KEGG ORTHOLOGY: K05438

ORTHOLOGY: K05438

Entry

K05438                      KO

Symbol

Name

growth hormone

Pathway

map04060

Cytokine-cytokine receptor interaction

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04935

Growth hormone synthesis, secretion and action

Disease

H00254

Growth hormone deficiency

H02035

Isolated growth hormone deficiency

H02039

Kowarski syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05438  GH; growth hormone
   04151 PI3K-Akt signaling pathway
    K05438  GH; growth hormone
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K05438  GH; growth hormone
   04081 Hormone signaling
    K05438  GH; growth hormone
   04060 Cytokine-cytokine receptor interaction
    K05438  GH; growth hormone
09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05438  GH; growth hormone
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05438  GH; growth hormone
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  CSF and other factors
   K05438  GH; growth hormone

Genes

HSA:	1442(CSH1) 1443(CSH2) 1444(CSHL1) 2688(GH1) 2689(GH2)

PTR:	100505396(GH2) 449574(PL-D) 449575(PL-B) 454774(GH1) 739315(CSH1)

PPS:	100971425 100972442 100973020 100983900 117976712 129392943

GGO:	101124194(GH1) 101125803 101126399 101126984 115934631 115934632 134756429

PON:	100446663(CSH2) 100447767(GH2) 100448861 103892869

PPYG:

129017951(CSH2) 129017952(GH2) 129017953 129017954 129017955

NLE:	100579700 100580921 100582356 100585742 115830369 115830462

HMH:

116458733

SSYN:

129469529 129469551 129469667 129469929 129469930 129469931 129469932

MCC:	114669732 114669819 114673168 114673169 700885(GHV) 717562(CSH2) 718116(CSH4) 718135(CSH3) 718156(GH1) 718474 735307

MCF:	102139443(CSH2) 102141100(CSH4) 102143728(GH1) 102973054(CSH3) 102973055(GHV) 123571569 135967741 135967742 135967819 135967886 135967887 135967888

MTHB:

126939474 126939475 126939476 126939559 126939561 126939562 126939566

MNI:	105468986 105468988(GH1) 105469367 105483028 105483030

CSAB:

103243211 103243213 103243214 103243843 108449889

CATY:

105590745 105590746 105590765

PANU:

100126758(GH1) 100379157(GHV) 100381193(CSH1) 100999056 110741552

TGE:	112617465 112617528 112617625 112617626 112617660 112617661 112617667

MLEU:

105551725 105551727 105551728 105551730 105551752

RRO:	104675453 104675456 104675458 104675500 104675501 104675502

RBB:	108511984 108536240 108536264 108536266 108536269

TFN:

117067429

PTEH:

111532246 111532415 111532431 111533513 113224568 113224570 113224571 113224572

CANG:

105515980 105515982 105515983 105515984 105515997 105519388

CJC:	100392546(GH1) 100412128(GH1P5) 100412471(GH1P6)

SBQ:	101039453 101041089 101053083 101053411 101053718 104649998 104649999

CIMI:

108295581(GH1) 108298936 108298937 108318254 108318256 108318314 119474203

CSYR:

103250786(GH1)

MMUR:

LCAT:

PCOQ:

OGA:

MMU:

14599(Gh)

MCAL:

110305672(Gh1)

MPAH:

110332223

RNO:	24391(Gh1)

MCOC:

116077584

ANU:

117711092

ASYL:

127693578(Gh1)

MUN:

110547057

CGE:	100770534(Gh1)

MAUA:

101843583(Gh1)

PROB:

127218378(Gh1)

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:	101712254(Gh1)

CPOC:

100379559(Gh1)

CCAN:

109700526(Gh1)

DORD:

105998539

DSP:

122103287

PLOP:

125366293(Gh1)

NCAR:

MMMA:

ITI:

OCU:

OPI:	101530491(GH1)

TUP:	102493219 102493625

GVR:	103595645(GH1)

CFA:	403795(GH1)

CLUD:

VVP:

VLG:

NPO:

AML:	100471532(GH1)

UMR:

103665901

UAH:	113265156(GH1)

UAR:	123803168(GH1)

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	493931(GH1)

PYU:

121015217

PCOO:

112864677

PBG:

122484753

PVIV:

125151566(GH1)

LRUF:

124512899

PTG:	102954011(GH1)

PPAD:

PUC:

AJU:

HHV:

BTA:	280804(GH1)

BOM:

102271788

BIU:

109574543

BBUB:

102406287(GH)

BBIS:

105000612

CHX:	100861230(GH1) 108638229

OAS:	114116958 443329(GH)

BTAX:

128065055(GH1)

CSUM:

138082805(GH1)

ODA:

120866938

CCAD:

122439621

MREE:

136149199

MBEZ:

129537887(GH1)

SSC:	396884(GH1)

CFR:

102518081

CBAI:

105069779

CDK:

105090400

VPC:	102537102(GH1)

BACU:

103018096(GH1)

BMUS:

118886641

LVE:	103077460(GH1)

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100034180(GH1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:	132219307(GH1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:	119035949 119035950 119036309

PDIC:

114502866

PHAS:

123816860

MMF:

118634340

PPAM:

129070175(GH1)

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:	107502287(GH1)

MJV:

108403155

TOD:

119231053

SARA:

101547182

SFUM:

130035640(GH1)

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	554243(GH1)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

OAA:	114815005(GH1)

GGA:	378781(GH)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

101790997(GH1)

ACYG:

125180016(GH1)

CATA:

118258263

AFUL:

116498334

TGU:	100218808 100232594

LSR:	110471658 110479562(GH1)

SCAN:

103821672 103823758

PMOA:

120498393 120500563

OTC:	121333015(GH1)

PRUF:

121350506 121353429

GFR:	102035525 102045001

FAB:	101810386(GH1) 101816810

OMA:	130254138 130263879

PHI:	102100455 102108332

PMAJ:

107199940 107215237(GH1)

CCAE:

111940061 111944001

CCW:	104686959 104698501

CBRC:

103613826 103616989

ACOE:

138099327 138100558

ETL:	114069211 114070629(GH1)

ZAB:	102068325 102073216

ZLE:	135442240 135458492

ACHL:

103803169 103807929

SVG:	106856603 106858240

MMEA:

130578084 130586144

HRT:	120748920 120766129(GH1)

SATI:

136372063 136373643

FPG:	101911583(GH1)

FCH:	102050341(GH1)

CCRI:

104163159

NNT:

104410485

SHAB:

115617777(GH1)

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:

PPUS:

135191782(GH1)

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

MUI:

PGUU:

PLET:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:	102387497(GH1)

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

101940316(GH1)

TST:	117869418(GH1)

CABI:

116817881

MRV:	120384947(GH1)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

131198195 131198196 131198209

PTEX:

113453619

NSS:	113429490 113429491 113429494 113429495

VKO:

123017384

PMUA:

114582042(GH1)

PRAF:

128400600

ZVI:	118094575(GH1)

HCG:	128331321 128332037

GJA:	107114953(GH1)

STOW:

125444957

EMC:

129339089

XLA:	373617(gh2.S) 378580(gh1.L) 399154(gh1.S)

XTR:	100490878(gh2) 100492540(gh1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:	117347125(GH1)

DRE:	407639(gh1) 572522(smtla)

SRX:	107709547 107739156 107740644 107754309

SANH:

107656966 107662423 107683683 107692520

SGH:	107582917 107585059 107590731

CCAR:

109047206 109052277 109070509 109081196 109097200 109104194 109110701

CAUA:

113046794 113048197 113061304 113110476 113114411 113118697

CGIB:

127934600 127946808 127952303 127977105

PTET:

122322898(smtla) 122341353(gh1)

LROH:

127163047(gh1) 127181149(smtla)

OMC:

131524509

PPRM:

120460015(smtla) 120489451(gh1)

RKG:	130070010(smtla) 130070317(gh1)

MAMB:

125254224(smtla) 125272631(gh1)

CIDE:

127499705 127509069

CERY:

137010691(gh1) 137022539(smtla)

MASI:

127417448 127450982 127451599

TROS:

130561333(gh1) 130562621(smtla)

TDW:	130426859(gh1) 130435547(smtla)

MANU:

129419308(smtla) 129436389(gh1)

IPU:	100305005(gh1)

IFU:	128616278(gh1) 128620178(smtlb)

PHYP:

113543885 113544880

SMEO:

124381993(gh1) 124393665(smtlb)

TFD:	113650380(smtlb) 113662765(gh1)

TVC:	132842137(gh1) 132863259(smtlb)

TRN:	134323380(smtla) 134333901(gh1)

AMEX:

103022738(gh1) 103037048(smtlb)

CMAO:

118803676(gh1) 118818426(smtla) 118824661(smtlb)

EEE:

113587837

CHAR:

105890783(gh1) 122133141(smtla)

SPIL:

134075821(gh1) 134100103(smtla)

TRU:	101061166 101070289

TFS:	130520103(gh1) 130535338(smtla)

TNG:	GSTEN00019559G001

LCO:	104931893 104940493

NCC:

104960967

TBEN:

117469146(gh1) 117470206(smtla)

CGOB:

115017825

PGEO:

117443967(gh1) 117457052(smtla)

GACU:

117551745(smtla) 117559415(gh1)

EMAC:

134878569(gh1) 134880391(smtla)

ELY:	117259303(smtla) 117269070(gh1)

EFO:	125879224(gh1) 125888767(smtla)

PLEP:

121943686(smtla) 121965607(gh1)

SLUC:

116043900(smtla) 116063544(gh1)

ECRA:

117941304(gh1) 117941781(smtla)

ESP:

116685715

PFLV:

114552555 114568956

GAT:	120827717(smtla) 120828067(gh1)

PPUG:

119220374(gh1) 119222108(smtla)

AFB:	129091691(smtla) 129098133(gh1)

CLUM:

117734622(gh1) 117741421(smtla)

PSWI:

130210864(smtla)

CANA:

137790606(smtla) 137803445(gh1)

CVE:	137874759(smtla) 137884027(gh1)

MSAM:

119882337(smtla) 119896148(gh1) 119911183

SCHU:

122869373(gh1) 122879413(smtla)

CUD:	121503512(gh1) 121522467(smtla)

SPUL:

138596989(smtla) 138604000(gh1)

LMIX:

132980039(smtla) 132995755(gh1)

ALAT:

119006997(smtla) 119013881(gh1)

ASTR:

137596796(smtla) 137609789(gh1)

MZE:	101468270 101482244

ONL:	100534452 100711096

OAU:	116319389(gh1) 116323295(smtla)

OLA:	100049402 101171460

OML:	112139712(gh1) 112149555(smtla)

CSAI:

133442278 133442289(smtla) 133457966(gh1)

XMA:	102222100 102233429

XCO:	114159494 114161391

XHE:	116736294 116737242

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122821807(gh1) 122832389(smtla)

PPRL:

129359144(smtla) 129373713(gh1)

CVG:	107083471 107089309

CTUL:

119781667(gh1) 119791036(smtla)

GMU:	124862327 124863788 124884283(smtla)

NFU:	107390293 107396211

KMR:	108238150(smtla) 108243233(gh1)

ALIM:

106526269 106528097

NWH:	119411187(smtla) 119421286(gh1)

AOCE:

111568175 111569181

EJA:	138196900(smtla) 138207908(gh1)

BFRE:

138616699(smtla) 138631359(gh1)

MCEP:

124997264(gh1) 125013566(smtla)

CSEM:

103377636 103387754

POV:	109634465 109643344

SSEN:

122773694(smtla) 122781992(gh1)

HHIP:

117766138(gh1) 117773484(smtla)

HSP:	118105694(smtla) 118124061(gh1)

PPLT:

128440254(smtla) 128458091(gh1)

SMAU:

118289219(gh1) 118299890(smtla)

LCF:	108873234(gh1) 108898852(smtla)

SDU:	111222547 111239800

SLAL:

111657519 111657876

XGL:	120783339(gh1) 120792076(smtla)

HCQ:	109512828 109513754

SSCV:

125972679(smtla) 125983358(gh1)

SBIA:

133504661(smtla) 133514222(gh1)

PEE:	133405015(smtla) 133414361(gh1)

PTAO:

133466395(gh1) 133482715(smtla)

BPEC:

110161975 110164350

MALB:

109960341 109972673

BSPL:

114861059(gh1) 114868472(smtla)

SJO:	128360650(smtla) 128378555(gh1)

SSCO:

133980376(smtla) 133999164(gh1)

SASA:

100136491 100136588(gh) 100196589 106607462

STRU:

115154053 115163535 115170947 115196507

OTW:	112225899 112228339(smtlb) 112258502(gh1) 112265609

OMY:	100136733(gh1) 100136734(gh2) 110507854 110534909(smtlb)

OGO:	123992659(smtla) 123994908(smtlb) 123999031(gh1) 124016361

ONE:	115104032 115110133 115136498 115137594

OKI:	109872980 109893213 109898300 109904868

OKE:	118365171 118384394 118389856(smtlb) 118397521(smtla)

SALP:

111950789 111980263 112070195

SNH:	120018744 120034139 120044469 120056470

CCLU:

121551272 121567031 121568185 121569713 121580136

ELS:	105023357 105028755

SFM:	108921486 108932297 108941578

PKI:	111849226 111850622 111856077

AANG:

118217101(gh1) 118236329(smtlb)

CCOG:

133114904(gh1) 133133183(smtlb)

LOC:	102687524 102694171

PSPA:

121304062(smtla) 121323985(gh1)

ARUT:

117397256 117433528 117435114(gh1) 117966556

PSEX:

120518007 120534924

LCM:	102349296 102356179

CMK:	103187720(gh1)

RTP:	109910501(gh1)

CPLA:

122539993

HOC:	132830750(gh1)

LERI:

129710393

» show all

Reference

PMID:20956999

Authors

Clayton PE, Banerjee I, Murray PG, Renehan AG

Title

Growth hormone, the insulin-like growth factor axis, insulin and cancer risk.

Journal

Nat Rev Endocrinol 7:11-24 (2011)
DOI:10.1038/nrendo.2010.171

Reference

PMID:3379057

Authors

Cooke NE, Ray J, Emery JG, Liebhaber SA

Title

Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.

