
    K23113  SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K23113  SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    Other NHEJ factors
     K23113  SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1

Genes

HSA:	23347(SMCHD1)

PTR:	455319(SMCHD1)

PPS:	100976685(SMCHD1)

GGO:	101123980(SMCHD1)

PON:	100454023(SMCHD1)

NLE:	100583915(SMCHD1)

HMH:	116468703(SMCHD1)

MCC:	695870(SMCHD1)

MCF:	101866667(SMCHD1)

MTHB:

126941152

MNI:	105478815(SMCHD1)

CSAB:

103222694(SMCHD1)

CATY:

105583957(SMCHD1)

PANU:

101020549(SMCHD1)

TGE:	112611490(SMCHD1)

MLEU:

105551175(SMCHD1)

RRO:	104654118(SMCHD1)

RBB:	108516707(SMCHD1)

TFN:	117064099(SMCHD1)

PTEH:

111553610(SMCHD1)

CANG:

105523063(SMCHD1)

CJC:	100386581(SMCHD1)

SBQ:	101031954(SMCHD1)

CIMI:

108302473(SMCHD1)

CSYR:

103277376(SMCHD1)

MMUR:

105860961(SMCHD1)

LCAT:

123621570(SMCHD1)

PCOQ:

105816594(SMCHD1)

MMU:	74355(Smchd1)

MCAL:

110312298(Smchd1)

RNO:	316732(Smchd1)

MCOC:

116088896(Smchd1)

ANU:	117693389(Smchd1)

MUN:	110558714(Smchd1)

CGE:	100770189(Smchd1)

MAUA:

101844954(Smchd1)

PROB:

127226788(Smchd1)

PLEU:

114696418(Smchd1)

MORG:

121434754 121458940

MFOT:

126516057

AAMP:

119803781(Smchd1)

NGI:	103735397(Smchd1)

HGL:	101725927(Smchd1)

CPOC:

100717339(Smchd1)

CCAN:

109682063

DORD:

105993770(Smchd1)

DSP:	122104441(Smchd1)

PLOP:

125364206(Smchd1)

NCAR:

124965470

MMMA:

107139351(Smchd1)

OCU:

100348571

OPI:	101519494(SMCHD1)

TUP:	102481782(SMCHD1)

GVR:	103587645(SMCHD1)

CFA:	490535(SMCHD1)

CLUD:

112648008(SMCHD1)

VVP:	112925259(SMCHD1)

VLG:	121486145(SMCHD1)

NPO:	129508829(SMCHD1)

AML:	100466431(SMCHD1)

UMR:	103662690(SMCHD1)

UAH:	113253255(SMCHD1)

UAR:	123782083(SMCHD1)

ELK:

111142431

LLV:

125082003

MPUF:

101689545(SMCHD1)

MNP:	132023508(SMCHD1)

MLK:	131810820(SMCHD1)

NVS:	122903005(SMCHD1)

ORO:	101373019(SMCHD1)

EJU:	114200305(SMCHD1)

ZCA:	113912632(SMCHD1)

MLX:	118004608(SMCHD1)

NSU:	110576830(SMCHD1)

LWW:	102740030(SMCHD1)

FCA:	101087430(SMCHD1)

PYU:	121033135(SMCHD1)

PCOO:

112868131(SMCHD1)

PBG:	122470598(SMCHD1)

PVIV:

125149061(SMCHD1)

LRUF:

124517648

PTG:	102948565(SMCHD1)

PPAD:

109248577(SMCHD1)

PUC:

125914793

AJU:

106986068

HHV:	120239080(SMCHD1)

BTA:	537894(SMCHD1)

BOM:	102271989(SMCHD1)

BIU:	109577842(SMCHD1)

BBUB:

102402007(SMCHD1)

BBIS:

104983296(SMCHD1)

CHX:	102168787(SMCHD1)

OAS:	101122749(SMCHD1)

BTAX:

128067410(SMCHD1)

ODA:	120881103(SMCHD1)

CCAD:

122425458(SMCHD1)

MBEZ:

129549756(SMCHD1)

SSC:	100627122(SMCHD1)

CFR:	102513149(SMCHD1)

CBAI:

105071407(SMCHD1)

CDK:	105086114(SMCHD1)

VPC:	102527839(SMCHD1)

BACU:

103007523(SMCHD1)

BMUS:

118906935(SMCHD1)

LVE:	103087089(SMCHD1)

OOR:	101287991(SMCHD1)

DLE:	111163067(SMCHD1)

PCAD:

102990901(SMCHD1)

PSIU:

116738772(SMCHD1)

NASI:

112409041(SMCHD1)

ECB:	100062029(SMCHD1)

EPZ:	103562361(SMCHD1)

