KEGG   ORTHOLOGY: K08737Help
Entry
K08737                      KO                                     

Name
MSH6
Definition
DNA mismatch repair protein MSH6
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08737  MSH6; DNA mismatch repair protein MSH6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08737  MSH6; DNA mismatch repair protein MSH6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08737  MSH6; DNA mismatch repair protein MSH6
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08737  MSH6; DNA mismatch repair protein MSH6
BRITE hierarchy
Genes
HSA: 2956(MSH6)
PTR: 459218(MSH6)
PPS: 100986695(MSH6)
GGO: 101148740(MSH6)
PON: 100458732(MSH6)
NLE: 100593553(MSH6)
MCC: 715701(MSH6)
MCF: 102143419(MSH6)
CSAB: 103220318(MSH6)
RRO: 104663162(MSH6)
RBB: 108527513(MSH6)
CJC: 100386465(MSH6)
SBQ: 101039649(MSH6)
MMU: 17688(Msh6)
MCAL: 110284330(Msh6)
MPAH: 110335576(Msh6)
RNO: 100360342(Msh6)
MUN: 110561037(Msh6)
CGE: 100771087(Msh6)
NGI: 103725738(Msh6)
HGL: 101708261(Msh6)
CCAN: 109691597(Msh6)
OCU: 100351645(MSH6)
TUP: 102476727(MSH6)
CFA: 474585(MSH6)
VVP: 112915230(MSH6)
AML: 100471984(MSH6)
UMR: 103671242(MSH6)
UAH: 113245929(MSH6)
ORO: 101368929(MSH6)
FCA: 101082303(MSH6)
PTG: 102953993(MSH6)
AJU: 106977218(MSH6)
BTA: 540526(MSH6)
BOM: 102269162(MSH6)
BIU: 109566061(MSH6)
BBUB: 102409894(MSH6)
PHD: 102321074(MSH6)
CHX: 102173474(MSH6)
OAS: 101107426(MSH6)
SSC: 100624450(MSH6)
CFR: 102513599(MSH6)
CDK: 105092358(MSH6)
BACU: 102999040(MSH6)
LVE: 103089181(MSH6)
OOR: 101271574(MSH6)
DLE: 111174785(MSH6)
PCAD: 102994456(MSH6)
ECB: 100068065(MSH6)
EPZ: 103558461(MSH6)
EAI: 106825979(MSH6)
MYB: 102245110(MSH6)
MYD: 102755448(MSH6)
MNA: 107544300(MSH6)
HAI: 109389905(MSH6)
RSS: 109456360(MSH6)
DRO: 112297935(MSH6)
PALE: 102892999(MSH6)
RAY: 107509550(MSH6)
LAV: 100677382(MSH6)
TMU: 101345932
MDO: 100033356(MSH6)
SHR: 100919645(MSH6)
PCW: 110218568(MSH6)
OAA: 103168521(MSH6)
GGA: 421291(MSH6)
MGP: 100541959(MSH6)
CJO: 107310861(MSH6)
NMEL: 110396244(MSH6)
APLA: 101799348(MSH6)
ACYG: 106043138(MSH6)
TGU: 100227810(MSH6)
LSR: 110475791(MSH6)
SCAN: 103819208(MSH6)
GFR: 102033560(MSH6)
FAB: 101815194(MSH6)
PHI: 102104034(MSH6)
PMAJ: 107201864(MSH6)
CCAE: 111926311(MSH6)
CCW: 104685591(MSH6)
ETL: 114060404(MSH6)
FPG: 101921710(MSH6)
FCH: 102051882(MSH6)
CLV: 102090300(MSH6)
EGZ: 104134625(MSH6)
NNI: 104018105(MSH6)
ACUN: 113478822(MSH6)
PADL: 103924992(MSH6)
AAM: 106490408(MSH6)
ASN: 102388051(MSH6)
AMJ: 102573895(MSH6)
PSS: 102456308(MSH6)
CMY: 102943356(MSH6)
CPIC: 101951836(MSH6)
ACS: 100562407(msh6)
PVT: 110079554(MSH6)
PBI: 103056083(MSH6)
PMUR: 107290122(MSH6)
GJA: 107124261(MSH6)
XLA: 734294(msh6.L)
XTR: 100145639(msh6)
NPR: 108787598(MSH6)
DRE: 260437(msh6)
SANH: 107679164(msh6) 107688801
SGH: 107588437
IPU: 108263456(msh6)
PHYP: 113542145(msh6)
AMEX: 103027666(msh6)
EEE: 113588072(msh6)
TRU: 101079280(msh6)
LCO: 104918635(msh6)
NCC: 104951340(msh6)
MZE: 101470032(msh6)
OLA: 101160935(msh6)
XMA: 102229772(msh6)
XCO: 114137762(msh6)
PRET: 103477050(msh6)
NFU: 107375752(msh6)
KMR: 108234081(msh6)
AOCE: 111567184(msh6)