Journal

J Biol Chem 263:9001-6 (1988)

Sequence

[hsa:2688 2689]

LinkDB

ORTHOLOGY: K05439

Entry

K05439                      KO

Symbol

PRL

Name

prolactin

Pathway

map04060

Cytokine-cytokine receptor interaction

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04917

Prolactin signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05439  PRL; prolactin
   04151 PI3K-Akt signaling pathway
    K05439  PRL; prolactin
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K05439  PRL; prolactin
   04081 Hormone signaling
    K05439  PRL; prolactin
   04060 Cytokine-cytokine receptor interaction
    K05439  PRL; prolactin
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K05439  PRL; prolactin
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05439  PRL; prolactin
Cytokines and neuropeptides [BR:ko04052]
Neuropeptides
  Neuropeptides (Unclassified)
   K05439  PRL; prolactin

Genes

HSA:

5617(PRL)

PTR:	462468(PRL)

PPS:	100970831(PRL)

GGO:	101141749(PRL)

PON:	100450466(PRL)

PPYG:

129038551(PRL)

NLE:	100596407(PRL)

HMH:	116459715(PRL)

SSYN:

129473412(PRL)

MCC:	707052(PRL)

MCF:	102133150(PRL)

MTHB:

126953311

MNI:	105482522(PRL)

CSAB:

103222073(PRL)

CATY:

105572608(PRL)

PANU:

100126745(PRL)

TGE:	112622266(PRL)

MLEU:

105552490(PRL)

RRO:	104654795(PRL)

RBB:	108530294(PRL)

TFN:	117086794(PRL)

PTEH:

111541106(PRL)

CANG:

105526699(PRL)

CJC:	100413643(PRL)

SBQ:	101037800(PRL)

CIMI:

108314939(PRL)

ANAN:

105721459(PRL)

CSYR:

103274641(PRL)

MMUR:

105865235(PRL)

LCAT:

123638329(PRL)

PCOQ:

105805714(PRL)

OGA:	100941749(PRL)

MMU:	19109(Prl) 19111(Prl6a1) 28078(Prl5a1)

MCAL:

110287831 110287897 110288311 110308241 110308314 110308482 110308603 110308620

MPAH:

110333583 110333863 110333918 110334155 110334192

RNO:	171556(Prl5a1) 24657(Prl6a1) 24683(Prl)

MCOC:

116081753 116081775 116081833(Prl) 116082128 116082207 116082394 116082402 116082510

ANU:	117713978(Prl) 117714273 117714284

ASYL:

127664539 127665233 127665288

MUN:	110542666 110542667 110543443 110563396 110563397 110563905 110564591 110564593 110564594

CGE:	100750601 100751675 100751961 100752249 100752545 100753747 100760990 100761279 100763308 100763880 113834987

MAUA:

101823615 101824659 101841774 101843376

PROB:

127229091 127229103 127229113 127229115

PLEU:

114701721(Prl) 114701738 114701749 114701759 114701771 114701802 114701853 114701863 114701884 114702114 114702123 114702144 114702170 114702177

MORG:

121433906 121433928 121433964 121433965

MFOT:

126501649 126501733 126501734 126501878

AAMP:

119817109 119817110 119817986

NGI:	103728734 103728735 103728738 103728739 103728740 103728741 103739983 103739984 103739985 103739987 103739988 103739991 103751156 103751328 108490016 108491197 108491199 108491200

HGL:	101696723(Prl) 101699327 106009625

CPOC:

100499538(Prl) 100499539(Prlrp1) 100499540(Prlrp2) 100713416 100713699 100714816 100715943 100716224 100716511 100735689 101788649 111754958

CCAN:

109677675 109677676 109677677 109677679 109677682 109677683 109677684 109680230 109680233 109680235 109703272 109703273

DORD:

106000048(Prl)

DSP:	122106999(Prl)

PLOP:

125352248(Prl)

NCAR:

124988947

MMMA:

107149428(Prl)

ITI:	101956739 101975416(Prl)

OCU:	100009394(PRL)

OPI:	101535717(PRL)

TUP:	102500251(PRL)

GVR:	103609539(PRL)

CFA:	488241(PRL)

CLUD:

112657409(PRL)

VVP:	112920503(PRL)

VLG:	121499905(PRL)

NPO:	129508079(PRL)

AML:	100481524(PRL)

UMR:	103678373(PRL)

UAH:	113264523(PRL)

UAR:	123791081(PRL)

ELK:

111138630

LLV:

125103145

MPUF:

101690481(PRL)

MNP:	132017641(PRL)

MLK:	131834809(PRL)

NVS:	122913189(PRL)

ORO:	101378550(PRL)

EJU:	114212615(PRL)

ZCA:	113927678(PRL)

MLX:	117997464(PRL)

NSU:	110586744(PRL)

LWW:	102743308(PRL)

FCA:	751517(PRL)

PYU:	121020441(PRL)

PCOO:

112853568(PRL)

PBG:	122490260(PRL)

PVIV:

125165886(PRL)

LRUF:

124527918

PTG:	102970648(PRL)

PPAD:

109252661(PRL)

AJU:

106987609

HHV:	120235246(PRL)

BTA:	100298767 280901(PRL) 281097(CSH2) 281429(PRP1) 281430(PRP3) 282007(PRP14) 404081(PRP6) 406200(PRP4) 497206(PRP-VII) 519859(PRP9) 613971(PRP8) 790470(PRP2)

BOM:	102269208 102271434 102271714 102272003 102274562 102275031 106701660

BIU:	109576744 109576772 109576773 109576787 109576792 109576814 109577296 109577452 109577453

BBUB:

102389179 102406514 102407630 102411580 102411913 102412228 102412560 102412882 102415969 102416621 112577752 112579588

BBIS:

104992619 104992620 104992622 104992623 104992624 104992625 104992626 104992627 104992629 104992631 104992632 104992637

CHX:	100860766(PRP1) 100861397(PRP6) 102170569 102171116 102178616 102180550 102184390 102190477 108638107

OAS:	100126189(PRP1) 100127213(PRP2) 101102463 101102796 101109399 101109654 101109921 101110459 105613815 114108610 114109603 114109612 443317(PRL) 443319

BTAX:

128055157 128055513 128056068 128056134 128056189 128056261 128056286 128056321 128056535

CSUM:

138069361 138097903 138097989 138097992 138098051 138098081

ODA:	120859475 120859476 120870251 120870252 120870254 120870256 120870291 120870296 120870297 120870299 120870300 120870301 120870302 120870303 120870304

MREE:

136151237 136151239 136151241 136151263 136151264 136151346 136151347 136151424 136151429 136151432 136151463 136151485 136151513 136151563 136151747

MBEZ:

129543303 129543305 129543400 129543410 129543476

SSC:	396965(PRL)

CFR:	102513256(PRL)

CBAI:

105084199(PRL)

CDK:	105089122(PRL)

VPC:	102543013(PRL)

BACU:

103005353(PRL)

BMUS:

118903739(PRL)

LVE:

103068298

OOR:	101289965(PRL)

DLE:	111181274(PRL)

PCAD:

102976160(PRL)

PSIU:

116762705(PRL)

NASI:

112396620(PRL)

ECB:	100034034(PRL)

EPZ:	103555098(PRL)

EAI:	106847015(PRL)

MYB:	102261680(PRL)

MYD:	102773602(PRL)

MMYO:

118675065(PRL)

MLF:	102420245(PRL)

MDT:	132229428(PRL)

PKL:	118723061(PRL)

EFUS:

103290147(PRL)

MNA:	107533698(PRL)

DRO:	112309295(PRL)

SHON:

118981253(PRL)

AJM:	119038724(PRL)

PDIC:

114497751(PRL)

PHAS:

123824055(PRL)

MMF:	118626233(PRL)

PPAM:

129085648(PRL)

HAI:	109381635(PRL)

RFQ:	117027368(PRL)

PALE:

102887064(PRL)

PGIG:

120605617(PRL)

PVP:	105306493(PRL)

RAY:	107514304(PRL)

MJV:	108385400(PRL)

TOD:	119253510(PRL)

SARA:

101538916(PRL)

SFUM:

130040483(PRL)

SETR:

125995838(PRL)

LAV:	100654812(PRL)

TMU:

101346160

ETF:	101657861(PRL)

DNM:	101429362(PRL)

MDO:	100017831(PRL)

SHR:	100932842(PRL)

AFZ:

127547204

PCW:	110208793(PRL)

TVP:	118833868(PRL)

PBRV:

138166479(PRL)

OAA:	100083427(PRL)

GGA:	396453(PRL) 417800(PRLL)

PCOC:

116226691 116240031(PRL)

MGP:	100303694(PRL) 100539893

CJO:	107309721 107309735(PRL)

TPAI:

128073539 128087818(PRL)

LMUT:

125691379(PRL) 125692554

NMEL:

110392634 110394973(PRL)

APLA:

101793561 101793643(PRL)

ACYG:

106038354(PRL) 106045491

CATA:

118246726 118249625(PRL)

AFUL:

116485803 116486120(PRL)

TGU:	100228929(PRL) 101232981

LSR:	110478547 110479833 110483467(PRL)

SCAN:

103819399(PRL) 103820421

PMOA:

120503517(PRL) 120510749

OTC:	121339522 121347817(PRL)

PRUF:

121352576 121357786(PRL)

GFR:	102032711(PRL) 102040600

FAB:	101807433(PRL) 101820588

OMA:	130249662(PRL) 130266541

PHI:	102099089(PRL) 102100779

PMAJ:

107198339(PRL) 107204650

CCAE:

111923970(PRL) 111932116

CCW:	104691439(PRL) 104698455

CBRC:

103613166(PRL) 103614868

ACOE:

138104465 138105775(PRL)

ETL:	114061970 114068494(PRL)

ZAB:	102066414(PRL) 102070454

ZLE:	135443177(PRL) 135456897

ACHL:

103805271(PRL) 103810242

SVG:	106850113 106854161(PRL)

MMEA:

130573594 130581771(PRL)

HRT:	120751706(PRL)

SATI:

136361937 136367471(PRL)

FPG:	101917226(PRL) 101923021

FCH:	102047707 102051915(PRL)

CCRI:

104168062(PRL)

NNT:	104401064(PRL)

SHAB:

115605551 115607066(PRL)

ACUN:

113476487(PRL)

TALA:

104366268(PRL) 116963364

ACHC:

115341694 115352951(PRL)

HALD:

104315575(PRL)

HLE:	104835264(PRL) 104835877

AGEN:

126044417 126048612

HHAR:

128139652(PRL) 128143181

GCL:	127013275 127029704

CSTI:

104555742(PRL)

LDI:	104341778(PRL) 104346752

MNB:	103775959 103777493(PRL)

DPUB:

104299117 104305670(PRL)

PPUS:

135175092 135184714(PRL)

AVIT:

104272504(PRL)

BRHI:

104488524 104498846(PRL)

EGZ:	104125480(PRL)

NNI:	104021796(PRL)

PCRI:

104029062(PRL)

PCAO:

104042007(PRL)

PADL:

103919057(PRL)

AFOR:

103903816(PRL)

FGA:	104071838(PRL)

GSTE:

104254111(PRL)

CLV:	102090354(PRL) 102092998

MUI:	104535328(PRL) 104541629

PGUU:

104470040(PRL)

PLET:

104624416(PRL)

EHS:	104506887(PRL)

CMAC:

104481069(PRL) 104484840

CUCA:

104062135(PRL) 128853733

TEO:	104371001 104376689(PRL)

BREG:

104635819(PRL)

OHA:	104335519(PRL)

ACAR:

104527398 104528215

CPEA:

104394873(PRL) 104396460

CVF:	104282757 104288088(PRL)

RTD:	128904311 128905559(PRL)

AAM:	106483309(PRL)

AROW:

112976885(PRL)

NPD:	112953904(PRL) 112956791

TGT:	104565282(PRL) 104576840

DNE:	112983055 112992511(PRL)

SCAM:

104153061(PRL) 104153349

ASN:	102380918(PRL)

AMJ:	102574258(PRL)

CPOO:

109324730(PRL)

GGN:	109299444(PRL)

PSS:	102450009(PRL) 102456053

CMY:	102931458(PRL) 102944759

CCAY:

125632196(PRL) 125635985

DCC:	119852109(PRL) 119859133

CPIC:

101940655 101943700(PRL)

TST:	117868484(PRL)

CABI:

116818046(PRL) 116821697

MRV:	120395496 120399442(PRL)

ACS:	100561954(prl)

ASAO:

132774634(PRL)

PVT:	110072918(PRL) 110079980

SUND:

121929103(PRL)

PBI:	103057526(PRL)

PMUR:

107289607(PRL)

CTIG:

120298694(PRL)

TSR:	106547056(PRL)

PGUT:

117672538(PRL)

APRI:

131195179(PRL)

PTEX:

113435408(PRL)

NSS:	113413556(PRL)

VKO:	123021524(PRL)

PMUA:

114601367(PRL) 114605534

PRAF:

128417720(PRL) 128422484

ZVI:	118090085(PRL) 118091115

HCG:	128324170(PRL) 128327556

GJA:	107125531(PRL)

STOW:

125439530(PRL)

EMC:	129333666(PRL)

XLA:	108695906 108697263(prl.2.S) 446320(prl.1.L) 734391(prl.1.S)

XTR:	100101709(prl.1) 100497196 100497278(prl.2) 100498019

NPR:	108792905(PRL) 108801639

RTEM:

120916582 120940764(PRL)

BBUF:

120998539 121002540(PRL)

BGAR:

122926151 122939601(PRL)

MUO:	115460303(PRL) 115466595

GSH:	117355739(PRL) 117368682

DRE:	799612(prl2)

SRX:	107725674 107729562 107729861 107758689

SANH:

107653684 107655571 107658486 107694228

SGH:	107577038 107582933 107583102 107587154

CCAR:

109107536 109109275

CAUA:

113048591 113056526 113063810 113074447

CGIB:

127956564 127971068

PTET:

122343304(prl2)

LROH:

127164406(prl2)

OMC:	131539338(prl2)

PPRM:

120476876(prl2)

RKG:	130079524(prl2)

MAMB:

125245545(prl2)

CERY:

137023893(prl2)

MASI:

127435006 127436922

TROS:

130548125(prl2)

TDW:	130421197(prl2)

MANU:

129432418(prl2)

IPU:	108279639(prl2) 108280547(prl)

IFU:	128623127(prl2)

PHYP:

113525009 113531964

SMEO:

124401562(prl2)

TFD:	113647299(prl2)

TVC:	132859289(prl2)

AMEX:

103023606(prl) 103029290(prl2)

CMAO:

118811322 118811348(prl2)

EEE:	113577446 113578112 113580270

CHAR:

105902836 105908780

SPIL:

134062568(prl2) 134094402

TRU:	101062490(prl) 101065978 778002(prl)

TFS:	130515210(prl) 130518908(prl2) 130536575

TNG:	GSTEN00021066G001

LCO:	104922938 104933293

NCC:	104950359 104962097 104964766

TBEN:

117483320(prl2) 117493927(prl) 117494943

CGOB:

115009427 115012292 115028346

PGEO:

117439375(prl2) 117441991(prl) 117448504

GACU:

117547159(prl2) 117547892 117557345(prl)

EMAC:

134878076(prl) 134879503(prl2) 134879698

ELY:	117249535(prl2) 117262852 117268060(prl)

EFO:	125879323(prl) 125883022(prl2) 125886918

PLEP:

121939765 121950753 121956319(prl) 121961619(prl2)

SLUC:

116038578 116042077(prl2) 116052940(prl)

ECRA:

117939001(prl2) 117949068 117957717(prl)

ESP:	116673223 116702640

PFLV:

114550554 114559706 114569629

GAT:	120817571(prl2) 120827589(prl)

PPUG:

119210242(prl2) 119221070(prl)

AFB:	129098411(prl) 129107982 129112754 129116847

CLUM:

117726355(prl2) 117735008(prl)

PSWI:

130190475(prl) 130194956(prl2)

CANA:

137786343(prl) 137791853(prl2) 137803713

CVE:	137877087 137881943

MSAM:

119882467 119882495 119882507 119884889 119918320

SCHU:

122868407(prl) 122871334

CUD:	121503352(prl) 121505708(prl2) 121514454

SPUL:

138599758(prl2) 138602645(prl) 138612661

LMIX:

132954538(prl) 132956400 132973484

ALAT:

119014169(prl) 119024675 119032632(prl2)

ASTR:

137589544 137593700 137609506(prl)

MZE:	101479120 101479404 101486003

ONL:	100534522(prl) 100534523 100697904(prl2)

OAU:	116309958(prl) 116309967 116332106(prl2)

OLA:	101172582 101174239(prl)

OML:	112140050(prl2) 112146698(prl)

CSAI:

133422811(prl) 133424187(prl2)

XMA:	102222748 102224017

XCO:	114147477 114160883

XHE:	116735598 116736491

PRET:

103459740(prl) 103468295

PFOR:

103129870(prl) 103149218

PLAI:

106939759 106959757

PMEI:

106908751(prl) 106932738

GAF:	122821353(prl) 122826092(prl2)

PPRL:

129363570(prl) 129376071(prl2)

CVG:	107100864 107100946 107100947

CTUL:

119777642(prl2) 119797420 119797430

GMU:	124863164 124864485 124883232(prl2)

NFU:	107374861 107395172

KMR:	108247088(prl) 108249070(prl2)

ALIM:

106521831 106530027

NWH:	119422059(prl)

AOCE:

111564969 111573136 111583853

EJA:	138202442 138205942 138215274(prl)

BFRE:

138619182 138627545(prl) 138631293

MCEP:

