KEGG   ORTHOLOGY: K08737
Entry
K08737                      KO                                     

Name
MSH6
Definition
DNA mismatch repair protein MSH6
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08737  MSH6; DNA mismatch repair protein MSH6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08737  MSH6; DNA mismatch repair protein MSH6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08737  MSH6; DNA mismatch repair protein MSH6
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08737  MSH6; DNA mismatch repair protein MSH6
Genes
HSA: 2956(MSH6)
PTR: 459218(MSH6)
PPS: 100986695(MSH6)
GGO: 101148740(MSH6)
PON: 100458732(MSH6)
NLE: 100593553(MSH6)
MCC: 715701(MSH6)
MCF: 102143419(MSH6)
CSAB: 103220318(MSH6)
RRO: 104663162(MSH6)
RBB: 108527513(MSH6)
CJC: 100386465(MSH6)
SBQ: 101039649(MSH6)
MMU: 17688(Msh6)
MCAL: 110284330(Msh6)
MPAH: 110335576(Msh6)
RNO: 100360342(Msh6)
MUN: 110561037(Msh6)
CGE: 100771087(Msh6)
NGI: 103725738(Msh6)
HGL: 101708261(Msh6)
CCAN: 109691597(Msh6)
OCU: 100351645(MSH6)
TUP: 102476727(MSH6)
CFA: 474585(MSH6)
VVP: 112915230(MSH6)
AML: 100471984(MSH6)
UMR: 103671242(MSH6)
UAH: 113245929(MSH6)
ORO: 101368929(MSH6)
ELK: 111148106
FCA: 101082303(MSH6)
PTG: 102953993(MSH6)
PPAD: 109247090(MSH6)
AJU: 106977218(MSH6)
BTA: 540526(MSH6)
BOM: 102269162(MSH6)
BIU: 109566061(MSH6)
BBUB: 102409894(MSH6)
CHX: 102173474(MSH6)
OAS: 101107426(MSH6)
SSC: 100624450(MSH6)
CFR: 102513599(MSH6)
CDK: 105092358(MSH6)
BACU: 102999040(MSH6)
LVE: 103089181(MSH6)
OOR: 101271574(MSH6)
DLE: 111174785(MSH6)
PCAD: 102994456(MSH6)
ECB: 100068065(MSH6)
EPZ: 103558461(MSH6)
EAI: 106825979(MSH6)
MYB: 102245110(MSH6)
MYD: 102755448(MSH6)
MNA: 107544300(MSH6)
HAI: 109389905(MSH6)
DRO: 112297935(MSH6)
PALE: 102892999(MSH6)
RAY: 107509550(MSH6)
MJV: 108394002(MSH6)
LAV: 100677382(MSH6)
TMU: 101345932
MDO: 100033356(MSH6)
SHR: 100919645(MSH6)
PCW: 110218568(MSH6)
OAA: 103168521(MSH6)
GGA: 421291(MSH6)
MGP: 100541959(MSH6)
CJO: 107310861(MSH6)
NMEL: 110396244(MSH6)
APLA: 101799348(MSH6)
ACYG: 106043138(MSH6)
TGU: 100227810(MSH6)
LSR: 110475791(MSH6)
SCAN: 103819208(MSH6)
GFR: 102033560(MSH6)
FAB: 101815194(MSH6)
PHI: 102104034(MSH6)
PMAJ: 107201864(MSH6)
CCAE: 111926311(MSH6)
CCW: 104685591(MSH6)
ETL: 114060404(MSH6)
FPG: 101921710(MSH6)
FCH: 102051882(MSH6)
CLV: 102090300(MSH6)
EGZ: 104134625(MSH6)
NNI: 104018105(MSH6)
ACUN: 113478822(MSH6)
PADL: 103924992(MSH6)
AAM: 106490408(MSH6)
ASN: 102388051(MSH6)
AMJ: 102573895(MSH6)
PSS: 102456308(MSH6)
CMY: 102943356(MSH6)
CPIC: 101951836(MSH6)
ACS: 100562407(msh6)
PVT: 110079554(MSH6)
PBI: 103056083(MSH6)
PMUR: 107290122(MSH6)
TSR: 106541523(MSH6)
PMUA: 114594849(MSH6)
GJA: 107124261(MSH6)
XLA: 734294(msh6.L)
XTR: 100145639(msh6)
NPR: 108787598(MSH6)
DRE: 260437(msh6)
SRX: 107725009
SANH: 107679164(msh6)
SGH: 107588437
IPU: 108263456(msh6)
PHYP: 113542145(msh6)
AMEX: 103027666(msh6)
EEE: 113588072(msh6)
TRU: 101079280(msh6)
LCO: 104918635(msh6)
NCC: 104951340(msh6)
MZE: 101470032(msh6)
ONL: 100710916(msh6)
OLA: 101160935(msh6)
XMA: 102229772(msh6)
XCO: 114137762(msh6)
PRET: 103477050(msh6)
CVG: 107089290(msh6)
NFU: 107375752(msh6)
KMR: 108234081(msh6)
ALIM: 106532862(msh6)
AOCE: 111567184(msh6)
CSEM: 103387561(msh6)
POV: 109632657(msh6)
LCF: 108894383(msh6)
SDU: 111220543(msh6)
SLAL: 111659027(msh6)