CSEM: 103387561(msh6)
POV: 109632657(msh6)
LCF: 108894383(msh6)
SDU: 111220543(msh6)
HCQ: 109516232(msh6)
BPEC: 110157016(msh6)
MALB: 109961974(msh6)
SASA: 106589736(msh6)
OTW: 112224594(msh6)
SALP: 111968060(msh6)
ELS: 105028409(msh6)
SFM: 108918060(msh6)
PKI: 111848812(msh6)
LCM: 102366015(MSH6)
CMK: 103180839(msh6)
CIN: 100185806
SPU: 593059
APLC: 110987988
SKO: 102805174
DME: Dmel_CG7003(Msh6)
DER: 6544520
DPE: 6596937
DSI: Dsimw501_GD12570(Dsim_GD12570)
DWI: 6645793
DAZ: 108613429
DNV: 108651428
DHE: 111595124
MDE: 101889577
LCQ: 111685162
AAG: 5575374
AME: 408815
BIM: 100745752
BTER: 100647842
SOC: 105205867
MPHA: 105831306
AEC: 105147089
ACEP: 105623738
PBAR: 105431572
VEM: 105565711
HST: 105183383
DQU: 106742167
CFO: 105255559
LHU: 105677715
PGC: 109859322
OBO: 105281412
PCF: 106789002
NVI: 100115613(Msh6)
TCA: 660174
DPA: 109543134
NVL: 108567736
BMOR: 101744671
PRAP: 110993015
TNL: 113499169
API: 100166946
DNX: 107173209
AGS: 114122759
BTAB: 109039982
CLEC: 106668181
ZNE: 110831875
FCD: 110851254
TUT: 107364943
CEL: CELE_Y47G6A.11(msh-6)
CBR: CBG14959(Cbr-msh-6)
BMY: Bm1_41770
PCAN: 112561418
CRG: 105344641
OBI: 106880162
LAK: 106155648
SHX: MS3_02714
EGL: EGR_01292
EPA: 110241459
PDAM: 113669812
SPIS: 111338428
AQU: 100631829
ATH: AT3G24495(MSH7) AT4G02070(MSH6)
LJA: Lj1g3v0246860.1(Lj1g3v0246860.1) Lj1g3v4862830.1(Lj1g3v4862830.1) Lj1g3v4862840.1(Lj1g3v4862840.1) Lj2g3v0777050.1(Lj2g3v0777050.1) Lj2g3v0777050.2(Lj2g3v0777050.2)
VVI: 100255608 100260983(MSH7)
CANN: 107877977
DOSA: Os01t0180600-01(Os01g0180600) Os09t0407600-01(Os09g0407600)
ATS: 109772035(LOC109772035) 109786772(LOC109786772)
APRO: F751_5249
SCE: YDR097C(MSH6)
ERC: Ecym_3519
KMX: KLMA_30293(MSH6)
NCS: NCAS_0B03980(NCAS0B03980)
NDI: NDAI_0J01520(NDAI0J01520)
TPF: TPHA_0B03370(TPHA0B03370)
TBL: TBLA_0F03840(TBLA0F03840)
TDL: TDEL_0A01290(TDEL0A01290)
KAF: KAFR_0A02370(KAFR0A02370)
PIC: PICST_81012(MSH6)
CAL: CAALFM_C113170CA(MSH6)
SLB: AWJ20_1503(MSH6)
NCR: NCU08135(msh6)
NTE: NEUTE1DRAFT124150(NEUTE1DRAFT_124150)
SMP: SMAC_03612(putative msh56)
MGR: MGG_00704
SSCK: SPSK_02949
MAW: MAC_02355
MAJ: MAA_06876
CMT: CCM_06095
BFU: BCIN_01g04490(Bcmsh6)
MBE: MBM_04714
ANI: AN1708.2
ANG: ANI_1_590184(An04g03050)
ABE: ARB_00228
TVE: TRV_05220
PTE: PTT_11611
SPO: SPCC285.16c(msh6)
CNE: CNK02590
CNB: CNBK0960
ABP: AGABI1DRAFT78171(AGABI1DRAFT_78171)
ABV: AGABI2DRAFT207943(AGABI2DRAFT_207943)
MGL: MGL_2919
DDI: DDB_G0268614(msh6)
DFA: DFA_09956(msh6)
EHI: EHI_193340(139.t00016)
PYO: PY17X_1106200(PY02936)
PCB: PCHAS_110480(PC000601.02.0)
TAN: TA19305
TPV: TP01_0185
BBO: BBOV_I004430(19.m02191)
CPV: cgd8_370
SMIN: v1.2.026874.t1(symbB.v1.2.026874.t1) v1.2.039566.t1(symbB.v1.2.039566.t1)
FCY: FRACYDRAFT_212924(MSH6)
TPS: THAPSDRAFT_261781(MutS)
SPAR: SPRG_05442
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC
  Title
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
  Journal
Oncogene 23:3749-56 (2004)
DOI:10.1038/sj.onc.1207462
  Sequence
[hsa:2956]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YDR097C]
LinkDB All DBs

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