124998163(prl) 125000262(prl2) 125015138

CSEM:

103380354 103383000 103393669

POV:	109624134 109637490 109645096

SSEN:

122766673 122776328 122785575(prl)

HHIP:

117757333 117763725 117766176(prl)

HSP:	118101718 118109419 118123594(prl)

PPLT:

128429129 128444152 128459231 128459261

SMAU:

118288423(prl) 118301562(prl2) 118315916

LCF:	108888483 108897437 108898587(prl)

SDU:	111223677 111225002 111229772

SLAL:

111650478 111657548 111662513

XGL:	120787440(prl) 120792895 120802235

HCQ:	109506923 109508838 109528800

SSCV:

125970521 125983080(prl) 125992532(prl2)

SBIA:

133493160(prl2) 133514419(prl)

PEE:	133397252(prl2) 133415125(prl)

PTAO:

133465825(prl) 133472222

BPEC:

110171728 110174228

MALB:

109951456

BSPL:

114861109(prl) 114861641(prl2)

SJO:	128353217(prl2) 128359389 128378539(prl)

SSCO:

133982469 134000115(prl) 134004195

SASA:

100136580(prl) 106592567 106593855

STRU:

115170860 115180378

OTW:	112252255 112258428(prl) 121845981(prl2)

OMY:	100136792(prl) 110521934 118938931 118943005

OGO:	123999159(prl) 124020533(prl2) 124037128

ONE:	115110067 115145511

OKI:	109884442 109893152 116360520 116363226

OKE:	118358976 118384327(prl) 127919695(prl2)

SALP:

111952258 111971890 111981266

SNH:	120040403(prl2) 120044447 120051943

CCLU:

121550384 121557239 121570599 123484576

ELS:	105028434 105031019

SFM:	108925139 108931404 108941677

PKI:	111833241 111836887 111851268

AANG:

118219314(prl2) 118231490

CCOG:

133119297(prl2) 133135635

LOC:

102686273

PSPA:

121305982(prl) 121319141(prl2)

ARUT:

117414987(prl2)

PSEX:

120533593(prl2) 120542337(prl)

LCM:	102358230 102365465

CMK:	103176856(prl)

RTP:

CPLA:

HOC:

PMRN:

LRJ:

SVS:

Reference

PMID:22205663

Authors

Trott JF, Schennink A, Petrie WK, Manjarin R, VanKlompenberg MK, Hovey RC

Title

Triennial Lactation Symposium: Prolactin: The multifaceted potentiator of mammary growth and function.

Journal

J Anim Sci 90:1674-86 (2012)
DOI:10.2527/jas.2011-4682

LinkDB

ORTHOLOGY: K05418

Entry

K05418                      KO

Symbol

OSM

Name

oncostatin M

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05418  OSM; oncostatin M
   04151 PI3K-Akt signaling pathway
    K05418  OSM; oncostatin M
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05418  OSM; oncostatin M
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05418  OSM; oncostatin M
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  CSF and other factors
   K05418  OSM; oncostatin M

Other DBs

GO:

0005147

Genes

HSA:

5008(OSM)

PTR:	736338(OSM)

PPS:	100971653(OSM)

GGO:	101138490(OSM)

PON:	100448170(OSM)

PPYG:

129023508(OSM)

NLE:	100603259(OSM)

HMH:	116458600(OSM)

SSYN:

129468355(OSM)

MCC:	717994(OSM)

MCF:	102128264(OSM)

MTHB:

126963983

MNI:	105487244(OSM)

CSAB:

103223157(OSM)

CATY:

105575714(OSM)

PANU:

101003425(OSM)

TGE:	112633333(OSM)

MLEU:

105538992(OSM)

RRO:	104659494(OSM)

RBB:	108517598(OSM)

TFN:	117096177(OSM)

PTEH:

111525348(OSM)

CANG:

105522991(OSM)

CJC:	100387903(OSM)

SBQ:	101043909(OSM)

CIMI:

108283330(OSM)

ANAN:

105725756(OSM)

CSYR:

103258532(OSM)

MMUR:

105870923(OSM)

LCAT:

123625829(OSM)

PCOQ:

105821285(OSM)

OGA:	100963412(OSM)

MMU:	18413(Osm)

MCAL:

110306250(Osm)

MPAH:

110330998(Osm)

RNO:	289747(Osm)

MCOC:

116069310(Osm)

ANU:	117713179(Osm)

ASYL:

127696305(Osm)

MUN:	110557889(Osm)

CGE:	100758591(Osm)

MAUA:

101837777(Osm)

PROB:

127233778(Osm)

PLEU:

114694090(Osm)

MORG:

121436395 121459274

MFOT:

126500689

AAMP:

119810132(Osm)

NGI:	103740483(Osm)

HGL:	101705496(Osm)

CPOC:

100724699(Osm)

CCAN:

109697282(Osm)

DORD:

105984160(Osm)

DSP:	122097174(Osm)

PLOP:

125347750(Osm)

NCAR:

124991097

MMMA:

107158508(Osm)

ITI:	101976425(Osm)

OCU:

100342491

OPI:	101530550(OSM)

TUP:	102469110(OSM)

GVR:	103589406(OSM)

CFA:	611921(OSM)

CLUD:

112676800(OSM)

VVP:	112909849(OSM)

VLG:	121475781(OSM)

NPO:	129508110(OSM)

AML:	100483167(OSM)

UMR:	103681110(OSM)

UAH:	113245027(OSM)

UAR:	123788158(OSM)

ELK:

111160020

LLV:

125082349

MPUF:

101674092(OSM)

MNP:	132023321(OSM)

MLK:	131811308(OSM)

NVS:	122902027(OSM)

ORO:	101366093(OSM)

EJU:	114225213(OSM)

ZCA:	113912855(OSM)

MLX:	118018643(OSM)

NSU:	110592544(OSM)

LWW:	102729555(OSM)

FCA:	101094379(OSM)

PYU:	121022610(OSM)

PCOO:

112870209(OSM)

PBG:	122470996(OSM)

PVIV:

125149195(OSM)

LRUF:

124518186

PTG:	102967884(OSM)

PPAD:

109253577(OSM)

PUC:

125914512

AJU:

106983325

HHV:	120227876(OSM)

BTA:	319086(OSM)

BOM:	102271854(OSM)

BIU:	109570838(OSM)

BBUB:

102390598(OSM)

BBIS:

104980138(OSM)

CHX:	102188790(OSM)

OAS:	101122466(OSM)

BTAX:

128062617(OSM)

CSUM:

138093904(OSM)

ODA:	120871235(OSM)

CCAD:

122421029(OSM)

MREE:

136145932(OSM)

MBEZ:

129542740(OSM)

SSC:	100152038(OSM)

CFR:	102518444(OSM)

CBAI:

105066072(OSM)

CDK:	105099450(OSM)

VPC:	102542579(OSM)

BACU:

103016655(OSM)

BMUS:

118880058(OSM)

LVE:	103072416(OSM)

OOR:	101277557(OSM)

DLE:	111162704(OSM)

PCAD:

102974009(OSM)

PSIU:

116739070(OSM)

NASI:

112415172(OSM)

ECB:	100064031(OSM)

EAI:	106827183(OSM)

MYB:	102259125(OSM)

MYD:	102767198(OSM)

MMYO:

118678304(OSM)

MDT:	132221834(OSM)

PKL:	118725380(OSM)

EFUS:

103286857(OSM)

MNA:	107526227(OSM)

DRO:	112310359(OSM)

SHON:

118991279(OSM)

AJM:	119055184(OSM)

PDIC:

114510381(OSM)

PHAS:

123810979(OSM)

MMF:	118640106(OSM)

PPAM:

129087277(OSM)

HAI:	109383043(OSM)

RFQ:	117017261(OSM)

PALE:

102889450(OSM)

PGIG:

120601898(OSM)

PVP:	105300916(OSM)

RAY:	107505411(OSM)

MJV:	108396879(OSM)

TOD:	119245295(OSM)

SARA:

101553975(OSM)

SFUM:

130025759(OSM)

LAV:	100660616(OSM)

TMU:

101357379

ETF:	101638351(OSM)

DNM:	101415586(OSM)

MDO:	103094214(OSM)

GAS:	123255575(OSM)

SHR:

105749464

PCW:	110215344(OSM)

TVP:	118844174(OSM)

PBRV:

138156314(OSM)

PVT:

SUND:

PMUR:

ONL:

ELS:

SFM:

TDC:

Reference

PMID:15743783

Authors

Okaya A, Kitanaka J, Kitanaka N, Satake M, Kim Y, Terada K, Sugiyama T, Takemura M, Fujimoto J, Terada N, Miyajima A, Tsujimura T

Title

Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes.

Journal

Am J Pathol 166:709-19 (2005)
DOI:10.1016/S0002-9440(10)62292-4

Sequence

[rno:289747]

Reference

PMID:21375496

Authors

White UA, Stephens JM

Title

The gp130 receptor cytokine family: regulators of adipocyte development and function.

Journal

Curr Pharm Des 17:340-6 (2011)
DOI:10.2174/138161211795164202

LinkDB

ORTHOLOGY: K05429

Entry

K05429                      KO

Symbol

IL2

Name

interleukin 2

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04151

PI3K-Akt signaling pathway

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04672

Intestinal immune network for IgA production

map04940

Type I diabetes mellitus

map05135

Yersinia infection

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05320

Autoimmune thyroid disease

map05321

Inflammatory bowel disease

map05330

Allograft rejection

map05332

Graft-versus-host disease

Disease

H00084

Graft-versus-host disease

H00408

Type 1 diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05429  IL2; interleukin 2
   04151 PI3K-Akt signaling pathway
    K05429  IL2; interleukin 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05429  IL2; interleukin 2
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05429  IL2; interleukin 2
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K05429  IL2; interleukin 2
   04660 T cell receptor signaling pathway
    K05429  IL2; interleukin 2
   04658 Th1 and Th2 cell differentiation
    K05429  IL2; interleukin 2
   04659 Th17 cell differentiation
    K05429  IL2; interleukin 2
   04672 Intestinal immune network for IgA production
    K05429  IL2; interleukin 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05429  IL2; interleukin 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05429  IL2; interleukin 2
   05171 Coronavirus disease - COVID-19
    K05429  IL2; interleukin 2
   05162 Measles
    K05429  IL2; interleukin 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05429  IL2; interleukin 2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05429  IL2; interleukin 2
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K05429  IL2; interleukin 2
   05321 Inflammatory bowel disease
    K05429  IL2; interleukin 2
   05330 Allograft rejection
    K05429  IL2; interleukin 2
   05332 Graft-versus-host disease
    K05429  IL2; interleukin 2
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K05429  IL2; interleukin 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05429  IL2; interleukin 2
   00536 Glycosaminoglycan binding proteins
    K05429  IL2; interleukin 2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05429  IL2; interleukin 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K05429  IL2; interleukin 2

Other DBs

GO:

0005134

Genes

HSA:

3558(IL2)

PTR:	461472(IL2)

PPS:	100984780(IL2)

GGO:	101132394(IL2)

PON:	100455248(IL2)

PPYG:

129034997(IL2)

NLE:	100591126(IL2)

HMH:	116479944(IL2)

SSYN:

129480656(IL2)

MCC:	708017(IL2)

MCF:	102129830(IL2)

MTHB:

126955754

MNI:	105486135(IL2)

CSAB:

103236209(IL2)

CATY:

105595801(IL2)

PANU:

100126754(IL2)

TGE:	112624904(IL2)

MLEU:

105538406(IL2)

RRO:	104661748(IL2)

RBB:	108515581(IL2)

TFN:	117084792(IL2)

PTEH:

111546287(IL2)

CANG:

105516414(IL2)

CJC:	100386848(IL2)

SBQ:	101028427(IL2)

CIMI:

108297648(IL2)

ANAN:

105731298(IL2)

CSYR:

103270878(IL2)

MMUR:

105882081(IL2)

LCAT:

123637712(IL2)

PCOQ:

105815260(IL2)

OGA:	100942002(IL2)

MMU:	16183(Il2)

MCAL:

110291180(Il2)

MPAH:

110320556(Il2)

RNO:	116562(Il2)

MCOC:

116094798(Il2)

ANU:	117707066(Il2)

ASYL:

127682390(Il2)

MUN:	110545874(Il2) 110560079

CGE:	100755773(Il2)

MAUA:

101835410(Il2)

PROB:

127223186(Il2)

PLEU:

114707177(Il2)

MORG:

121452714(Il2)

MFOT:

126499332

AAMP:

119825919(Il2)

NGI:	103746951(Il2)

HGL:	101720581(Il2)

CPOC:

100379540(Il2)

CCAN:

109691916(Il2)

DORD:

105989886(Il2)

DSP:	122119081(Il2)

PLOP:

125341318(Il2)

NCAR:

124994815

MMMA:

107136571(Il2)

ITI:	101967608(Il2)

OCU:	100302458(IL2)

OPI:	101519556(IL2)

TUP:	102478615(IL2)

GVR:	103593609(IL2)

CFA:	403989(IL2)

CLUD:

112642744(IL2)

VVP:	112933619(IL2)

VLG:	121492803(IL2)

NPO:	129504325(IL2)

AML:	100480862(IL2)

UMR:	103661804(IL2)

UAH:	113255635(IL2)

UAR:	123793114(IL2)

ELK:

111154869

LLV:

125093350

MPUF:

101674110(IL2)

MNP:	132014406(IL2)

MLK:	131828386(IL2)

NVS:	122890130(IL2)

ORO:	101386196(IL2)

EJU:	114208234(IL2)

ZCA:	113925933(IL2)

MLX:	118022354(IL2)

NSU:	110573034(IL2)

LWW:	102742200(IL2)

FCA:	751114(IL2)

PYU:	121030128(IL2)

PCOO:

112858002(IL2)

PBG:	122476434(IL2)

PVIV:

125164688(IL2)

LRUF:

124520662

PTG:	102957506(IL2)

PPAD:

109248906(IL2)

PUC:

125923086

AJU:

106977102

HHV:	120238026(IL2)

BTA:	280822(IL2)

BOM:	102272426(IL2)

BIU:	109571028(IL2)

BBUB:

102395421(IL2)

BBIS:

105003236(IL2)

CHX:	102183089(IL2)

OAS:	443401(IL2)

BTAX:

128062529(IL2)

CSUM:

138093855(IL2)

ODA:	120870984(IL2)

CCAD:

122453281(IL2)

MREE:

136145870(IL2)

MBEZ:

129542297(IL2)

SSC:	396868(IL2)

CFR:	102514894(IL2)

CBAI:

105067115(IL2)

CDK:	105093664(IL2)

VPC:	102532988(IL2)

BACU:

103017896(IL2)

BMUS:

118895628(IL2)

LVE:	103071508(IL2)

OOR:	101274648(IL2)

DLE:	111186150(IL2)

PCAD:

102990654(IL2)

PSIU:

116754231(IL2)

NASI:

112399755(IL2)

ECB:	100034204(IL2)

EPZ:	103557874(IL2)

EAI:	106834088(IL2)

MYB:	102246940(IL2)

MYD:	102773629(IL2)

MMYO:

118658725(IL2)

MLF:	102433200(IL2)

MDT:	132234311(IL2)

PKL:	118711847(IL2)

EFUS:

103287584(IL2)

MNA:	107529760(IL2)

DRO:	112312503(IL2)

SHON:

118995277(IL2)

AJM:	119037638(IL2)

PDIC:

114502552(IL2)

PHAS:

123814106(IL2)

MMF:	118643998(IL2)

PPAM:

129061444(IL2)

HAI:	109395924(IL2)

RFQ:	117038186(IL2)

PALE:

102895516(IL2)

PGIG:

120616276(IL2)

PVP:	105302208(IL2)

RAY:	107505383(IL2)

MJV:	108383567(IL2)

TOD:	119233628(IL2)

SARA:

101556429(IL2)

SFUM:

130042363(IL2)

SETR:

126004457(IL2)

LAV:	100656398(IL2)

TMU:

101360180

ETF:	101658181(IL2)

DNM:	101413757(IL2)

MDO:	100619184(IL2)

GAS:	123251137(IL2)

SHR:

100935068

AFZ:

127541142

PCW:

110223001

TVP:	118852823(IL2)

PBRV:

138174507(IL2)

GGA:	373958(IL2)

PCOC:

116231224

MGP:

100303688

LMUT:

125692515

APLA:

101794925(IL-2)

ACYG:

125184558

FAB:	101807567(IL2)

CBRC:

CCRI:

TALA:

HALD:

HLE:

AGEN:

AFOR:

GSTE:

CLV:

PGUU:

TEO:

ASAO:

Reference

PMID:6312994

Authors

Maeda S, Nishino N, Obaru K, Mita S, Nomiyama H, Shimada K, Fujimoto K, Teranishi T, Hirano T, Onoue K

Title

Cloning of interleukin 2 mRNAs from human tonsils.