EAI:	106825861(SMCHD1)

MYB:	102262183(SMCHD1)

MYD:	102751418(SMCHD1)

MMYO:

118663605(SMCHD1)

MLF:	102441302(SMCHD1)

PKL:	118707448(SMCHD1)

EFUS:

103304663(SMCHD1)

MNA:	107535893(SMCHD1)

DRO:	112322563(SMCHD1)

SHON:

118997073(SMCHD1)

AJM:	119048207 119065943(SMCHD1)

PDIC:

114506995(SMCHD1)

PHAS:

123826056(SMCHD1)

MMF:	118618663(SMCHD1)

PPAM:

129078617(SMCHD1)

HAI:	109394735(SMCHD1)

RFQ:	117011749(SMCHD1)

PALE:

102883943(SMCHD1)

PGIG:

120588040(SMCHD1)

PVP:	105292298(SMCHD1)

RAY:	107516781(SMCHD1)

MJV:	108392793(SMCHD1)

TOD:	119243162(SMCHD1)

SARA:

101543986(SMCHD1)

SETR:

126004492(SMCHD1)

LAV:	100671161(SMCHD1)

TMU:

101352494

ETF:	101649389(SMCHD1)

DNM:	101416232(SMCHD1)

MDO:	100012023(SMCHD1)

GAS:	123239440(SMCHD1)

SHR:	100921922(SMCHD1)

AFZ:

127543982

PCW:	110197058(SMCHD1)

OAA:	100077368(SMCHD1)

GGA:	421057(SMCHD1)

PCOC:

116226176(SMCHD1)

MGP:	100551356(SMCHD1)

CJO:	107310038(SMCHD1)

TPAI:

128090797(SMCHD1)

LMUT:

125690942(SMCHD1)

NMEL:

110393566(SMCHD1)

APLA:

101800540(SMCHD1)

ACYG:

106034915(SMCHD1)

CATA:

118256761(SMCHD1)

AFUL:

116485629(SMCHD1)

TGU:	100220166(SMCHD1)

LSR:	110482373(SMCHD1)

SCAN:

103826891(SMCHD1)

PMOA:

120500823(SMCHD1)

OTC:	121333231(SMCHD1)

PRUF:

121359067(SMCHD1)

GFR:	102039397(SMCHD1)

FAB:	101821313(SMCHD1)

OMA:	130249623(SMCHD1)

PHI:	102102664(SMCHD1)

PMAJ:

107200514(SMCHD1)

CCAE:

111923998(SMCHD1)

CCW:	104687302(SMCHD1)

CBRC:

103618421(SMCHD1)

ETL:	114058733(SMCHD1)

ZAB:	102070118(SMCHD1)

SVG:	106850152(SMCHD1)

MMEA:

130572892(SMCHD1)

HRT:	120750867(SMCHD1)

FPG:	101922712(SMCHD1)

FCH:	102050400(SMCHD1)

CLV:	102084331(SMCHD1)

EGZ:	104125220(SMCHD1)

NNI:	104015765 104018143

PCRI:

104032019(SMCHD1)

PLET:

104621184(SMCHD1)

EHS:	104509345(SMCHD1)

PCAO:

104043613(SMCHD1)

ACUN:

113476112(SMCHD1)

TALA:

104364665(SMCHD1)

PADL:

103917796(SMCHD1)

AFOR:

103902992(SMCHD1)

ACHC:

115340151(SMCHD1)

HALD:

104319483(SMCHD1)

HLE:	104842499(SMCHD1)

AGEN:

126046245

GCL:

127012636

CCRI:

104167517(SMCHD1)

CSTI:

104553075(SMCHD1)

CMAC:

104486911(SMCHD1)

BREG:

104634440(SMCHD1)

FGA:	104080356(SMCHD1)

GSTE:

104253298(SMCHD1)

MNB:	103777269(SMCHD1)

OHA:	104326622(SMCHD1)

SHAB:

115606026(SMCHD1)

DPUB:

104296787

PGUU:

104471856(SMCHD1)

ACAR:

104530220(SMCHD1)

CPEA:

104396939(SMCHD1)

AVIT:

104278452(SMCHD1)

CVF:	104287909(SMCHD1)

RTD:	128905961(SMCHD1)

CUCA:

104065484(SMCHD1)

TEO:	104374813(SMCHD1)

BRHI:

104501925

AAM:	106482205(SMCHD1)

AROW:

112968355(SMCHD1)

NPD:	112944129(SMCHD1)

TGT:	104575032(SMCHD1)

DNE:	112997008(SMCHD1)

SCAM:

104139134(SMCHD1)

ASN:	102377199(SMCHD1)

AMJ:	102569707(SMCHD1)

CPOO:

109317787(SMCHD1)

GGN:	109303659(SMCHD1)

PSS:	102446910(SMCHD1)

CMY:	102940396(SMCHD1)

CCAY:

125632347(SMCHD1)

DCC:	119850767(SMCHD1)

CPIC:

101941440(SMCHD1)

TST:	117873382(SMCHD1)

CABI:

116820200(SMCHD1)

MRV:	120399108(SMCHD1)

ACS:

100565669

ASAO:

132774742(SMCHD1)

PVT:	110079441(SMCHD1)

SUND:

121917290 121917327

PBI:	103059470 103060396

PMUR:

107294000(SMCHD1)

CTIG:

120311484(SMCHD1)

TSR:	106544659 106553728

PGUT:

117672677(SMCHD1)

APRI:

131194959(SMCHD1)

PTEX:

113435498(SMCHD1)

VKO:	123020576(SMCHD1)

PMUA:

114601359(SMCHD1)

PRAF:

128417580(SMCHD1)

ZVI:	118089913(SMCHD1)

HCG:	128323088(SMCHD1)

GJA:	107112740(SMCHD1)

STOW:

125438893(SMCHD1)

EMC:	129333099(SMCHD1)

XLA:	108719212(smchd1.L)

XTR:	100380032(smchd1)

NPR:	108784510(SMCHD1)

RTEM:

120940899(SMCHD1)

BBUF:

121001448(SMCHD1)

BGAR:

122938201(SMCHD1)

MUO:	115476570(SMCHD1)

GSH:	117355431(SMCHD1)

DRE:	497282(smchd1)

SRX:	107728652 107745317

SANH:

107675396 107691829

SGH:	107559929(smchd1) 107601142 107601143

CCAR:

109045611

CAUA:

113051717 113106407(smchd1)

CGIB:

127962307 128016438

PTET:

122347874(smchd1)

LROH:

127168274(smchd1)

OMC:	131543935(smchd1)

PPRM:

120477388 120477408

RKG:	130090459(smchd1)

MAMB:

125265208(smchd1)

CIDE:

127515503

MASI:

127423167 127450177

TROS:

130554982(smchd1)

TDW:	130419989(smchd1)

MANU:

129453164(smchd1)

IPU:

108267874

IFU:	128609640(smchd1)

PHYP:

113540252(smchd1)

SMEO:

124387303(smchd1)

TFD:	113657486(smchd1)

TVC:	132848460(smchd1)

AMEX:

103045413(smchd1)

CMAO:

118826756(smchd1)

EEE:	113579288(smchd1)

CHAR:

105894784(smchd1)

LCO:	104925298(smchd1)

NCC:	104949662(smchd1)

TBEN:

117495610(smchd1)

CGOB:

115025408(smchd1)

PGEO:

117465539(smchd1)

GACU:

117544703(smchd1)

EMAC:

134884087(smchd1)

ELY:	117264627(smchd1)

EFO:	125881610(smchd1)

PLEP:

121960551(smchd1)

SLUC:

116045287(smchd1)

ECRA:

117938140(smchd1)

ESP:	116672265(smchd1)

PFLV:

114548873(smchd1)

GAT:	120812080(smchd1)

PPUG:

119198598(smchd1)

AFB:	129110516(smchd1)

CLUM:

117749763(smchd1)

PSWI:

130206089(smchd1)

MSAM:

119911223(smchd1)

SCHU:

122866914(smchd1)

CUD:	121527114(smchd1)

ALAT:

119008572(smchd1)

MZE:	101482681(smchd1)

ONL:	102077272 102078558(smchd1)

OAU:	116315976(smchd1) 116315979

OLA:	101162718(smchd1)

OML:	112151452(smchd1)

CSAI:

133423376(smchd1)

XMA:	102219806 102220065

XCO:	114136584 114136585

XHE:	116711878 116711879

PRET:

103456865 103456942

PFOR:

103132263 103140500 103149815

PLAI:

106945077 106962118

PMEI:

106911947 106915380

GAF:

122824297

PPRL:

129364923(smchd1)

CVG:	107080671 107085383 107085398 107102105(smchd1)

CTUL:

119791644 119791680

GMU:	124857889 124858117(smchd1)

NFU:	107382515(smchd1)

KMR:	108230468(smchd1)

ALIM:

106520959(smchd1)

NWH:	119426375(smchd1)

AOCE:

111569341(smchd1)

MCEP:

124995916(smchd1)

CSEM:

103377452(smchd1)

POV:	109629560(smchd1)

SSEN:

122781202(smchd1)

HHIP:

117753661(smchd1)

HSP:	118098612(smchd1)

SMAU:

118287715(smchd1)

LCF:

108895001

SDU:	111237830(smchd1)