HCQ: 109516232(msh6)
BPEC: 110157016(msh6)
MALB: 109961974(msh6)
SASA: 106589736(msh6)
OTW: 112224594(msh6)
SALP: 111968060(msh6)
ELS: 105028409(msh6)
SFM: 108918060(msh6)
PKI: 111848812(msh6)
LCM: 102366015(MSH6)
CMK: 103180839(msh6)
RTP: 109919222
BFO: 118404634
CIN: 100185806
SPU: 593059
APLC: 110987988
SKO: 102805174
DME: Dmel_CG7003(Msh6)
DER: 6544520
DSE: 6605754
DSI: Dsimw501_GD12570(Dsim_GD12570)
DAN: 6493604
DSR: 110176127
DPE: 6596937
DMN: 108151407
DWI: 6645793
DAZ: 108613429
DNV: 108651428
DHE: 111595124
DVI: 6623428
MDE: 101889577
LCQ: 111685162
AAG: 5575374
AALB: 109414186
AME: 408815
BIM: 100745752
BTER: 100647842
CCAL: 108625901
OBB: 114872506
SOC: 105205867
MPHA: 105831306
AEC: 105147089
ACEP: 105623738
PBAR: 105431572
VEM: 105565711
HST: 105183383
DQU: 106742167
CFO: 105255559
LHU: 105677715
PGC: 109859322
OBO: 105281412
PCF: 106789002
NVI: 100115613
CSOL: 105362758
TCA: 660174
DPA: 109543134
ATD: 109596295
NVL: 108567736
BMOR: 101744671
BMAN: 114249524
PMAC: 106709764
PRAP: 110993015
HAW: 110379891
TNL: 113499169
API: 100166946
DNX: 107173209
AGS: 114122759
BTAB: 109039982
CLEC: 106668181
ZNE: 110831875
FCD: 110851254
PVM: 113803547
TUT: 107364943
DPTE: 113790436
CSCU: 111620331
PTEP: 107448365
CEL: CELE_Y47G6A.11(msh-6)
CBR: CBG14959(Cbr-msh-6)
BMY: Bm1_41770
TSP: Tsp_09358
PCAN: 112561418
CRG: 105344641
MYI: 110458103
OBI: 106880162
LAK: 106155648
SHX: MS3_02714
EGL: EGR_01292
NVE: 5518402
EPA: 110241459
AMIL: 114963837
PDAM: 113669812
SPIS: 111338428
DGT: 114528604
HMG: 100209507
AQU: 100631829
ATH: AT3G24495(MSH7) AT4G02070(MSH6)
LJA: Lj1g3v0246860.1(Lj1g3v0246860.1) Lj2g3v0777050.1(Lj2g3v0777050.1)
AIP: 107646082
VVI: 100255608 100260983(MSH7)
CANN: 107877977
DOSA: Os01t0180600-01(Os01g0180600) Os09t0407600-01(Os09g0407600)
ATS: 109772035(LOC109772035) 109786772(LOC109786772)
MNG: MNEG_2780
APRO: F751_5249
SCE: YDR097C(MSH6)
ERC: Ecym_3519
KMX: KLMA_30293(MSH6)
NCS: NCAS_0B03980(NCAS0B03980)
NDI: NDAI_0J01520(NDAI0J01520)
TPF: TPHA_0B03370(TPHA0B03370)
TBL: TBLA_0F03840(TBLA0F03840)
TDL: TDEL_0A01290(TDEL0A01290)
KAF: KAFR_0A02370(KAFR0A02370)
PIC: PICST_81012(MSH6)
CAL: CAALFM_C113170CA(MSH6)
SLB: AWJ20_1503(MSH6)
NCR: NCU08135(msh6)
NTE: NEUTE1DRAFT124150(NEUTE1DRAFT_124150)
SMP: SMAC_03612(putative msh56)
MGR: MGG_00704
SSCK: SPSK_02949
MAW: MAC_02355
MAJ: MAA_06876
CMT: CCM_06095
BFU: BCIN_01g04490(Bcmsh6)
MBE: MBM_04714
ANI: AN1708.2
ANG: ANI_1_590184(An04g03050)
ABE: ARB_00228
TVE: TRV_05220
PTE: PTT_11611
SPO: SPCC285.16c(msh6)
CNE: CNK02590
CNB: CNBK0960
TASA: A1Q1_04720
ABP: AGABI1DRAFT78171(AGABI1DRAFT_78171)
ABV: AGABI2DRAFT207943(AGABI2DRAFT_207943)
MGL: MGL_2919
MRT: MRET_3520
DDI: DDB_G0268614(msh6)
DFA: DFA_09956(msh6)
EHI: EHI_193340(139.t00016)
PCB: PCHAS_110480(PC000601.02.0)
TAN: TA19305
TPV: TP01_0185
BBO: BBOV_I004430(19.m02191)
CPV: cgd8_370
SMIN: v1.2.026874.t1(symbB.v1.2.026874.t1)
FCY: FRACYDRAFT_212924(MSH6)
TPS: THAPSDRAFT_261781(MutS)
SPAR: SPRG_05442
 » show all
Reference
  Authors
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC
  Title
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
  Journal
Oncogene 23:3749-56 (2004)
DOI:10.1038/sj.onc.1207462
  Sequence
[hsa:2956]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YDR097C]
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