Journal

Biochem Biophys Res Commun 115:1040-7 (1983)
DOI:10.1016/S0006-291X(83)80040-0

Sequence

[hsa:3558]

LinkDB

ORTHOLOGY: K04736

Entry

K04736                      KO

Symbol

IL3

Name

interleukin 3

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04664

Fc epsilon RI signaling pathway

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05221

Acute myeloid leukemia

map05310

Asthma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04736  IL3; interleukin 3
   04151 PI3K-Akt signaling pathway
    K04736  IL3; interleukin 3
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04736  IL3; interleukin 3
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04736  IL3; interleukin 3
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04736  IL3; interleukin 3
   04664 Fc epsilon RI signaling pathway
    K04736  IL3; interleukin 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04736  IL3; interleukin 3
   05202 Transcriptional misregulation in cancer
    K04736  IL3; interleukin 3
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K04736  IL3; interleukin 3
  09163 Immune disease
   05310 Asthma
    K04736  IL3; interleukin 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04736  IL3; interleukin 3
   00536 Glycosaminoglycan binding proteins
    K04736  IL3; interleukin 3
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K04736  IL3; interleukin 3
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K04736  IL3; interleukin 3

Other DBs

GO:

0005135

Genes

HSA:

3562(IL3)

PTR:	471626(IL3)

PPS:	100967294(IL3)

GGO:	101132913(IL3)

PON:	100447057(IL3)

PPYG:

129037390(IL3)

NLE:	100593178(IL3)

HMH:	116470325(IL3)

SSYN:

129493430(IL3)

MCC:	706946(IL3)

MCF:	102118362(IL3)

MTHB:

126956031

MNI:	105467189(IL3)

CSAB:

103244501(IL3)

CATY:

105599729(IL3)

PANU:

100137199(IL3)

TGE:	112626632(IL3)

MLEU:

105531358(IL3)

RRO:	104659849(IL3)

RBB:	108521978(IL3)

TFN:	117064606(IL3)

PTEH:

111527574(IL3)

CANG:

105518178(IL3)

SBQ:	101043897(IL3)

CIMI:

108307022(IL3)

ANAN:

105716213(IL3)

MMU:	16187(Il3)

MCAL:

110306329

MPAH:

110332758

RNO:	24495(Il3)

MCOC:

ANU:

ASYL:

MUN:

PROB:

PLEU:

DORD:

105998923(Il3)

DSP:	122115398(Il3)

NCAR:

124986433

MMMA:

107147998(Il3)

ITI:	101960709(Il3)

CFA:	481497(IL3)

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

MPUF:

MNP:

MLK:

NVS:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:

PYU:	121010877(IL3)

PCOO:

112860682(IL3)

PBG:	122472647(IL3)

LRUF:

124509424

PPAD:

109250815(IL3)

PUC:

125935200

AJU:

113604567

BTA:	280823(IL3)

BOM:	102275760(IL3)

BIU:

109561219

BBUB:

102413882(IL3)

BBIS:

105005553

CHX:

102190507

OAS:	443438(IL3)

BTAX:

128051755

CSUM:

138085127(IL3)

ODA:

CCAD:

MREE:

MBEZ:

BACU:

103019984(IL3)

BMUS:

118892530

LVE:	103088921(IL3)

OOR:

DLE:

PCAD:

PSIU:

NASI:

MLF:

DRO:	112301616(IL3)

AJM:	119037702(IL3)

PDIC:

114510347(IL3)

PPAM:

129066330

HAI:	109382577(IL3)

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

LAV:

DNM:

Reference

PMID:15062647

Authors

Barreda DR, Hanington PC, Belosevic M

Title

Regulation of myeloid development and function by colony stimulating factors.

Journal

Dev Comp Immunol 28:509-54 (2004)
DOI:10.1016/j.dci.2003.09.010

Reference

PMID:20007140

Authors

He WY, Lan Y, Yao HY, Li Z, Wang XY, Li XS, Zhang JY, Zhang Y, Liu B, Mao N

Title

Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region.

Journal

Haematologica 95:875-83 (2010)
DOI:10.3324/haematol.2009.014241

Sequence

[mmu:16187]

LinkDB

ORTHOLOGY: K05405

Entry

K05405                      KO

Symbol

IL6

Name

interleukin 6

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01523

Antifolate resistance

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04151

PI3K-Akt signaling pathway

map04218

Cellular senescence

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04657

IL-17 signaling pathway

map04659

Th17 cell differentiation

map04668

TNF signaling pathway

map04672

Intestinal immune network for IgA production

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05133

Pertussis

map05134

Legionellosis

map05135

Yersinia infection

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05332

Graft-versus-host disease

map05410

Hypertrophic cardiomyopathy

map05417

Lipid and atherosclerosis

Disease

H00084

Graft-versus-host disease

H00286

Crohn disease

H00630

Rheumatoid arthritis

H01479

Castleman disease

H01672

Juvenile idiopathic arthritis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05405  IL6; interleukin 6
   04668 TNF signaling pathway
    K05405  IL6; interleukin 6
   04066 HIF-1 signaling pathway
    K05405  IL6; interleukin 6
   04068 FoxO signaling pathway
    K05405  IL6; interleukin 6
   04151 PI3K-Akt signaling pathway
    K05405  IL6; interleukin 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05405  IL6; interleukin 6
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05405  IL6; interleukin 6
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K05405  IL6; interleukin 6
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05405  IL6; interleukin 6
   04620 Toll-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04621 NOD-like receptor signaling pathway
    K05405  IL6; interleukin 6
   04623 Cytosolic DNA-sensing pathway
    K05405  IL6; interleukin 6
   04625 C-type lectin receptor signaling pathway
    K05405  IL6; interleukin 6
   04659 Th17 cell differentiation
    K05405  IL6; interleukin 6
   04657 IL-17 signaling pathway
    K05405  IL6; interleukin 6
   04672 Intestinal immune network for IgA production
    K05405  IL6; interleukin 6
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05405  IL6; interleukin 6
   05202 Transcriptional misregulation in cancer
    K05405  IL6; interleukin 6
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05405  IL6; interleukin 6
   05161 Hepatitis B
    K05405  IL6; interleukin 6
   05171 Coronavirus disease - COVID-19
    K05405  IL6; interleukin 6
   05164 Influenza A
    K05405  IL6; interleukin 6
   05162 Measles
    K05405  IL6; interleukin 6
   05168 Herpes simplex virus 1 infection
    K05405  IL6; interleukin 6
   05163 Human cytomegalovirus infection
    K05405  IL6; interleukin 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05405  IL6; interleukin 6
   05169 Epstein-Barr virus infection
    K05405  IL6; interleukin 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05405  IL6; interleukin 6
   05132 Salmonella infection
    K05405  IL6; interleukin 6
   05135 Yersinia infection
    K05405  IL6; interleukin 6
   05133 Pertussis
    K05405  IL6; interleukin 6
   05134 Legionellosis
    K05405  IL6; interleukin 6
   05152 Tuberculosis
    K05405  IL6; interleukin 6
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05405  IL6; interleukin 6
   05144 Malaria
    K05405  IL6; interleukin 6
   05142 Chagas disease
    K05405  IL6; interleukin 6
   05143 African trypanosomiasis
    K05405  IL6; interleukin 6
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05405  IL6; interleukin 6
   05321 Inflammatory bowel disease
    K05405  IL6; interleukin 6
   05332 Graft-versus-host disease
    K05405  IL6; interleukin 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05405  IL6; interleukin 6
   05020 Prion disease
    K05405  IL6; interleukin 6
   05022 Pathways of neurodegeneration - multiple diseases
    K05405  IL6; interleukin 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05405  IL6; interleukin 6
   05410 Hypertrophic cardiomyopathy
    K05405  IL6; interleukin 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05405  IL6; interleukin 6
   04932 Non-alcoholic fatty liver disease
    K05405  IL6; interleukin 6
   04931 Insulin resistance
    K05405  IL6; interleukin 6
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05405  IL6; interleukin 6
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05405  IL6; interleukin 6
   01523 Antifolate resistance
    K05405  IL6; interleukin 6
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05405  IL6; interleukin 6
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05405  IL6; interleukin 6

Other DBs

GO:

0005138

Genes

HSA:

3569(IL6)

PTR:	463288(IL6)

PPS:	100967827(IL6)

GGO:	101151687(IL6)

PON:	100453941(IL6)

PPYG:

129040398(IL6)

NLE:	100586527(IL6)

HMH:	116813186(IL6)

SSYN:

129479410(IL6)

MCC:	705819(IL6)

MCF:	102138971(IL6)

MTHB:

126950025

MNI:	105475680(IL6)

CSAB:

103226390(IL6)

CATY:

105595383(IL6)

PANU:

100381195(IL6)

TGE:	112621592(IL6)

MLEU:

105534984(IL6)

RRO:	104675233(IL6)

RBB:	108529326(IL6)

TFN:	117072793(IL6)

PTEH:

111545050(IL6)

CANG:

105513330(IL6)

CJC:	100393440(IL6)

SBQ:	101034757(IL6)

CIMI:

108303199(IL6)

ANAN:

105713966(IL6)

CSYR:

103268608(IL6)

MMUR:

105875882(IL6)

LCAT:

123646908(IL6)

PCOQ:

105822445(IL6)

OGA:	100949231(IL6)

MMU:	16193(Il6)

MCAL:

110295330(Il6)

MPAH:

110317140(Il6)

RNO:	24498(Il6)

MCOC:

116097436(Il6)

ANU:	117720807(Il6)

MUN:	110539463(Il6)

CGE:	100689186(Il6)

MAUA:

101839443(Il6)

PROB:

127235558(Il6)

PLEU:

114689756(Il6)

MORG:

121439902(Il6)

MFOT:

126491159

AAMP:

119808459(Il6)

NGI:	103740849(Il6)

HGL:	101702602(Il6)

CPOC:

106027696(Il6)

CCAN:

109679557(Il6)

DORD:

105991375(Il6)

DSP:	122112101 122112102 122112217

NCAR:

124990183

MMMA:

107146026(Il6)

ITI:	101955981(Il6)

OCU:	100008733(IL6)

OPI:	101531329(IL6)

TUP:	102490996 102496137(IL6) 106733357 106733358 106733575 106733746 106734037 106734038 106734039

GVR:	103585928(IL6)

CFA:	403985(IL6)

CLUD:

112670562(IL6)

VVP:	112915865(IL6)

VLG:	121474963(IL6)

NPO:	129502880(IL6)

AML:	100477151(IL6) 117803984

UMR:	103658871(IL6)

UAH:	113261280(IL6)

UAR:	123788681(IL6)

ELK:

111147365

LLV:

125081177

MPUF:

101671465(IL6)

MNP:	132015023(IL6)

MLK:	131829493(IL6)

NVS:	122904064(IL6)

ORO:	101377851(IL6)

EJU:	114221211(IL6)

ZCA:	113911910(IL6)

MLX:	118020856(IL6)

NSU:	110580018(IL6)

LWW:	102745902(IL6)

FCA:	493687(IL6)

PYU:	121028638(IL6)

PCOO:

112866659(IL6)

PBG:	122487989(IL6)

PVIV:

125152182(IL6)

LRUF:

124524718

PTG:	102968780(IL6)

PPAD:

109263814(IL6)

PUC:

125930836

AJU:

106982277

HHV:	120236228(IL6)

BTA:	280826(IL6)

BOM:	102287919(IL6)

BIU:	109558077(IL6)

BBUB:

102415101(IL6)

BBIS:

104987936(IL6)

CHX:	100860785(IL6)

OAS:	443406(IL6)

BTAX:

128046952(IL6)

CSUM:

138080389(IL6)

ODA:	120878073(IL6)

CCAD:

122438196(IL6)

MREE:

136171080(IL6)

SSC:	399500(IL6)

CFR:	102515320(IL6)

CBAI:

105079801(IL6)

CDK:	105095065(IL6)

VPC:	102529729(IL6)

BACU:

103008558(IL6)

BMUS:

118900814(IL6)

LVE:	103081545(IL6)

OOR:	101281783(IL6)

DLE:	111181978(IL6)

PCAD:

102980126(IL6)

PSIU:

116759822(IL6)

NASI:

112395338(IL6)

ECB:	100034196(IL6)

EPZ:	103561141(IL6)

EAI:	106824372(IL6)

MYB:	102243367(IL6)

MYD:	102760336(IL6)

MMYO:

118666134(IL6)

MLF:	102431882(IL6)

MDT:	132243029(IL6)

PKL:	118714203(IL6)

EFUS:

103292051(IL6)

MNA:	107540295(IL6)

DRO:	112306851(IL6)

AJM:	119042560(IL6)

PDIC:

114508090(IL6)

PHAS:

123811876(IL6)

MMF:	118620458(IL6)

PPAM:

129063428(IL6)

HAI:	109387871(IL6)

RFQ:	117012414(IL6)

PALE:

102895746(IL6)

PGIG:

120602335(IL6)

PVP:	105293152(IL6)

RAY:	107518120(IL6)

MJV:	108398622(IL6)

TOD:	119243289(IL6)

SARA:

101540363(IL6)

SFUM:

130027422(IL6)

LAV:	100660846(IL6)

TMU:

101351590

ETF:	101644240(IL6) 123522712

DNM:	101429481 101443963(IL6)

MDO:	103104339(IL6)

GAS:	123255152(IL6)

SHR:	105750762(IL6)

PCW:	110213115(IL6)

TVP:	118852003(IL6)

PBRV:

138161797(IL6)

OAA:	100083298(IL6)

GGA:	395337(IL6)

PCOC:

116227028(IL6)

MGP:	100548599(IL6)

CJO:	107309150(IL6)

TPAI:

128085831(IL6)

LMUT:

125695972(IL6)

NMEL:

110394224(IL6)

APLA:

101798321(IL6)

ACYG:

106030150(IL6)

CATA:

118255869(IL6)

AFUL:

116486491(IL6)

TGU:	100220682(IL6)

LSR:	110474585(IL6)

SCAN:

103813132(IL6)

PMOA:

120501209(IL6)

OTC:	121339595(IL6)

PRUF:

121353190(IL6)

GFR:	102040265(IL6)

FAB:	101806545(IL6)

OMA:	130248751(IL6)

PHI:	102109522(IL6)

PMAJ:

107215587(IL6)

CCAE:

111924309(IL6)

CCW:	104689316(IL6)

CBRC:

103613552(IL6)

ACOE:

138105695(IL6)

ETL:	114063967(IL6)

ZAB:	102065743(IL6)

ZLE:	135442901(IL6)

ACHL:

103797180(IL6)

SVG:	106863974(IL6)

MMEA:

130584730(IL6)

HRT:	120751263(IL6)

SATI:

136360955(IL6)

FPG:	101911163(IL6)

FCH:	102047657(IL6)

CCRI:

104156476(IL6)

NNT:	104411997(IL6)

SHAB:

115607542(IL6)

ACUN:

113476314(IL6)