SLAL:

111656609(smchd1)

XGL:	120789968(smchd1)

BPEC:

110170049(smchd1)

MALB:

109953779

BSPL:

114853020 114853021 114853022

SJO:	128382827(smchd1)

SASA:

106590141(smchd1)

STRU:

115195790(smchd1)

OTW:	112227966(smchd1)

OMY:	110489940(smchd1)

OGO:	124039785(smchd1)

ONE:	115130364(smchd1)

OKI:	109899485(smchd1)

OKE:	118373603(smchd1)

SALP:

111953281(smchd1)

SNH:	120051149(smchd1)

CCLU:

121569882(smchd1)

ELS:	105019337(smchd1)

SFM:	108937082(smchd1)

PKI:	111857741(smchd1)

AANG:

118225431(smchd1)

LOC:	102682984(smchd1)

PSPA:

121313157(smchd1)

ARUT:

117400525(smchd1)

PSEX:

120530378(smchd1)

LCM:	102347541(SMCHD1)

CMK:	103183455(smchd1)

RTP:	109929510(smchd1)

CPLA:

122549043(smchd1)

HOC:	132814847(smchd1)

LERI:

129696049(smchd1)

PMRN:

116951597(SMCHD1)

LRJ:	133340886(SMCHD1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	100890804 100891020 105439373 105444851 105447417 115924981 583320 590026

LPIC:

129259471

APLC:

110978240

AJC:

117113710

SKO:	100368546 102805280

FCD:	110848345 110859636 110859954 110861719

DSV:

RSAN:

RMP:

CSCU:

LPOL:

LGI:	LOTGIDRAFT_135415

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111102211 111123252

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:	5508140 5511712

EPA:	110236167 110242949

ATEN:

116290087 116293005

ADF:	107330334 107341445 107358564

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:	130647496 130649448

ATH:	AT5G24280(GMI1)

ALY:

9310250

CRB:	17882032 17884597

CSAT:

104706733 104738142 104770816 104770817 104772508

EUS:	EUTSA_v10003512mg EUTSA_v10003513mg

BRP:	103874292 103874295

BNA:	106348272 106348274 106415214

BOE:

106306185

RSZ:	108853959 130506018 130506019

THJ:

104798901

CPAP:

110823352

CIT:

102628315

CIC:	CICLE_v10018477mg

MINC:

123225535

TCC:

18605777

GRA:

105801832

GHI:	107904564 107923070

GAB:

108455111

HSYR:

120146867 120200116 120207015

EGR:

GMX:

GSJ:

CCAJ:

APRC:

MTR:	11433315 11434186

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj4g3v1316180.1(Lj4g3v1316180.1)

LANG:

109354273

QSA:	O6P43_014997

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

115715860 115716455 115717470

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SDUL:

CANN:

LBB:

NTA:	107778613 107784267

NSY:

104231421

NTO:

104101890

NAU:

109231428

INI:	109183397 109183399 109183435

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:	110872940 110872941 110872943

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:	104888575 104888577 109134607

SOE:	110783057 110783062

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

113299014 113336107 113358431

BDI:

100829204

ATS:

109743344

TDC:	119329699 119335990

TAES:

123147618 123162993 123166490

TUA:

LPER:

LRD:

SBI:

SITA:

PVIR:

120653419 120655552 120698983

PDA:

EGU:

MUS:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_432188 SELMODRAFT_432347

PPP:	112275003 112285361

CRE:	CHLRE_06g294050v5

VCN:	VOLCADRAFT_86759

MNG:

MNEG_7541

CSL:	COCSUDRAFT_58530

CVR:	CHLNCDRAFT_138232

APRO:

F751_6302

MBR:	MONBRDRAFT_39255

SRE:	PTSG_08498 PTSG_08499

DDI:	DDB_G0277185

DPP:	DICPUDRAFT_49947

DFA:

DFA_03409

GTT:	GUITHDRAFT_121490 GUITHDRAFT_141368 GUITHDRAFT_162886

NGR:	NAEGRDRAFT_64819

» show all

Reference

PMID:25294876

Authors

Tang M, Li Y, Zhang X, Deng T, Zhou Z, Ma W, Songyang Z

Title

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.

Journal

J Biol Chem 289:34024-32 (2014)
DOI:10.1074/jbc.M114.601179

Sequence

[hsa:23347]

Reference

PMID:23542155

Authors

Nozawa RS, Nagao K, Igami KT, Shibata S, Shirai N, Nozaki N, Sado T, Kimura H, Obuse C

Title

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

Journal

Nat Struct Mol Biol 20:566-73 (2013)
DOI:10.1038/nsmb.2532

Sequence

[hsa:23347]

LinkDB

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