TALA:

104367691(IL6)

ACHC:

115339802(IL6)

HALD:

104319966(IL6)

HLE:	104838075(IL6)

AGEN:

126037943

HHAR:

128137211(IL6)

GCL:

127013522

CSTI:

104552073(IL6)

LDI:	104345065(IL6)

MNB:	103776824(IL6)

DPUB:

104307634(IL6)

PPUS:

135187894(IL6)

AVIT:

104269024(IL6)

BRHI:

104488697(IL6)

EGZ:	104126108(IL6)

NNI:	104013985(IL6)

PCAO:

104042564(IL6)

PADL:

103918452(IL6)

AFOR:

103901234(IL6)

FGA:	104076983(IL6)

CLV:	102097240(IL6)

MUI:	104535351(IL6)

PGUU:

104459984(IL6)

PLET:

104615743(IL6)

EHS:	104517166(IL6)

CMAC:

104475791(IL6)

CUCA:

104068044(IL6)

TEO:	104371132(IL6)

BREG:

104634214(IL6)

OHA:	104326589(IL6)

CPEA:

104397654(IL6)

CVF:	104281556(IL6)

RTD:	128905108(IL6)

AAM:	106483538(IL6)

AROW:

112974163(IL6)

NPD:	112942428(IL6)

DNE:	112986051(IL6)

SCAM:

104145141(IL6)

ASN:	102377828(IL6)

AMJ:	102567649(IL6)

CPOO:

109307916(IL6)

GGN:	109291522(IL6)

PSS:	102450313(IL6)

CMY:	102935916(IL6)

CCAY:

125631011(IL6)

DCC:	119851076(IL6)

CPIC:

101951588(IL6)

TST:	117871704(IL6)

CABI:

116831337(IL6)

MRV:	120398388(IL6)

ACS:	103279135(il6)

ASAO:

132779144(IL6)

PVT:	110073207(IL6)

SUND:

121935009(IL6)

PBI:	103067562(IL6)

PMUR:

107282781(IL6)

CTIG:

120307373(IL6)

PGUT:

117655168(IL6)

APRI:

131197508(IL6)

PTEX:

113440061(IL6)

NSS:	113418902(IL6)

VKO:	123033826(IL6)

PMUA:

114593429 114593430 114607734(IL6)

PRAF:

128424368(IL6)

ZVI:	118092352(IL6)

HCG:	128331359(IL6)

GJA:	107116125(IL6)

STOW:

125440811(IL6)

EMC:	129337334(IL6)

XLA:	108718487(il6.L)

XTR:	100493927(il6)

NPR:

108797293

RTEM:

120940157(IL6)

BBUF:

121002283(IL6)

BGAR:

122939048(IL6)

MUO:	115471029(IL6)

GSH:	117354071(IL6)

DRE:	100885851(il6)

SRX:

107755962

SANH:

107667573 107704752

SGH:	107570916 107571360

CCAR:

109055884

CAUA:

113062448 113069455 113119662 113119663

CGIB:

127935925 127979671

PTET:

122335307(il6)

LROH:

127182390(il6)

OMC:	131525177(il6)

PPRM:

120483438 120483439

RKG:	130069051(il6)

MAMB:

125276183(il6)

CIDE:

127501686

CERY:

137002101(il6)

MASI:

127420890 127425535

TROS:

130567230(il6)

TDW:	130415247(il6)

MANU:

129455845(il6)

IPU:

108257494

IFU:	128600806(il6)

PHYP:

113536255 113536325

SMEO:

124376403(il6)

TFD:	113661640(il6)

TVC:	132837483(il6)

TRN:	134301525(il6)

AMEX:

111191914(il6)

CMAO:

118806159(il6)

CHAR:

116225031

TRU:	503562(il-6)

TFS:

130518667

TNG:	GSTEN00003507G001

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

116066855(il6)

ECRA:

117956362(il6)

ESP:

PFLV:

GAT:

PPUG:

CLUM:

PSWI:

CANA:

137785018(il6)

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:

OAU:

OML:

CVG:

CTUL:

GMU:

NFU:

NWH:

AOCE:

EJA:	138214706(il6)

BFRE:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SBIA:

133495334(il6)

PEE:

PTAO:

BPEC:

MALB:

SJO:

SSCO:

SASA:

106570581(IL6) 106588787

STRU:

115173233 115175363

OTW:	112235861(il6) 112264462

OMY:	100136689(il6) 110496949

OGO:	124013382 124042693(il6)

ONE:	115117812 115119806

OKI:	109880070 109908688

OKE:	118371869 118372807(il6)

SALP:

112068887 112071421

SNH:	120022750 120041044(il6)

CCLU:

121573028(il6) 121585646

ELS:

105012469

SFM:	108933304(il6)

PKI:	111846921(il6)

AANG:

118234251

CCOG:

133137755

LOC:	107078662(il6)

PSPA:

121315084(il6)

ARUT:

117394993(il6)

LCM:	102347088(IL6)

CMK:	103185303(il6)

RTP:	109925317(il6) 109925335 125485471

CPLA:

122550242 122550281(il6)

HOC:	132815932(il6)

LERI:

129705909 129712701(il6)

» show all

Reference

PMID:19189867

Authors

Fonseca JE, Santos MJ, Canhao H, Choy E

Title

Interleukin-6 as a key player in systemic inflammation and joint destruction.

Journal

Autoimmun Rev 8:538-42 (2009)
DOI:10.1016/j.autrev.2009.01.012

Reference

PMID:3500852

Authors

Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T

Title

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

Journal

EMBO J 6:2939-45 (1987)
DOI:10.1002/j.1460-2075.1987.tb02598.x

Sequence

[hsa:3569]

LinkDB

ORTHOLOGY: K05430

Entry

K05430                      KO

Symbol

IL4

Name

interleukin 4

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04672

Intestinal immune network for IgA production

map05140

Leishmaniasis

map05200

Pathways in cancer

map05310

Asthma

map05320

Autoimmune thyroid disease

map05321

Inflammatory bowel disease

map05330

Allograft rejection

Disease

H00079

Asthma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05430  IL4; interleukin 4
   04151 PI3K-Akt signaling pathway
    K05430  IL4; interleukin 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05430  IL4; interleukin 4
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05430  IL4; interleukin 4
   04660 T cell receptor signaling pathway
    K05430  IL4; interleukin 4
   04658 Th1 and Th2 cell differentiation
    K05430  IL4; interleukin 4
   04659 Th17 cell differentiation
    K05430  IL4; interleukin 4
   04657 IL-17 signaling pathway
    K05430  IL4; interleukin 4
   04664 Fc epsilon RI signaling pathway
    K05430  IL4; interleukin 4
   04672 Intestinal immune network for IgA production
    K05430  IL4; interleukin 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05430  IL4; interleukin 4
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K05430  IL4; interleukin 4
  09163 Immune disease
   05310 Asthma
    K05430  IL4; interleukin 4
   05320 Autoimmune thyroid disease
    K05430  IL4; interleukin 4
   05321 Inflammatory bowel disease
    K05430  IL4; interleukin 4
   05330 Allograft rejection
    K05430  IL4; interleukin 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05430  IL4; interleukin 4
   00536 Glycosaminoglycan binding proteins
    K05430  IL4; interleukin 4
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05430  IL4; interleukin 4
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K05430  IL4; interleukin 4

Other DBs

GO:

0005136

Genes

HSA:

3565(IL4)

PTR:	449565(IL4)

PPS:	100988878(IL4)

GGO:	101140015(IL4)

PON:	100451705(IL4)

PPYG:

129036373(IL4)

NLE:	100597165(IL4)

HMH:	116470836(IL4)

SSYN:

129493362(IL4)

MCC:	574281(IL4)

MCF:	107130068(IL4)

MTHB:

126956021

MNI:	105467168(IL4)

CSAB:

103244520(IL4)

CATY:

105599747(IL4)

PANU:

100126747(IL4)

TGE:	112626412(IL4)

MLEU:

105531344(IL4)

RRO:	104659834(IL4)

RBB:	108529583(IL4)

TFN:	117065885(IL4)

PTEH:

111529515(IL4)

CANG:

105518194(IL4)

CJC:	100406536(IL4)

SBQ:	101038267(IL4)

CIMI:

108307166(IL4)

ANAN:

105711654(IL4)

CSYR:

103259257(IL4)

MMUR:

105869954(IL4)

LCAT:

123637755(IL4)

PCOQ:

105816021(IL4)

OGA:	100946038(IL4)

MMU:	16189(Il4)

MCAL:

110306003(Il4)

MPAH:

110332760(Il4)

RNO:	287287(Il4)

MCOC:

116078788(Il4)

ANU:	117710319(Il4)

ASYL:

127695269(Il4)

MUN:	110548759(Il4)

CGE:	100755642(Il4)

MAUA:

101843742(Il4)

PROB:

127219302(Il4)

PLEU:

114681924(Il4)

MORG:

121445651(Il4)

MFOT:

126510971

AAMP:

119811116(Il4)

NGI:	103747047(Il4)

HGL:	101706414(Il4)

CPOC:

100720403(Il4)

CCAN:

109694185(Il4)

DORD:

105996721(Il4)

DSP:	122115397(Il4)

NCAR:

124986432

MMMA:

107148001(Il4)

OCU:	100302454(IL4)

OPI:	101524093(IL4)

TUP:	102483778(IL4)

GVR:	103589624(IL4)

CFA:	403785(IL4)

VVP:	112917033(IL4)

VLG:	121496081(IL4)

NPO:	129494903(IL4)

AML:	100482473(IL4)

UMR:	103663832(IL4)

UAH:	113261716(IL4)

UAR:	123790366(IL4)

ELK:

111141099

LLV:

125100382

MPUF:

101686417(IL4)

MNP:	132027869(IL4)

MLK:	131831369(IL4)

NVS:	122901601(IL4)

ORO:	101384443(IL4)

EJU:	114209547(IL4)

ZCA:	113929402(IL4)

MLX:	118017175(IL4)

NSU:	110590985(IL4)

LWW:	102750729(IL4)

FCA:	751514(IL4)

PYU:	121010879(IL4)

PCOO:

112861021(IL4)

PBG:	122472844(IL4)

PVIV:

125171069(IL4)

LRUF:

124523858

PTG:	102963113(IL4)

PPAD:

109250887(IL4)

PUC:

125935484

AJU:

106970698

HHV:	120223325(IL4)

BTA:	280824(IL4)

BOM:	102272045(IL4)

BIU:	109561213(IL4)

BBUB:

102397131(IL4)

BBIS:

105005564(IL4)

CHX:	100860814(IL4)

OAS:	101122781(IL4)

BTAX:

128051558(IL4)

CSUM:

138086101(IL4)

ODA:	120864752(IL4)

CCAD:

122439281(IL4)

MREE:

136167044(IL4)

MBEZ:

129558702(IL4)

SSC:	397225(IL4)

CFR:	102515500(IL4)

CBAI:

105082107(IL4)

CDK:	105090136(IL4)

VPC:	102541329(IL4)

BACU:

103010027(IL4)

BMUS:

118892463(IL4)

LVE:	103069012(IL4)

OOR:	101290331(IL4)

DLE:	111182418(IL4)

PCAD:

102983897(IL4)

PSIU:

116751393(IL4)

NASI:

112401382(IL4)

ECB:	100034225(IL4)

EPZ:	103563367(IL4)

EAI:	106841015(IL4)

MYB:	102243627(IL4)

MYD:	102773980(IL4)

MMYO:

118657905(IL4)

MLF:	102437928(IL4)

MDT:	132236148(IL4)

PKL:	118711589(IL4)

EFUS:

103290101(IL4)

MNA:	107525027(IL4)

DRO:	112318159(IL4)

SHON:

118990129(IL4)

AJM:	119037707(IL4)

PDIC:

114510341(IL4)

PHAS:

123812938(IL4)

MMF:	118616277(IL4)

PPAM:

129066327(IL4)

HAI:	109382592(IL4)

RFQ:	117017057(IL4)

PALE:

102890025(IL4)

PGIG:

120616686(IL4)

PVP:	105293550(IL4)

RAY:	107497063(IL4)

MJV:	108390065(IL4)

TOD:	119243728(IL4)

SARA:

101539338(IL4)

SFUM:

130033065(IL4)

SETR:

126028368(IL4)

LAV:	100674484(IL4)

TMU:

101341010

ETF:	101653709(IL4)

DNM:	101420628(IL4)

GAS:	123233889(IL4)

SHR:	100914681(IL4)

PCW:	110211817(IL4)

TVP:	118841351(IL4)

PBRV:

138173679(IL4)

GGA:	416330(IL4)

NMEL:

110405326(IL4)

ACYG:

106032665

CATA:

118254981(IL4)

AFUL:

116494649(IL4)

TGU:

100231557

OTC:

121332428

PRUF:

121361464

FAB:	101822266(IL4)

ACOE:

138118353(IL4)

ETL:	114070738(IL4)

MMEA:

130583993(IL4)

HRT:	120759362(IL4)

SATI:

136367760(IL4)

FPG:	101920907(IL4)

FCH:

102059582

NNT:	104407025(IL4)

SHAB:

115616044(IL4)

ACUN:

113485357(IL4)

ACHC:

115334326(IL4)

AGEN:

126050785

HHAR:

128134464(IL4)

GCL:

127022176

LDI:	104352758(IL4)

PPUS:

135185476(IL4)

EGZ:	104133729(IL4)

NNI:

104012053

PADL:

103915856(IL4)

AFOR:

103904589(IL4)

FGA:	104079596(IL4)

PGUU:

104468070(IL4)

CPEA:

104391890(IL4)

CVF:	104291981(IL4)

NPD:	112952713(IL4)

DNE:

112994150

SCAM:

104147025

ASN:	102374890(IL4)

TST:

117881532

DRE:	100188894(il4)

CCAR:

109064937

CAUA:

113078138

CGIB:

128027363

PTET:

122357735(il4)

LROH:

127176371(il4)

OMC:	131553278(il4)

PPRM:

120461073(il4)

RKG:	130084822(il4)

CERY:

137005067(il4)

TROS:

130563397(il4)

TDW:	130438518(il4)

MANU:

129422938(il4)

CMK:

RTP:

CPLA:

Reference

PMID:2535858

Authors

Arai N, Nomura D, Villaret D, DeWaal Malefijt R, Seiki M, Yoshida M, Minoshima S, Fukuyama R, Maekawa M, Kudoh J, et al.

Title

Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

Journal

J Immunol 142:274-82 (1989)

Sequence

[hsa:3565]

LinkDB

ORTHOLOGY: K05431

Entry

K05431                      KO

Symbol

IL7

Name

interleukin 7

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map05200

Pathways in cancer

Disease

H00842

Epidermodysplasia verruciformis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05431  IL7; interleukin 7
   04151 PI3K-Akt signaling pathway
    K05431  IL7; interleukin 7
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05431  IL7; interleukin 7
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05431  IL7; interleukin 7
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05431  IL7; interleukin 7
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05431  IL7; interleukin 7
   00536 Glycosaminoglycan binding proteins
    K05431  IL7; interleukin 7
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interleukins
   K05431  IL7; interleukin 7
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K05431  IL7; interleukin 7

Other DBs

GO:

0005139

Genes

HSA:

3574(IL7)

PTR:	464245(IL7)

PPS:	100986540(IL7)

GGO:	101138372(IL7)

PON:	100447454(IL7)

PPYG:

129042195(IL7)

NLE:	100606680(IL7)

HMH:	116813340(IL7)

SSYN:

129486530(IL7)

MCC:	574168(IL7)

MCF:	102135001(IL7)

MTHB:

126961637

MNI:	105483548(IL7)

CSAB:

103237005(IL7)

CATY:

105572942(IL7)

PANU:

101004703(IL7)

TGE:	112630480(IL7)

MLEU:

105545992(IL7)

RRO:	104665836(IL7)

RBB:	108526207(IL7)

TFN:	117079493(IL7)

PTEH:

111553128(IL7)

CANG:

105508296(IL7)

CJC:	100387798(IL7)

SBQ:	101048813(IL7)

CIMI:

108299533(IL7)

ANAN:

105716324(IL7)

CSYR:

103273840(IL7)

MMUR:

105857580(IL7)

LCAT:

123644763(IL7)

PCOQ:

105825332(IL7)

OGA:	100943181(IL7)

MMU:	16196(Il7)

MCAL:

110290996(Il7)

MPAH:

110321006(Il7)

RNO:	25647(Il7)

MCOC:

116094928(Il7)

ANU:	117719170(Il7)

ASYL:

127683547(Il7)

MUN:	110556314(Il7)

CGE:	100756443(Il7)

MAUA:

110340351(Il7)

PROB:

127231164(Il7)

PLEU:

114707629(Il7)

MORG:

121458462(Il7)

MFOT:

126513375

AAMP:

119826635(Il7)

NGI:	103727963(Il7)

HGL:	101713773(Il7)

CPOC:

100725811(Il7)

CCAN:

109698220(Il7)

DORD:

105994808(Il7)

DSP:	122108695(Il7)

PLOP:

125360703(Il7)

NCAR:

124983142

MMMA:

107142463(Il7)

ITI:	101968385(Il7)

OCU:

100345409

OPI:	101535938(IL7)

TUP:	102487954(IL7)

GVR:	103593320(IL7)

CFA:	751768(IL7)

CLUD:

112678641(IL7)

VVP:	112930472(IL7)

VLG:	121498816(IL7)

NPO:	129505389(IL7)

AML:	100481194(IL7)

UMR:	103661362(IL7)

UAH:	113253022(IL7)

UAR:	123797942(IL7)

ELK:

111156814

LLV:

125098019

MPUF:

101676635(IL7)

MNP:	132014103(IL7)

MLK:	131826682(IL7)

NVS:	122904498(IL7)

ORO:	101374293(IL7)

EJU:	114214977(IL7)

ZCA:	113933467(IL7)

MLX:	118014946(IL7)

NSU:	110579061(IL7)

LWW:	102729985(IL7)

FCA:	101084597(IL7)

PYU:	121038088(IL7)

PCOO:

112859431(IL7)

PBG:	122495513(IL7)

PVIV:

125156710(IL7)

LRUF:

124507732

PTG:	102960296(IL7)

PPAD:

109269381(IL7)

PUC:

125924837

AJU:

106984935

HHV:	120223141(IL7)

BTA:	280827(IL7)

BOM:	102286767(IL7)

BIU:	109568650(IL7)

BBUB:

102393345(IL7)

BBIS:

104995049(IL7)

CHX:	102182054(IL7)

OAS:	443341(IL7)

BTAX:

128059511(IL7)

CSUM:

138088645(IL7)

ODA:	120878987(IL7)

CCAD:

122451349(IL7)

MREE:

136144865(IL7)

MBEZ:

129560364(IL7)

SSC:	397253(IL7)

CFR:	102504417(IL7)

CBAI:

105066278(IL7)

CDK:	105088534(IL7)

VPC:	102537288(IL7)

BACU:

103000105(IL7)

BMUS:

118883535(IL7)

LVE:	103075444(IL7)

OOR:	101276026(IL7)

DLE:	111164935(IL7)

PCAD:

102976783(IL7)

PSIU:

116742373(IL7)

NASI:

112403878(IL7)

ECB:	100059131(IL7)

EPZ:	103547400(IL7)

EAI:	106839170(IL7)

MYB:	102263096(IL7)

MYD:	102751370(IL7)

MMYO:

118671020(IL7)

MLF:	102418120(IL7)

MDT:	132219918(IL7)

PKL:	118718444(IL7)

EFUS:

103283856(IL7)

MNA:	107539481(IL7)

DRO:	112320869(IL7)

SHON:

118997775(IL7)

AJM:	119052729(IL7)

PDIC:

114501947(IL7)

PHAS:

123825829(IL7)

MMF:	118631690(IL7)

PPAM:

129088356(IL7)

HAI:	109387835(IL7)

RFQ:	117033967(IL7)

PALE:

112472586(IL7)

PGIG:

120585527(IL7)

PVP:	105302950(IL7)

RAY:	107514111(IL7)

MJV:	108398928(IL7)

TOD:	119240528(IL7)

SARA:

101540970(IL7)

SFUM:

130016246(IL7)

SETR:

126020552(IL7)

LAV:	100658284(IL7)

TMU:

101345060

ETF:	101642813(IL7)

DNM:	101423605(IL7)

MDO:	103106447(IL7)

GAS:	123231657(IL7)

SHR:	116420560(IL7)

AFZ:

127546501

PCW:	110199192(IL7)

TVP:	118829859(IL7)

PBRV:

138170676(IL7)

OAA:	114813216(IL7)

GGA:	420193(IL7)

CJO:

116652977

APLA:

106015872

ACYG:

106030637(IL7)

CATA:

118247918

AFUL:

116485351

TGU:	101234120(IL7)

LSR:	110481797(IL7)

SCAN:

103816360(IL7)

PMOA:

120499321(IL7)

OTC:	121340187(IL7)

PRUF:

121351959(IL7)

OMA:	130249898(IL7)

PHI:	102102794(IL7)

PMAJ:

107200924(IL7)

CCW:	120409642(IL7)

CBRC:

103619872

ACOE:

138105234(IL7)

ETL:	114058655(IL7)

ZAB:	106629757(IL7)

ZLE:

135443347

ACHL:

103810074

SVG:	106849836(IL7)

MMEA:

130584383(IL7)

SATI:

136369646(IL7)

FCH:

114017616

CCRI:

104156586

SHAB:

115616408(IL7)

ACUN:

113476147

TALA:

116965317(IL7)

ACHC:

115340800(IL7)

HALD:

104316015

HLE:

104837056

AGEN:

126048479

HHAR:

128142409(IL7)

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

EGZ:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

MUI:

PGUU:

CUCA:

104068116(IL7)

TEO:

OHA:

ACAR:

CPEA:

CVF:

RTD:	128906373(IL7)

AAM:

106484576

AROW:

112974010(IL7)

TGT:

104574704

DNE:

112988716

SCAM:

104153524

PSS:	102452006(IL7)

CMY:	102945832(IL7)

CCAY:

125632580(IL7)

DCC:	119850846(IL7)

CPIC:

101942941(IL7)

TST:	117873599(IL7)

CABI:

116838149(IL7)

MRV:	120399626(IL7)

ACS:

103278502

PGUT:

117672910

APRI:

131194149(IL7)

PTEX:

113439959(IL7)

NSS:	113428936(IL7)

STOW:

125438807(IL7)

EMC:	129333142(IL7)

MUO:	115478443(IL7)

GSH:	117355157(IL7)

ARUT:

117435586

LCM:	102353780(IL7)

RTP:

CPLA:

HOC:

NVE:

Reference

PMID:21889323

Authors

Liao W, Lin JX, Leonard WJ

Title

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.

Journal

Curr Opin Immunol 23:598-604 (2011)
DOI:10.1016/j.coi.2011.08.003

LinkDB

ORTHOLOGY: K05414

Entry

K05414                      KO

Symbol

IFNA

Name

interferon alpha

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04217

Necroptosis

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04936

Alcoholic liver disease

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05320

Autoimmune thyroid disease

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05414  IFNA; interferon alpha
   04151 PI3K-Akt signaling pathway
    K05414  IFNA; interferon alpha
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05414  IFNA; interferon alpha
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05414  IFNA; interferon alpha
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04621 NOD-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04622 RIG-I-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04623 Cytosolic DNA-sensing pathway
    K05414  IFNA; interferon alpha
   04650 Natural killer cell mediated cytotoxicity
    K05414  IFNA; interferon alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05414  IFNA; interferon alpha
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05414  IFNA; interferon alpha
   05161 Hepatitis B
    K05414  IFNA; interferon alpha
   05160 Hepatitis C
    K05414  IFNA; interferon alpha
   05171 Coronavirus disease - COVID-19
    K05414  IFNA; interferon alpha
   05164 Influenza A
    K05414  IFNA; interferon alpha
   05162 Measles
    K05414  IFNA; interferon alpha
   05168 Herpes simplex virus 1 infection
    K05414  IFNA; interferon alpha
   05163 Human cytomegalovirus infection
    K05414  IFNA; interferon alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05414  IFNA; interferon alpha
   05169 Epstein-Barr virus infection
    K05414  IFNA; interferon alpha
   05165 Human papillomavirus infection
    K05414  IFNA; interferon alpha
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05414  IFNA; interferon alpha
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K05414  IFNA; interferon alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05414  IFNA; interferon alpha
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05414  IFNA; interferon alpha
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05414  IFNA; interferon alpha
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interferons
   K05414  IFNA; interferon alpha

Other DBs

GO:

0005132

Genes

HSA:	3439(IFNA1) 3440(IFNA2) 3441(IFNA4) 3442(IFNA5) 3443(IFNA6) 3444(IFNA7) 3445(IFNA8) 3446(IFNA10) 3447(IFNA13) 3448(IFNA14) 3449(IFNA16) 3451(IFNA17) 3452(IFNA21)

PTR:	473185(IFNA21) 473191 473193(IFNA14) 473195(IFNA5) 473196(IFNA6) 473197 473198(IFNA2) 473199(IFNA8) 741660 741747 741797 741978 742651 744748

PPS:	100967539 100968231 100969275 100969624 100970300 100970658 100971675(IFNA6) 100972005 100972354 100972691(IFNA8) 100973049 100995734 117981650 117981652

GGO:	101137870(IFNA21) 101138981 101139336 101139713 101140412 101141176(IFNA6) 101141543 101141916(IFNA2) 101142301(IFNA8) 101142673 115935827 115935829 115935831 115935832 115935833 115935834 134756937

PON:	100432153 100432532(IFNA8) 100432906(IFNA2) 100433301 100434036(IFNA6) 100434796 100435169 100438149 100438871 100439978(IFNA21) 100443523 100445711 100459543 112134962 134759750

PPYG:

129043459 129044025 129044032 129044045 129044048(IFNA2) 129044057(IFNA6) 129044058 129044062(IFNA8) 129044063 129044064 129044068 129044069(IFNA21) 129044073 129044074 129044156

NLE:	100594907 100595254(IFNA8) 100595585(IFNA2) 100595932 100596272(IFNA6) 100596946 100597288 100597620 100597957 100598307

HMH:	116458330 116458331 116458332 116458527 116458611 116458660

SSYN:

129490328 129490329 129490330(IFNA6) 129490331 129490333 129490334 129490335 129490336 129490337 129490338 129490339

MCC:	106992322 106995851(IFNA6) 114672663 114672664 694631 709559(IFNA13) 709755(IFNA8) 709948(IFNA2) 710487 710528 710568 710654(IFNA10) 710751 710848 711088 711252(IFNA21)

MCF:	102115289 102140303 102140954(IFNA8) 102141352 102141744 102142148 102143043 102144479 102144833 102145208 102145962 102146344 102146717 102147079 123569038 135967426

MTHB:

126937598 126937600 126937601 126937602 126937603 126937604 126937605 126937606 126937607 126937608 126937609 126937610 126937611 126937612 126937613 126937615 126947451

MNI:	105465888(IFNA21) 105498418 105498422(IFNA8) 105498424 105498425 105498426 105498430

CSAB:

103219366 103219367(IFNA8) 103219368(IFNA2) 103219370 103219372 103219377 103219378 103219379 103219381

CATY:

105591326 105591327(IFNA8) 105591328(IFNA2) 105591330 105591332 105591336 105591337 105591338

PANU:

101016516 101017918 101018287 101018652 101019008 101019380 101021706 101023118 101023828 116270026

TGE:	112608216 112608221(IFNA21) 112608232 112608255 112608259 112608273 112608278 112608298 112617922

MLEU:

105533798 105533799(IFNA8) 105533800(IFNA2) 105537891(IFNA6) 105537892 105537894

RRO:	104670273 104670275(IFNA8) 104670276 104670278(IFNA6) 104670280 104670290 104670292 104680728 115893964 115893973

RBB:	108525122 108525752 108536968(IFNA8) 108536996 108537115 108537124(IFNA6) 108538560

TFN:	117098645 117098649 117098650 117098651 117098652(IFNA2) 117099353 117099354 117099355(IFNA8) 117099357

PTEH:

111526141 111537187 111537188 111537189 111537190 111537191

CANG:

105503436 105503438(IFNA8) 105503439(IFNA2) 105503440 105503441 105503442 105503444(IFNA14) 105503445 105503446 105503447 105503449

CJC:	100387372 100390201 100406098 100406466 100414516 103793369 128928158 128932203

SBQ:	101032308 101032622 101032943(IFNA13) 101034105 101034416 101034728(IFNA21) 104649849

CIMI:

108296165(IFNA21) 108296167 108296168 108296180 108296181 108296183 108296184

ANAN:

105715583 105715584 105715624(IFNA21) 105715625 105715626 105715629

CSYR:

103260907 103260908 103260910 103274154 103274155 103274156 103274157 103274161 103274163 103274165 103274168

MMUR:

105874211 105874212 105874214 105874217

LCAT:

123645632 123645638 123645752 123645754 123645755 123645758 123646712

PCOQ:

105827001

OGA:	100945309 100945944 100946255 100955951 100956963 100957574 100958440 100958763 100959074 100962353

MMU:	15962(Ifna1) 15964(Ifna11) 15965(Ifna2) 15967(Ifna4) 15968(Ifna5) 15969(Ifna6) 15970(Ifna7) 15972(Ifna9) 15974(Ifnab) 230396(Ifna13) 230398(Ifna16) 242517(Ifna15) 242519(Ifna12) 404549(Ifna14)

MCAL:

110288626 110288627 110288628 110292605 110292939 110292945 110292969 110292975 110292981 110293011 110293017 110293025 110293074

MPAH:

110315179 110315688 110322994 110323165 110323303 110323342 110323382 110323390 110323408 110323416 110323424 110323427

RNO:	100911527(Ifna4l1) 100912314 100912356 134487075 134487077 298205(Ifna4) 298210(Ifna5) 298213(Ifna2) 500491(Ifna16l1) 502959(Ifna1l1) 502961(Ifna4l2) 690894(Ifna1)

MCOC:

116095401 116095403 116095406 116095408 116095410 116095417 116095418 116095419 116095420 116095421 116096218

ANU:	117708733 117709002 117709023 117709053 117709056 117709071 117709072 117709075 117709078 117709079 117709081 117709083 117709084 117709085 117709086 117709102

MUN:	110543198 110543200 110544130 110544619 132646742 132646744 132646745 132646746 132646775

CGE:	100750635 100750928 100751221 100759741 100760028 100760323 100760616 100762064 100762655 100765269 100765849 100766144 100766726 100769352 100769640

MAUA:

101824534 101824794 101836618 101836898 121144094 121144095 121144097 121144098 121144100 121144101 121144102 121144103 121144104 121144105

PROB:

127224801 127224803 127224841 127224844 127224845 127224846 127224847 127224848 127224849

MFOT:

126510709 126510710 126510711 126510712 126510718 126510725 126510729 126510739 126510740

NGI:	103731654 103732546 103736148 103746653 103746654

HGL:

101697163

CPOC:

100714884 100716684 100717234 100717707 100718817 100720391 100721849 100722040 100722772 100724988 100725261 100726990 100728098 100728479 100729220 100730474 100734117 100734169 100735600

CCAN:

109688729 109688957 109689103 109689580 109689666 109689888 109689981 109690286 109690431 109690928 109702568

DORD:

105988955 105988956 105988976 105988979 105988997 105988998 105989000

DSP:	122118940 122118944 122118945 122118948 122118949 122118950 122118956 122118961 122118984

PLOP:

125352688 125352696 125352709 125355685 125355696 125355728 125355740 125355751

NCAR:

124964632 124964656 124964659 124964665 124964666 124964667 124964668 124964675 124964679 124964683 124964869

MMMA:

107134700 107135123 107147930 107156481 107156482 107156485 107156486 107156487 107156488

ITI:	101969049 101969327 101970097 101970392 101970683 101971255 101971535 101974316 101976283

OCU:	100353390 100354654 100355669 100355912 100356419 100356678 100357194 100357708

OPI:	101532843 101533081

TUP:	102469574 102472952 102475056 102475482 102475884 102498386 106733346

GVR:	103598039 103598040 103598043 103598044

CFA:	100682977 100683045 100683567 100685213 100686162 100688005 100688084 442934(IFNA5) 474181(IFNA7) 611406

CLUD:

112650216 112650218 112650347 112650391 112650394 112650424 112650509 112662614 112662615 112662616 118350179 118350181 118350183 118350222 118350223 118350228 125756056 125756057

VVP:	112911635 112911642 112911646 112911647 112911648 112911649 112921941 112921942 112921945

VLG:	121494194 121494460 121495211 121495363 121495364 121495366 121496252 121496295

AML:	100476812 100477312 100477562 100478068 100478321

UMR:	103662147 103662148 103662149 103666985 103680385 103680386 121103043

UAH:	113260290 113260291 113260293 113260294 125283239 125283240 125283241 125283243 125283244 125283245 125283246 125283247 125283248

UAR:	123781241 123781249 123781251 123781252 123781255 123781256 123781260 123781283 123781329

ELK:	111140329 111140335 111140336 111140482 111140592 111156578 111156593 111156594 111156604 111156606 111156609 111159856 111159858 111159859 111159861 111159862

LLV:	125082970 125083068 125083069 125083072 125083073 125083074 125083075 125083077 125083078 125083082 125083083 125083084 125083482 125083790 125084017 125084018

MPUF:

101674940 101675243 101675758 101676633 101677422 101678184 101678496 101678795 101683200 101684074 101684365 101684645 101685546 101686116

MNP:	132008962 132009102 132009158 132009205 132009311 132024131 132024132 132024134 132025116 132025119 132025120 132025121 132025122 132025123 132025124

MLK:	131812130 131812466 131812513 131812526 131812530 131812531 131812533 131812535 131812554 131812572 131812581 131812595 131812613 131812617 131812618 131812658 131812659 131812838

NVS:	122916735 122916921 122916922 122916923 122916924 122916925 122916926 122916927 122916929 122916930 122916931 122916932 122916933 122916934 122916935 122916936 122916937 122917563 122917564

ORO:	101374322 101374610 101377641 101378214(IFNA5) 101379735

EJU:	114203995 114204306 114212415 114212437 114212451

ZCA:	113912225 113934655 113934667 113934678 113934682 113934985

MLX:	117998991 117998992 117998993 117999009

NSU:	110587126 110587131 123326492 123326498

LWW:	102727550 102747471 102747757 102748540 102749740 102750324

FCA:	101081371 101088440 111557596 123381775 493648(IFNA8) 493653(IFNA7) 493840(IFNA5)

PYU:	121034395 121035166

PCOO:

112849322 112857196

PBG:	122474263 122474291 122474324 122474333 122474338 122475087

PVIV:

125150359 125150391 125150421 125150431 125150435 125150749 125150820

LRUF:

124524295 124525665 124525682 124525697 124525706 124525727

PTG:

102956750

PPAD:

109247112 109247120 109247123 109261306 109261307

PUC:	125925935 125925953

AJU:	106971015 106971043 106971134 106989747 128312015 128312017 128312193

HHV:	120223241 120223242 120239878

BTA:	100329204(IFNAD) 100329206(IFNAG) 100329207(IFNAH) 100329210(INFAF) 100335490 132345931 281236(IFNAC) 510726(IFNA16) 515951(IFNAA) 517108 523244 617556 618947 783912 787343

BOM:	102266354 102266466 102267762 102270981 102285417 102285459 138988994

BIU:	109562638 109562641 109562644 109562652 109562656 109562659 109562660 109562665 109562668 109562670 109562673 109562847

BBUB:

102393701 102393818 102402789 102414434 102415114 102416204 112577736 112583541 112583544 112583545 112583546 112583548 112583867 112583876 112583880

BBIS:

104984810 104985507 104989082 104992606 104994732 104995056 104996675 104997583 104999951 105000964 105003125

CHX:	100860850(IFNA) 102174842 102179943 102180761 102181299 108633160 108635529 108636621 108636627

OAS:	101102963 101103872 101105135 101105632 101111435 105601948 114112827 114113084 114113089 114113090 121818512 492823(IFN1)

BTAX:

128052429 128052430 128052431 128052432 128052433 128052459 128052476 128052682 128052694 128052696 128052697 128052706

CSUM:

138080686 138080887 138080888 138080958 138080962 138080975 138080980 138080981 138080982 138081038

ODA:	120859897 120860147 120862199 120862207 120862234

CCAD:

122452950 122452998 122452999 122453000 122453001 122453141 122453310 122453350

MREE:

136148477 136148480 136148486 136148487 136148488 136148489 136148490 136148491 136148493 136148494 136148502 136148635

MBEZ:

129557109 129557111 129557266 129557270 129557271 129557272 129557274 129557279 129557285 129557286

SSC:	100152100(IFN-ALPHA-13) 100152504(IFN-ALPHA-15) 100153325 100153661 100153724(IFN-ALPHA-8) 100154938(IFN-ALPHA-17) 100156561(IFN-ALPHA-10) 100156936 100157352(IFN-ALPHA-1) 100157735(IFN-ALPHA-16) 100157766(IFN-ALPHA-9) 100303758(IFN-ALPHA-5) 100310806(IFN-ALPHAOMEGA) 100737904 397686(IFNA1)

CFR:	102512333 102513056 102513158 102516460 102519964 106730619 116663075 116663078

CBAI:

105061875 105061876 105061880 105061913 105082393

CDK:	105095932 105105457 105105461 105105541 116152603 116152604

VPC:	102539757 102540000 102544554 116280218

BACU:

103007162 103008826 103009695(IFNA7) 103010469 103010766

BMUS:

118896746 118896908 118896929 118896943 118897134

LVE:	103068617 103069181 103069739 103073219 103090661 103091202

OOR:	101274041 101275016 101275275 101287367 125964698 125964699 125964701 125964702 125964703

DLE:	111163101 111163130 111171121 111171122

PCAD:

102980314 112065747

PSIU:

116755247 116755466 116755467 116756115

NASI:

112395020 112395023 112395027 112407025

ECB:	100052818(IFN-ALPHA2) 100052921 100053022(IFNA1) 100053110 100053210 100064468 100064551 100064612 100064731(IFND1) 100064975(IFND2) 100629885 100629951

EPZ:	103544584 103558747 103558748 103558749 103558750 103563154 103567855 139078371 139078428 139078534 139078706

EAI:	106824699 106824700 106824701 106824784 106824785 106824786 106828271 106833890 123280233 123280237 123280245 123280259

MYB:

106724769

MYD:

102766079

MMYO:

118667586

MDT:	132211867 132211868 132211869 132211870

DRO:	112297048 112302798 112302800

SHON:

118978917 118984066 118997983

AJM:	119045866 119045867 119049818 119056303 119058844

PDIC:

114490401 114490854 114502765 114502773 114503306

PHAS:

123819865 123819961 123819962

MMF:	118629333 118629850

PPAM:

129078455

HAI:

109374670

RFQ:	117032089 117032090

PALE:

102890009 102893886

PGIG:

120589528 120589531 120605312 120606426 120617124

PVP:	105298437 105309143 105309144 105309148

RAY:	107506761 107507170 107507171 107507173 107507175 107507179 107507611 107507612 107507614 107508426 107508852 107509253 107510611 107511342 107511568 107518584 107518586 107518587

MJV:	108388277 108397409

TOD:

119232539

SARA:

101549593

SETR:

126003615 126003784(IFNA6)

LAV:	100659984 100660270 100660554 100661135 100661986 100662831 100663685 100665583

TMU:	101341058 101341314 101341564 101342581 101342828 101343075 101343586 101344616 101345099 101350125

ETF:

101650862

DNM:	101418868 101419317 101419758 101425111 101432987 101447879

MDO:	100021290(IFN3) 100021311(IFN7) 100021340(IFN4) 100021368 100021419 100021467 100021487(IFN2)

GAS:	123231251 123231252 123231254 123250404 123250411 123250422

SHR:	100914703 100914965 100920968 116420987 116420989

AFZ:	127544839 127544846 127552476 127552756 127552856

PCW:	110199230 110199240 110199247 110199249 110199250 110199251 110199253 110199254 110199255 110201183 110201199 110201202 110201203

TVP:	118831614 118831665 118831668 118831684 118833434 118833537 118833550 118833552 118833554 118833559 118833564 118833565 118833567 118833589 118833624 118840427 118840434 118840441

PBRV:

138144616 138161236 138161241

OAA:	100075323(IFN3)

GGA:	100857744(IFNAL4) 100857947(IFNAL5) 100858177 100859032(IFNAL6) 101750245(IFNKL1) 396398(IFNA3) 768614(IFA3L)

PCOC:

116239796 116240988

MGP:

104915046

CJO:

107306162

TPAI:

128074651 128074653 128074654 128074655 128074656 128074657 128074658 128074659 128074661 128089382

LMUT:

125686989 125687311 125687312 125687313 125687314 125687315 125687316

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:	100228379 105760863 115491042 116806752

LSR:

110470691

SCAN:

103819513 115485133(IFNK)

PMOA:

120506850 120512099

OTC:

121333061

PRUF:

121363354

GFR:	102032434 102037863 102045642(IFNK) 106631905

FAB:	101811547(IFNW1) 101815751

OMA:

130265253

PHI:	102105799 102110728 102112315(IFNK) 106628561 106628562 106628563 106628564

PMAJ:

107215808

CCAE:

111940613 111941171 111941173 111945250

CCW:

104685212

CBRC:

103613130

ACOE:

138103907

ETL:	114056561 114060161 114073315

ZAB:	102061452 102064879

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

FPG:	101915699(IFNW1)

FCH:	102059593 114016448(IFNK)

CCRI:

104154797

NNT:

104411022

SHAB:

115600831(IFNK) 115619639

ACUN:

113490068 113490202(IFNK)

TALA:

104368839

ACHC:

115336480

HALD:

104310525 104324729

HLE:	104829915 104838436

AGEN:

HHAR:

GCL:

CSTI:

LDI:	104352179 104353719

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:	104123041 104128161

NNI:	104013672(IFNE) 104017291 104017293 104017929

PCRI:

PCAO:

PADL:

AFOR:

FGA:	104075839 104076431

GSTE:

104255408

CLV:

102092004

MUI:	104533588 104539464

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:	104326741 104336587

ACAR:

104527107

CPEA:

104391698 104398336

CVF:	104292172 104296060

RTD:

128902910

AAM:	106484418 106495014

AROW:

112969822 112978363

NPD:	112951392 112956287

TGT:	104573472 104578601(IFNA7)

DNE:	112981885 112985898

SCAM:

104145483(IFNB1) 104147423

ASN:	102375321 102376462 112552120

AMJ:	102570269 109281289

CPOO:

109307775 109309578 109323284

GGN:	109297976 109301008

PSS:	102450184 102451131 102462379

CCAY:

125636389 125636992 125637194 125637195 125637196 125637406 125637408 125637409

DCC:	119854558 119855399 119856142 119856222 119856313

CPIC:

101937920 101941771 101942832 101943112

TST:	117878676 117879265 117879539 117879636 117879637 117879638 117879639 117879640 117879641 117879642

CABI:

116820753 116824507 116825810 116825951 116826477 116826478 116835077 116835091 116835092 116835093 116835094

MRV:	120407278 120407284 120407285 120407286 120407287 120407288 120407289 120407291 120407292 120407293 120407294 120407295 120407296 120407297 120407300 120407302 120407541 120407717 120408182

ACS:	100562865 103277687

ASAO:

132765406 132765408 132765409 132765410 132765411 132765412 132765413 132766469 132767057

PVT:	110077377 110077387 110077388 110080479

SUND:

121920523 121920524 121920526 121920528 121920529 121923586 121924215

PMUR:

107293819

CTIG:

120314223

TSR:

106542110

PGUT:

117661924 117661925 117661926 132711520 132711521

APRI:

131190689 131190690 131190691 131190692 131190693 131190694 131190695

PTEX:

113447915 113448051

NSS:	113420402 113430413 113430433 113430434 113430553

VKO:	123018678 123022415

PMUA:

114588052(IFNK)

PRAF:

128405340 128405341 128405342 128423622

ZVI:	118075236 118075241(IFNK) 118077107

HCG:	128343650 128343651 128343656(IFNK)

GJA:

107108155

STOW:

125437014 125437015

EMC:	129335154 129335155 129335156 129335157 129335158

XLA:	108702184 108702185 108702186

XTR:	105945198 116407924 116408033

MUO:

115481865

DRE:	100126803(ifnphi3) 360134(ifnphi1)

SRX:	107730829 107740662 107740663 107740677 107754306 107754313 107754314

SANH:

107662420 107662421 107662433 107683682 107683685 107683686

SGH:	107579891 107579948 107582919 107582949 107585083 107585099

CCAR:

109046410 109056156 109059985 109073631 109104193 109104467 109105488

CAUA:

113041692 113041702 113046550 113046692 113047358 113047618 113048206 113048217 113048228 113048238 113054007

CGIB:

127942845 127946653 127946773 127952691

PTET:

122341354(ifnphi3) 122341864(ifnphi1)

LROH:

127157613 127157629 127157650 127163118(ifnphi1)

OMC:	131537137(ifnphi1) 131537782(ifnphi3)

PPRM:

120490098(ifnphi3) 120490237(ifnphi1)

RKG:	130070297(ifnphi1) 130070313(ifnphi3)

MAMB:

125250057(ifnphi3) 125268605 125272663(ifnphi1)

CIDE:

127507370 127509065

CERY:

137010665(ifnphi1) 137010678(ifnphi3)

MASI:

127450537 127450538 127450540 127450541 127451485 127451486 127451487 127451488 127451598

TROS:

130561720(ifnphi1) 130561905(ifnphi3)

TDW:	130425819(ifnphi1) 130426410(ifnphi3)

MANU:

129423862(ifnphi3) 129436390(ifnphi1) 129436392

IPU:	108256834(ifnphi3) 108256835 108256863 128629058 128629094

IFU:	128600248 128600537 128600538 128600748 128600790 128600791

PHYP:

113546226 113546315

SMEO:

124376206 124376353(ifnphi3) 124376354 124376442

TFD:	113647893 113647895(ifnphi3) 125140175 125140186

TVC:	132863950 132863952 132864201 132864274

TRN:	134301647 134301662 134301672 134301682 134309219

AMEX:

103031198 111196927 111197617 125799275

CMAO:

118803659 118803660 118803661 118804958 118804959 118804960 118804962

EEE:	113569132 113569389 113587842 113587843

CHAR:

105912823 105912836(ifnphi1) 116221457 116224217 116224338 116224342

SPIL:

134070545 134070605 134075823 134075824 134075825 134076515 134076516(ifnphi1)

TRU:	101064747 115251511

TFS:	130519757(ifnphi1) 130539874 130539880

LCO:	109138476 109139382

TBEN:

117473858 117500071

CGOB:

115004918 115024686 115024709 115024715 115024716 115024718

PGEO:

117441935 117465098 117465100 117465104 117465108

GACU:

117547421 117547422 117547424

EMAC:

134870800 134871102 134878662(ifnphi1)

ELY:	117247002 117247636 117268730(ifnphi1)

EFO:	125880948 125880949 125880950 125880951 125880952 125880953 125881287

PLEP:

121938392 121959016 121966704

SLUC:

116035211 116055130(ifnphi1) 116061515 116061516

ECRA:

117936743(ifnphi4) 117940493

ESP:

116670973

PFLV:

114548188 114548191 114570267 114570269

GAT:	120819490 120819506 120819562 120828074(ifnphi1)

PPUG:

119212932 119212933 119220758(ifnphi1)

AFB:	129091508 129091523 129091525 129091528 129091532 129098191(ifnphi1)

CLUM:

117734698(ifnphi1) 117748853 117748885(ifnphi4)

PSWI:

130188424(ifnphi1) 130203731 130203732 130203734 130203736 130203744

CANA:

137789683(ifnphi4) 137789684 137789685 137803480(ifnphi1)

CVE:	137883990(ifnphi1)

MSAM:

119884992 119884993 119884994 119916205 119916217 119916225 119916231 119916538 119917542

SCHU:

122867615 122867624 122869125(ifnphi1)

CUD:	121528703 121528709 121529546 121529547

SPUL:

138593079 138593704 138603972 138604436

LMIX:

132954463(ifnphi1) 132954464 132955604 132955837

ALAT:

119009736 119009740 119013828 119014327

ASTR:

137588393 137609325

MZE:	101477485 101478048 106674844 106674847 112435237

ONL:	100690759 100691025 100691290 100691561 100696424 100704886 100706412 102083274 109203135 109203155 109203208 109203209 109203210 109203266 109203267 112841720 112847709 112847710

OAU:	116319382 116319383 116322724 116322793 116322795 116322798 116330609 116330610 120441501 120441502 120441503 120441504 120441525 120441526 120441527 120441528 120441529 120441530

OLA:	110014574 110017164 111946454

OML:	112153944 112154525 112154638

CSAI:

133419213 133419232 133419243 133419251

XMA:	106699651 106700431 111609837

XCO:	114151693 114151694 114152279

XHE:	116727478(ifnk) 116727593 116727594 116735419

PRET:

108167267

PFOR:

107833139 107833145 107833146 107837727 107838661

PLAI:

106934517 106964457 106964460 106964461 106964462

PMEI:

106921383 106921384 106921385 106921387 106921388 106925204

GAF:	122821861 122823089 122823091 122823475

PPRL:

129367933 129367934 129368161

CVG:

107092889

CTUL:

119782059 119791038 119791039 119791047

GMU:	124862497 124874854 124875419 124875421 124875563 124875564

NFU:	107387649 107387650

KMR:	108247211 108247218

ALIM:

106535558

NWH:

119423813

AOCE:

111570784 111570786

EJA:	138204511 138204877 138207730(ifnphi1)

BFRE:

138624465 138624466 138631380(ifnphi1)

POV:

109642673

SSEN:

122759083 122759582 122785501

HHIP:

117752524 117752526(ifnphi4) 117758149 117766140(ifnphi1)

HSP:	118099784 118100748 118100772 118100928

PPLT:

128426495 128426496 128426497 128458089(ifnphi1) 128460073

SMAU:

118287389 118287837 118288843

LCF:	108873245 108886873 108886874 108894812 127138975 127139318

SDU:	111220037 111220091

SLAL:

111656186

XGL:	120784271 120784276 120794508 120794519

SBIA:

133495998(ifnphi4) 133514304(ifnphi1)

PEE:	133414847(ifnphi1)

PTAO:

133466487(ifnphi1) 133469710(ifnphi4)

BPEC:

110154330

BSPL:

114846466

SJO:	128381469 128381470 128381471 128381473 128381474 128381876

SSCO:

133999179(ifnphi1) 134003539 134003548

SALP:

111977360 111979919 111980193 111980627 112068968 112068969 112068970 112070198 112070199 112070201 112075982(ifna16) 112075984 112075985 112075987 112075988 112076865

ELS:	105008644 105008645 105023354 105023355 105023401 106024123 106024529 109616238 114828768 114840176 114840178 114840421 114840426

SFM:	108924755 114911089

PKI:	111855896 111856010 111856012 111856795 111856801

AANG:

118215933 118216116 118217094 118221758

LOC:	102693774 107076357 107079271 107079272

PSPA:

121323949 121324007 121324185 121324186 121324187 121324196 121324208 121324212 121324348 121324899 121324900 121324901 121324902

ARUT:

117434482 117434484 117434485 117434486 117434487 117434490 117434491 117434609 117434834 117434857 117434859 117434868 117434872 117964166 117964173 117969715 117969716 117969717

LCM:	102349122 102349391

CMK:	103173021 103187738

RTP:	109937603 109937604 109937605 109937606 109937655

CPLA:

122539638 122539994 122545111 122550331

HOC:	132830747(ifnphi4) 132830748

LERI:

129710038 129710039 129710040 129710041 129710045 129710046 129710396 129710398 129710399 129710400 129710401

» show all

Reference

PMID:6157600

Authors

Mantei N, Schwarzstein M, Streuli M, Panem S, Nagata S, Weissmann C

Title

The nucleotide sequence of a cloned human leukocyte interferon cDNA.

Journal

Gene 10:1-10 (1980)
DOI:10.1016/0378-1119(80)90137-7

Sequence

[hsa:3439]

LinkDB

ORTHOLOGY: K05415

Entry

K05415                      KO

Symbol

IFNB

Name

interferon beta

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04217

Necroptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05131

Shigellosis

map05135

Yersinia infection

map05142

Chagas disease

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05415  IFNB; interferon beta
   04668 TNF signaling pathway
    K05415  IFNB; interferon beta
   04151 PI3K-Akt signaling pathway
    K05415  IFNB; interferon beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05415  IFNB; interferon beta
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05415  IFNB; interferon beta
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04621 NOD-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04622 RIG-I-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04623 Cytosolic DNA-sensing pathway
    K05415  IFNB; interferon beta
   04650 Natural killer cell mediated cytotoxicity
    K05415  IFNB; interferon beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05415  IFNB; interferon beta
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05415  IFNB; interferon beta
   05161 Hepatitis B
    K05415  IFNB; interferon beta
   05160 Hepatitis C
    K05415  IFNB; interferon beta
   05171 Coronavirus disease - COVID-19
    K05415  IFNB; interferon beta
   05164 Influenza A
    K05415  IFNB; interferon beta
   05162 Measles
    K05415  IFNB; interferon beta
   05168 Herpes simplex virus 1 infection
    K05415  IFNB; interferon beta
   05163 Human cytomegalovirus infection
    K05415  IFNB; interferon beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05415  IFNB; interferon beta
   05169 Epstein-Barr virus infection
    K05415  IFNB; interferon beta
   05165 Human papillomavirus infection
    K05415  IFNB; interferon beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05415  IFNB; interferon beta
   05135 Yersinia infection
    K05415  IFNB; interferon beta
   05152 Tuberculosis
    K05415  IFNB; interferon beta
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05415  IFNB; interferon beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05415  IFNB; interferon beta
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05415  IFNB; interferon beta
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05415  IFNB; interferon beta
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interferons
   K05415  IFNB; interferon beta

Other DBs

GO:

0005132

Genes

HSA:	3456(IFNB1)

PTR:	473183(IFNB1)

PPS:	100995851(IFNB1)

GGO:	101137136(IFNB1)

PON:	100441074(IFNB1)

PPYG:

129044486(IFNB1)

NLE:	100598986(IFNB1)

HMH:	116458843(IFNB1)

SSYN:

129490755(IFNB1)

MCC:	711414(IFNB1)

MCF:	102115670(IFNB1)

MTHB:

126937702

MNI:	105465886(IFNB1)

CSAB:

103219383(IFNB1)

CATY:

105584002(IFNB1)

PANU:

101024523(IFNB1)

TGE:	112608413(IFNB1)

MLEU:

105545746(IFNB1)

RRO:	104670295(IFNB1)

RBB:	108538565(IFNB1)

TFN:	117098642(IFNB1)

PTEH:

111526147(IFNB1)

CANG:

105503452(IFNB1)

CJC:	100388391(IFNB1)

SBQ:	101035681(IFNB1)

CIMI:

108296169(IFNB1)

ANAN:

105715622(IFNB1)

CSYR:

103260915(IFNB1)

MMUR:

105874210(IFNB1)

LCAT:

123646249(IFNB1)

PCOQ:

105827006(IFNB1)

OGA:	100959385(IFNB1)

MMU:	15977(Ifnb1)

MCAL:

110293791(Ifnb1)

MPAH:

110323346(Ifnb1)

RNO:	24481(Ifnb1)

MCOC:

116095400(Ifnb1)

ANU:	117709633(Ifnb1)

ASYL:

127679947(Ifnb1)

MUN:	110541303(Ifnb1)

CGE:	103160615(Ifnb1)

MAUA:

121144026(Ifnb1)

PROB:

127224840(Ifnb1)

PLEU:

114685139(Ifnb1)

MORG:

121447990(Ifnb1)

MFOT:

126510741

AAMP:

119816165(Ifnb1) 119817276

NGI:	103743951(Ifnb1) 103746144

HGL:	101699042(Ifnb1) 101723869

CPOC:

100733284 100734449 111757491(Ifnb1)

DORD:

105988975(Ifnb1)

DSP:	122118962(Ifnb1)

PLOP:

125352673(Ifnb1)

NCAR:

124963924 124963958 124964114 124964969 124965019

MMMA:

107156465 107156489(Ifnb1)

ITI:	101968765(Ifnb1) 101971846 101975152 101975434 101975998

OCU:

100342931

OPI:	101533318(IFNB1)

TUP:	102493858(IFNB1)

GVR:	103584029 103609847 103609850

CFA:	481558(IFNB1)

CLUD:

112650215(IFNB1)

VVP:	112921940(IFNB1)

VLG:	121494639(IFNB1)

NPO:	129494739(IFNB1)

AML:	100476556(IFNB1)

UMR:	103662150(IFNB1)

UAH:	113260295(IFNB1)

UAR:	123781031(IFNB1)

ELK:

111156577

LLV:

125083789

MPUF:

101679100(IFNB1)

MNP:	132025125(IFNB1)

MLK:	131813182(IFNB1)

NVS:	122916938(IFNB1)

ORO:	101374900(IFNB1)

EJU:	114212404(IFNB1)

ZCA:	113934419(IFNB1)

MLX:	117998994(IFNB1)

NSU:	110587130(IFNB1)

LWW:	102748842(IFNB1)

FCA:	493849(IFNB1)

PYU:

121034394

PCOO:

112849621(IFNB1)

PBG:	122474874(IFNB1)

PVIV:

125150775

LRUF:

124525672

PTG:	102960421(IFNB1)

PPAD:

109247124(IFNB1)

PUC:

125925944

AJU:

106971145

HHV:	120239877(IFNB1)

BTA:	100848709 112441471 112441480 112447877 112447878 112447879 112447880 281845(IFNB1) 517016 525550 616977 618946(IFNB3) 784525

BOM:	102280497 102281065 102282466 102284581

BIU:	109562667 109562671 109562674 109562675 109562852 109562853 109562855

BBUB:

102402056 102402367 102402697 102408434 112583883 112583884 112583885 112583886 123332785 123465588 123465589

BBIS:

104983695 104996149 105000961(IFNB1) 105000962 105000963

CHX:	102181595 102181867 102189208 108633243 108636544 108636629 108636632 108636634

OAS:	101103376 101103623 101103702 114112819 114112830 114112835 114112840 114112883 114113004 114113016 114113206 121818657

BTAX:

128052625 128052626 128052627 128052628 128052635 128052636 128052637 128052638 128052639 128052640 128052652

CSUM:

138081397(IFNB1) 138081398 138081399 138081400 138081401 138081410 138081421 138081422 138081423 138081424 138081425 138081426 138081433 138081525

ODA:	120860069 120860132 120860137 120862218 120862226 120862257

CCAD:

122453394 122453395 122453396 122453397 122453398 122453400

MREE:

136148258 136148259 136148388 136148389 136148420 136148421 136148422 136148545 136148546 136148694 136148695 136148697 136148700

MBEZ:

129557110 129557288 129557307 129557308

SSC:	445459(IFNB1)

CFR:	102513411(IFNB1)

CBAI:

105061881(IFNB1)

CDK:	105095933(IFNB1)

VPC:	102540243(IFNB1)

BACU:

103011926

BMUS:

118897323(IFNB1)

LVE:

103073772

OOR:	101289058(IFNB1)

DLE:	111174560(IFNB1)

PCAD:

102990155(IFNB1)

PSIU:

116755914(IFNB1)

NASI:

112407026(IFNB1)

ECB:	100052545(IFNB1) 100052658 100147174

EPZ:	103563147 103563148(IFNB1) 103563150

EAI:	106828272 106834164 106834179 106834202 123280255 123280293

MYB:	102261905(IFNB1)

MYD:	102765800(IFNB1)

MMYO:

118666805(IFNB1)

MLF:	102417209(IFNB1)

MDT:	132212752(IFNB1)

PKL:	118716770(IFNB1)

EFUS:

103289195(IFNB1)

MNA:	107531433(IFNB1)

DRO:	112300024(IFNB1)

SHON:

118997987 118997988 118997989 118997990

AJM:	119055662(IFNB1)

PDIC:

114512515(IFNB1)

PHAS:

123820149 123820232(IFNB1)

MMF:	118629329(IFNB1)

PPAM:

129078454(IFNB1)

HAI:	109396418(IFNB1)

RFQ:	117032413(IFNB1)

PALE:

102890512(IFNB1)

PGIG:

120605473(IFNB1)

PVP:	105309141(IFNB1)

RAY:	107518589(IFNB1)

MJV:	108402531(IFNB1)

TOD:	119231101(IFNB1)

SARA:

101548268(IFNB1)

SFUM:

130026530(IFNB1)

SETR:

126002675(IFNB1)

LAV:	100666438(IFNB1)

TMU:

101349610

ETF:	101650550(IFNB1)

DNM:	101410923(IFNB1)

MDO:	100021258(IFNB1)

GAS:

123250431

SHR:

100914443

AFZ:

127552925

PCW:	110199211 110199212 110199213 110199216 110199218

TVP:	118834723 118834733 118836026 118836153 118836347 118840459 118849866

PBRV:

138161235 138161237

OAA:	100082925(IFNB1)

GGA:	554219(IFNW1)

MGP:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106045178 125180135 125180136 136788419 136788956 136788957 136788988 136788998 136788999 136789085 136789086 136789087 136789088

CATA:

118257698 118257699 118257700 118257701 118257702 118257703 118257704 126913675 126913676

AFUL:

116500389 116500390 116500391 116500392 116501035

LSR:

SCAN:

OTC:

PRUF:

OMA:	130265549 130265550

CBRC:

108449705

ZAB:

102066024

ZLE:	135459301 135459312 135459314 135459315 135459316 135459317 135459318 135459319 135459544 135459642 135459800 135459801

ACHL:

103802741

SVG:

106865001

MMEA:

130573264 130575640

HRT:	120765091 120765092 120765093 120765094 120765095

SATI:

136373436 136373684 136373696 136373709 136373746

FPG:

101921672

NNT:

104400091

SHAB:

115619468 115619469 115619470 115619471

TALA:

122153561

ACHC:

115337094 115337096 115337097

HLE:

104827847

HHAR:

128137198 128137206 128137208 128137209 128137210 128137213 128137216 128137217 128137218 128137232 128137240

GCL:	127027303 127027304 127027305 127027306

LDI:

104350945

MNB:

103781025

PPUS:

135173522 135173563 135173564 135193079 135193110 135193182 135193225 135193251

NNI:

PCAO:

AFOR:

FGA:

MUI:

EHS:

CMAC:

CUCA:

ACAR:

CPEA:

CVF:

RTD:

AROW:

SCAM:

TVC:

Reference

PMID:16593086

Authors

Ohno S, Taniguchi T

Title

Structure of a chromosomal gene for human interferon beta.

Journal

Proc Natl Acad Sci U S A 78:5305-9 (1981)
DOI:10.1073/pnas.78.9.5305

Sequence

[hsa:3456]

LinkDB

DBGET integrated database retrieval system